Muc5ac (mucin 5, subtypes A and C, tracheobronchial/gastric) - Rat Genome Database

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Gene: Muc5ac (mucin 5, subtypes A and C, tracheobronchial/gastric) Mus musculus
Analyze
Symbol: Muc5ac
Name: mucin 5, subtypes A and C, tracheobronchial/gastric
RGD ID: 62293
MGI Page MGI
Description: Acts upstream of or within maintenance of lens transparency. Located in extracellular space. Is expressed in male reproductive gland or organ; nasal cavity epithelium; respiratory system; and stomach. Used to study dry eye syndrome. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease and dry eye syndrome. Orthologous to human MUC5AC (mucin 5AC, oligomeric mucus/gel-forming).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2210005L13Rik; gastric mucin; MGM; mucin-5AC
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397141,342,695 - 141,372,964 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7141,342,709 - 141,372,968 (+)EnsemblGRCm39 Ensembl
GRCm387141,788,958 - 141,819,227 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7141,788,972 - 141,819,231 (+)EnsemblGRCm38mm10GRCm38
MGSCv377148,974,916 - 149,005,040 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367148,974,916 - 149,005,040 (+)NCBIMGSCv36mm8
Celera7141,544,129 - 141,573,772 (+)NCBICelera
Cytogenetic Map7F5NCBI
cM Map787.23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(E)-roxithromycin  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (EXP)
1,4-naphthoquinone  (EXP)
1,8-cineole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
4,4'-sulfonyldiphenol  (EXP)
6alpha-methylprednisolone  (ISO)
8'-apo-beta,psi-caroten-8'-al  (ISO)
9-cis-retinoic acid  (ISO)
acrolein  (EXP,ISO)
afatinib  (ISO)
aflatoxin B1  (ISO)
aflatoxin M1  (ISO)
alizarin  (ISO)
all-trans-4-hydroxyretinoic acid  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-4-oxoretinol  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
allyl isothiocyanate  (ISO)
aluminium hydroxide  (EXP)
amitrole  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
astragaloside IV  (ISO)
Atractylodin  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beta-carotene  (ISO)
bisphenol A  (EXP)
bleomycin A2  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
capsaicin  (ISO)
capsazepine  (ISO)
carbon nanotube  (EXP)
ceric oxide  (EXP,ISO)
CHIR 99021  (ISO)
chlorphenamine  (ISO)
chromium(6+)  (EXP)
citric acid  (ISO)
coniferyl aldehyde  (ISO)
curcumin  (ISO)
decabromodiphenyl ether  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
dihydroxyacetone  (ISO)
dimethyl sulfoxide  (ISO)
dioscin  (EXP)
dioxygen  (EXP)
elemental selenium  (ISO)
emodin  (EXP)
erlotinib hydrochloride  (EXP)
ethyl methanesulfonate  (ISO)
euxanthone  (ISO)
Fidarestat  (ISO)
flavonoids  (ISO)
fluoranthene  (ISO)
formaldehyde  (ISO)
fumonisin B1  (ISO)
gamma-tocopherol  (ISO)
gefitinib  (ISO)
glycerol  (ISO)
glycyrrhizinic acid  (ISO)
histamine  (ISO)
hydrogen peroxide  (ISO)
icariin  (ISO)
kaempferol  (ISO)
lead diacetate  (EXP)
leukotriene B4  (ISO)
leukotriene C4  (ISO)
leukotriene D4  (ISO)
leukotriene E4  (ISO)
lipopolysaccharide  (ISO)
lixisenatide  (ISO)
LY294002  (ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
mevalonic acid  (ISO)
MitoTEMPO  (ISO)
MK 571  (EXP,ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
naringin  (EXP,ISO)
nickel atom  (EXP)
Niflumic acid  (ISO)
Nivalenol  (ISO)
nobiletin  (ISO)
ochratoxin A  (ISO)
ozone  (EXP,ISO)
Paeonol  (ISO)
paracetamol  (EXP)
paraquat  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
platycodin D  (ISO)
platycodin D3  (ISO)
potassium dichromate  (EXP)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (ISO)
scopolamine  (EXP,ISO)
selenium atom  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
StemRegenin 1  (ISO)
sulforaphane  (EXP)
tebuconazole  (ISO)
theaflavin  (ISO)
Theaflavin 3,3'-digallate  (ISO)
tobramycin  (ISO)
triamcinolone acetonide  (ISO)
trimellitic anhydride  (EXP)
triptonide  (EXP)
tyrphostin AG 1478  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
zearalenone  (ISO)
zileuton  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Gastric mucin phenotype defines tumour progression and prognosis of intrahepatic cholangiocarcinoma: gastric foveolar type is associated with aggressive tumour behaviour. Aishima S, etal., Histopathology. 2006 Jul;49(1):35-44.
