Xdh (xanthine dehydrogenase) - Rat Genome Database

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Gene: Xdh (xanthine dehydrogenase) Mus musculus
Analyze
Symbol: Xdh
Name: xanthine dehydrogenase
RGD ID: 62335
MGI Page MGI
Description: Enables oxidoreductase activity, acting on CH or CH2 groups. Involved in several processes, including purine nucleobase catabolic process; purine nucleoside catabolic process; and purine nucleoside monophosphate catabolic process. Acts upstream of or within iron-sulfur cluster assembly; lactation; and regulation of epithelial cell differentiation. Located in sarcoplasmic reticulum. Is active in cytosol. Is expressed in several structures, including adrenal gland; genitourinary system; intestine; liver; and spleen. Human ortholog(s) of this gene implicated in several diseases, including Lesch-Nyhan syndrome; artery disease (multiple); chronic kidney disease; hyperuricemia; and xanthinuria type I. Orthologous to human XDH (xanthine dehydrogenase).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: X; xanthine dehydrogenase/oxidase; xanthine oxidase; xanthine oxidoreductase; XO; Xor; Xox; Xox-; Xox-1; Xox1
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391774,190,890 - 74,257,191 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1774,190,890 - 74,257,191 (-)EnsemblGRCm39 Ensembl
GRCm381773,883,895 - 73,950,397 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1773,883,895 - 73,950,196 (-)EnsemblGRCm38mm10GRCm38
MGSCv371774,233,248 - 74,299,522 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361773,788,790 - 73,855,081 (-)NCBIMGSCv36mm8
Celera1778,175,030 - 78,239,710 (-)NCBICelera
Cytogenetic Map17E2NCBI
cM Map1745.25NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (IDA,ISO)
Acute Lung Injury  (ISO)
Animal Mammary Neoplasms  (ISO)
Arterial Thrombosis  (ISO)
autistic disorder  (ISO)
Autoinflammation with Infantile Enterocolitis  (ISO)
Brain Injuries  (ISO)
Carbon Monoxide Poisoning  (ISO)
carcinoma  (ISO)
cardiomyopathy  (ISO)
cardiovascular system disease  (ISO)
carotid artery disease  (ISO)
cataract  (ISO)
cholestasis  (ISO)
chronic kidney disease  (ISO)
Colonic Neoplasms  (ISO)
congestive heart failure  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (IMP,ISO)
Dwarfism  (ISO)
Eczema  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Mammary Neoplasms  (ISO)
familial cold autoinflammatory syndrome 4  (ISO)
Fetal Growth Retardation  (ISO)
genetic disease  (ISO)
gout  (ISO)
heart disease  (ISO)
hepatocellular carcinoma  (ISO)
hereditary spastic paraplegia 4  (ISO)
hydronephrosis  (ISO)
Hyperoxaluria  (ISO)
Hyperoxic Lung Injury  (ISO)
hypertension  (ISO)
hyperuricemia  (IEP,IMP,ISO)
Hypotension  (ISO)
interstitial nephritis  (ISO)
Intestinal Reperfusion Injury  (ISO)
ischemia  (ISO)
kidney failure  (IAGP,IMP)
Kidney Reperfusion Injury  (ISO)
laryngeal squamous cell carcinoma  (ISO)
Left Ventricular Hypertrophy  (ISO)
Lesch-Nyhan syndrome  (ISO)
Liver Reperfusion Injury  (ISO)
major depressive disorder  (ISO)
middle cerebral artery infarction  (ISO)
multiple myeloma  (ISO)
Multiple Organ Failure  (ISO)
muscular disease  (ISO)
Myocardial Reperfusion Injury  (ISO)
Nerve Degeneration  (ISO)
neutropenia  (ISO)
obesity  (ISO)
pancreatitis  (ISO)
Penetrating Wounds  (ISO)
peritonitis  (ISO)
Pneumoperitoneum  (ISO)
portal hypertension  (ISO)
protein-losing enteropathy  (ISO)
Pseudovaginal Perineoscrotal Hypospadias  (ISO)
pulmonary embolism  (ISO)
Puromycin Aminonucleoside Nephrosis  (ISO)
renal fibrosis  (ISO)
Renal Ischemia  (ISO)
Reperfusion Injury  (ISO)
Retina Reperfusion Injury  (ISO)
Sepsis  (ISO)
Shock  (ISO)
Spinal Cord Injuries  (ISO)
Testis Reperfusion Injury  (ISO)
thrombocytopenia  (ISO)
Transplant Rejection  (ISO)
Urachal Cyst  (ISO)
urinary bladder cancer  (ISO)
xanthinuria  (ISO)
xanthinuria type I  (ISO)
xanthinuria type II  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-taxifolin  (ISO)
(R)-adrenaline  (ISO)
(R)-lipoic acid  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1,4-dithiothreitol  (ISO)
1-methyl-7H-xanthine  (ISO)
1-methyluric acid  (ISO)
1-naphthyl isothiocyanate  (EXP)
11-deoxycorticosterone  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (EXP)
2,4-dinitrotoluene  (ISO)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-hydroxypropanoic acid  (ISO)
2-nitroanisole  (ISO)
2-nitrofluorene  (EXP,ISO)
3',5'-cyclic GMP  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,7-dihydropurine-6-thione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-methylcholanthrene  (EXP,ISO)
3-phenylprop-2-enal  (ISO)
4'-epidoxorubicin  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-azaorotic acid  (EXP)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP,ISO)
7H-xanthine  (EXP,ISO)
9H-xanthine  (EXP,ISO)
acetaldehyde  (ISO)
acetic acid  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP)
allantoin  (ISO)
allopurinol  (EXP,ISO)
alloxan  (ISO)
alloxanthine  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
amitrole  (ISO)
ammonium acetate  (ISO)
ammonium chloride  (ISO)
anthocyanin  (ISO)
apocynin  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
aspartame  (EXP)
avobenzone  (ISO)
baicalein  (EXP)
baicalin  (EXP)
Benoxacor  (EXP)
benzo[a]pyrene  (EXP,ISO)
Benzoyl peroxide  (EXP)
beta-D-glucosamine  (ISO)
beta-naphthoflavone  (EXP)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bosentan  (ISO)
buspirone  (ISO)
butanal  (ISO)
C60 fullerene  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (EXP)
carboplatin  (ISO)
carvacrol  (EXP)
Chloramine  (ISO)
chloroprene  (EXP)
chlorpyrifos  (ISO)
chlorzoxazone  (ISO)
chromium(6+)  (EXP)
cis-caffeic acid  (EXP)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
clofibric acid  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cordycepin  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cycloartenol  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (ISO)
D-glucose  (ISO)
DDE  (ISO)
DDT  (ISO)
dehydroepiandrosterone  (ISO)
dexamethasone  (EXP,ISO)
dextromethorphan  (ISO)
diallyl trisulfide  (EXP,ISO)
diethylstilbestrol  (EXP,ISO)
diisopropyl fluorophosphate  (ISO)
diosmin  (EXP,ISO)
dioxygen  (ISO)
