Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Limk2 | Mouse | 1,2-dimethylhydrazine | decreases expression | EXP | | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of LIMK2 mRNA | CTD | PMID:22206623 | Limk2 | Mouse | 1-naphthyl isothiocyanate | increases expression | ISO | Limk2 (Rattus norvegicus) | 6480464 | 1-Naphthylisothiocyanate results in increased expression of LIMK2 mRNA | CTD | PMID:25380136 and PMID:30723492 | Limk2 | Mouse | 17alpha-ethynylestradiol | decreases expression | ISO | Limk2 (Rattus norvegicus) | 6480464 | Ethinyl Estradiol results in decreased expression of LIMK2 mRNA | CTD | PMID:17557909 | Limk2 | Mouse | 17alpha-ethynylestradiol | affects expression | ISO | Limk2 (Rattus norvegicus) | 6480464 | Ethinyl Estradiol affects the expression of LIMK2 mRNA | CTD | PMID:20170705 and PMID:26865667 | Limk2 | Mouse | 17alpha-ethynylestradiol | affects expression | ISO | LIMK2 (Homo sapiens) | 6480464 | Ethinyl Estradiol affects the expression of LIMK2 mRNA | CTD | PMID:20170705 and PMID:26865667 | Limk2 | Mouse | 17alpha-ethynylestradiol | decreases expression | ISO | LIMK2 (Homo sapiens) | 6480464 | Ethinyl Estradiol results in decreased expression of LIMK2 mRNA | CTD | PMID:18936297 | Limk2 | Mouse | 17beta-estradiol | decreases expression | ISO | Limk2 (Rattus norvegicus) | 6480464 | Estradiol results in decreased expression of LIMK2 mRNA | CTD | PMID:32145629 | Limk2 | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Limk2 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of LIMK2 mRNA | CTD | PMID:21215274 | Limk2 | Mouse | 3,3',4,4',5-pentachlorobiphenyl | decreases expression | ISO | Limk2 (Rattus norvegicus) | 6480464 | 3 more ... | CTD | PMID:19692669 | Limk2 | Mouse | 4,4'-diaminodiphenylmethane | increases expression | ISO | Limk2 (Rattus norvegicus) | 6480464 | 4 and 4'-diaminodiphenylmethane results in increased expression of LIMK2 mRNA | CTD | PMID:25380136 | Limk2 | Mouse | 5-fluorouracil | affects response to substance | ISO | LIMK2 (Homo sapiens) | 6480464 | LIMK2 protein affects the susceptibility to Fluorouracil | CTD | PMID:16217747 | Limk2 | Mouse | 6-propyl-2-thiouracil | increases expression | ISO | Limk2 (Rattus norvegicus) | 6480464 | Propylthiouracil results in increased expression of LIMK2 mRNA | CTD | PMID:24780913 | Limk2 | Mouse | acetamide | increases expression | ISO | Limk2 (Rattus norvegicus) | 6480464 | acetamide results in increased expression of LIMK2 mRNA | CTD | PMID:31881176 | Limk2 | Mouse | aflatoxin B1 | affects expression | ISO | LIMK2 (Homo sapiens) | 6480464 | Aflatoxin B1 affects the expression of LIMK2 protein | CTD | PMID:20106945 | Limk2 | Mouse | aflatoxin B1 | increases expression | ISO | Limk2 (Rattus norvegicus) | 6480464 | Aflatoxin B1 results in increased expression of LIMK2 mRNA | CTD | PMID:33354967 | Limk2 | Mouse | aflatoxin B1 | increases expression | ISO | LIMK2 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased expression of LIMK2 mRNA | CTD | PMID:22100608 | Limk2 | Mouse | all-trans-retinoic acid | increases expression | ISO | LIMK2 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of LIMK2 mRNA | CTD | PMID:33167477 | Limk2 | Mouse | ammonium chloride | affects expression | ISO | Limk2 (Rattus norvegicus) | 6480464 | Ammonium Chloride affects the expression of LIMK2 mRNA | CTD | PMID:16483693 | Limk2 | Mouse | amphetamine | decreases expression | ISO | Limk2 (Rattus norvegicus) | 6480464 | Amphetamine results in decreased expression of LIMK2 mRNA | CTD | PMID:30779732 | Limk2 | Mouse | aristolochic acid A | increases expression | ISO | LIMK2 (Homo sapiens) | 6480464 | aristolochic acid I results in increased expression of LIMK2 mRNA | CTD | PMID:33212167 | Limk2 | Mouse | benzo[a]pyrene | affects methylation | ISO | LIMK2 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of LIMK2 promoter | CTD | PMID:27901495 | Limk2 | Mouse | benzo[a]pyrene | increases expression | ISO | LIMK2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of LIMK2 mRNA | CTD | PMID:32234424 | Limk2 | Mouse | benzo[a]pyrene | decreases methylation | ISO | LIMK2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of LIMK2 exon | CTD | PMID:27901495 | Limk2 | Mouse | bisphenol A | affects expression | ISO | LIMK2 (Homo sapiens) | 6480464 | bisphenol A affects the expression of LIMK2 mRNA | CTD | PMID:20170705 | Limk2 | Mouse | bisphenol A | affects methylation | ISO | LIMK2 (Homo sapiens) | 6480464 | bisphenol A affects the methylation of LIMK2 gene | CTD | PMID:31601247 | Limk2 | Mouse | bisphenol A | affects expression | ISO | Limk2 (Rattus norvegicus) | 6480464 | bisphenol A affects the expression of LIMK2 mRNA | CTD | PMID:25181051 | Limk2 | Mouse | bisphenol F | decreases expression | EXP | | 6480464 | bisphenol F results in decreased expression of LIMK2 mRNA | CTD | PMID:38685157 | Limk2 | Mouse | cadmium dichloride | decreases expression | ISO | LIMK2 (Homo sapiens) | 6480464 | Cadmium Chloride results in decreased expression of LIMK2 mRNA | CTD | PMID:38568856 | Limk2 | Mouse | caffeine | decreases phosphorylation | ISO | LIMK2 (Homo sapiens) | 6480464 | Caffeine results in decreased phosphorylation of LIMK2 protein | CTD | PMID:35688186 | Limk2 | Mouse | cannabidiol | affects methylation | ISO | Limk2 (Rattus norvegicus) | 6480464 | Cannabidiol affects the methylation of LIMK2 gene | CTD | PMID:30521419 | Limk2 | Mouse | CGP 52608 | multiple interactions | ISO | LIMK2 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to LIMK2 gene] | CTD | PMID:28238834 | Limk2 | Mouse | cisplatin | increases expression | ISO | LIMK2 (Homo sapiens) | 6480464 | Cisplatin results in increased expression of LIMK2 mRNA | CTD | PMID:27594783 | Limk2 | Mouse | copper(II) sulfate | decreases expression | ISO | LIMK2 (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of LIMK2 mRNA | CTD | PMID:19549813 | Limk2 | Mouse | CU-O LINKAGE | decreases expression | ISO | LIMK2 (Homo sapiens) | 6480464 | cupric oxide results in decreased expression of LIMK2 mRNA | CTD | PMID:22077320 | Limk2 | Mouse | cyclosporin A | increases expression | ISO | LIMK2 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of LIMK2 mRNA | CTD | PMID:20106945 | Limk2 | Mouse | dexamethasone | increases expression | EXP | | 6480464 | Dexamethasone results in increased expression of LIMK2 mRNA | CTD | PMID:22733784 | Limk2 | Mouse | Dibutyl phosphate | affects expression | ISO | LIMK2 (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of LIMK2 mRNA | CTD | PMID:37042841 | Limk2 | Mouse | diuron | decreases expression | ISO | Limk2 (Rattus norvegicus) | 6480464 | Diuron results in decreased expression of LIMK2 mRNA | CTD | PMID:21551480 | Limk2 | Mouse | doxorubicin | affects expression | ISO | LIMK2 (Homo sapiens) | 6480464 | Doxorubicin affects the expression of LIMK2 mRNA | CTD | PMID:29803840 | Limk2 | Mouse | endosulfan | decreases expression | ISO | Limk2 (Rattus norvegicus) | 6480464 | Endosulfan results in decreased expression of LIMK2 mRNA | CTD | PMID:29391264 | Limk2 | Mouse | ethanol | affects splicing | EXP | | 6480464 | Ethanol affects the splicing of LIMK2 mRNA | CTD | PMID:30319688 | Limk2 | Mouse | ethyl methanesulfonate | increases expression | ISO | LIMK2 (Homo sapiens) | 6480464 | Ethyl Methanesulfonate results in increased expression of LIMK2 mRNA | CTD | PMID:23649840 | Limk2 | Mouse | fasudil | multiple interactions | ISO | Limk2 (Rattus norvegicus) | 6480464 | fasudil inhibits the reaction [Streptozocin results in increased phosphorylation of LIMK2 protein] | CTD | PMID:22062134 | Limk2 | Mouse | flutamide | increases expression | ISO | Limk2 (Rattus norvegicus) | 6480464 | Flutamide results in increased expression of LIMK2 mRNA | CTD | PMID:24136188 | Limk2 | Mouse | formaldehyde | increases expression | ISO | LIMK2 (Homo sapiens) | 6480464 | Formaldehyde results in increased expression of LIMK2 mRNA | CTD | PMID:23649840 | Limk2 | Mouse | FR900359 | decreases phosphorylation | ISO | LIMK2 (Homo sapiens) | 6480464 | FR900359 results in decreased phosphorylation of LIMK2 protein | CTD | PMID:37730182 | Limk2 | Mouse | genistein | affects expression | ISO | LIMK2 (Homo sapiens) | 6480464 | Genistein affects the expression of LIMK2 mRNA | CTD | PMID:26865667 | Limk2 | Mouse | leflunomide | increases expression | ISO | Limk2 (Rattus norvegicus) | 6480464 | leflunomide results in increased expression of LIMK2 mRNA | CTD | PMID:24136188 | Limk2 | Mouse | leflunomide | increases expression | ISO | LIMK2 (Homo sapiens) | 6480464 | leflunomide results in increased expression of LIMK2 mRNA | CTD | PMID:28988120 | Limk2 | Mouse | lidocaine | increases expression | ISO | Limk2 (Rattus norvegicus) | 6480464 | Lidocaine results in increased expression of LIMK2 mRNA | CTD | PMID:35283115 | Limk2 | Mouse | maneb | multiple interactions | EXP | | 6480464 | [Paraquat co-treated with Maneb] results in decreased expression of LIMK2 mRNA | CTD | PMID:18386188 | Limk2 | Mouse | methyl methanesulfonate | increases expression | ISO | LIMK2 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in increased expression of LIMK2 mRNA | CTD | PMID:23649840 | Limk2 | Mouse | methylmercury chloride | decreases expression | ISO | LIMK2 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of LIMK2 mRNA | CTD | PMID:28001369 | Limk2 | Mouse | N-nitrosodimethylamine | increases expression | ISO | Limk2 (Rattus norvegicus) | 6480464 | Dimethylnitrosamine results in increased expression of LIMK2 mRNA | CTD | PMID:25380136 | Limk2 | Mouse | ozone | multiple interactions | ISO | LIMK2 (Homo sapiens) | 6480464 | [Air Pollutants results in increased abundance of Ozone] which affects the expression of LIMK2 mRNA | CTD | PMID:35430440 | Limk2 | Mouse | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of LIMK2 mRNA | CTD | PMID:17585979 | Limk2 | Mouse | paracetamol | decreases expression | ISO | Limk2 (Rattus norvegicus) | 6480464 | Acetaminophen results in decreased expression of LIMK2 mRNA | CTD | PMID:33387578 | Limk2 | Mouse | paracetamol | increases expression | ISO | LIMK2 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of LIMK2 mRNA | CTD | PMID:25704631 | Limk2 | Mouse | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of LIMK2 mRNA | CTD | PMID:17562736 | Limk2 | Mouse | paraquat | multiple interactions | EXP | | 6480464 | [Paraquat co-treated with Maneb] results in decreased expression of LIMK2 mRNA | CTD | PMID:18386188 | Limk2 | Mouse | perfluorooctanoic acid | increases expression | ISO | Limk2 (Rattus norvegicus) | 6480464 | perfluorooctanoic acid results in increased expression of LIMK2 mRNA | CTD | PMID:19162173 | Limk2 | Mouse | phenobarbital | increases expression | ISO | Limk2 (Rattus norvegicus) | 6480464 | Phenobarbital results in increased expression of LIMK2 mRNA | CTD | PMID:19162173 | Limk2 | Mouse | pregnenolone 16alpha-carbonitrile | increases expression | ISO | Limk2 (Rattus norvegicus) | 6480464 | Pregnenolone Carbonitrile results in increased expression of LIMK2 mRNA | CTD | PMID:19162173 | Limk2 | Mouse | Sanggenon C | decreases expression | ISO | Limk2 (Rattus norvegicus) | 6480464 | sanggenone C results in decreased expression of LIMK2 protein | CTD | PMID:32240450 | Limk2 | Mouse | sevoflurane | affects expression | ISO | Limk2 (Rattus norvegicus) | 6480464 | sevoflurane affects the expression of LIMK2 mRNA | CTD | PMID:15967596 | Limk2 | Mouse | sodium arsenite | decreases expression | ISO | LIMK2 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of LIMK2 mRNA | CTD | PMID:38568856 | Limk2 | Mouse | streptozocin | increases phosphorylation | ISO | Limk2 (Rattus norvegicus) | 6480464 | Streptozocin results in increased phosphorylation of LIMK2 protein | CTD | PMID:22062134 | Limk2 | Mouse | streptozocin | multiple interactions | ISO | Limk2 (Rattus norvegicus) | 6480464 | fasudil inhibits the reaction [Streptozocin results in increased phosphorylation of LIMK2 protein] | CTD | PMID:22062134 | Limk2 | Mouse | sunitinib | increases expression | ISO | LIMK2 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of LIMK2 mRNA | CTD | PMID:31533062 | Limk2 | Mouse | tauroursodeoxycholic acid | decreases expression | ISO | Limk2 (Rattus norvegicus) | 6480464 | ursodoxicoltaurine results in decreased expression of LIMK2 mRNA | CTD | PMID:15885361 | Limk2 | Mouse | testosterone | multiple interactions | EXP | | 6480464 | 1 more ... | CTD | PMID:33848595 | Limk2 | Mouse | testosterone | increases expression | EXP | | 6480464 | Testosterone deficiency results in increased expression of LIMK2 mRNA | CTD | PMID:33848595 | Limk2 | Mouse | testosterone enanthate | affects expression | ISO | LIMK2 (Homo sapiens) | 6480464 | testosterone enanthate affects the expression of LIMK2 mRNA | CTD | PMID:17440010 | Limk2 | Mouse | thioacetamide | increases expression | ISO | Limk2 (Rattus norvegicus) | 6480464 | Thioacetamide results in increased expression of LIMK2 mRNA | CTD | PMID:34492290 | Limk2 | Mouse | titanium dioxide | increases methylation | EXP | | 6480464 | titanium dioxide results in increased methylation of LIMK2 gene | CTD | PMID:35295148 | Limk2 | Mouse | topotecan | affects response to substance | ISO | LIMK2 (Homo sapiens) | 6480464 | LIMK2 protein affects the susceptibility to Topotecan | CTD | PMID:16217747 | Limk2 | Mouse | triphenyl phosphate | affects expression | ISO | LIMK2 (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of LIMK2 mRNA | CTD | PMID:37042841 | Limk2 | Mouse | triptonide | increases expression | EXP | | 6480464 | triptonide results in increased expression of LIMK2 mRNA | CTD | PMID:33045310 | Limk2 | Mouse | undecane | decreases expression | ISO | Limk2 (Rattus norvegicus) | 6480464 | undecane results in decreased expression of LIMK2 protein | CTD | PMID:17337753 | Limk2 | Mouse | valproic acid | increases expression | EXP | | 6480464 | Valproic Acid results in increased expression of LIMK2 mRNA | CTD | PMID:20546886 | Limk2 | Mouse | valproic acid | affects expression | ISO | LIMK2 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of LIMK2 mRNA | CTD | PMID:25979313 | Limk2 | Mouse | valproic acid | decreases expression | ISO | LIMK2 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of LIMK2 mRNA | CTD | PMID:28001369 | Limk2 | Mouse | vinclozolin | increases methylation | ISO | Limk2 (Rattus norvegicus) | 6480464 | vinclozolin results in increased methylation of LIMK2 gene | CTD | PMID:31079544 | |