2. Altered expression of MUC2, MUC4, and MUC5 mucin genes in pancreas tissues and cancer cell lines. Balague C, etal., Gastroenterology. 1994 Apr;106(4):1054-61.
3. In situ hybridization shows distinct patterns of mucin gene expression in normal, benign, and malignant pancreas tissues. Balague C, etal., Gastroenterology. 1995 Sep;109(3):953-64.
4. Prognostic value of serum MUC5AC mucin in patients with cholangiocarcinoma. Boonla C, etal., Cancer. 2003 Oct 1;98(7):1438-43.
5. MUC1 and MUC5AC mucin expression in liver fluke-associated intrahepatic cholangiocarcinoma. Boonla C, etal., World J Gastroenterol. 2005 Aug 28;11(32):4939-46.
6. Effect of Myrtol standardized on mucus hypersecretion and clearance of Pseudomonas aeruginosa in a rat model of chronic obstructive pulmonary disease. Cao L, etal., Arzneimittelforschung. 2011;61(12):685-92. doi: 10.1055/s-0031-1300588.
7. Mucinous nonneoplastic cyst of the pancreas: apomucin phenotype distinguishes this entity from intraductal papillary mucinous neoplasm. Cao W, etal., Hum Pathol. 2010 Apr;41(4):513-21. Epub 2009 Dec 1.
8. MUC5AC expression is increased in bronchial submucosal glands of stable COPD patients. Caramori G, etal., Histopathology. 2009 Sep;55(3):321-31.
9. Phenotypic alterations of mucins and cytokeratins during gallbladder carcinogenesis. Chang HJ, etal., Pathol Int. 2004 Aug;54(8):576-84.
10. In vivo characterization of the molecular-genetic changes in gastric mucosa during the development of acute gastritis and stress ulceration. Choo D, etal., J Trauma. 2002 Apr;52(4):720-5; discussion 725-6.
11. Roflumilast, a phosphodiesterase 4 inhibitor, alleviates bleomycin-induced lung injury. Cortijo J, etal., Br J Pharmacol. 2009 Feb;156(3):534-44.
12. Alterations of the ocular surface epithelial MUC16 and goblet cell MUC5AC in patients with atopic keratoconjunctivitis. Dogru M, etal., Allergy. 2008 Oct;63(10):1324-34. doi: 10.1111/j.1398-9995.2008.01781.x.
13. Ocular surface and MUC5AC alterations in atopic patients with corneal shield ulcers. Dogru M, etal., Curr Eye Res. 2005 Oct;30(10):897-908.
14. Mucin deficiency causes functional and structural changes of the ocular surface. Floyd AM, etal., PLoS One. 2012;7(12):e50704. doi: 10.1371/journal.pone.0050704. Epub 2012 Dec 18.
15. Spatial and temporal expression of CCR3 and the common beta chain of the IL-3, IL-5 and GM-CSF receptor in the nasal epithelium and lymphoid tissues in a rat model of allergic rhinitis. Fortin M, etal., Cytokine. 2010 Aug 7.
16. Effect of Bifidobacterium bifidum BF-1 on gastric protection and mucin production in an acute gastric injury rat model. Gomi A, etal., J Dairy Sci. 2013 Feb;96(2):832-7. doi: 10.3168/jds.2012-5950. Epub 2012 Nov 29.
17. Respiratory syncytial virus in allergic lung inflammation increases Muc5ac and gob-5. Hashimoto K, etal., Am J Respir Crit Care Med. 2004 Aug 1;170(3):306-12. Epub 2004 May 6.