diquat  (EXP)
diuron  (ISO)
dizocilpine maleate  (ISO)
doxorubicin  (EXP,ISO)
edaravone  (ISO)
endosulfan  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (EXP)
erdosteine  (ISO)
ethanol  (ISO)
ethylenediaminetetraacetic acid  (EXP)
febuxostat  (ISO)
fipronil  (ISO)
flavonoids  (ISO)
fluocinolone acetonide  (EXP)
fluoranthene  (EXP)
formaldehyde  (ISO)
fructose  (ISO)
gallic acid  (ISO)
genistein  (EXP)
glucose  (ISO)
glutathione  (ISO)
glyburide  (EXP)
hydrogen peroxide  (ISO)
hydroxyl  (ISO)
hydroxytyrosol  (ISO)
hypoxanthine  (EXP,ISO)
indometacin  (ISO)
isoprenaline  (EXP,ISO)
isotretinoin  (EXP)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (ISO)
L-glutamine  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP)
liraglutide  (ISO)
Lithospermic acid  (ISO)
lupeol  (EXP)
luteolin  (ISO)
mercaptopurine  (ISO)
Mesaconitine  (ISO)
methamphetamine  (EXP)
methapyrilene  (ISO)
methimazole  (ISO)
methylglyoxal  (ISO)
methylisothiazolinone  (ISO)
mitomycin C  (ISO)
molybdate  (ISO)
monosodium L-glutamate  (EXP)
myo-inositol hexakisphosphate  (ISO)
myricetin  (ISO)
N-acetyl-L-cysteine  (ISO)
N-acetyl-L-tryptophan  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
nefazodone  (ISO)
nickel atom  (ISO)
nicorandil  (EXP,ISO)
nicotine  (ISO)
nitric oxide  (ISO)
nitroprusside  (ISO)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
palytoxin  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
pentachlorophenol  (EXP)
pentanal  (ISO)
pentetrazol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenobarbital  (EXP,ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
piperonyl butoxide  (ISO)
pirinixic acid  (EXP,ISO)
Potassium 2,6-dihydroxytriazinecarboxylate  (EXP)
potassium bromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propanal  (ISO)
propiconazole  (EXP)
purine-6-thiol  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
reactive oxygen species  (EXP,ISO)
resveratrol  (ISO)
rotenone  (ISO)
rutin  (ISO)
SB 203580  (ISO)
Senkirkine  (ISO)
serotonin  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium acetate trihydrate  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium benzoate  (ISO)
sodium disulfite  (ISO)
sodium fluoride  (EXP)
sodium molybdate (anhydrous)  (ISO)
sodium nitrate  (EXP)
sodium tungstate  (ISO)
streptozocin  (ISO)
sulfadimethoxine  (ISO)
superoxide  (ISO)
taurine  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (ISO)
toluene  (ISO)
trans-caffeic acid  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
trovafloxacin  (EXP)
tubocurarine  (ISO)
tungsten  (EXP,ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
vitamin E  (ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity involved in apoptotic process  (IEA,ISO)
adenosine catabolic process  (IDA,IMP,ISO)
allantoin metabolic process  (IDA,IMP,ISO)
amide catabolic process  (IDA,IMP,ISO)
AMP catabolic process  (IDA,ISO)
cellular response to interleukin-1  (ISO)
cellular response to tumor necrosis factor  (ISO)
dAMP catabolic process  (IDA)
deoxyadenosine catabolic process  (IDA)
deoxyguanosine catabolic process  (IDA)
deoxyinosine catabolic process  (IDA,IMP,ISO)
dGMP catabolic process  (IDA)
GMP catabolic process  (IDA)
guanine catabolic process  (IDA,ISO)
hypoxanthine catabolic process  (IDA,IMP,ISO)
IMP catabolic process  (IDA,ISO)
inosine catabolic process  (IDA,IMP,ISO)
iron-sulfur cluster assembly  (IDA)
lactation  (IMP)
negative regulation of endothelial cell differentiation  (IEA,ISO)
negative regulation of endothelial cell proliferation  (ISO)
negative regulation of gene expression  (IEA,ISO)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
negative regulation of protein phosphorylation  (IEA,ISO)
negative regulation of vascular endothelial growth factor signaling pathway  (IEA,ISO)
negative regulation of vasculogenesis  (ISO)
positive regulation of p38MAPK cascade  (IEA,ISO)
positive regulation of reactive oxygen species metabolic process  (IEA,ISO)
regulation of epithelial cell differentiation  (IMP)
response to aluminum ion  (ISO)
response to azide  (ISO)
response to carbon monoxide  (ISO)
response to hydrogen peroxide  (ISO)
response to lipopolysaccharide  (ISO)
xanthine catabolic process  (IBA,IDA,ISO,ISS)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal involution of the mammary gland  (IAGP)
abnormal kidney cortex morphology  (IAGP)
abnormal kidney development  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal lactation  (IAGP)
abnormal lipid homeostasis  (IAGP)
abnormal lung morphology  (IEA)
abnormal mammary gland growth during lactation  (IAGP)
abnormal milk composition  (IAGP)
abnormal peritoneal macrophage morphology  (IAGP)
abnormal renal glomerulus morphology  (IAGP)
abnormal renal tubule epithelium morphology  (IAGP)
abnormal renal tubule morphology  (IAGP)
abnormal skeletal muscle morphology  (IAGP)
abnormal skin morphology  (IEA)
abnormal vitreous body morphology  (IEA)
cataract  (IEA)
crystalluria  (IAGP)
decreased abdominal adipose tissue amount  (IAGP)
decreased blood uric acid level  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased total body fat amount  (IAGP)
dilated renal tubule  (IAGP)
hypoxia  (IAGP)
increased activity of parathyroid  (IAGP)
increased blood urea nitrogen level  (IAGP)
increased circulating alkaline phosphatase level  (IAGP)
increased circulating amylase level  (IAGP)
increased circulating calcium level  (IAGP)
increased circulating creatinine level  (IAGP)
increased circulating hypoxanthine level  (IAGP)
increased circulating xanthine level  (IAGP)
increased triglyceride level  (IAGP)
increased urine hypoxanthine level  (IAGP)
increased urine xanthine level  (IAGP)
kidney failure  (IAGP)
male infertility  (IEA)
oxidative stress  (IAGP)
pale kidney  (IAGP)
persistence of hyaloid vascular system  (IEA)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
renal interstitial fibrosis  (IAGP)
slow postnatal weight gain  (IAGP)
small kidney  (IAGP)
tubulointerstitial nephritis  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Activities of xanthine oxidoreductase and antioxidant enzymes in different tissues of diabetic rats. Aliciguzel Y, etal., J Lab Clin Med 2003 Sep;142(3):172-7.
