Hes1 (hes family bHLH transcription factor 1) - Rat Genome Database

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Gene: Hes1 (hes family bHLH transcription factor 1) Mus musculus
Analyze
Symbol: Hes1
Name: hes family bHLH transcription factor 1
RGD ID: 62373
MGI Page MGI
Description: Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; HLH domain binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including circulatory system development; kidney development; and regulation of gliogenesis. Acts upstream of or within several processes, including hepaticobiliary system development; negative regulation of cell differentiation; and nervous system development. Located in cytoplasm and nucleus. Part of protein-containing complex. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; foot bone; and sensory organ. Orthologous to human HES1 (hes family bHLH transcription factor 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: bHLHb3; bHLHb39; hairy and enhancer of split 1; hairy and enhancer of split 1 (Drosophila); Hr; Hry; transcription factor HES-1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391629,883,259 - 29,886,614 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1629,883,202 - 29,886,614 (+)EnsemblGRCm39 Ensembl
GRCm381630,065,357 - 30,067,796 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1630,064,384 - 30,067,796 (+)EnsemblGRCm38mm10GRCm38
MGSCv371630,065,443 - 30,067,882 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361629,985,104 - 29,987,543 (+)NCBIMGSCv36mm8
Celera1630,572,496 - 30,574,749 (+)NCBICelera
Cytogenetic Map16B2NCBI
cM Map1621.09NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (EXP)
1,2-dimethylhydrazine  (EXP)
1,4-dioxane  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,6-dinitrotoluene  (ISO)
2-hydroxypropanoic acid  (ISO)
2-tert-butylhydroquinone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-methyladenine  (EXP)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroperoxycyclophosphamide  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
acetaldehyde  (ISO)
aconitine  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-D-galactose  (EXP)
alpha-naphthoflavone  (ISO)
alpha-Zearalanol  (ISO)
ammonium chloride  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
arecoline  (EXP)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azoxystrobin  (ISO)
baicalein  (ISO)
baicalin  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
buspirone  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calciol  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
captan  (EXP)
carbon nanotube  (EXP)
carbonyl sulfide  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (EXP)
cis-caffeic acid  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (ISO)
curcumin  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cypermethrin  (EXP,ISO)
DAPT  (EXP,ISO)
deguelin  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diallyl disulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
diethylstilbestrol  (ISO)
dioxygen  (EXP,ISO)
disulfiram  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
Enterolactone  (ISO)
enzalutamide  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
EUK-134  (ISO)
fenofibrate  (EXP)
fenpyroximate  (ISO)
flavonoids  (ISO)
fluoranthene  (EXP)
fluoxetine  (ISO)
flusilazole  (EXP)
flutamide  (ISO)
folic acid  (EXP)
folpet  (EXP)
formaldehyde  (ISO)
galactose  (EXP)
genistein  (ISO)
gentamycin  (ISO)
glycyrrhizinic acid  (ISO)
glyphosate  (ISO)
hexaconazole  (EXP)
hydrogen peroxide  (ISO)
imidacloprid  (ISO)
indometacin  (ISO)
inulin  (EXP)
irinotecan  (ISO)
isoprenaline  (EXP)
juglone  (ISO)
kaempferol 3-O-beta-D-glucoside  (EXP)
L-ascorbic acid  (ISO)
L-methionine  (EXP)
lead(0)  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
mebendazole  (ISO)
menadione  (ISO)
methamphetamine  (ISO)
methotrexate  (EXP)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
mifepristone  (EXP)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
nickel sulfate  (ISO)
niclosamide  (EXP,ISO)
nirogacestat  (ISO)
nitrofen  (ISO)
ochratoxin A  (ISO)
orphenadrine  (ISO)
oxaliplatin  (ISO)
oxidopamine  (ISO)
ozone  (EXP)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
Paeonol  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenol  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
pluronic P-123  (ISO)
Poloxamer  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propiconazole  (EXP)
pyrimidifen  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
retinyl acetate  (EXP)
rotenone  (ISO)
Salidroside  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sirolimus  (EXP,ISO)
sodium arsenite  (EXP,ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
Theaflavin 3,3'-digallate  (ISO)
thiabendazole  (ISO)
thimerosal  (ISO)
thioacetamide  (ISO)
thiram  (ISO)
thyroxine  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
trans-caffeic acid  (ISO)
triadimefon  (EXP)
Tributyltin oxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
Triptolide  (EXP,ISO)
triptonide  (EXP)
troglitazone  (EXP)
tunicamycin  (EXP)
tyrphostin AG 1478  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vitamin E  (ISO)
XL147  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenohypophysis development  (IMP)
amacrine cell differentiation  (IMP)