18. Mucin gene deficiency in mice impairs host resistance to an enteric parasitic infection. Hasnain SZ, etal., Gastroenterology. 2010 May;138(5):1763-71. doi: 10.1053/j.gastro.2010.01.045. Epub 2010 Feb 4.
19. MUC5AC and MUC5B mucins increase in cystic fibrosis airway secretions during pulmonary exacerbation. Henke MO, etal., Am J Respir Crit Care Med. 2007 Apr 15;175(8):816-21. Epub 2007 Jan 25.
20. Rhinovirus induces MUC5AC in a human infection model and in vitro via NF-kappaB and EGFR pathways. Hewson CA, etal., Eur Respir J. 2010 Dec;36(6):1425-35. Epub 2010 Jun 4.
21. Cloning of rat Muc5AC mucin gene: comparison of its structure and tissue distribution to that of human and mouse homologues. Inatomi T, etal., Biochem Biophys Res Commun 1997 Jul 30;236(3):789-97.
22. Differences in the expression of mucins in various forms of cystitis glandularis. Jankovic Velickovic L, etal., Pathol Res Pract. 2007;203(9):653-8. Epub 2007 Jul 30.
23. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
24. MUC5AC expression in human middle ear epithelium of patients with otitis media. Kerschner JE, etal., Arch Otolaryngol Head Neck Surg. 2010 Aug;136(8):819-24. doi: 10.1001/archoto.2010.123.
25. Effects of normal saline and selenium-enriched hot spring water on experimentally induced rhinosinusitis in rats. Kim DH and Yeo SW, Int J Pediatr Otorhinolaryngol. 2013 Jan;77(1):117-22. doi: 10.1016/j.ijporl.2012.10.008. Epub 2012 Nov 3.
26. Panax ginseng ameliorates airway inflammation in an ovalbumin-sensitized mouse allergic asthma model. Kim DY and Yang WM, J Ethnopharmacol. 2011 Jun 14;136(1):230-5. doi: 10.1016/j.jep.2011.04.048. Epub 2011 Apr 28.
27. Relation of epidermal growth factor receptor expression to mucus hypersecretion in diffuse panbronchiolitis. Kim JH, etal., Chest. 2004 Sep;126(3):888-95.
28. Up-regulation of MUC5AC mRNA expression in endotoxin-induced otitis media. Kim YT, etal., Acta Otolaryngol. 2001 Apr;121(3):364-70.
29. Altered mucin gene expression in stone-containing intrahepatic bile ducts and cholangiocarcinomas. Lee KT and Liu TS, Dig Dis Sci. 2001 Oct;46(10):2166-72.
30. Effects of sulfur dioxide on the expressions of MUC5AC and ICAM-1 in airway of asthmatic rats. Li R, etal., Regul Toxicol Pharmacol. 2007 Aug;48(3):284-91. Epub 2007 May 21.
31. [Toll-like receptor 2 and Toll-like receptor 4 participates in mediation of acute otitis media and mortality in pneumococcal infections in mice]. Li SL, etal., Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2011 Dec;46(12):1009-18.
32. A mouse dry eye model induced by topical administration of benzalkonium chloride. Lin Z, etal., Mol Vis. 2011 Jan 25;17:257-64.
33. The tear fluid mucin 5AC change of primary angle-closure glaucoma patients after short-term medications and phacotrabeculectomy. Liu W, etal., Mol Vis. 2010 Nov 9;16:2342-6.
34. [Expression of MUC5AC in human nasal polyp and inferior turbinate epithelium]. Lü H, etal., Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2004 Nov;18(11):649-50.
35. Oral N-acetylcysteine reduces bleomycin-induced lung damage and mucin Muc5ac expression in rats. Mata M, etal., Eur Respir J. 2003 Dec;22(6):900-5.
36. MUC4 and MUC5AC are highly specific tumour-associated mucins in biliary tract cancer. Matull WR, etal., Br J Cancer. 2008 May 20;98(10):1675-81. Epub 2008 May 13.
37. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
38. MGDs mouse GO annotations MGD data from the GO Consortium
39. Gastric mucosal protection via enhancement of MUC5AC and MUC6 by geranylgeranylacetone. Nam SY, etal., Dig Dis Sci. 2005 Nov;50(11):2110-20.
40. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
41. Mouse MP Annotation Import Pipeline RGD automated import pipeline
42. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
43. Elastase- and LPS-exposed mice display altered responses to rhinovirus infection. Sajjan U, etal., Am J Physiol Lung Cell Mol Physiol. 2009 Nov;297(5):L931-44. Epub 2009 Sep 11.
44. Temporal analysis of goblet cells and mucin gene expression in murine models of allergic asthma. Shahzeidi S, etal., Exp Lung Res. 2003 Dec;29(8):549-65.
45. Neurturin-deficient mice develop dry eye and keratoconjunctivitis sicca. Song XJ, etal., Invest Ophthalmol Vis Sci. 2003 Oct;44(10):4223-9.
46. Trefoil factor family 1, MUC5AC and human leucocyte antigen-DR expression by conjunctival cells in patients with glaucoma treated with chronic drugs: could these markers predict the success of glaucoma surgery? Souchier M, etal., Br J Ophthalmol. 2006 Nov;90(11):1366-9. Epub 2006 Jun 29.
47. The effect of formoterol on airway goblet cell hyperplasia and protein Muc5ac expression in asthmatic mice. Tan YF, etal., Eur Rev Med Pharmacol Sci. 2011 Jul;15(7):743-50.
48. Otitis media in a new mouse model for CHARGE syndrome with a deletion in the Chd7 gene. Tian C, etal., PLoS One. 2012;7(4):e34944. doi: 10.1371/journal.pone.0034944. Epub 2012 Apr 23.
49. Rapid and specific alterations of goblet cell mucin in rat airway and small intestine associated with resistance against Nippostrongylus brasiliensis reinfection. Tsubokawa D, etal., Exp Parasitol. 2012 Mar;130(3):209-17. doi: 10.1016/j.exppara.2012.01.002. Epub 2012 Jan 18.
50. Metaplasia of the duodenum shows a Helicobacter pylori-correlated differentiation into gastric-type protein expression. Van De Bovenkamp JH, etal., Hum Pathol. 2003 Feb;34(2):156-65.
51. Efficacy of a 2-month dietary supplementation with polyunsaturated fatty acids in dry eye induced by scopolamine in a rat model. Viau S, etal., Graefes Arch Clin Exp Ophthalmol. 2009 Aug;247(8):1039-50. Epub 2009 May 5.
52. Gamma-tocopherol attenuates ozone-induced exacerbation of allergic rhinosinusitis in rats. Wagner JG, etal., Toxicol Pathol. 2009 Jun;37(4):481-91. doi: 10.1177/0192623309335630. Epub 2009 Apr 23.
53. Increased expression of human calcium-activated chloride channel 1 gene is correlated with mucus overproduction in Chinese asthmatic airway. Wang K, etal., Cell Biol Int. 2007 Nov;31(11):1388-95. Epub 2007 Jun 29.
54. Increased expression of human calcium-activated chloride channel 1 is correlated with mucus overproduction in the airways of Chinese patients with chronic obstructive pulmonary disease. Wang K, etal., Chin Med J (Engl). 2007 Jun 20;120(12):1051-7.
55. Mucin 5 subtype AC expression and upregulation in the nasal mucosa of allergic rhinitis rats. Wang W and Zheng M, Otolaryngol Head Neck Surg. 2012 Dec;147(6):1012-9. doi: 10.1177/0194599812460977. Epub 2012 Sep 12.
56. Ocular surface and tear functions after topical cyclosporine treatment in dry eye patients with chronic graft-versus-host disease. Wang Y, etal., Bone Marrow Transplant. 2008 Feb;41(3):293-302. Epub 2007 Nov 5.
57. Diagnostic value of mucins (MUC1, MUC2 and MUC5AC) expression profile in endoscopic ultrasound-guided fine-needle aspiration specimens of the pancreas. Wang Y, etal., Int J Cancer. 2007 Dec 15;121(12):2716-22.
