Ddit3 (DNA-damage inducible transcript 3) - Rat Genome Database

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Gene: Ddit3 (DNA-damage inducible transcript 3) Mus musculus
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Symbol: Ddit3
Name: DNA-damage inducible transcript 3
RGD ID: 62396
MGI Page MGI
Description: Enables several functions, including DNA-binding transcription factor binding activity; protein heterodimerization activity; and transcription regulator activator activity. Involved in several processes, including blood vessel development; intracellular signal transduction; and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including ER overload response; calcium ion import; and diaphragm contraction. Located in late endosome and nucleus. Part of CHOP-C/EBP complex. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in myxoid liposarcoma. Orthologous to human DDIT3 (DNA damage inducible transcript 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AltDDIT3; alternative DDIT3 proteins; C/EBP homoologous protein 10; C/EBP zeta; c/EBP-homologous protein 10; CCAAT/enhancer-binding protein homologous protein; ch; chop; CHOP-; CHOP-10; CHOP10; DDIT-3; DNA damage-inducible transcript 3 protein; gadd15; gadd153; growth arrest and DNA-damage-inducible protein GADD153
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910127,126,662 - 127,132,160 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10127,126,698 - 127,129,622 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm39 Ensembl10127,126,643 - 127,132,157 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3810127,290,793 - 127,296,291 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10127,290,829 - 127,293,753 (+)Ensemblmm10GRCm38
GRCm38.p6 Ensembl10127,290,774 - 127,296,288 (+)Ensemblmm10GRCm38
MGSCv3710126,727,849 - 126,733,344 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3610126,693,759 - 126,699,235 (+)NCBIMGSCv36mm8
Celera10129,683,104 - 129,688,599 (+)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1074.5NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(+)-schisandrin B  (ISO)
(+)-Tetrandrine  (ISO)
(-)-anisomycin  (ISO)
(-)-citrinin  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-gambogic acid  (ISO)
(-)-quinic acid  (ISO)
(20S)-ginsenoside Rg3  (EXP,ISO)
(E)-thiamethoxam  (EXP)
(R)-lipoic acid  (EXP,ISO)
(R)-noradrenaline  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(R,S)-Scoulerine  (ISO)
(S)-amphetamine  (EXP)
(S)-colchicine  (ISO)
(S)-nicotine  (EXP,ISO)
(Z)-3-butylidenephthalide  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
1,4-dithiothreitol  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP,ISO)
1-naphthyl isothiocyanate  (ISO)
1-nitropyrene  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
15-acetyldeoxynivalenol  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
1H-pyrazole  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4,6-trinitrotoluene  (ISO)
2,4-D  (EXP)
2,4-diaminotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dichlorophenol  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,5-dimethylcelecoxib  (ISO)
2,6-dinitrotoluene  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-arachidonoylglycerol  (ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (EXP)
2-butoxyethanol  (EXP)
2-deoxy-D-glucose  (ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
2-tert-butylhydroquinone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,3'-diindolylmethane  (ISO)
3,4-dihydrocoumarin  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3-acetyldeoxynivalenol  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (ISO)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester  (ISO)
4-nitrophenol  (EXP)
4-phenylbutylamine  (EXP)
4-phenylbutyric acid  (EXP,ISO)
4-phenylcoumarin  (EXP)
5-(N,N-hexamethylene)amiloride  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-Methoxyflavone  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
[6]-Shogaol  (ISO)
acetaldehyde  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (ISO)
aconitic acid  (EXP,ISO)
acrolein  (EXP,ISO)
acrylamide  (ISO)
acrylonitrile  (EXP,ISO)
actinomycin D  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
agomelatine  (ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
Alisol B  (ISO)
all-trans-retinal  (ISO)
all-trans-retinoic acid  (EXP,ISO)
allopurinol  (ISO)
alloxan  (EXP)
Aloe emodin  (ISO)
alpha-(methylamino)isobutyric acid  (EXP)
alpha-D-galactose  (ISO)
alpha-naphthoflavone  (EXP)
aluminium sulfate (anhydrous)  (EXP)
AM-251  (ISO)
amiloride  (EXP)
amino acid  (EXP)
amiodarone  (EXP,ISO)
ammonium chloride  (ISO)
Ammothamnine  (ISO)
amosite asbestos  (ISO)
amphibole asbestos  (ISO)
amphotericin B  (ISO)
anandamide  (EXP,ISO)
andrographolide  (ISO)
aniline  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimony trichloride  (EXP)
antimony(0)  (EXP)
antimycin A  (EXP,ISO)
antirheumatic drug  (ISO)
apigenin  (EXP)
arachidonyl-2'-chloroethylamide  (EXP)
Archazolid B  (ISO)
arecoline  (EXP)
aristolochic acid A  (ISO)
arsane  (EXP,ISO)
arsenic acid  (ISO)
arsenic atom  (EXP,ISO)
arsenic trichloride  (EXP)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
atazanavir sulfate  (ISO)
atrazine  (EXP,ISO)