anterior/posterior pattern specification  (IBA)
aorta morphogenesis  (IMP)
artery morphogenesis  (IMP)
ascending aorta morphogenesis  (IMP)
BMP signaling pathway  (IGI)
Cajal-Retzius cell differentiation  (IGI)
cardiac neural crest cell development involved in outflow tract morphogenesis  (IMP)
cell adhesion  (IGI)
cell fate commitment  (IMP)
cell fate determination  (IMP)
cell maturation  (IGI)
cell migration  (IGI)
cell morphogenesis involved in neuron differentiation  (IGI)
cell population proliferation  (IMP)
cellular response to fatty acid  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to nerve growth factor stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
cochlea development  (IGI,IMP)
comma-shaped body morphogenesis  (IEP)
common bile duct development  (IMP)
embryonic heart tube morphogenesis  (IMP)
establishment of epithelial cell polarity  (IGI)
forebrain radial glial cell differentiation  (ISO)
glomerulus vasculature development  (IEP)
hair cell differentiation  (ISO)
hindbrain morphogenesis  (IGI)
in utero embryonic development  (IGI)
inhibition of neuroepithelial cell differentiation  (IMP)
inner ear auditory receptor cell differentiation  (IGI)
inner ear receptor cell stereocilium organization  (IGI)
labyrinthine layer blood vessel development  (IMP)
lateral inhibition  (IMP)
liver development  (IMP)
lung development  (IMP)
metanephric nephron tubule morphogenesis  (IEP)
midbrain development  (IGI)
midbrain-hindbrain boundary morphogenesis  (IGI)
negative regulation of amacrine cell differentiation  (IMP)
negative regulation of calcium ion import  (ISO)
negative regulation of cell differentiation  (IMP)
negative regulation of cell fate determination  (IMP)
negative regulation of DNA-binding transcription factor activity  (IDA)
negative regulation of DNA-templated transcription  (IMP,ISO)
negative regulation of forebrain neuron differentiation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of glial cell proliferation  (IDA)
negative regulation of inner ear auditory receptor cell differentiation  (IGI,IMP)
negative regulation of inner ear receptor cell differentiation  (IMP)
negative regulation of neurogenesis  (ISO)
negative regulation of neuron differentiation  (IBA,IGI,IMP)
negative regulation of neuron projection development  (ISO)
negative regulation of oligodendrocyte differentiation  (IDA,ISO)
negative regulation of pancreatic A cell differentiation  (IMP)
negative regulation of pro-B cell differentiation  (ISO)
negative regulation of stem cell differentiation  (ISO)
negative regulation of stomach neuroendocrine cell differentiation  (IMP)
negative regulation of transcription by RNA polymerase II  (IDA,IGI,IMP,ISO)
neural tube development  (IGI)
neuroendocrine cell differentiation  (IMP)
neuron differentiation  (IGI,IMP,ISO)
neuronal stem cell population maintenance  (IMP,ISO)
Notch signaling pathway  (IBA,IDA,ISO,NAS,TAS)
oculomotor nerve development  (IGI)
outflow tract morphogenesis  (IMP)
pancreas development  (IMP)
pancreatic A cell differentiation  (IMP)
pattern specification process  (IGI,IMP)
pharyngeal arch artery morphogenesis  (IMP)
pituitary gland development  (IGI,IMP)
positive regulation of astrocyte differentiation  (IDA)
positive regulation of BMP signaling pathway  (IGI)
positive regulation of cell population proliferation  (IMP)
positive regulation of DNA-templated transcription  (IMP)
positive regulation of gene expression  (ISO)
positive regulation of glial cell differentiation  (ISO)
positive regulation of mitotic cell cycle, embryonic  (IMP)
positive regulation of Notch signaling pathway  (IMP)
positive regulation of receptor signaling pathway via JAK-STAT  (IDA)
positive regulation of T cell proliferation  (IMP)
positive regulation of transcription by RNA polymerase II  (IGI,IMP)
positive regulation of tyrosine phosphorylation of STAT protein  (IDA)
protein-containing complex assembly  (IDA)
regulation of DNA-templated transcription  (IEA)
regulation of epithelial cell proliferation  (IGI)
regulation of fat cell differentiation  (IMP)
regulation of neurogenesis  (IBA,IGI)
regulation of neuron differentiation  (IGI)
regulation of protein-containing complex assembly  (ISO)
regulation of receptor signaling pathway via JAK-STAT  (IDA)
regulation of secondary heart field cardioblast proliferation  (IMP)
regulation of timing of cell differentiation  (IMP)
regulation of timing of neuron differentiation  (IGI,IMP)
regulation of transcription by RNA polymerase II  (IBA,IGI)
renal interstitial fibroblast development  (IEP)
response to alkaloid  (ISO)
response to organic cyclic compound  (ISO)
response to thyroid hormone  (ISO)
S-shaped body morphogenesis  (IEP)
smoothened signaling pathway  (IDA)
somatic stem cell population maintenance  (IMP)
stomach neuroendocrine cell differentiation  (IMP)
T cell proliferation  (IMP)
telencephalon development  (IGI,IMP)
thymus development  (IMP)
trochlear nerve development  (IGI)
ureteric bud morphogenesis  (IEP)
vascular associated smooth muscle cell development  (IMP)
ventricular septum development  (IMP)
ventricular septum morphogenesis  (IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal astrocyte morphology  (IAGP)
abnormal bile duct development  (IAGP)
abnormal bile duct morphology  (IAGP)
abnormal brain development  (IAGP)
abnormal brain morphology  (IAGP)