58. Expression and localization of MUC1, MUC2, MUC5AC and small intestinal mucin antigen in pancreatic tumors. Yamasaki H, etal., Int J Oncol. 2004 Jan;24(1):107-13.
59. Gene expression of gastric type mucin (MUC5AC) in pancreatic tumors: its relationship with the biological behavior of the tumor. Yonezawa S, etal., Pathol Int. 1999 Jan;49(1):45-54.
60. MUC19 expression in human ocular surface and lacrimal gland and its alteration in Sjogren syndrome patients. Yu DF, etal., Exp Eye Res. 2008 Feb;86(2):403-11. doi: 10.1016/j.exer.2007.11.013. Epub 2007 Nov 28.
61. The prevalence and nature of glycan alterations on specific proteins in pancreatic cancer patients revealed using antibody-lectin sandwich arrays. Yue T, etal., Mol Cell Proteomics. 2009 Jul;8(7):1697-707. Epub 2009 Apr 17.
62. Analysis of the correlations of mucins, inflammatory markers, and clinical tests in dry eye. Zhang J, etal., Cornea. 2013 Jul;32(7):928-32. doi: 10.1097/ICO.0b013e3182801622.
Additional References at PubMed
PMID:7487932   PMID:7543410   PMID:9843919   PMID:10349636   PMID:10611155   PMID:11042159   PMID:11076861   PMID:11208732   PMID:11587997   PMID:11992401   PMID:12676567   PMID:14570593  
PMID:14718370   PMID:14984930   PMID:16141072   PMID:16141073   PMID:16936271   PMID:17383628   PMID:17400733   PMID:17463395   PMID:17487773   PMID:17522155   PMID:17855428   PMID:17882221  
PMID:18006877   PMID:18258655   PMID:18356571   PMID:18558092   PMID:18782768   PMID:18787101   PMID:19059885   PMID:19110483   PMID:19158956   PMID:19201815   PMID:19369400   PMID:19710174  
PMID:19835973   PMID:20117097   PMID:20413542   PMID:20430747   PMID:21307095   PMID:21402740   PMID:21444682   PMID:21502330   PMID:21505443   PMID:21565611   PMID:21653907   PMID:21681751  
PMID:21791528   PMID:21873635   PMID:21982232   PMID:22303480   PMID:22421361   PMID:22554936   PMID:22675208   PMID:22797898   PMID:22809996   PMID:22878411   PMID:23012413   PMID:23187315  
PMID:23213461   PMID:23392704   PMID:23691121   PMID:23832516   PMID:23832517   PMID:23860410   PMID:23884469   PMID:24194600   PMID:24317696   PMID:24327612   PMID:24583134   PMID:25043473  
PMID:25358791   PMID:25516972   PMID:25687754   PMID:25772331   PMID:26132778   PMID:26235047   PMID:26751774   PMID:26881857   PMID:26882546   PMID:26932670   PMID:27122169   PMID:27161092  
PMID:27435107   PMID:27736991   PMID:27878831   PMID:28546511   PMID:28564633   PMID:28607090   PMID:28859094   PMID:29463648   PMID:29700203   PMID:30061200   PMID:30089720   PMID:30923168  
PMID:31030254   PMID:31242448   PMID:31399638   PMID:31582416   PMID:31776260   PMID:31875961   PMID:32060135   PMID:32317081   PMID:32348677   PMID:32401676   PMID:32557739   PMID:32878924  
PMID:33127746   PMID:33332733   PMID:33431872   PMID:33938323   PMID:34010630   PMID:34111600   PMID:34158522   PMID:34247492   PMID:34391772   PMID:34534538   PMID:34998785   PMID:35219699  
PMID:35239513   PMID:35303432   PMID:35776514   PMID:36057966   PMID:36111525   PMID:36539616   PMID:36719141   PMID:36738214   PMID:38355793  


Genomics

Comparative Map Data
Muc5ac
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397141,342,695 - 141,372,964 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7141,342,709 - 141,372,968 (+)EnsemblGRCm39 Ensembl
GRCm387141,788,958 - 141,819,227 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7141,788,972 - 141,819,231 (+)EnsemblGRCm38mm10GRCm38
MGSCv377148,974,916 - 149,005,040 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367148,974,916 - 149,005,040 (+)NCBIMGSCv36mm8
Celera7141,544,129 - 141,573,772 (+)NCBICelera
Cytogenetic Map7F5NCBI
cM Map787.23NCBI
MUC5AC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38111,157,953 - 1,201,138 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl111,157,953 - 1,201,138 (+)EnsemblGRCh38hg38GRCh38