auraptene  (ISO)
Auriculasin  (ISO)
Aurin  (ISO)
avermectin  (ISO)
azathioprine  (ISO)
azoxystrobin  (ISO)
baicalein  (ISO)
BAPTA  (EXP,ISO)
Bardoxolone methyl  (ISO)
benomyl  (ISO)
benzalkonium chloride  (ISO)
benzene  (EXP)
benzene-1,2,4-triol  (ISO)
benzethonium chloride  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP,ISO)
Benzo[ghi]perylene  (ISO)
bepridil  (ISO)
beta-cyclodextrin  (ISO)
beta-D-glucosamine  (EXP,ISO)
beta-lapachone  (ISO)
betulinic acid  (EXP,ISO)
bexarotene  (ISO)
bilirubin IXalpha  (EXP,ISO)
biphenyl-4-amine  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (ISO)
bongkrekic acid  (ISO)
boric acid  (ISO)
borrelidin  (ISO)
bortezomib  (EXP,ISO)
brefeldin A  (EXP,ISO)
brequinar  (ISO)
Brevetoxin B  (ISO)
bromoacetate  (ISO)
bromobenzene  (ISO)
bufalin  (ISO)
Bufotalin  (ISO)
busulfan  (EXP)
butanal  (ISO)
butylated hydroxyanisole  (EXP)
Butylbenzyl phthalate  (EXP)
Butylparaben  (EXP,ISO)
butyric acid  (ISO)
C.I. Natural Red 20  (ISO)
cadmium acetate  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
Calcimycin  (EXP,ISO)
calcitriol  (ISO)
calcium carbonate  (ISO)
camptothecin  (ISO)
canagliflozin  (ISO)
cannabidiol  (EXP,ISO)
Cannabidivarin  (ISO)
cantharidin  (ISO)
capsaicin  (ISO)
capsazepine  (ISO)
captan  (EXP,ISO)
carbamazepine  (ISO)
carbaryl  (ISO)
carbon atom  (ISO)
carbon nanotube  (EXP,ISO)
carboplatin  (ISO)
carboxy-PTIO  (EXP,ISO)
carfilzomib  (ISO)
casticin  (EXP)
celastrol  (ISO)
celecoxib  (ISO)
ceruletide  (EXP)
chenodeoxycholic acid  (ISO)
chlormequat chloride  (ISO)
chloroacetaldehyde  (ISO)
chloroacetic acid  (EXP)
Chloroacetonitrile  (EXP)
chloroform  (ISO)
chlorogenic acid  (ISO)
chloropicrin  (ISO)
chloroquine  (EXP,ISO)
chlorotoluron  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (EXP)
cholesterol  (EXP)
cholic acid  (EXP)
choline  (EXP,ISO)
chromium atom  (ISO)
chromium(6+)  (ISO)
chrysazin  (ISO)
chrysophanol  (ISO)
cibenzoline  (ISO)
cidofovir anhydrous  (ISO)
ciglitazone  (ISO)
cimetidine  (EXP)
cisplatin  (EXP,ISO)
clodronic acid  (ISO)
clofibrate  (EXP)
cobalt atom  (EXP,ISO)
cobalt dichloride  (ISO)
cobicistat  (EXP)
cocaine  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
corilagin  (EXP)
corticosterone  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (ISO)
curcumin  (EXP,ISO)
cyanocob(III)alamin  (EXP,ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cyfluthrin  (ISO)
cylindrospermopsin  (ISO)
D-cycloserine  (ISO)
D-glucose  (EXP,ISO)
D-mannopyranose  (ISO)
D-penicillamine  (ISO)
dantrolene  (EXP,ISO)
dapagliflozin  (ISO)
DDE  (ISO)
deguelin  (ISO)
demethoxycurcumin  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (EXP,ISO)
desferrioxamine B  (ISO)
desipramine  (ISO)
dexamethasone  (EXP,ISO)
Di-n-octyl phthalate  (EXP)
diarsenic trioxide  (EXP,ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (EXP)
Dibromoacetonitrile  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (ISO)
diclofenac  (EXP,ISO)
dicrotophos  (ISO)
Didecyldimethylammonium  (ISO)
dieldrin  (ISO)
diethyl malate  (ISO)
diethyl maleate  (ISO)
diethyl phthalate  (EXP)
diethylstilbestrol  (ISO)
dihydroartemisinin  (ISO)
dihydrocapsaicin  (ISO)
dihydroxyacetone  (ISO)
Diisodecyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dimethyl sulfoxide  (ISO)
dimethyl-(phenylmethyl)-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethyl]ammonium  (ISO)
dimethylarsinic acid  (ISO)
dimethylarsinous acid  (ISO)
Dinitramine  (EXP)
dinophysistoxin 1  (ISO)
dioxygen  (EXP,ISO)
diquat  (EXP)
disodium selenite  (ISO)
disulfiram  (ISO)
diuron  (ISO)
dorsomorphin  (EXP,ISO)
doxazosin  (EXP)
doxorubicin  (EXP,ISO)
duvoglustat  (ISO)
echinacoside  (ISO)
efavirenz  (ISO)
elaidic acid  (ISO)
elemental carbon  (ISO)
emodin  (ISO)
empagliflozin  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
erastin  (EXP,ISO)
erlotinib hydrochloride  (EXP,ISO)
erythromycin estolate  (ISO)
esketamine  (ISO)
etacrynic acid  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
ethylene glycol  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP,ISO)
EUK-134  (ISO)
Evodiamine  (ISO)
excitatory amino acid agonist  (EXP)
fangchinoline  (ISO)
fenofibrate  (ISO)
fenpyroximate  (ISO)
ferric oxide  (EXP)
ferrostatin-1  (EXP,ISO)
fisetin  (ISO)
flavokawain B  (ISO)
flavonoids  (ISO)
flufenoxuron  (EXP)
fluoranthene  (EXP)
flutamide  (EXP,ISO)
folic acid  (EXP,ISO)
folpet  (EXP)
fomepizole  (EXP)
formaldehyde  (ISO)
fructose  (ISO)
fumonisin B1  (ISO)
furan  (EXP,ISO)
furazolidone  (ISO)
furosemide  (EXP)
gadolinium atom  (EXP)
gadolinium trichloride  (ISO)
galactose  (ISO)
gedunin  (ISO)
genistein  (ISO)
gentamycin  (EXP,ISO)
geraniol  (ISO)
ginsenoside Re  (ISO)
ginsenoside Rg1  (ISO)
glafenine  (ISO)
glucose  (EXP,ISO)
glutathione  (EXP,ISO)
glycine  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
graphite  (ISO)
GSK-J4  (ISO)
GSK2656157  (EXP,ISO)
Guanabenz  (EXP,ISO)
GW 4064  (EXP)
halothane  (EXP)
helenalin  (ISO)
hemin  (EXP,ISO)
hesperetin  (ISO)
hexachlorophene  (ISO)
hexadecanoic acid  (EXP,ISO)
homocysteine  (ISO)
Honokiol  (ISO)
hydralazine  (EXP)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (EXP,ISO)
hydroxychloroquine  (ISO)
hydroxytyrosol  (ISO)
hypochlorous acid  (EXP)
Ibutilide  (ISO)
ifosfamide  (ISO)