2. Hypovolemic shock promotes neutrophil sequestration in lungs by a xanthine oxidase-related mechanism. Anderson BO, etal., J Appl Physiol (1985). 1991 Nov;71(5):1862-5.
3. Lipid peroxidation and antioxidant enzyme activities in cancerous bladder tissue and their relation with bacterial infection: a controlled clinical study. Bayraktar N, etal., J Clin Lab Anal. 2010;24(1):25-30. doi: 10.1002/jcla.20356.
4. Modification of the xanthine-converting enzyme of perfused rat heart during ischemia and oxidative stress. Bindoli A, etal., Free Radic Biol Med. 1988;4(3):163-7.
5. Effects of imperatorin, the active component from Radix Angelicae (Baizhi), on the blood pressure and oxidative stress in 2K,1C hypertensive rats. Cao YJ, etal., Phytomedicine. 2013 Jun 6. pii: S0944-7113(13)00199-2. doi: 10.1016/j.phymed.2013.04.021.
6. Polydatin ameliorates renal injury by attenuating oxidative stress-related inflammatory responses in fructose-induced urate nephropathic mice. Chen L, etal., Food Chem Toxicol. 2013 Feb;52:28-35. doi: 10.1016/j.fct.2012.10.037. Epub 2012 Nov 5.
7. [Study on Therapeutic Effects of Ermiao Pill and Ermiao Pill Categorized Formula in Hyperuricemic Rats Using Spectroscopic Methods]. Chen WJ, etal., Guang Pu Xue Yu Guang Pu Fen Xi. 2015 Apr;35(4):956-60.
8. Lack of conversion of xanthine dehydrogenase to xanthine oxidase during warm renal ischemia. Cighetti G, etal., FEBS Lett. 1990 Nov 12;274(1-2):82-4.
9. Protective effect of endogenous hydrogen sulfide against oxidative stress in gastric ischemia-reperfusion injury. Cui J, etal., Exp Ther Med. 2013 Mar;5(3):689-694. Epub 2012 Dec 20.
10. Taurine ameliorates alloxan-induced diabetic renal injury, oxidative stress-related signaling pathways and apoptosis in rats. Das J and Sil PC, Amino Acids. 2012 Oct;43(4):1509-23.
11. The effects of Nigella sativa oil, thymoquinone, propolis, and caffeic acid phenethyl ester on radiation-induced cataract. Demir E, etal., Wien Klin Wochenschr. 2016 Dec;128(Suppl 8):587-595. doi: 10.1007/s00508-015-0736-4. Epub 2015 Apr 10.
12. Lung oxidant changes after zymosan peritonitis: relationship between physiologic and biochemical changes. Demling R, etal., Am Rev Respir Dis. 1992 Nov;146(5 Pt 1):1272-8.
13. The effect of acute nonbacterial dependent peritonitis on lung and liver oxidant stress and antioxidant activity. Demling R, etal., Surgery. 1993 Sep;114(3):571-8.
14. Adenosine deaminase, 5' nucleotidase, xanthine oxidase, superoxide dismutase, and catalase activities in cancerous and noncancerous human laryngeal tissues. Durak I, etal., Free Radic Biol Med. 1993 Dec;15(6):681-4. doi: 10.1016/0891-5849(93)90174-s.
15. Xanthine oxidase inhibition alleviates the cardiac complications of insulin resistance: effect on low grade inflammation and the angiotensin system. El-Bassossy HM and Watson ML, J Transl Med. 2015 Mar 6;13:82. doi: 10.1186/s12967-015-0445-9.
16. Hyperoxia and xanthine dehydrogenase/oxidase activities in rat lung and heart. Elsayed NM and Tierney DF, Arch Biochem Biophys. 1989 Sep;273(2):281-6.
17. Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial. Feig DI, etal., JAMA. 2008 Aug 27;300(8):924-32. doi: 10.1001/jama.300.8.924.
18. Remote ischemic preconditioning differentially affects NADPH oxidase isoforms during hepatic ischemia-reperfusion. Garab D, etal., Life Sci. 2014 Jun 6;105(1-2):14-21. doi: 10.1016/j.lfs.2014.04.014. Epub 2014 Apr 24.
19. Mobilization of xanthine oxidase from the gastrointestinal tract in acute pancreatitis. Granell S, etal., BMC Gastroenterol. 2004 Jan 19;4:1.