abnormal cell differentiation  (IAGP)
abnormal centroacinar cell of Langerhans morphology  (IAGP)
abnormal choroid plexus morphology  (IAGP)
abnormal CNS glial cell morphology  (IAGP)
abnormal cochlear hair cell morphology  (IAGP)
abnormal common bile duct morphology  (IAGP)
abnormal cystic duct morphology  (IAGP)
abnormal dopaminergic neuron morphology  (IAGP)
abnormal dorsal root ganglion morphology  (IAGP)
abnormal embryonic neuroepithelium morphology  (IAGP)
abnormal embryonic/fetal subventricular zone morphology  (IAGP)
abnormal ependyma morphology  (IAGP)
abnormal exocrine pancreas morphology  (IAGP)
abnormal extrahepatic bile duct morphology  (IAGP)
abnormal forebrain morphology  (IAGP)
abnormal inner ear vestibule morphology  (IAGP)
abnormal intestine morphology  (IAGP)
abnormal locus ceruleus morphology  (IAGP)
abnormal midbrain morphology  (IAGP)
abnormal midbrain-hindbrain boundary morphology  (IAGP)
abnormal nasal placode morphology  (IAGP)
abnormal neural tube morphology  (IAGP)
abnormal neurohypophysis morphology  (IAGP)
abnormal neuron differentiation  (IAGP)
abnormal oculomotor nucleus morphology  (IAGP)
abnormal pancreas development  (IAGP)
abnormal pancreas morphology  (IAGP)
abnormal pancreas physiology  (IAGP)
abnormal pancreatic beta cell differentiation  (IAGP)
abnormal pituitary diverticulum morphology  (IAGP)
abnormal pituitary gland development  (IAGP)
abnormal pituitary gland morphology  (IAGP)
abnormal pituitary infundibular stalk morphology  (IAGP)
abnormal retina neuronal layer morphology  (IAGP)
abnormal spinal cord morphology  (IAGP)
abnormal stomach morphology  (IAGP)
abnormal T cell differentiation  (IAGP)
abnormal utricle morphology  (IAGP)
abnormal vestibular saccule morphology  (IAGP)
absent choroid plexus  (IAGP)
absent gallbladder  (IAGP)
absent oculomotor nerve  (IAGP)
absent oligodendrocytes  (IAGP)
absent optic vesicle  (IAGP)
absent pituitary intermediate lobe  (IAGP)
absent trochlear nerve  (IAGP)
anencephaly  (IAGP)
decreased B cell number  (IAGP)
decreased body length  (IAGP)
decreased club cell number  (IAGP)
decreased DN1 thymic pro-T cell number  (IAGP)
decreased DN2 thymocyte number  (IAGP)
decreased DN3 thymocyte number  (IAGP)
decreased DN4 thymocyte number  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased embryo size  (IAGP)
decreased gamma-delta T cell number  (IAGP)
decreased lymphoma incidence  (IAGP)
disorganized retina layers  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
everted embryonic neuroepithelium  (IAGP)
exencephaly  (IAGP)
incomplete rostral neuropore closure  (IAGP)
increased Cajal-Retzius cell number  (IAGP)
increased cochlear inner hair cell number  (IAGP)
increased cochlear outer hair cell number  (IAGP)
increased DN1 thymic pro-T cell number  (IAGP)
increased immature B cell number  (IAGP)
increased number of pulmonary neuroendocrine bodies  (IAGP)
increased pancreatic acinar cell number  (IAGP)
increased solitary pulmonary neuroendocrine cell number  (IAGP)
increased somatotroph cell number  (IAGP)
increased vestibular hair cell number  (IAGP)
kinked neural tube  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
microcephaly  (IAGP)
neuron hypertrophy  (IAGP)
no abnormal phenotype detected  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
pituitary gland hypoplasia  (IAGP)
premature neuronal precursor differentiation  (IAGP)
small lung  (IAGP)
small stomach  (IAGP)
thymus hypoplasia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Delta-Notch--and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors. Fischer A and Gessler M, Nucleic Acids Res. 2007;35(14):4583-96. Epub 2007 Jun 22.
2. [Effect of fermented cordyceps powder and prednisone on the Notch2/Hes-1 signaling activation in the kidney tubules of rats with acute aristolochic acid nephropathy]. Huang RF, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2013 Aug;33(8):1116-21.
3. Arecoline N-oxide regulates oral squamous cell carcinoma development through NOTCH1 and FAT1 expressions. Kuo TM, etal., J Cell Physiol. 2019 Aug;234(8):13984-13993. doi: 10.1002/jcp.28084. Epub 2019 Jan 9.
4. Genetically engineered bone marrow mesenchymal stem cells improve functional outcome in a rat model of epilepsy. Long Q, etal., Brain Res. 2013 Sep 26;1532:1-13. doi: 10.1016/j.brainres.2013.07.020. Epub 2013 Aug 6.
5. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
6. MGDs mouse GO annotations MGD data from the GO Consortium
7. MGD IEA MGD IEA
8. NOTCH1 signaling induces pathological vascular permeability in diabetic retinopathy. Miloudi K, etal., Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4538-4547. doi: 10.1073/pnas.1814711116. Epub 2019 Feb 20.
9. Hes1 immortalizes committed progenitors and plays a role in blast crisis transition in chronic myelogenous leukemia. Nakahara F, etal., Blood. 2010 Apr 8;115(14):2872-81. doi: 10.1182/blood-2009-05-222836. Epub 2009 Oct 27.
10. Activation of multiple angiogenic signaling pathways in hemangiopericytoma. Pierscianek D, etal., Brain Tumor Pathol. 2016 Jul;33(3):200-8. doi: 10.1007/s10014-016-0256-6. Epub 2016 Mar 7.
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. Mouse MP Annotation Import Pipeline RGD automated import pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split. Sasai Y, etal., Genes Dev 1992 Dec;6(12B):2620-34.