Ilimaquinone  (ISO)
imidazopyrazole  (ISO)
indinavir  (ISO)
indometacin  (EXP,ISO)
ionomycin  (EXP)
iprodione  (ISO)
irinotecan  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
iron(III) citrate  (ISO)
isoliquiritigenin  (ISO)
isoniazide  (ISO)
isoprenaline  (EXP,ISO)
itraconazole  (EXP)
ivermectin  (EXP,ISO)
ketamine  (EXP,ISO)
ketoconazole  (EXP,ISO)
KN-93  (EXP,ISO)
kojic acid  (ISO)
L-1,4-dithiothreitol  (EXP,ISO)
L-ascorbic acid  (ISO)
L-glutamic acid  (ISO)
L-glutamine  (ISO)
L-methionine  (EXP,ISO)
lactacystin  (ISO)
lamivudine  (ISO)
lead diacetate  (EXP,ISO)
lead nitrate  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
Leonurine  (EXP,ISO)
letrozole  (ISO)
Licochalcone A  (ISO)
Licochalcone B  (ISO)
licoricidin  (ISO)
linagliptin  (EXP)
linderalactone  (EXP)
linoleic acid  (EXP)
linsidomine  (ISO)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (ISO)
lomustine  (ISO)
lucanthone  (ISO)
luteolin  (EXP,ISO)
LY294002  (EXP,ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (ISO)
melatonin  (EXP,ISO)
menadione  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP,ISO)
metacetamol  (EXP)
metformin  (EXP,ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (ISO)
methotrexate  (EXP,ISO)
methoxychlor  (ISO)
methyl beta-cyclodextrin  (ISO)
methyl methanesulfonate  (EXP,ISO)
methylarsonic acid  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
methylseleninic acid  (ISO)
methyltestosterone  (ISO)
metyrapone  (ISO)
mevastatin  (EXP)
microcystin-LR  (EXP,ISO)
minocycline  (ISO)
MitoTEMPO  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
Monobutylphthalate  (ISO)
monocrotaline  (EXP)
montelukast  (EXP)
morin  (ISO)
morphine  (EXP)
morusin  (ISO)
motexafin gadolinium  (ISO)
myriocin  (ISO)
N(4)-hydroxycytidine  (EXP)
N(gamma)-nitro-L-arginine methyl ester  (EXP)
N,N-dimethylformamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-hexadecanoylsphingosine  (EXP)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-D-aspartic acid  (ISO)
N-methylnicotinate  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
naltrexone  (ISO)
naringin  (ISO)
NCX-4040  (ISO)
nefazodone  (ISO)
nelfinavir  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotine  (EXP,ISO)
nifedipine  (ISO)
Niflumic acid  (ISO)
nilotinib  (ISO)
nimesulide  (ISO)
nitrofen  (ISO)
nitroprusside  (EXP,ISO)
NMS-873  (ISO)
nobiletin  (ISO)
Nodularin  (ISO)
Nonidet P-40  (ISO)
nonivamide  (EXP,ISO)
Nonylphenol  (ISO)
Norbinaltorphimine  (ISO)
NORCANTHARIDIN  (ISO)
NS-398  (ISO)
NSC 23766  (EXP)
Nutlin-3  (ISO)
obeticholic acid  (EXP)
ochratoxin A  (ISO)
Octicizer  (EXP)
okadaic acid  (ISO)
olaparib  (ISO)
oleanolic acid  (EXP,ISO)
oleic acid  (EXP,ISO)
oleuropein  (ISO)
omeprazole  (ISO)
orlistat  (ISO)
ouabain  (ISO)
oxaliplatin  (ISO)
oxidopamine  (ISO)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
Pachymic acid  (ISO)
paclitaxel  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parthenolide  (ISO)
patulin  (ISO)
pemetrexed  (ISO)
Pendulone  (ISO)
pentachlorophenol  (EXP)
perfluorobutyric acid  (ISO)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (EXP,ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoropentanoic acid  (ISO)
perfluoroundecanoic acid  (EXP)
perhexiline  (ISO)
Perhexiline maleate  (ISO)
permethrin  (ISO)
phalloidin  (EXP)
phenethyl caffeate  (EXP)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
phenytoin  (EXP)
picoxystrobin  (ISO)
pinostrobin  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
platycodin D  (ISO)
plumbagin  (ISO)
poly(guanylic acid)  (ISO)
polymyxin B2  (ISO)
potassium bromate  (ISO)
potassium chromate  (ISO)
potassium dichromate  (EXP,ISO)
potassium iodide  (ISO)
procymidone  (EXP)
progesterone  (ISO)
propiconazole  (EXP)
propylparaben  (EXP)
prostaglandin E2  (ISO)
prothioconazole  (ISO)
psoralen  (EXP,ISO)
Ptaquiloside  (ISO)
pterostilbene  (ISO)
pyrazinecarboxamide  (ISO)
pyrimidifen  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quartz  (ISO)
quercetin  (ISO)
quercetin 3-O-beta-D-galactopyranoside  (ISO)
rac-lactic acid  (ISO)
raspberry ketone  (EXP,ISO)
reactive oxygen species  (EXP)
Repaglinide  (ISO)
resorcinol  (ISO)
resveratrol  (EXP,ISO)
riboflavin  (ISO)
rifampicin  (EXP,ISO)
rimonabant  (ISO)
roflumilast  (ISO)
rotenone  (EXP,ISO)
rottlerin  (ISO)
rutin  (ISO)
ryanodine  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
Salidroside  (EXP)
Salinomycin  (ISO)
salubrinal  (EXP,ISO)
Salvianolic acid A  (EXP)
salvianolic acid B  (ISO)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
SB-239063  (ISO)
SCH 23390  (ISO)
scopoletin  (ISO)
Se-methyl-L-selenocysteine  (EXP)
Se-methylselenocysteine  (EXP)
selenomethionine  (ISO)
serpentine asbestos  (EXP)
sertraline  (ISO)
Shikonin  (ISO)
sibutramine  (ISO)
silibinin  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
sinapic acid  (EXP,ISO)
sirolimus  (EXP,ISO)
SKF-96365 hydrochloride  (ISO)
sodium arsenate  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium disulfite  (ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (EXP,ISO)
Sodium iodate  (ISO)
Soman  (ISO)
sorafenib  (ISO)
SR 144528  (ISO)
staurosporine  (ISO)
streptozocin  (EXP,ISO)
SU6656  (EXP)
succimer  (EXP)
sulfasalazine  (EXP)
sulforaphane  (EXP,ISO)