20. Xanthine oxidoreductase and neurological sequelae of carbon monoxide poisoning. Han ST, etal., Toxicol Lett. 2007 Apr 25;170(2):111-5. Epub 2007 Feb 20.
21. Upregulation of xanthine oxidase by lipopolysaccharide, interleukin-1, and hypoxia. Role in acute lung injury. Hassoun PM, etal., Am J Respir Crit Care Med. 1998 Jul;158(1):299-305.
22. The prophylactic protective effect of sesamol against ferric-nitrilotriacetate-induced acute renal injury in mice. Hsu DZ, etal., Food Chem Toxicol. 2008 Aug;46(8):2736-41. doi: 10.1016/j.fct.2008.04.029. Epub 2008 Apr 29.
23. [The protective effects of carbachol on visceral ischemia-induced lipid peroxidation injury in rats with sepsis]. Hu S, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2009 Sep;21(9):552-4.
24. High Sodium-Induced Oxidative Stress and Poor Anticrystallization Defense Aggravate Calcium Oxalate Crystal Formation in Rat Hyperoxaluric Kidneys. Huang HS and Ma MC, PLoS One. 2015 Aug 4;10(8):e0134764. doi: 10.1371/journal.pone.0134764. eCollection 2015.
25. Identification of two mutations in human xanthine dehydrogenase gene responsible for classical type I xanthinuria. Ichida K, etal., J Clin Invest. 1997 May 15;99(10):2391-7.
26. Decreased concentration of xanthine dehydrogenase (EC 1.1.1.204) in rat hepatomas. Ikegami T, etal., Cancer Res. 1986 Aug;46(8):3838-41.
27. The efficacy and safety of febuxostat for urate lowering in gout patients >/=65 years of age. Jackson RL, etal., BMC Geriatr. 2012 Mar 21;12:11. doi: 10.1186/1471-2318-12-11.
28. Allopurinol benefits left ventricular mass and endothelial dysfunction in chronic kidney disease. Kao MP, etal., J Am Soc Nephrol. 2011 Jul;22(7):1382-9. doi: 10.1681/ASN.2010111185. Epub 2011 Jun 30.
29. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
30. Antioxidant and antiapoptotic effects of darbepoetin-a against traumatic brain injury in rats. Kertmen H, etal., Arch Med Sci. 2015 Oct 12;11(5):1119-28. doi: 10.5114/aoms.2015.54869.
31. Mannitol attenuates kidney damage induced by xanthine oxidase-associated pancreas ischemia-reperfusion. Khoury W, etal., J Surg Res. 2010 May 1;160(1):163-8. doi: 10.1016/j.jss.2008.10.016. Epub 2008 Dec 30.
32. Renal oxidative stress following CO2 pneumoperitoneum-like conditions. Khoury W, etal., Surg Endosc. 2009 Apr;23(4):776-82. doi: 10.1007/s00464-008-0054-2. Epub 2008 Jul 16.
33. Serum level of Xanthine oxidase, Uric Acid, and NADPH oxidase1 in Stage I of Multiple Myeloma. Kohsari M, etal., Asian Pac J Cancer Prev. 2020 Aug 1;21(8):2237-2242. doi: 10.31557/APJCP.2020.21.8.2237.
34. Effect of lowering uric acid on renal disease in the type 2 diabetic db/db mice. Kosugi T, etal., Am J Physiol Renal Physiol. 2009 Aug;297(2):F481-8. doi: 10.1152/ajprenal.00092.2009. Epub 2009 May 20.
35. Role of xanthine oxidoreductase in the anti-thrombotic effects of nitrite in rats in vivo. Kramkowski K, etal., Platelets. 2016;27(3):245-53. doi: 10.3109/09537104.2015.1083545. Epub 2015 Sep 16.
36. Multiple antioxidants improve cardiac complications and inhibit cardiac cell death in streptozotocin-induced diabetic rats. Kumar S, etal., PLoS One. 2013 Jul 2;8(7):e67009. doi: 10.1371/journal.pone.0067009. Print 2013.
37. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
38. MGDs mouse GO annotations MGD data from the GO Consortium
39. MGD IEA MGD IEA
40. Xanthine oxidase activity in intestinal tumors induced by 1,2-dimethylhydrazine dihydrochloride. Mitidieri E, etal., Arch Geschwulstforsch. 1988;58(2):79-80.
41. New developments in anthracycline-induced cardiotoxicity. Mordente A, etal., Curr Med Chem. 2009;16(13):1656-72.
42. Xanthine oxidoreductase depletion induces renal interstitial fibrosis through aberrant lipid and purine accumulation in renal tubules. Ohtsubo T, etal., Hypertension. 2009 Oct;54(4):868-76. doi: 10.1161/HYPERTENSIONAHA.109.135152. Epub 2009 Aug 10.
43. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
44. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
45. Use of xanthine oxidase inhibitor febuxostat inhibits renal interstitial inflammation and fibrosis in unilateral ureteral obstructive nephropathy. Omori H, etal., Clin Exp Nephrol. 2012 Aug;16(4):549-56. doi: 10.1007/s10157-012-0609-3. Epub 2012 Feb 18.
46. Sialic acid supplementation ameliorates puromycin aminonucleoside nephrosis in rats. Pawluczyk IZ, etal., Lab Invest. 2015 Sep;95(9):1019-28. doi: 10.1038/labinvest.2015.78. Epub 2015 Jun 29.
47. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
48. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
49. A mouse model of early-onset renal failure due to a xanthine dehydrogenase nonsense mutation. Piret SE, etal., PLoS One. 2012;7(9):e45217. Epub 2012 Sep 14.
50. Malignant transformation-linked imbalance: decreased xanthine oxidase activity in hepatomas. Prajda N and Weber G, FEBS Lett. 1975 Nov 15;59(2):245-9.
51. The role of xanthine oxidase in platelet activating factor induced intestinal injury in the rat. Qu XW, etal., Gut. 1999 Feb;44(2):203-11.