15. Determination of relative Notch1 and gamma-secretase-related gene expression in puromycin-treated microdissected rat kidneys. Simic D, etal., Gene Expr. 2013;16(1):39-47.
16. Notch pathway is activated in cell culture and mouse models of mutant SOD1-related familial amyotrophic lateral sclerosis, with suppression of its activation as an additional mechanism of neuroprotection for lithium and valproate. Wang SY, etal., Neuroscience. 2015 Aug 20;301:276-88. doi: 10.1016/j.neuroscience.2015.06.002. Epub 2015 Jun 8.
17. Olmesartan attenuates cardiac remodeling through DLL4/Notch1 pathway activation in pressure overload mice. You J, etal., J Cardiovasc Pharmacol. 2013 Feb;61(2):142-51. doi: 10.1097/FJC.0b013e31827a0278.
18. Triggering of a Dll4-Notch1 loop impairs wound healing in diabetes. Zheng X, etal., Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):6985-6994. doi: 10.1073/pnas.1900351116. Epub 2019 Mar 18.
Additional References at PubMed
PMID:7906273   PMID:7909512   PMID:8543157   PMID:8607991   PMID:8687460   PMID:8747921   PMID:8892234   PMID:9102301   PMID:9152013   PMID:9291577   PMID:9806930   PMID:9874198  
PMID:10205173   PMID:10323870   PMID:10330372   PMID:10349636   PMID:10383933   PMID:10393120   PMID:10464095   PMID:10476967   PMID:10512199   PMID:10516314   PMID:10605019   PMID:10615124  
PMID:10627606   PMID:10704388   PMID:10804175   PMID:10821758   PMID:10825208   PMID:10842072   PMID:10851137   PMID:10868931   PMID:10922068   PMID:10952889   PMID:11023859   PMID:11042159  
PMID:11076861   PMID:11095750   PMID:11124811   PMID:11217851   PMID:11260262   PMID:11399758   PMID:11412999   PMID:11425898   PMID:11500373   PMID:11567612   PMID:11739954   PMID:11807030  
PMID:11923214   PMID:11934853   PMID:11937492   PMID:12032823   PMID:12130660   PMID:12130776   PMID:12163409   PMID:12167404   PMID:12208538   PMID:12370315   PMID:12397111   PMID:12399594  
PMID:12466851   PMID:12477932   PMID:12478609   PMID:12560091   PMID:12617809   PMID:12642482   PMID:12649319   PMID:12666205   PMID:12866128   PMID:12921743   PMID:12972610   PMID:14517990  
PMID:14607778   PMID:14651921   PMID:14681479   PMID:14687546   PMID:14702043   PMID:14732396   PMID:14757642   PMID:14764602   PMID:14766969   PMID:15019995   PMID:15033430   PMID:15060169  
PMID:15156153   PMID:15198674   PMID:15280211   PMID:15288261   PMID:15459106   PMID:15465493   PMID:15489334   PMID:15496443   PMID:15496460   PMID:15536134   PMID:15548585   PMID:15563463  
PMID:15578515   PMID:15591414   PMID:15607978   PMID:15618518   PMID:15645444   PMID:15659488   PMID:15670790   PMID:15689374   PMID:15731404   PMID:15821257   PMID:15866158   PMID:15870295  
PMID:15905075   PMID:15976303   PMID:16000382   PMID:16038893   PMID:16061358   PMID:16107537   PMID:16120638   PMID:16141072   PMID:16141073   PMID:16169709   PMID:16192304   PMID:16214363  
PMID:16230531   PMID:16236765   PMID:16287482   PMID:16292344   PMID:16314515   PMID:16324690   PMID:16365048   PMID:16399505   PMID:16489008   PMID:16508307   PMID:16508312   PMID:16518823  
PMID:16524929   PMID:16539717   PMID:16543950   PMID:16554359   PMID:16602821   PMID:16651378   PMID:16682500   PMID:16710472   PMID:16728479   PMID:16766699   PMID:16840533   PMID:16899237  
PMID:16902998   PMID:16914494   PMID:16916793   PMID:17015435   PMID:17079689   PMID:17095659   PMID:17107998   PMID:17150554   PMID:17150988   PMID:17196193   PMID:17257418   PMID:17267606  
PMID:17306789   PMID:17360543   PMID:17367776   PMID:17426285   PMID:17476283   PMID:17558399   PMID:17559664   PMID:17591923   PMID:17592117   PMID:17611704   PMID:17681138   PMID:17687036  
PMID:17804764   PMID:17823936   PMID:17880938   PMID:18093989   PMID:18173746   PMID:18227155   PMID:18287091   PMID:18287559   PMID:18292208   PMID:18297083   PMID:18302773   PMID:18308300  
PMID:18344989   PMID:18400163   PMID:18410734   PMID:18430630   PMID:18495817   PMID:18498355   PMID:18499474   PMID:18528438   PMID:18557763   PMID:18565209   PMID:18579678   PMID:18588871  
PMID:18635610   PMID:18638478   PMID:18694942   PMID:18762022   PMID:18777163   PMID:18816825   PMID:18840712   PMID:18927153   PMID:18940587   PMID:18950867   PMID:18976936   PMID:18996108  
PMID:19030180   PMID:19050759   PMID:19123128   PMID:19124651   PMID:19139274   PMID:19161597   PMID:19191219   PMID:19214430   PMID:19223466   PMID:19306043   PMID:19318120   PMID:19343206  
PMID:19369396   PMID:19369400   PMID:19369401   PMID:19383720   PMID:19386638   PMID:19403103   PMID:19416500   PMID:19439425   PMID:19466597   PMID:19474320   PMID:19487809   PMID:19501159  
PMID:19502490   PMID:19521500   PMID:19525946   PMID:19541765   PMID:19542352   PMID:19546852   PMID:19549527   PMID:19551907   PMID:19574443   PMID:19590010   PMID:19598246   PMID:19609448  
PMID:19619492   PMID:19666558   PMID:19670267   PMID:19684110   PMID:19688092   PMID:19723505   PMID:19723774   PMID:19782673   PMID:19828801   PMID:19855134   PMID:19906857   PMID:19914171  