sulfur dioxide  (ISO)
sulindac  (ISO)
sunitinib  (EXP,ISO)
superoxide  (EXP)
syringic acid  (ISO)
T-2 toxin  (EXP,ISO)
tacrine  (ISO)
tacrolimus hydrate  (EXP)
tamoxifen  (ISO)
Tanshinone I  (ISO)
taurine  (EXP)
tauroursodeoxycholic acid  (EXP,ISO)
tebufenpyrad  (ISO)
telmisartan  (ISO)
TEMPO  (ISO)
Terfenadine  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
tetrahydrocurcumin  (ISO)
thalidomide  (ISO)
thapsigargin  (EXP,ISO)
Theaflavin 3,3'-digallate  (ISO)
thiamethoxam  (EXP)
thifluzamide  (ISO)
thioacetamide  (EXP,ISO)
thiostrepton  (ISO)
thiram  (ISO)
thymoquinone  (ISO)
Tiron  (EXP)
titanium dioxide  (EXP)
topotecan  (ISO)
torin 1  (EXP,ISO)
triacetin  (ISO)
tributyl phosphate  (EXP)
tributylstannane  (ISO)
Tributyltin oxide  (EXP,ISO)
trichloroethene  (EXP,ISO)
triclosan  (EXP,ISO)
trimethylamine N-oxide  (ISO)
triphenyl phosphate  (EXP,ISO)
Triptolide  (EXP)
triptonide  (EXP)
tris(2-butoxyethyl) phosphate  (EXP)
tris(2-chloroethyl) phosphate  (EXP)
troglitazone  (EXP,ISO)
trovafloxacin  (EXP,ISO)
tungsten  (ISO)
tunicamycin  (EXP,ISO)
umbelliferone  (ISO)
undecane  (ISO)
uranium atom  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
ursolic acid  (EXP,ISO)
usnic acid  (ISO)
valproic acid  (EXP,ISO)
valsartan  (ISO)
vanillic acid  (ISO)
vemurafenib  (ISO)
verapamil  (ISO)
vildagliptin  (ISO)
vinclozolin  (ISO)
vincristine  (ISO)
vitexin  (EXP)
VX nerve agent  (ISO)
WIN 55212-2  (ISO)
withaferin A  (ISO)
wortmannin  (ISO)
XAV939  (EXP,ISO)
zearalenone  (EXP)
zidovudine  (ISO)
zileuton  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc oxide  (EXP)
zinc protoporphyrin  (ISO)
zinc pyrithione  (ISO)
zinc(0)  (ISO)
zingerone  (ISO)
ziram  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anterior/posterior axis specification  (IDA)
apoptotic process  (IEA,IMP)
artery development  (IMP)
blood vessel maturation  (IMP)
calcium ion import  (IGI)
cell redox homeostasis  (IEA,ISO)
cellular response to manganese ion  (ISO)
diaphragm contraction  (IGI)
embryonic organ development  (ISO)
endoplasmic reticulum unfolded protein response  (IDA,IMP)
ER overload response  (IBA,IEA,IMP,ISO)
establishment of protein localization to mitochondrion  (IDA)
GDF15-GFRAL signaling pathway  (ISO)
gene expression  (IGI)
HRI-mediated signaling  (IEA,ISO)
integrated stress response signaling  (IEA,ISO)
intracellular signal transduction  (IEA,ISO)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (IBA,IDA,IEA,IMP,ISO)
intrinsic apoptotic signaling pathway in response to nitrosative stress  (IDA)
luteolysis  (ISO)
negative regulation of canonical Wnt signaling pathway  (IDA)
negative regulation of cold-induced thermogenesis  (IMP)
negative regulation of CREB transcription factor activity  (ISO)
negative regulation of determination of dorsal identity  (IDA,IEA,ISO)
negative regulation of DNA-templated transcription  (IDA,IEA,IMP,ISO)
negative regulation of fat cell differentiation  (IGI)
negative regulation of interleukin-17 production  (IEA,ISO)
negative regulation of interleukin-4 production  (IEA,ISO)
negative regulation of myoblast differentiation  (IMP)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IBA,IDA,IEA,IGI,ISO,ISS)
negative regulation of type II interferon production  (IEA,ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of autophagy in response to ER overload  (ISO)
positive regulation of DNA-templated transcription  (IDA,IEA,ISO)
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (IEA,ISO)
positive regulation of interleukin-8 production  (IEA,ISO)
positive regulation of intrinsic apoptotic signaling pathway  (IEA,ISO,ISS)
positive regulation of neuron apoptotic process  (IEA,IMP,ISO,ISS)
positive regulation of transcription by RNA polymerase II  (IEA,IGI,IMP,ISO,NAS)
proteasome-mediated ubiquitin-dependent protein catabolic process  (IEA,ISO)
regulation of autophagy  (ISO,ISS)
regulation of cell cycle  (IEA)
regulation of DNA-templated transcription  (IEA,IMP,ISO)
regulation of transcription by RNA polymerase II  (IEA,ISO)
release of sequestered calcium ion into cytosol  (IMP)
response to amphetamine  (ISO)
response to caloric restriction  (IDA)
response to endoplasmic reticulum stress  (IDA,IEA,ISO)
response to hydrogen peroxide  (ISO)
response to kainic acid  (ISO)
response to nutrient  (ISO)
response to oxidative stress  (ISO)
response to platelet-derived growth factor  (IMP)
response to starvation  (IDA)
response to toxic substance  (ISO)
response to unfolded protein  (IEA,ISO)
response to wounding  (IMP)
response to xenobiotic stimulus  (ISO)
sensory perception of sound  (IGI)
vascular associated smooth muscle cell migration  (IMP)
vascular associated smooth muscle cell proliferation  (IMP)
Wnt signaling pathway  (IEA)

Cellular Component
CHOP-ATF3 complex  (IBA,IEA,ISO)
CHOP-ATF4 complex  (IBA,IEA,ISO)
CHOP-C/EBP complex  (IBA,IEA,IPI,ISO)
cytoplasm  (IBA,IDA,IEA,ISO)
late endosome  (IDA)
nucleoplasm  (TAS)
nucleus  (IC,IDA,IEA,ISO,NAS)
protein-DNA complex  (IEA,ISO)
RNA polymerase II transcription regulator complex  (IEA,IPI,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Rearrangement of the transcription factor gene CHOP in myxoid liposarcomas with t(12;16)(q13;p11). Aman P, etal., Genes Chromosomes Cancer. 1992 Nov;5(4):278-85.