52. The role of xanthine oxidase and xanthine dehydrogenase in skin ischemia. Rees R, etal., J Surg Res. 1994 Feb;56(2):162-7.
53. Mouse MP Annotation Import Pipeline RGD automated import pipeline
54. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
55. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
56. Concentrations of adenosine and its metabolites in the rat retina/choroid during reperfusion after ischemia. Roth S, etal., Curr Eye Res. 1997 Sep;16(9):875-85.
57. A tungsten supplemented diet attenuates bacterial translocation in chronic portal hypertensive and cholestatic rats: role of xanthine dehydrogenase and xanthine oxidase. Schimpl G, etal., Gut. 1999 Dec;45(6):904-10.
58. The impact of hepatic xanthine oxidase and xanthine dehydrogenase activities on liver function in chronic cholestasis. Schimpl G, etal., Pediatr Surg Int. 2000;16(4):297-301.
59. Febuxostat improves the local and remote organ changes induced by intestinal ischemia/reperfusion in rats. Shafik AN, Dig Dis Sci. 2013 Mar;58(3):650-9. doi: 10.1007/s10620-012-2391-1. Epub 2012 Sep 26.
60. Simultaneous treatment with citrate prevents nephropathy induced by FYX-051, a xanthine oxidoreductase inhibitor, in rats. Shimo T, etal., Toxicol Sci. 2005 Sep;87(1):267-76. Epub 2005 Jun 2.
61. The xanthine oxidase inhibitor oxypurinol reduces cancer cachexia-induced cardiomyopathy. Springer J, etal., Int J Cardiol. 2013 Jun 7. pii: S0167-5273(13)00991-1. doi: 10.1016/j.ijcard.2013.05.063.
62. Nephroprotective efficacy of chrysin against cisplatin-induced toxicity via attenuation of oxidative stress. Sultana S, etal., J Pharm Pharmacol. 2012 Jun;64(6):872-81. doi: 10.1111/j.2042-7158.2012.01470.x. Epub 2012 Mar 22.
63. Nicorandil, a K(atp) channel opener, alleviates chronic renal injury by targeting podocytes and macrophages. Tamura Y, etal., Am J Physiol Renal Physiol. 2012 Aug 1;303(3):F339-49. doi: 10.1152/ajprenal.00158.2012. Epub 2012 May 23.
64. Effect of allopurinol on cardiovascular incidence among hypertensive nephropathy patients: the Gonryo study. Terawaki H, etal., Clin Exp Nephrol. 2012 Nov 29.
65. Leukocytes in carbon monoxide-mediated brain oxidative injury. Thom SR, Toxicol Appl Pharmacol. 1993 Dec;123(2):234-47.
66. Efficacy and safety of allopurinol in patients with hypoxanthine-guanine phosphoribosyltransferase deficiency. Torres RJ, etal., Metabolism. 2007 Sep;56(9):1179-86.
67. Febuxostat suppressed renal ischemia-reperfusion injury via reduced oxidative stress. Tsuda H, etal., Biochem Biophys Res Commun. 2012 Oct 19;427(2):266-72. doi: 10.1016/j.bbrc.2012.09.032. Epub 2012 Sep 17.
68. Exaggerated liver injury induced by renal ischemia reperfusion in diabetes: effect of exenatide. Vaghasiya JD, etal., Saudi J Gastroenterol. 2010 Jul-Sep;16(3):174-80. doi: 10.4103/1319-3767.65187.
69. Xanthine oxidase activity in the dexamethasone-induced hypertensive rat. Wallwork CJ, etal., Microvasc Res. 2003 Jul;66(1):30-7.
70. Quercetin Protects against Cadmium-Induced Renal Uric Acid Transport System Alteration and Lipid Metabolism Disorder in Rats. Wang J, etal., Evid Based Complement Alternat Med. 2012;2012:548430. doi: 10.1155/2012/548430. Epub 2012 May 29.
71. Oxidative state and oxidative metabolism in the brain of rats with adjuvant-induced arthritis. Wendt MM, etal., Exp Mol Pathol. 2015 Jun;98(3):549-57. doi: 10.1016/j.yexmp.2015.04.002. Epub 2015 Apr 11.
72. Dietary nicotinamide supplementation increases xanthine oxidoreductase activity in the kidney and heart but not liver of obese Zucker rats. Wu X and Wang M, J Nutr. 1995 Jul;125(7):1841-6.
73. Xanthine oxidase in experimental spinal cord injury. Xu J, etal., J Neurotrauma. 1991 Spring;8(1):11-8.
74. Associations of hypertension and its complications with variations in the xanthine dehydrogenase gene. Yang J, etal., Hypertens Res. 2008 May;31(5):931-40. doi: 10.1291/hypres.31.931.
75. Lipid peroxidation and changes in cytochrome c oxidase and xanthine oxidase activity in organophosphorus anticholinesterase induced myopathy. Yang ZP and Dettbarn WD, J Physiol Paris. 1998 Jun-Aug;92(3-4):157-61.
76. Hypouricemic effect of the methanol extract from Prunus mume fruit in mice. Yi LT, etal., Pharm Biol. 2012 Nov;50(11):1423-7. doi: 10.3109/13880209.2012.683115. Epub 2012 Sep 11.
77. Hyperbaric Oxygen Therapy in Rats Attenuates Ischemia-reperfusion Testicular Injury Through Blockade of Oxidative Stress, Suppression of Inflammation, and Reduction of Nitric Oxide Formation. Zhang Y, etal., Urology. 2013 Jun 12. pii: S0090-4295(13)00472-X. doi: 10.1016/j.urology.2013.04.016.