PMID:20007915   PMID:20017954   PMID:20048339   PMID:20059953   PMID:20067572   PMID:20105280   PMID:20110912   PMID:20122914   PMID:20134146   PMID:20147383   PMID:20233719   PMID:20235092  
PMID:20237281   PMID:20335360   PMID:20346184   PMID:20392836   PMID:20418906   PMID:20431921   PMID:20448145   PMID:20460368   PMID:20503368   PMID:20506217   PMID:20510365   PMID:20545770  
PMID:20547764   PMID:20610746   PMID:20625432   PMID:20627076   PMID:20628571   PMID:20652258   PMID:20652960   PMID:20678473   PMID:20691176   PMID:20727876   PMID:20808958   PMID:20833714  
PMID:20883684   PMID:20947685   PMID:20950430   PMID:21062863   PMID:21074523   PMID:21084301   PMID:21084383   PMID:21089298   PMID:21093323   PMID:21167918   PMID:21169561   PMID:21194568  
PMID:21205788   PMID:21221806   PMID:21259317   PMID:21262812   PMID:21266405   PMID:21267068   PMID:21270765   PMID:21300049   PMID:21302255   PMID:21311046   PMID:21349854   PMID:21354131  
PMID:21364918   PMID:21389783   PMID:21402740   PMID:21414292   PMID:21420948   PMID:21451052   PMID:21481105   PMID:21490060   PMID:21502507   PMID:21525287   PMID:21606479   PMID:21670299  
PMID:21677159   PMID:21677750   PMID:21703454   PMID:21729740   PMID:21731673   PMID:21743007   PMID:21744064   PMID:21745596   PMID:21750033   PMID:21781958   PMID:21786021   PMID:21791528  
PMID:21798254   PMID:21829655   PMID:21841314   PMID:21856296   PMID:21873635   PMID:21880902   PMID:21888903   PMID:21991352   PMID:22015720   PMID:22031906   PMID:22037762   PMID:22056382  
PMID:22069190   PMID:22069191   PMID:22090505   PMID:22096075   PMID:22096492   PMID:22146645   PMID:22167192   PMID:22173065   PMID:22185794   PMID:22228100   PMID:22232070   PMID:22232434  
PMID:22258620   PMID:22274697   PMID:22275127   PMID:22318232   PMID:22323600   PMID:22331706   PMID:22360968   PMID:22371696   PMID:22406641   PMID:22434868   PMID:22461559   PMID:22529374  
PMID:22649105   PMID:22652674   PMID:22675208   PMID:22675211   PMID:22689348   PMID:22718343   PMID:22778136   PMID:22783020   PMID:22840391   PMID:22982865   PMID:22993445   PMID:23023701  
PMID:23071096   PMID:23083737   PMID:23123965   PMID:23132245   PMID:23134481   PMID:23152541   PMID:23160044   PMID:23197712   PMID:23199335   PMID:23207146   PMID:23213461   PMID:23223237  
PMID:23223288   PMID:23255132   PMID:23267012   PMID:23274689   PMID:23277114   PMID:23284756   PMID:23315998   PMID:23319657   PMID:23325756   PMID:23362348   PMID:23364326   PMID:23386589  
PMID:23449471   PMID:23454273   PMID:23454691   PMID:23489689   PMID:23499991   PMID:23509692   PMID:23526992   PMID:23555292   PMID:23604318   PMID:23630292   PMID:23686616   PMID:23699523  
PMID:23749646   PMID:23776550   PMID:23850665   PMID:23852729   PMID:23860410   PMID:23871867   PMID:23884446   PMID:23884928   PMID:23951403   PMID:24012753   PMID:24015274   PMID:24019535  
PMID:24146773   PMID:24148613   PMID:24153254   PMID:24164893   PMID:24179156   PMID:24185616   PMID:24198274   PMID:24227653   PMID:24300895   PMID:24337118   PMID:24376126   PMID:24391519  
PMID:24402046   PMID:24431450   PMID:24449835   PMID:24486648   PMID:24491691   PMID:24523460   PMID:24552588   PMID:24583262   PMID:24594350   PMID:24673559   PMID:24755984   PMID:24859004  
PMID:24952961   PMID:25005473   PMID:25063451   PMID:25072663   PMID:25084035   PMID:25100656   PMID:25234168   PMID:25268479   PMID:25331604   PMID:25398052   PMID:25401743   PMID:25446530  
PMID:25451153   PMID:25535395   PMID:25535917   PMID:25546423   PMID:25556712   PMID:25605944   PMID:25687338   PMID:25691540   PMID:25701255   PMID:25715394   PMID:25715395   PMID:25733872  
PMID:25784680   PMID:25842978   PMID:25846153   PMID:25907274   PMID:25919081   PMID:25936505   PMID:26002917   PMID:26023097   PMID:26033091   PMID:26051942   PMID:26116661   PMID:26166575  
PMID:26209882   PMID:26212322   PMID:26276819   PMID:26286942   PMID:26297811   PMID:26348989   PMID:26411367   PMID:26439398   PMID:26450967   PMID:26453796   PMID:26494792   PMID:26534985  
PMID:26598619   PMID:26651607   PMID:26655730   PMID:26689699   PMID:26697723   PMID:26711912   PMID:26720614   PMID:26728556   PMID:26740489   PMID:26791579   PMID:26804914   PMID:26837467  
PMID:26856890   PMID:26911688   PMID:26912775   PMID:26928066   PMID:26932672   PMID:26939553   PMID:27005988   PMID:27009199   PMID:27046831   PMID:27112428   PMID:27122169   PMID:27160681  
PMID:27184845   PMID:27224017   PMID:27322654   PMID:27354375   PMID:27405330   PMID:27510977   PMID:27531557   PMID:27537524   PMID:27596755   PMID:27621062   PMID:27631609   PMID:27639167  
PMID:27697904   PMID:27719760   PMID:27922003   PMID:27974206   PMID:27991863   PMID:27993987   PMID:28036337   PMID:28094771   PMID:28192800   PMID:28205312   PMID:28248965   PMID:28286920  