GRCh37111,151,580 - 1,222,364 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,169,363 - 1,178,940 (+)NCBINCBI36Build 36hg18NCBI36
Build 34111,141,594 - 1,152,361NCBI
Celera111,216,270 - 1,325,135 (+)NCBICelera
Cytogenetic Map11p15.5NCBI
HuRef11979,261 - 1,006,024 (+)NCBIHuRef
CHM1_1111,141,384 - 1,221,279 (+)NCBICHM1_1
T2T-CHM13v2.0111,229,366 - 1,272,380 (+)NCBIT2T-CHM13v2.0
Muc5ac
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81206,293,717 - 206,326,006 (+)NCBIGRCr8
mRatBN7.21196,864,336 - 196,896,475 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1196,864,336 - 196,896,475 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01214,725,482 - 214,756,653 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1214,727,416 - 214,741,252 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.01221,642,507 - 221,671,770 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1194,493,496 - 194,524,940 (+)NCBICelera
Cytogenetic Map1q41NCBI
Muc5ac
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495547611,061,405 - 11,084,294 (-)NCBIChiLan1.0ChiLan1.0
MUC5AC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v293,571,337 - 3,614,623 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1112,783,098 - 2,826,292 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0111,191,223 - 1,234,373 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1111,225,362 - 1,272,411 (+)NCBIpanpan1.1PanPan1.1panPan2
MUC5AC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11845,471,232 - 45,498,961 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1844,080,267 - 44,110,233 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01846,149,914 - 46,180,208 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11845,598,266 - 45,628,540 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01845,178,618 - 45,208,933 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01845,916,410 - 45,946,691 (+)NCBIUU_Cfam_GSD_1.0
Muc5ac
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947875,887 - 905,133 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936816129,926 - 159,396 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MUC5AC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.12757,897 - 790,321 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MUC5AC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11981,515 - 1,018,242 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603898,106,473 - 98,148,026 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Muc5ac
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476621,439,023 - 21,461,108 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Muc5ac
1537 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:670
Count of miRNA genes:344
Interacting mature miRNAs:378
Transcripts:ENSMUST00000041924, ENSMUST00000148171, ENSMUST00000155534, ENSMUST00000163321
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753249748143153737Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773149748143153737Mouse
11059562Lmr21b_mleishmaniasis resistance 21b (mouse)7110967235144967336Mouse
1302032Alcp12_malcohol preference locus 12 (mouse)Not determined7111166122144995196Mouse
1301590Pbwg3_mpostnatal body weight growth 3 (mouse)Not determined7127311241144995196Mouse
1300566Sluc8_msusceptibility to lung cancer 8 (mouse)Not determined7127398151144995196Mouse
14700684Civq1_mcerebral infarct volume QTL 1 (mouse)7109707335143707335Mouse
1300670Sluc19_msusceptibility to lung cancer 19 (mouse)Not determined7111166122144995196Mouse
14746988Manh63_mmandible shape 63 (mouse)7127735437144995196Mouse
14700687Civq5_mcerebral infarct volume QTL 5 (mouse)7109707335143707335Mouse
14700688Civq6_mcerebral infarct volume QTL 6 (mouse)7109707335143707335Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
4142444Femwf5_mfemur work to failure 5 (mouse)Not determined112552248144995196Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