Additional References at PubMed
PMID:1590774   PMID:1619276   PMID:3443108   PMID:4207016   PMID:6895582   PMID:7835888   PMID:7864814   PMID:8064675   PMID:8226898   PMID:8537361   PMID:8541302   PMID:8562047  
PMID:8661045   PMID:8661125   PMID:8751373   PMID:8798497   PMID:8920983   PMID:9169125   PMID:10349636   PMID:10753524   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12456835  
PMID:12477932   PMID:12502743   PMID:14681479   PMID:15486091   PMID:15528468   PMID:15857914   PMID:15863459   PMID:15878860   PMID:16141072   PMID:16141073   PMID:16452486   PMID:16537416  
PMID:16632522   PMID:17276354   PMID:17364940   PMID:17597094   PMID:18287332   PMID:18669934   PMID:18767115   PMID:19076165   PMID:19531472   PMID:19800018   PMID:19828843   PMID:20142047  
PMID:21224483   PMID:21267068   PMID:21310927   PMID:21626205   PMID:21677750   PMID:21775420   PMID:21873635   PMID:22095983   PMID:22723833   PMID:23380026   PMID:23426966   PMID:23951137  
PMID:24024171   PMID:24158515   PMID:25044064   PMID:25800347   PMID:25879627   PMID:25999428   PMID:26903297   PMID:26987748   PMID:27433030   PMID:27609225   PMID:27696407   PMID:27914912  
PMID:28539355   PMID:29101234   PMID:29502045   PMID:29895374   PMID:30312761   PMID:30333137   PMID:30336599   PMID:30936145   PMID:30938853   PMID:31659168   PMID:31850710   PMID:32126884  
PMID:32239172   PMID:32325033   PMID:33448693   PMID:33805516   PMID:34938960   PMID:36525890   PMID:36655326   PMID:36906950   PMID:38355793  


Genomics

Comparative Map Data
Xdh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391774,190,890 - 74,257,191 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1774,190,890 - 74,257,191 (-)EnsemblGRCm39 Ensembl
GRCm381773,883,895 - 73,950,397 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1773,883,895 - 73,950,196 (-)EnsemblGRCm38mm10GRCm38
MGSCv371774,233,248 - 74,299,522 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361773,788,790 - 73,855,081 (-)NCBIMGSCv36mm8
Celera1778,175,030 - 78,239,710 (-)NCBICelera
Cytogenetic Map17E2NCBI
cM Map1745.25NCBI
XDH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38231,334,321 - 31,414,742 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl231,334,321 - 31,414,742 (-)EnsemblGRCh38hg38GRCh38
GRCh37231,557,187 - 31,637,608 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36231,410,692 - 31,491,115 (-)NCBINCBI36Build 36hg18NCBI36
Build 34231,470,146 - 31,549,264NCBI
Celera231,399,873 - 31,481,045 (-)NCBICelera
Cytogenetic Map2p23.1NCBI
HuRef231,294,906 - 31,375,846 (-)NCBIHuRef
CHM1_1231,487,808 - 31,568,252 (-)NCBICHM1_1
T2T-CHM13v2.0231,378,697 - 31,459,436 (-)NCBIT2T-CHM13v2.0
Xdh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8627,282,319 - 27,344,022 (+)NCBIGRCr8
mRatBN7.2621,530,463 - 21,592,172 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl621,530,113 - 21,592,268 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx621,859,036 - 21,920,809 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0622,174,874 - 22,236,649 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0621,655,317 - 21,717,086 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0625,149,570 - 25,211,273 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl625,149,235 - 25,211,494 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0634,996,983 - 35,059,195 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4621,417,685 - 21,590,015 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1621,420,637 - 21,592,968 (+)NCBI
Celera621,081,179 - 21,143,279 (+)NCBICelera
Cytogenetic Map6q13NCBI
XDH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21295,076,064 - 95,156,263 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A95,080,039 - 95,160,238 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A31,356,011 - 31,435,111 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A31,425,183 - 31,504,455 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A31,425,183 - 31,504,455 (-)Ensemblpanpan1.1panPan2
XDH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11724,900,708 - 24,960,748 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1724,901,447 - 24,971,935 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1724,694,965 - 24,754,929 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01725,464,496 - 25,524,534 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1725,465,095 - 25,524,434 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11724,767,742 - 24,827,816 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01724,830,189 - 24,890,224 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01724,929,639 - 24,989,647 (-)NCBIUU_Cfam_GSD_1.0
Xdh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629269,015,034 - 69,076,787 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364931,762,869 - 1,823,238 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364931,762,814 - 1,824,501 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
XDH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3107,987,126 - 108,053,169 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13107,987,060 - 108,052,043 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23114,732,427 - 114,796,636 (+)NCBISscrofa10.2Sscrofa10.2susScr3
XDH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11476,084,693 - 76,162,840 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1476,085,368 - 76,163,936 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604535,902,856 - 35,979,384 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Xdh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473813,115,982 - 13,181,352 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473813,116,317 - 13,180,935 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Xdh
1860 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:154
Count of miRNA genes:140
Interacting mature miRNAs:149
Transcripts:ENSMUST00000024866
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141758Pstc5_mperiosteal circumference 5 (mouse)Not determined175710765191107803Mouse
4142201Obrq15_mobesity resistance QTL 15 (mouse)Not determined5753444780885776Mouse
4141879Chlq9_mcirculating hormone level QTL 9 (mouse)Not determined175175842585758612Mouse
1357532Bmch7_mbone mechanical trait 7 (mouse)Not determined175175842585758612Mouse
11528551Sluc32_msusceptibility to lung cancer 32 (mouse)176230101095294699Mouse
1301338Lmr1_mleishmaniasis resistance 1 (mouse)Not determined171008134086996400Mouse
11565819Ppipq1_mprepulse inhibition percentage QTL 1 (mouse)177105765575377655Mouse
12910536Nrq8a_mnoise-induced hearing loss resistant QTL 8a (mouse)175710765191107803Mouse
1357528Nhdlq3_mnon-HDL QTL 3 (mouse)Not determined177339513295294699Mouse
12910537Nrq8_mnoise-induced hearing loss resistant QTL 8 (mouse)175710765191107803Mouse
