Ptgs1 (prostaglandin-endoperoxide synthase 1) - Rat Genome Database

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Gene: Ptgs1 (prostaglandin-endoperoxide synthase 1) Rattus rattus
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Symbol: Ptgs1
Name: prostaglandin-endoperoxide synthase 1
RGD ID: 625904031
Description: ENCODES a protein that exhibits oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen (ortholog); peroxidase activity (ortholog); prostaglandin-endoperoxide synthase activity (ortholog); INVOLVED IN cyclooxygenase pathway (ortholog); learning (ortholog); maintenance of blood-brain barrier (ortholog); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); Anaphylaxis (ortholog); autism spectrum disorder (ortholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulum lumen (ortholog); nuclear envelope (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: prostaglandin G/H synthase 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Rrattus_CSIRO_v1 - Rrattus_CSIRO_v1 Assembly
Position:
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1513,224,081 - 13,245,665 (-)NCBIRrattus_CSIRO_v1



Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acetylsalicylic acid pharmacodynamics pathway  (ISO)
antipyrine drug pathway  (ISO)
arachidonic acid metabolic pathway  (ISO)
celecoxib pharmacodynamics pathway  (ISO)
celecoxib pharmacokinetics pathway   (ISO)
cyclooxygenase mediated pathway of arachidonic acid metabolism  (ISO)
diclofenac pharmacodynamics pathway  (ISO)
diflunisal pharmacodynamics pathway  (ISO)
etodolac pharmacodynamics pathway  (ISO)
etoposide pharmacodynamics pathway  (ISO)
etoposide pharmacokinetics pathway  (ISO)
fenoprofen pharmacodynamics pathway  (ISO)
flurbiprofen pharmacodynamics pathway  (ISO)
ibuprofen pharmacodynamics pathway  (ISO)
ibuprofen pharmacokinetics pathway  (ISO)
indometacin pharmacodynamics pathway  (ISO)
indometacin pharmacodynamics pathway  (ISO)
ketoprofen pharmacodynamics pathway  (ISO)
ketorolac pharmacodynamics pathway  (ISO)
leukotriene C4 synthase deficiency pathway  (ISO)
lornoxicam pharmacodynamics pathway  (ISO)
magnesium salicylate pharmacodynamics pathway  (ISO)
mefenamic acid pharmacodynamics pathway  (ISO)
meloxicam pharmacodynamics pathway  (ISO)
nabumetone pharmacodynamics pathway  (ISO)
naproxen pharmacodynamics pathway   (ISO)
paracetamol drug pathway  (ISO)
piroxicam pharmacodynamics pathway   (ISO)
prostanoid biosynthetic pathway  (ISO)
salicylic acid pharmacodynamics pathway  (ISO)
sodium salicylate pharmacodynamics pathway  (ISO)
sulindac pharmacodynamics pathway  (ISO)
tenoxicam pharmacodynamics pathway  (ISO)
tiaprofenic acid pharmacodynamics pathway  (ISO)
tolmetin pharmacodynamics pathway  (ISO)
valdecoxib pharmacodynamics pathway  (ISO)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Ptgs1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1513,224,081 - 13,245,665 (-)NCBIRrattus_CSIRO_v1
PTGS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389122,370,533 - 122,395,703 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9122,370,530 - 122,395,705 (+)Ensemblhg38GRCh38
GRCh379125,132,812 - 125,157,982 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369124,173,050 - 124,197,802 (+)NCBIBuild 36Build 36hg18NCBI36
Build 349122,212,782 - 122,237,535NCBI
Celera995,781,549 - 95,806,298 (+)NCBICelera
Cytogenetic Map9q33.2NCBI
HuRef994,747,532 - 94,772,698 (+)NCBIHuRef
CHM1_19125,280,871 - 125,306,038 (+)NCBICHM1_1
T2T-CHM13v2.09134,568,002 - 134,593,163 (+)NCBIT2T-CHM13v2.0
Ptgs1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39236,106,758 - 36,142,287 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl236,120,438 - 36,142,284 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38236,216,742 - 36,258,593 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl236,230,426 - 36,252,272 (+)Ensemblmm10GRCm38
MGSCv37236,085,946 - 36,107,789 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36236,052,536 - 36,074,271 (+)NCBIMGSCv36mm8
Celera235,934,252 - 35,956,092 (+)NCBICelera
Cytogenetic Map2BNCBI
cM Map224.19NCBI
Ptgs1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8339,981,419 - 40,002,993 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl339,981,415 - 40,002,990 (+)EnsemblGRCr8
mRatBN7.2319,584,015 - 19,605,589 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl319,584,015 - 19,605,586 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx322,661,928 - 22,683,470 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0331,246,853 - 31,268,395 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0329,494,672 - 29,516,226 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0315,560,685 - 15,582,339 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl315,560,712 - 15,582,344 (+)Ensemblrn6Rnor6.0
Rnor_5.0320,869,915 - 20,891,512 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4315,343,832 - 15,365,412 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera314,295,836 - 14,317,392 (+)NCBICelera
RGSC_v3.1315,240,203 - 15,261,784 (+)NCBI
Cytogenetic Map3p11NCBI
Ptgs1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554195,678,694 - 5,699,305 (-)Ensembl
ChiLan1.0NW_0049554195,678,750 - 5,699,305 (-)NCBIChiLan1.0ChiLan1.0
PTGS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21116,953,759 - 16,975,988 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1916,953,703 - 16,978,307 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0993,495,365 - 93,517,557 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19121,837,095 - 121,859,283 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9121,837,095 - 121,859,283 (+)EnsemblpanPan2panpan1.1
PTGS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1960,195,118 - 60,216,847 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl960,195,124 - 60,216,819 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha959,390,579 - 59,412,227 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0961,110,468 - 61,132,351 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl961,110,470 - 61,132,343 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1959,884,516 - 59,906,289 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0960,200,281 - 60,222,098 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0960,289,919 - 60,311,671 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ptgs1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947190,976,385 - 190,990,294 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648710,745,327 - 10,758,823 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648710,745,465 - 10,758,812 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTGS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1262,456,155 - 262,483,035 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11262,456,106 - 262,482,159 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21294,753,789 - 294,779,835 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTGS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11217,195,403 - 17,218,450 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1217,192,628 - 17,218,315 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603525,831,631 - 25,856,861 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptgs1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476012,915,206 - 12,937,824 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476012,917,244 - 12,937,858 (-)NCBIHetGla 1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_032903168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAAIVD010000023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: XM_032903168   ⟹   XP_032759059
Type: CODING
Position:
Black Rat AssemblyChrPosition (strand)Source
Rrattus_CSIRO_v1513,224,081 - 13,245,665 (-)NCBI
Protein Sequences
Protein RefSeqs XP_032759059 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_032759059   ⟸   XM_032903168


Additional Information

Database Acc Id Source(s)
NCBI Gene Ptgs1 ENTREZGENE