2. Expression and function of C/EBP homology protein (GADD153) in podocytes. Bek MF, etal., Am J Pathol. 2006 Jan;168(1):20-32.
3. A collection of cDNAs enriched in upper cortical layers of the embryonic mouse brain. Garcia-Frigola C, etal., Brain Res Mol Brain Res 2004 Mar 30;122(2):133-50.
4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
5. The protective effect of dantrolene on ischemic neuronal cell death is associated with reduced expression of endoplasmic reticulum stress markers. Li F, etal., Brain Res. 2005 Jun 28;1048(1-2):59-68.
6. Ginsenoside-Rg1 inhibits endoplasmic reticulum stress-induced apoptosis after unilateral ureteral obstruction in rats. Li SS, etal., Ren Fail. 2015 Jun;37(5):890-5. doi: 10.3109/0886022X.2015.1015427. Epub 2015 Feb 24.
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8. Cellular communication network factor 1 (CCN1) knockdown exerts a protective effect for hepatic ischemia/reperfusion injury by deactivating the MEK/ERK pathway. Liu H, etal., Clin Res Hepatol Gastroenterol. 2021 Sep;45(5):101737. doi: 10.1016/j.clinre.2021.101737. Epub 2021 Jun 16.
9. Bax inhibitor-1 suppresses early brain injury following experimental subarachnoid hemorrhage in rats. Liu J, etal., Int J Mol Med. 2018 Nov;42(5):2891-2902. doi: 10.3892/ijmm.2018.3858. Epub 2018 Sep 5.
10. Role of HMGB1 in Post-traumatic Endoplasmic Reticulum Stress in Rat Lung Tissues. Lu JF, etal., Fa Yi Xue Za Zhi. 2018 Aug;34(4):347-351. doi: 10.12116/j.issn.1004-5619.2018.04.001. Epub 2018 Aug 25.
11. Comparison of Human and Experimental Pulmonary Veno-Occlusive Disease. Manaud G, etal., Am J Respir Cell Mol Biol. 2020 Jul;63(1):118-131. doi: 10.1165/rcmb.2019-0015OC.
12. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
13. MGDs mouse GO annotations MGD data from the GO Consortium
14. The unfolded protein response in lens epithelial cells from galactosemic rat lenses. Mulhern ML, etal., Invest Ophthalmol Vis Sci. 2006 Sep;47(9):3951-9.
15. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. Mouse MP Annotation Import Pipeline RGD automated import pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Induction of ER stress in macrophages of tuberculosis granulomas. Seimon TA, etal., PLoS One. 2010 Sep 15;5(9):e12772. doi: 10.1371/journal.pone.0012772.
21. Valsartan Protects Against Contrast-Induced Acute Kidney Injury in Rats by Inhibiting Endoplasmic Reticulum Stress-Induced Apoptosis. Sun Y, etal., Curr Vasc Pharmacol. 2017;15(2):174-183. doi: 10.2174/1570161114666161025100656.
22. Induction of GADD153, a CCAAT/enhancer-binding protein (C/EBP)-related gene, during the acute phase response in rats. Evidence for the involvement of C/EBPs in regulating its expression. Sylvester SL, etal., J Biol Chem. 1994 Aug 5;269(31):20119-25.
23. ZIKV infection activates the IRE1-XBP1 and ATF6 pathways of unfolded protein response in neural cells. Tan Z, etal., J Neuroinflammation. 2018 Sep 21;15(1):275. doi: 10.1186/s12974-018-1311-5.
24. LncRNA H19 inhibits ER stress induced apoptosis and improves diabetic cardiomyopathy by regulating PI3K/AKT/mTOR axis. Wang S, etal., Aging (Albany NY). 2022 Aug 30;14(16):6809-6828. doi: 10.18632/aging.204256. Epub 2022 Aug 30.
25. Endoplasmic reticulum stress and neurodegeneration in rats neonatally infected with borna disease virus. Williams BL and Lipkin WI, J Virol. 2006 Sep;80(17):8613-26. doi: 10.1128/JVI.00836-06.
26. [Effects of acupuncture intervention on expression of glucose-regulated protein 78 and C/EBP homologous protein in hippocampal CA 1 region in rats with hyperspasmia]. Yang F, etal., Zhen Ci Yan Jiu. 2014 Aug;39(4):267-71.
27. MTORC1 coordinates the autophagy and apoptosis signaling in articular chondrocytes in osteoarthritic temporomandibular joint. Yang H, etal., Autophagy. 2020 Feb;16(2):271-288. doi: 10.1080/15548627.2019.1606647. Epub 2019 Apr 21.