PMID:28344005   PMID:28402857   PMID:28438836   PMID:28489825   PMID:28526753   PMID:28530678   PMID:28536281   PMID:28577314   PMID:28602625   PMID:28655839   PMID:28656980   PMID:28675662  
PMID:28794157   PMID:28808228   PMID:28816361   PMID:28916710   PMID:28974640   PMID:29058721   PMID:29070679   PMID:29140246   PMID:29171783   PMID:29241683   PMID:29249622   PMID:29297498  
PMID:29326173   PMID:29351579   PMID:29385539   PMID:29389974   PMID:29445148   PMID:29449451   PMID:29491143   PMID:29496446   PMID:29507213   PMID:29513653   PMID:29567677   PMID:29578405  
PMID:29712641   PMID:29798841   PMID:29869113   PMID:29885287   PMID:29887318   PMID:29902458   PMID:29950673   PMID:29961574   PMID:30001316   PMID:30059908   PMID:30090006   PMID:30093553  
PMID:30201687   PMID:30260951   PMID:30292786   PMID:30428088   PMID:30487608   PMID:30504829   PMID:30514723   PMID:30551562   PMID:30590051   PMID:30635555   PMID:30670317   PMID:30692224  
PMID:30705405   PMID:30745427   PMID:30862660   PMID:30862661   PMID:30951556   PMID:30953627   PMID:31015298   PMID:31053533   PMID:31068677   PMID:31080134   PMID:31160641   PMID:31178417  
PMID:31220272   PMID:31320326   PMID:31340161   PMID:31412026   PMID:31412250   PMID:31442404   PMID:31504280   PMID:31634536   PMID:31636950   PMID:31721388   PMID:31767679   PMID:31845891  
PMID:31875961   PMID:31907354   PMID:31924792   PMID:31949107   PMID:31988190   PMID:32059775   PMID:32071286   PMID:32094111   PMID:32129527   PMID:32274496   PMID:32454795   PMID:32467237  
PMID:32497091   PMID:32518258   PMID:32708917   PMID:32747435   PMID:32800756   PMID:32845239   PMID:32857879   PMID:32950463   PMID:32957483   PMID:33067264   PMID:33222180   PMID:33264418  
PMID:33314792   PMID:33371813   PMID:33428890   PMID:33531431   PMID:33575260   PMID:33591268   PMID:33622250   PMID:33637744   PMID:33675998   PMID:33730615   PMID:33773996   PMID:33830085  
PMID:33898448   PMID:34150743   PMID:34189436   PMID:34233187   PMID:34234180   PMID:34407390   PMID:34590699   PMID:34742737   PMID:34824237   PMID:34928956   PMID:34990407   PMID:34998785  
PMID:35084365   PMID:35103284   PMID:35228746   PMID:35247391   PMID:35263597   PMID:35303432   PMID:35322202   PMID:35377797   PMID:35451126   PMID:35512705   PMID:35575074   PMID:35577801  
PMID:35676931   PMID:35682694   PMID:35732696   PMID:35906071   PMID:35951005   PMID:35998585   PMID:36064547   PMID:36075324   PMID:36194632   PMID:36218069   PMID:36253375   PMID:36459481  
PMID:36639541   PMID:36681690   PMID:36899896   PMID:36973704   PMID:37073980   PMID:37172728   PMID:37200191   PMID:37269288   PMID:37369584   PMID:37471646   PMID:37565579   PMID:37573008  
PMID:37751417   PMID:38159855   PMID:38227267   PMID:38459621   PMID:38772376   PMID:38834239  


Genomics

Comparative Map Data
Hes1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391629,883,259 - 29,886,614 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1629,883,202 - 29,886,614 (+)EnsemblGRCm39 Ensembl
GRCm381630,065,357 - 30,067,796 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1630,064,384 - 30,067,796 (+)EnsemblGRCm38mm10GRCm38
MGSCv371630,065,443 - 30,067,882 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361629,985,104 - 29,987,543 (+)NCBIMGSCv36mm8
Celera1630,572,496 - 30,574,749 (+)NCBICelera
Cytogenetic Map16B2NCBI
cM Map1621.09NCBI
HES1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383194,136,148 - 194,138,732 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3194,136,148 - 194,138,732 (+)EnsemblGRCh38hg38GRCh38
GRCh373193,853,937 - 193,856,521 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363195,336,628 - 195,339,090 (+)NCBINCBI36Build 36hg18NCBI36
Celera3192,270,388 - 192,272,854 (+)NCBICelera
Cytogenetic Map3q29NCBI
HuRef3191,241,261 - 191,243,734 (+)NCBIHuRef
CHM1_13193,816,827 - 193,819,297 (+)NCBICHM1_1
T2T-CHM13v2.03196,832,819 - 196,835,403 (+)NCBIT2T-CHM13v2.0
Hes1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81184,210,632 - 84,213,045 (-)NCBIGRCr8
mRatBN7.21170,705,763 - 70,708,176 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1170,705,764 - 70,708,192 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1179,549,796 - 79,552,209 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01172,184,221 - 72,186,634 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01171,238,898 - 71,241,311 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01174,312,837 - 74,315,249 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1174,312,806 - 74,315,248 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01177,360,109 - 77,362,521 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41172,603,482 - 72,605,673 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11172,661,439 - 72,663,801 (-)NCBI
Celera1169,677,011 - 69,679,422 (-)NCBICelera
Cytogenetic Map11q22NCBI
Hes1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542014,564,283 - 14,568,447 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542014,565,921 - 14,568,447 (-)NCBIChiLan1.0ChiLan1.0