4141040Hmtb9_mhemostasis and thrombosis rebleeding time 9 (mouse)Not determined5758908991589197Mouse
4142256Nilac12_mnicotine induced locomotor activity 12 (mouse)Not determined176894131995294699Mouse
1302017Aliq3_macute lung injury QTL 3 (mouse)Not determined176388554895294699Mouse
1357447Heal13_mwound healing/regeneration 13 (mouse)Not determined175710765191107803Mouse
26884428Cvht3_mcranial vault height 3, 5 week (mouse)174651092682407429Mouse
14928308Manh82_mmandible shape 82 (mouse)176631524395294699Mouse
1301107Scc4_mcolon tumor susceptibility 4 (mouse)Not determined176230101095294699Mouse
11039498Ltpr7b_mLeishmania tropica response 7b (mouse)177070119895294699Mouse
11039499Ltpr7a_mLeishmania tropica response 7a (mouse)177070119895294699Mouse
11039500Ltpr7c_mLeishmania tropica response 7c (mouse)177070119895294699Mouse
4141011Bmd26_mbone mineral density 26 (mouse)Not determined175710765191107803Mouse
1300735Pgia20_mproteoglycan induced arthritis 20 (mouse)Not determined175710765191107803Mouse
1357754Ahl3_mage related hearing loss 3 (mouse)Not determined175020395784204103Mouse
4142414Pregq4_mpregnancy QTL 4 (mouse)Not determined175753444793507179Mouse
11039514Ltpr7_mLeishmania tropica response 7 (mouse)177070119895294699Mouse
1301728Ffal1_mfree fatty acid level 1 (mouse)Not determined176521493895294699Mouse
13464254Ifvrq3_minfluenza virus resistance QTL 3 (mouse)176795765583908089Mouse
4141195Nilac11_mnicotine induced locomotor activity 11 (mouse)Not determined177339513295294699Mouse
4141319Hmtb8_mhemostasis and thrombosis rebleeding time 8 (mouse)Not determined4053444774534623Mouse
4142150Stheal11_msoft tissue heal 11 (mouse)Not determined171228621183361768Mouse
15039324Nmrs48_mNAFLD-associated magnetic resonance shift 48 (mouse)174093918774939187Mouse
4141697Hbnr3_mHeligmosomoides bakeri nematode resistance 3 (mouse)Not determined7410765193507179Mouse

Markers in Region
X62932  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381773,884,037 - 73,884,159UniSTSGRCm38
MGSCv371774,233,377 - 74,233,499UniSTSGRCm37
Celera1778,175,163 - 78,175,285UniSTS
Cytogenetic Map17E2UniSTS
cM Map1745.3UniSTS
Whitehead/MRC_RH17863.06UniSTS
Xdh  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17E2UniSTS
cM Map1745.3UniSTS
04.MMHAP91FLB1.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381773,891,279 - 73,891,462UniSTSGRCm38
MGSCv371774,240,619 - 74,240,802UniSTSGRCm37
Celera1778,180,189 - 78,180,372UniSTS
Cytogenetic Map17E2UniSTS
cM Map1745.3UniSTS
Whitehead_YAC17 UniSTS


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_011723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_189051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011246381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC101679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC159187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI323529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK008517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK034256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK036869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK090058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK134156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK143412 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK144700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK160010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK161529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK164764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC032077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC065699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC141183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY318674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY322557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT025731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X62932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75136 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75137 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75138 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75141 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75148 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000024866   ⟹   ENSMUSP00000024866
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1774,190,890 - 74,257,177 (-)Ensembl
GRCm38.p6 Ensembl1773,883,895 - 73,950,182 (-)Ensembl
Ensembl Acc Id: ENSMUST00000232717
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1774,191,305 - 74,193,837 (-)Ensembl
GRCm38.p6 Ensembl1773,884,310 - 73,886,842 (-)Ensembl
Ensembl Acc Id: ENSMUST00000232783   ⟹   ENSMUSP00000156753
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1774,241,797 - 74,257,110 (-)Ensembl
GRCm38.p6 Ensembl1773,934,802 - 73,950,115 (-)Ensembl
Ensembl Acc Id: ENSMUST00000232843
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1774,247,925 - 74,257,173 (-)Ensembl
GRCm38.p6 Ensembl1773,940,930 - 73,950,178 (-)Ensembl
Ensembl Acc Id: ENSMUST00000232957
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1774,250,343 - 74,257,091 (-)Ensembl
GRCm38.p6 Ensembl1773,943,348 - 73,950,096 (-)Ensembl
Ensembl Acc Id: ENSMUST00000233162
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1774,190,903 - 74,257,140 (-)Ensembl
GRCm38.p6 Ensembl1773,883,908 - 73,950,145 (-)Ensembl
Ensembl Acc Id: ENSMUST00000233352
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1774,195,974 - 74,202,776 (-)Ensembl
GRCm38.p6 Ensembl1773,888,979 - 73,895,781 (-)Ensembl
Ensembl Acc Id: ENSMUST00000233392   ⟹   ENSMUSP00000156860
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1774,190,890 - 74,207,402 (-)Ensembl
GRCm38.p6 Ensembl1773,883,895 - 73,900,407 (-)Ensembl
Ensembl Acc Id: ENSMUST00000233433
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1774,233,605 - 74,255,254 (-)Ensembl
GRCm38.p6 Ensembl1773,926,610 - 73,948,259 (-)Ensembl
Ensembl Acc Id: ENSMUST00000233449
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1774,242,355 - 74,257,087 (-)Ensembl
GRCm38.p6 Ensembl1773,935,360 - 73,950,092 (-)Ensembl
Ensembl Acc Id: ENSMUST00000233570
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1774,241,307 - 74,257,133 (-)Ensembl
GRCm38.p6 Ensembl1773,934,312 - 73,950,138 (-)Ensembl
Ensembl Acc Id: ENSMUST00000233621   ⟹   ENSMUSP00000156944
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1774,190,903 - 74,257,191 (-)Ensembl
GRCm38.p6 Ensembl1773,883,908 - 73,950,196 (-)Ensembl
Ensembl Acc Id: ENSMUST00000233807
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1774,191,406 - 74,193,745 (-)Ensembl
GRCm38.p6 Ensembl1773,884,411 - 73,886,750 (-)Ensembl
Ensembl Acc Id: ENSMUST00000233946
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1774,222,735 - 74,225,905 (-)Ensembl