28. The induction of cell cycle regulatory and DNA repair proteins in cisplatin-induced acute renal failure. Zhou H, etal., Toxicol Appl Pharmacol. 2004 Oct 15;200(2):111-20.
Additional References at PubMed
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PMID:22761832   PMID:22815481   PMID:22815824   PMID:22873727   PMID:22925884   PMID:22933109   PMID:22959274   PMID:22961085   PMID:22988430   PMID:23022383   PMID:23028046   PMID:23037953  
PMID:23074209   PMID:23080229   PMID:23193662   PMID:23235477   PMID:23281479   PMID:23314846   PMID:23350942   PMID:23361066   PMID:23364451   PMID:23374428   PMID:23395000   PMID:23468099  
PMID:23494705   PMID:23533630   PMID:23547100   PMID:23564995   PMID:23618865   PMID:23624402   PMID:23646198   PMID:23665281   PMID:23720735   PMID:23749468   PMID:23761072   PMID:23937658  
PMID:24041971   PMID:24060278   PMID:24194321   PMID:24194600   PMID:24248597   PMID:24339898   PMID:24367269   PMID:24370435   PMID:24403532   PMID:24416259   PMID:24475193   PMID:24489101  
PMID:24519940   PMID:24523853   PMID:24530784   PMID:24558358   PMID:24657471   PMID:24662293   PMID:24664731   PMID:24691093   PMID:24694561   PMID:24726366   PMID:24776803   PMID:24795271  
PMID:24850428   PMID:24859004   PMID:24900988   PMID:24920846   PMID:24952961   PMID:25132496   PMID:25178318   PMID:25238096   PMID:25314137   PMID:25332179   PMID:25343248   PMID:25387528  
PMID:25414185   PMID:25529350   PMID:25670032   PMID:25788370   PMID:25795214   PMID:25872946   PMID:25895586   PMID:25902191   PMID:25985795   PMID:26001784   PMID:26005208   PMID:26022690  
PMID:26027784   PMID:26051941   PMID:26071644   PMID:26111448   PMID:26134251   PMID:26135354   PMID:26157144   PMID:26167872   PMID:26173459   PMID:26222436   PMID:26247732   PMID:26299268  
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PMID:34380029   PMID:34471408   PMID:34491597   PMID:34616039   PMID:34752818   PMID:34847358   PMID:34866573   PMID:34877504   PMID:35129674   PMID:35147267   PMID:35185885   PMID:35237793  
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PMID:36000401   PMID:36048019   PMID:36154620   PMID:36167070   PMID:36421460   PMID:36450915   PMID:36539111   PMID:36623733   PMID:36841836   PMID:36868076   PMID:37146542   PMID:37153733  
PMID:37188818   PMID:37235961   PMID:37243354   PMID:37280306   PMID:37353485   PMID:37729023   PMID:37829188   PMID:37967789   PMID:37998373   PMID:38042368   PMID:38056583   PMID:38177915  
PMID:38218976   PMID:38320000   PMID:38355793   PMID:38355795   PMID:38402623   PMID:38408589   PMID:38475919   PMID:38588611   PMID:38719085   PMID:38849354   PMID:39097882   PMID:39181129  
PMID:39328932   PMID:39682701   PMID:39747033   PMID:39870620   PMID:40071146   PMID:40199910   PMID:40487428   PMID:40530690   PMID:40841608  


Genomics

Comparative Map Data
Ddit3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910127,126,662 - 127,132,160 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10127,126,698 - 127,129,622 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm39 Ensembl10127,126,643 - 127,132,157 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3810127,290,793 - 127,296,291 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10127,290,829 - 127,293,753 (+)Ensemblmm10GRCm38
GRCm38.p6 Ensembl10127,290,774 - 127,296,288 (+)Ensemblmm10GRCm38
MGSCv3710126,727,849 - 126,733,344 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3610126,693,759 - 126,699,235 (+)NCBIMGSCv36mm8
Celera10129,683,104 - 129,688,599 (+)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1074.5NCBI
DDIT3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381257,516,588 - 57,520,517 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1257,516,588 - 57,521,737 (-)Ensemblhg38GRCh38
GRCh371257,910,371 - 57,914,300 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361256,196,638 - 56,200,567 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341256,196,639 - 56,200,567NCBI
Celera1257,566,204 - 57,570,133 (-)NCBICelera
Cytogenetic Map12q13.3NCBI
HuRef1254,948,369 - 54,952,298 (-)NCBIHuRef
CHM1_11257,878,226 - 57,882,156 (-)NCBICHM1_1
T2T-CHM13v2.01257,484,816 - 57,488,745 (-)NCBIT2T-CHM13v2.0
Ddit3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8765,001,695 - 65,006,517 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl765,005,501 - 65,006,509 (+)EnsemblGRCr8
mRatBN7.2763,115,645 - 63,121,203 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl763,116,380 - 63,121,201 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx765,005,654 - 65,010,476 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0767,208,074 - 67,212,896 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0767,009,429 - 67,014,244 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0770,578,564 - 70,585,074 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl770,580,198 - 70,585,084 (+)Ensemblrn6Rnor6.0
Rnor_5.0770,753,800 - 70,759,220 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4767,247,749 - 67,252,571 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera760,256,651 - 60,261,474 (+)NCBICelera
RGSC_v3.1767,268,487 - 67,273,294 (+)NCBI
Cytogenetic Map7q22NCBI
Ddit3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554585,232,979 - 5,238,513 (-)Ensembl
ChiLan1.0NW_0049554585,232,979 - 5,238,513 (-)NCBIChiLan1.0ChiLan1.0
DDIT3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21036,823,643 - 36,824,526 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11236,820,414 - 36,821,297 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01231,406,332 - 31,410,293 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11231,664,766 - 31,668,699 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1231,664,743 - 31,668,701 (+)EnsemblpanPan2panpan1.1