HES1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22192,057,229 - 192,060,673 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13192,062,515 - 192,065,400 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03191,432,513 - 191,435,387 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13201,749,044 - 201,751,591 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3201,749,044 - 201,754,257 (+)Ensemblpanpan1.1panPan2
HES1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha2352,257,121 - 52,259,752 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02353,157,666 - 53,160,303 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2353,153,934 - 53,160,310 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12352,667,374 - 52,670,002 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02352,721,885 - 52,724,518 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02353,007,809 - 53,010,447 (+)NCBIUU_Cfam_GSD_1.0
Hes1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602123,607,220 - 123,609,806 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936711639,905 - 642,622 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936711640,002 - 642,580 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HES1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13131,135,725 - 131,138,237 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113131,135,970 - 131,137,865 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213140,633,207 - 140,635,734 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HES1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11588,220,093 - 88,222,563 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1588,220,083 - 88,223,243 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604161,888,842 - 61,891,572 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hes1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473063,563,754 - 63,566,781 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473063,563,848 - 63,566,303 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hes1
80 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:673
Count of miRNA genes:447
Interacting mature miRNAs:512
Transcripts:ENSMUST00000023171, ENSMUST00000160592, ENSMUST00000161676, ENSMUST00000161839
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11059560Lmr12b_mleishmaniasis resistance 12b (mouse)162879281362792952Mouse
26884376Skwq4_mskull length QTL 4, 5 week (mouse)16841786490896888Mouse
1301841Lrnx9_mlearning-contextual 9 (mouse)Not determined161222536046225471Mouse
4141179Ipng3_mimprinted postnatal growth 3 (mouse)Not determined2277525257594076Mouse
38501069Tip4_mtuberculosis immunophenotype 4, IFN-g level (mouse)16431786444520363Mouse
26884432Zlq7_mzygomatic length QTL 7, 10 week (mouse)16381786464620363Mouse
11049571Lmr12c_mleishmaniasis resistance 12c (mouse)162879281362792952Mouse
1301086Lprm5_mlymphoproliferation modifier 5 (mouse)Not determined161184882445848923Mouse
27226768Tibl9_mtibia length 9, 5 week (mouse)16331786451420363Mouse
11059559Lmr12a_mleishmaniasis resistance 12a (mouse)162879281362792952Mouse
1301443Mopkd2_mmodifier of polycystic kidney disease progression 2 (mouse)Not determined16464631438646414Mouse
10043978Obq35_mobesity QTL 35 (mouse)Not determined16988163143881631Mouse
1357763Lp1_mlymphocyte proliferation 1 (mouse)Not determined16654297965466552Mouse
1357517Bwtn1_mbody weight at necropsy 1 (mouse)Not determined162001932985600826Mouse
1300943Skts9_mskin tumor susceptibility 9 (mouse)Not determined16577525239775440Mouse
10412289Ppsl_mplasma P-selectin levels (mouse)Not determined16130814572Mouse
1300915Lmr12_mleishmaniasis resistance 12 (mouse)Not determined162879281362792952Mouse
1300656Bgeq15_mbody growth early QTL 15 (mouse)Not determined16577525239775440Mouse
4142236Pstc4_mperiosteal circumference 4 (mouse)Not determined161552290949523112Mouse
1301559Bbaa19_mB.burgdorferi-associated arthritis 19 (mouse)Not determined16130066977Mouse
1300534Bmd15_mbone mineral density 15 (mouse)Not determined162193838355938574Mouse
11251724Ewc6_methanol withdrawal and consumption 6 (mouse)16822605242226052Mouse
1300987Skull23_mskull morphology 23 (mouse)Not determined16577525239775440Mouse
1301945Skl7_mskeletal size (tail length) 7 (mouse)Not determined16577525239775440Mouse
4141010Bbq1_mbrain and behavior QTL 1 (mouse)Not determined16647700935021216Mouse
10045614Rapop6_mradiation-induced apoptosis 6 (mouse)Not determined161480292148803032Mouse
15092062Egrme4_mearly growth rate, maternal effect 4 (mouse)162521866444220250Mouse
27095908Scvln7_msacral vertebrae length 2, 5 week (mouse)16331786439820362Mouse
27226785Feml12_mfemur length 12, 5 week (mouse)16331786464620363Mouse

Markers in Region
Hes1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381630,065,674 - 30,067,039UniSTSGRCm38