GRCm38.p6 Ensembl1773,915,740 - 73,918,910 (-)Ensembl
RefSeq Acc Id: NM_011723   ⟹   NP_035853
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391774,190,890 - 74,257,191 (-)NCBI
GRCm381773,883,895 - 73,950,196 (-)NCBI
MGSCv371774,233,248 - 74,299,522 (-)RGD
Celera1778,175,017 - 78,239,724 (-)NCBI
cM Map17 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_189051
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391774,190,928 - 74,257,139 (-)NCBI
RefSeq Acc Id: XM_011246381   ⟹   XP_011244683
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391774,190,890 - 74,223,867 (-)NCBI
GRCm381773,883,906 - 73,916,872 (-)NCBI
Sequence:
RefSeq Acc Id: NP_035853   ⟸   NM_011723
- UniProtKB: E9QLM9 (UniProtKB/Swiss-Prot),   Q00519 (UniProtKB/Swiss-Prot),   Q3UMS6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011244683   ⟸   XM_011246381
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSMUSP00000156944   ⟸   ENSMUST00000233621
Ensembl Acc Id: ENSMUSP00000156860   ⟸   ENSMUST00000233392
Ensembl Acc Id: ENSMUSP00000156753   ⟸   ENSMUST00000232783
Ensembl Acc Id: ENSMUSP00000024866   ⟸   ENSMUST00000024866
Protein Domains
2Fe-2S ferredoxin-type   Aldehyde oxidase/xanthine dehydrogenase first   Aldehyde oxidase/xanthine dehydrogenase second   FAD-binding PCMH-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q00519-F1-model_v2 AlphaFold Q00519 1-1335 view protein structure

Promoters
RGD ID:13676758
Promoter ID:EPDNEW_M22528
Type:initiation region
Name:Xdh_1
Description:Mus musculus xanthine dehydrogenase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381773,950,144 - 73,950,204EPDNEW
RGD ID:6847479
Promoter ID:MM_ACW:23502
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Liver,   Lung
Transcripts:XDH.KSEP07,   XDH.MSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361774,235,506 - 74,236,006 (-)MPROMDB
RGD ID:6847481
Promoter ID:MM_ACW:23503
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:XDH.OSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361774,240,391 - 74,240,891 (-)MPROMDB
RGD ID:6828892
Promoter ID:MM_KWN:24181
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   BoneMarrow_4Hour,   Lung
Transcripts:UC008DNR.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361774,258,621 - 74,259,672 (-)MPROMDB
RGD ID:6828890
Promoter ID:MM_KWN:24182
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Liver,   Lung,   Spleen
Transcripts:NM_011723,   UC008DNP.1,   UC008DNQ.1,   UC008DNS.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361774,299,076 - 74,300,522 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98973 AgrOrtholog
Ensembl Genes ENSMUSG00000024066 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000024866 ENTREZGENE
  ENSMUST00000024866.6 UniProtKB/Swiss-Prot
  ENSMUST00000232783.2 UniProtKB/TrEMBL
  ENSMUST00000233392.2 UniProtKB/TrEMBL
  ENSMUST00000233621.2 UniProtKB/TrEMBL
Gene3D-CATH 3.10.20.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.43.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.465.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  [2Fe-2S]-binding domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CO dehydrogenase flavoprotein, C-terminal domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 2Fe-2S-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2Fe-2S-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2Fe-2S_ferredoxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2Fe-2S_ferredoxin-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2Fe2S_fd_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_Oxase/Xan_DH_a/b UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_Oxase/Xan_DH_a/b_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_Oxase/xanthine_DH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AldOxase/xan_DH_MoCoBD2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AldOxase/xan_DH_Mopterin-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AldOxase/xan_DH_Mopterin-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Beta-grasp_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CO_DH_flav_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CO_DH_flav_C_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD-bd_PCMH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD-bd_PCMH-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD-bd_PCMH_sub1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD-bd_PCMH_sub2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mopterin_DH_FAD-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OxRdtase_Mopterin_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Xanthine_DH_Mopterin-bd_su UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Xanthine_DH_ssu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:22436 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:98973 ENTREZGENE
NCBI Gene 22436 ENTREZGENE
PANTHER XANTHINE DEHYDROGENASE UniProtKB/Swiss-Prot
  XANTHINE DEHYDROGENASE UniProtKB/TrEMBL
  XANTHINE DEHYDROGENASE UniProtKB/TrEMBL
  XANTHINE DEHYDROGENASE UniProtKB/TrEMBL
  XANTHINE DEHYDROGENASE_OXIDASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ald_Xan_dh_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_Xan_dh_C2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CO_deh_flav_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD_binding_5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fer2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fer2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MoCoBD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB XDH RGD
PhenoGen Xdh PhenoGen
PIRSF Xanthine_DH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE 2FE2S_FER_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2FE2S_FER_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD_PCMH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MOLYBDOPTERIN_EUK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Ald_Xan_dh_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CO_deh_flav_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47741 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54292 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54665 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55447 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56003 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56176 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A3B2W454_MOUSE UniProtKB/TrEMBL
  A0A3B2WBF8_MOUSE UniProtKB/TrEMBL
  A0A3B2WDA8_MOUSE UniProtKB/TrEMBL
  B2RUJ7_MOUSE UniProtKB/TrEMBL
  E9QLM9 ENTREZGENE
  Q00519 ENTREZGENE
  Q3TAT6_MOUSE UniProtKB/TrEMBL
  Q3TP30_MOUSE UniProtKB/TrEMBL
  Q3UMS6 ENTREZGENE, UniProtKB/TrEMBL
  Q99KV3_MOUSE UniProtKB/TrEMBL
  Q9CVF2_MOUSE UniProtKB/TrEMBL
  XDH_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary E9QLM9 UniProtKB/Swiss-Prot