DDIT3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1101,606,693 - 1,612,410 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl101,606,693 - 1,611,303 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha101,669,927 - 1,675,567 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0101,615,759 - 1,621,400 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl101,615,759 - 1,620,369 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1101,593,774 - 1,599,407 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0101,835,463 - 1,841,297 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0101,960,652 - 1,966,292 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ddit3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494557,201,026 - 57,205,216 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366461,665,019 - 1,669,193 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366461,665,019 - 1,669,212 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DDIT3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl522,785,445 - 22,789,829 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1522,785,441 - 22,789,867 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
LOC103238566
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11153,424,693 - 53,429,094 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1153,424,868 - 53,425,576 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037192,535,088 - 192,539,471 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ddit3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462480210,437,998 - 10,443,278 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ddit3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11205,725,495 - 205,730,292 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ddit3
205 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:443
Count of miRNA genes:282
Interacting mature miRNAs:317
Transcripts:ENSMUST00000026475, ENSMUST00000134686, ENSMUST00000139091
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142461Bmd25_mbone mineral density 25 (mouse)Not determined1097217101130530862Mouse
1301968Estq4_mestradiol regulated response QTL 4 (mouse)Not determined10100986516130530862Mouse
12904001Opfaq10_mopen field activity QTL 10 (mouse)10125633671129466375Mouse
12879490Frct3_mfear conditioning traits 3 (mouse)10122785970129466996Mouse
11049570Lmr25b_mleishmaniasis resistance 25b (mouse)10108575094130530862Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
11533921Mvb2_mmodifier of vibrator 2 (mouse)1097217101130530862Mouse
4141361Cfmq3_mcystic fibrosis modifier QTL 3 (mouse)Not determined10101497164130530862Mouse
4141487Tgq21_mtriglyceride QTL 21 (mouse)Not determined104110021130530862Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039175996129635869Mouse
1301895Exq1_mexploratory and excitability QTL 1 (mouse)Not determined10102847852130530862Mouse
1300679Nociq2_mnociceptive sensitivity inflammatory QTL 2 (mouse)Not determined10105041304130530862Mouse
1300678Leg2_mlongevity extending gene 2 (mouse)Not determined10102506908130530862Mouse
14746996Manh69_mmandible shape 69 (mouse)10104763638130530862Mouse
12880413V125Dq9_mvitamin D active form serum level QTL 9 (mouse)1097535905130530862Mouse
1301901Im5_mimmunoregulatory 5 (mouse)Not determined10101497164130530862Mouse
4141153Ltgq2_mliver triglyceride QTL 2 (mouse)Not determined108515907130530862Mouse
11039496Ltpr5b_mLeishmania tropica response 5b (mouse)10108575094130530862Mouse
1357744Cfbw4_mcystic fibrosis body weight 4 (mouse)Not determined10100986516130530862Mouse
4141402T2dm1sa_mtype 2 diabetes mellitus 1 in SMXA RI mice (mouse)Not determined97758644130530862Mouse
11041664Lmr25_mleishmaniasis resistance 25 (mouse)10108575094130530862Mouse
1302200Sle12_msystematic lupus erythematosus susceptibility 12 (mouse)Not determined10105041304130530862Mouse
26884405Huml2_mhumerus length 2, 5 week (mouse)1069735830130430862Mouse
11533919Mvb4_mmodifier of vibrator 4 (mouse)397217101130530862Mouse
4141007Obrq10_mobesity resistance QTL 10 (mouse)Not determined103243727130530862Mouse
12911220Frct3c_mfear conditioning traits 3c (mouse)10122785970129466996Mouse
11049563Lmr25a_mleishmaniasis resistance 25a (mouse)10108575094130530862Mouse
4142089Obrq9_mobesity resistance QTL 9 (mouse)Not determined108515907130530862Mouse
14696727Kidrq2_mkidney weight, right QTL 2 (mouse)10102902508130530862Mouse
12911218Frct3a_mfear conditioning traits 3a (mouse)10122785970129466996Mouse
11040593Lmr5e_mleishmaniasis resistance 5e (mouse)1099220635130530862Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039175996129635869Mouse
11040594Lmr5f_mleishmaniasis resistance 5f (mouse)10105179713130530862Mouse
11040595Lmr5c_mleishmaniasis resistance 5c (mouse)1099220635130530862Mouse
1357544Vtbt10_mvertebral trabecular bone trait 10 (mouse)Not determined1097217101130530862Mouse
11040596Lmr5d_mleishmaniasis resistance 5d (mouse)10105179713130530862Mouse
11040597Lmr5a_mleishmaniasis resistance 5a (mouse)1099220635130530862Mouse
1357482Nhdlq4_mnon-HDL QTL 4 (mouse)Not determined10105041304130530862Mouse
11040598Lmr5b_mleishmaniasis resistance 5b (mouse)10105179713130530862Mouse

Markers in Region
X67083  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810127,296,104 - 127,296,214UniSTSGRCm38
MGSCv3710126,733,160 - 126,733,270UniSTSGRCm37
Celera10129,688,415 - 129,688,525UniSTS
Cytogenetic Map10D3UniSTS
Whitehead/MRC_RH101383.37UniSTS
PMC125041P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810127,295,354 - 127,295,968UniSTSGRCm38
MGSCv3710126,732,410 - 126,733,024UniSTSGRCm37
Celera10129,687,665 - 129,688,279UniSTS
Cytogenetic Map10D3UniSTS
PMC150726P4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810127,295,840 - 127,296,142UniSTSGRCm38
MGSCv3710126,732,896 - 126,733,198UniSTSGRCm37
Celera10129,688,151 - 129,688,453UniSTS
Cytogenetic Map10D3UniSTS
PMC152658P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810127,295,392 - 127,296,051UniSTSGRCm38
MGSCv3710126,732,448 - 126,733,107UniSTSGRCm37
Celera10129,687,703 - 129,688,362UniSTS