MGSCv371630,065,760 - 30,067,125UniSTSGRCm37
Celera1630,572,813 - 30,574,179UniSTS
Cytogenetic Map16B2UniSTS
cM Map1627.0UniSTS
Hes1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381630,067,325 - 30,067,725UniSTSGRCm38
MGSCv371630,067,411 - 30,067,811UniSTSGRCm37
Cytogenetic Map16B2UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000023171   ⟹   ENSMUSP00000023171
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1629,884,158 - 29,886,614 (+)Ensembl
GRCm38.p6 Ensembl1630,065,340 - 30,067,796 (+)Ensembl
Ensembl Acc Id: ENSMUST00000160592
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1629,883,202 - 29,884,398 (+)Ensembl
GRCm38.p6 Ensembl1630,064,384 - 30,065,580 (+)Ensembl
Ensembl Acc Id: ENSMUST00000161676
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1629,884,915 - 29,885,941 (+)Ensembl
GRCm38.p6 Ensembl1630,066,097 - 30,067,123 (+)Ensembl
Ensembl Acc Id: ENSMUST00000161839
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1629,885,156 - 29,886,137 (+)Ensembl
GRCm38.p6 Ensembl1630,066,338 - 30,067,319 (+)Ensembl
RefSeq Acc Id: NM_001413568   ⟹   NP_001400497
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391629,885,238 - 29,886,614 (+)NCBI
RefSeq Acc Id: NM_001416728   ⟹   NP_001403657
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391629,884,162 - 29,886,614 (+)NCBI
RefSeq Acc Id: NM_001416729   ⟹   NP_001403658
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391629,883,259 - 29,886,614 (+)NCBI
RefSeq Acc Id: NM_001416730   ⟹   NP_001403659
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391629,884,162 - 29,886,614 (+)NCBI
RefSeq Acc Id: NM_001416731   ⟹   NP_001403660
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391629,885,238 - 29,886,614 (+)NCBI
RefSeq Acc Id: NM_008235   ⟹   NP_032261
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391629,884,162 - 29,886,614 (+)NCBI
GRCm381630,065,357 - 30,067,796 (+)ENTREZGENE
MGSCv371630,065,443 - 30,067,882 (+)RGD
Celera1630,572,496 - 30,574,749 (+)RGD
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_032261   ⟸   NM_008235
- Peptide Label: isoform 1
- UniProtKB: P35428 (UniProtKB/Swiss-Prot),   Q3UZZ2 (UniProtKB/TrEMBL),   Q3V1C5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000023171   ⟸   ENSMUST00000023171
RefSeq Acc Id: NP_001403658   ⟸   NM_001416729
- Peptide Label: isoform 1
- UniProtKB: P35428 (UniProtKB/Swiss-Prot),   Q3V1C5 (UniProtKB/TrEMBL),   Q3UZZ2 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001403659   ⟸   NM_001416730
- Peptide Label: isoform 2
- UniProtKB: Q3V1C5 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001403657   ⟸   NM_001416728
- Peptide Label: isoform 1
- UniProtKB: P35428 (UniProtKB/Swiss-Prot),   Q3V1C5 (UniProtKB/TrEMBL),   Q3UZZ2 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001400497   ⟸   NM_001413568
- Peptide Label: isoform 3
RefSeq Acc Id: NP_001403660   ⟸   NM_001416731
- Peptide Label: isoform 3
Protein Domains
bHLH   Orange

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35428-F1-model_v2 AlphaFold P35428 1-282 view protein structure

Promoters
RGD ID:6827121
Promoter ID:MM_KWN:20673
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000023171
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361630,064,496 - 30,065,877 (+)MPROMDB
RGD ID:8685928
Promoter ID:EPDNEW_M20995
Type:multiple initiation site
Name:Hes1_1
Description:Mus musculus hes family bHLH transcription factor 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381630,065,344 - 30,065,404EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:104853 AgrOrtholog
Ensembl Genes ENSMUSG00000022528 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000023171 ENTREZGENE
  ENSMUST00000023171.8 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.250.980 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro bHLH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HES_HEY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Orange_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:15205 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:104853 ENTREZGENE
NCBI Gene 15205 ENTREZGENE
PANTHER BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRANSCRIPTION FACTOR HES-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Hairy_orange UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hes1 PhenoGen
PROSITE BHLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ORANGE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ORANGE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Orange domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47459 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt HES1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3UZZ2 ENTREZGENE, UniProtKB/TrEMBL
  Q3V1C5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-10-31 Hes1  hes family bHLH transcription factor 1    hairy and enhancer of split 1 (Drosophila)  Symbol and/or name change 5135510 APPROVED