Cytogenetic Map10D3UniSTS
UniSTS:225335  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810127,296,123 - 127,296,278UniSTSGRCm38
MGSCv3710126,733,179 - 126,733,334UniSTSGRCm37
Celera10129,688,434 - 129,688,589UniSTS
Cytogenetic Map10D3UniSTS
Ddit3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10D3UniSTS
cM Map10 UniSTS
PMC186318P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810127,295,741 - 127,296,185UniSTSGRCm38
MGSCv3710126,732,797 - 126,733,241UniSTSGRCm37
Celera10129,688,052 - 129,688,496UniSTS
Cytogenetic Map10D3UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001290183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001428453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001428454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_007837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006513197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030244867 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA929408 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC144852 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK028120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK040004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC013718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE134148 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY121546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF982562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X67083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000026475   ⟹   ENSMUSP00000026475
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10127,126,643 - 127,132,157 (+)Ensembl
GRCm38.p6 Ensembl10127,290,774 - 127,296,288 (+)Ensembl
Ensembl Acc Id: ENSMUST00000134686
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10127,126,663 - 127,130,451 (+)Ensembl
GRCm38.p6 Ensembl10127,290,794 - 127,294,582 (+)Ensembl
Ensembl Acc Id: ENSMUST00000139091   ⟹   ENSMUSP00000118339
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10127,126,662 - 127,131,934 (+)Ensembl
GRCm38.p6 Ensembl10127,290,793 - 127,296,065 (+)Ensembl
Ensembl Acc Id: ENSMUST00000230446   ⟹   ENSMUSP00000155363
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10127,126,698 - 127,129,622 (+)Ensembl
GRCm38.p6 Ensembl10127,290,829 - 127,293,753 (+)Ensembl
RefSeq Acc Id: NM_001290183   ⟹   NP_001277112
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910127,126,662 - 127,132,157 (+)NCBI
GRCm3810127,290,793 - 127,296,288 (+)NCBI
Celera10129,683,104 - 129,688,599 (+)NCBI
Sequence:
RefSeq Acc Id: NM_007837   ⟹   NP_031863
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910127,126,662 - 127,132,157 (+)NCBI
GRCm3810127,290,793 - 127,296,288 (+)NCBI
MGSCv3710126,727,849 - 126,733,344 (+)RGD
Celera10129,683,104 - 129,688,599 (+)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006513197   ⟹   XP_006513260
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910127,126,662 - 127,132,160 (+)NCBI
GRCm3810127,290,793 - 127,296,291 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030244867   ⟹   XP_030100727
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910127,129,581 - 127,132,157 (+)NCBI
GRCm3810127,293,712 - 127,296,288 (+)NCBI
Sequence:
RefSeq Acc Id: NP_031863   ⟸   NM_007837
- UniProtKB: Q91YW9 (UniProtKB/Swiss-Prot),   P35639 (UniProtKB/Swiss-Prot),   Q3V405 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006513260   ⟸   XM_006513197
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: NP_001277112   ⟸   NM_001290183
- UniProtKB: Q91YW9 (UniProtKB/Swiss-Prot),   P35639 (UniProtKB/Swiss-Prot),   Q3V405 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030100727   ⟸   XM_030244867
- Peptide Label: isoform X1
- UniProtKB: Q3V405 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000118339   ⟸   ENSMUST00000139091
Ensembl Acc Id: ENSMUSP00000026475   ⟸   ENSMUST00000026475
Ensembl Acc Id: ENSMUSP00000155363   ⟸   ENSMUST00000230446
Protein Domains
bZIP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35639-F1-model_v2 AlphaFold P35639 1-168 view protein structure

Promoters
RGD ID:6819170
Promoter ID:MM_KWN:5883
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000080968,   OTTMUST00000080969,   OTTMUST00000080970
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3610126,726,931 - 126,727,947 (+)MPROMDB
RGD ID:6846716
Promoter ID:MM_ACW:6327
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day6
Transcripts:DDIT3.CSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3610126,732,151 - 126,732,651 (+)MPROMDB
RGD ID:8673490
Promoter ID:EPDNEW_M14775
Type:multiple initiation site
Name:Ddit3_1
Description:Mus musculus DNA-damage inducible transcript 3 , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3810127,290,797 - 127,290,857EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:109247 AgrOrtholog
Ensembl Genes ENSMUSG00000025408 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSG00000116429 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000026475 ENTREZGENE
  ENSMUST00000026475.15 UniProtKB/Swiss-Prot
  ENSMUST00000139091 ENTREZGENE
  ENSMUST00000230446.2 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot
InterPro bZIP UniProtKB/Swiss-Prot
  bZIP_sf UniProtKB/Swiss-Prot
  DNA_damage_induc_transcript_3 UniProtKB/Swiss-Prot
KEGG Report mmu:13198 UniProtKB/Swiss-Prot
MGD MGI:109247 ENTREZGENE
NCBI Gene 13198 ENTREZGENE
PANTHER DNA DAMAGE-INDUCIBLE TRANSCRIPT 3 PROTEIN UniProtKB/Swiss-Prot
  PTHR16833 UniProtKB/Swiss-Prot
PharmGKB DDIT3 RGD
PhenoGen Ddit3 PhenoGen
PIRSF C/EBPzeta_CHOP_DDIT3 UniProtKB/Swiss-Prot
PROSITE BZIP UniProtKB/Swiss-Prot
SMART BRLZ UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57959 UniProtKB/Swiss-Prot
UniProt A0A2R8VHR8 ENTREZGENE
  D3YX14_MOUSE UniProtKB/TrEMBL
  DDIT3_MOUSE UniProtKB/Swiss-Prot
  DT3UO_MOUSE UniProtKB/Swiss-Prot
  P35639 ENTREZGENE
  Q3V405 ENTREZGENE, UniProtKB/TrEMBL
  Q91YW9 ENTREZGENE
UniProt Secondary Q91YW9 UniProtKB/Swiss-Prot