1300677Bmd9_mbone mineral density 9 (mouse)Not determined7116634089144995196Mouse
1300747Skts2_mskin tumor susceptibility 2 (mouse)Not determined7112922733144995196Mouse
1301898Alcp14_malcohol preference locus 14 (mouse)Not determined7111166122144995196Mouse
1357711Adbg1_madult body growth 1 (mouse)Not determined7118693381144398314Mouse
10402499Lmr21_mleishmaniasis resistance 21 (mouse)Not determined7110967235144967336Mouse
1301773Stheal7_msoft tissue heal 7 (mouse)Not determined7119132573144995196Mouse

Markers in Region
Muc5ac  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387141,818,082 - 141,818,908UniSTSGRCm38
MGSCv377149,003,987 - 149,004,813UniSTSGRCm37
Celera7141,572,719 - 141,573,545UniSTS
Cytogenetic Map7F5UniSTS
cM Map769.0UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000041924   ⟹   ENSMUSP00000039699
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7141,342,748 - 141,372,623 (+)Ensembl
GRCm38.p6 Ensembl7141,789,011 - 141,818,886 (+)Ensembl
Ensembl Acc Id: ENSMUST00000155534   ⟹   ENSMUSP00000122353
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7141,342,709 - 141,372,968 (+)Ensembl
GRCm38.p6 Ensembl7141,788,972 - 141,819,231 (+)Ensembl
Ensembl Acc Id: ENSMUST00000163321   ⟹   ENSMUSP00000131681
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7141,342,748 - 141,372,872 (+)Ensembl
GRCm38.p6 Ensembl7141,789,011 - 141,819,135 (+)Ensembl
RefSeq Acc Id: NM_010844   ⟹   NP_034974
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397141,342,705 - 141,372,964 (+)NCBI
GRCm387141,788,968 - 141,819,227 (+)NCBI
MGSCv377148,974,916 - 149,005,040 (+)RGD
Celera7141,544,129 - 141,573,772 (+)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006508499   ⟹   XP_006508562
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397141,342,695 - 141,372,954 (+)NCBI
GRCm387141,788,958 - 141,819,217 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006508500   ⟹   XP_006508563
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397141,342,695 - 141,372,954 (+)NCBI
GRCm387141,788,958 - 141,819,217 (+)NCBI
Sequence:
RefSeq Acc Id: NP_034974   ⟸   NM_010844
- Peptide Label: precursor
- UniProtKB: E9QAQ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006508562   ⟸   XM_006508499
- Peptide Label: isoform X1
- UniProtKB: E9QAQ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006508563   ⟸   XM_006508500
- Peptide Label: isoform X2
- UniProtKB: E9QAQ8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000131681   ⟸   ENSMUST00000163321
Ensembl Acc Id: ENSMUSP00000039699   ⟸   ENSMUST00000041924
Ensembl Acc Id: ENSMUSP00000122353   ⟸   ENSMUST00000155534
Protein Domains
CTCK   VWFC   VWFD   WxxW

Promoters
RGD ID:8666161
Promoter ID:EPDNEW_M11112
Type:single initiation site
Name:Muc5ac_1
Description:Mus musculus mucin 5, subtypes A and C, tracheobronchial/gastric, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387141,788,969 - 141,789,029EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:104697 AgrOrtholog
Ensembl Genes ENSMUSG00000037974 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000041924 ENTREZGENE
  ENSMUST00000041924.14 UniProtKB/TrEMBL
  ENSMUST00000155534 ENTREZGENE
  ENSMUST00000155534.9 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
InterPro Cys_knot_C UniProtKB/TrEMBL
  Cystine-knot_cytokine UniProtKB/TrEMBL
  Mucin_vWF_Thrombospondin_sf UniProtKB/TrEMBL
  Ser_inhib-like_sf UniProtKB/TrEMBL
  TIL_dom UniProtKB/TrEMBL
  Unchr_dom_Cys-rich UniProtKB/TrEMBL
  VWF_C UniProtKB/TrEMBL
  VWF_type-D UniProtKB/TrEMBL
  WxxW_domain UniProtKB/TrEMBL
KEGG Report mmu:17833 UniProtKB/TrEMBL
MGD MGI:104697 ENTREZGENE
NCBI Gene 17833 ENTREZGENE
PANTHER EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED UniProtKB/TrEMBL
  MUCIN-5AC UniProtKB/TrEMBL
Pfam Mucin2_WxxW UniProtKB/TrEMBL
  PF08742 UniProtKB/TrEMBL
  TIL UniProtKB/TrEMBL
  VWD UniProtKB/TrEMBL
PhenoGen Muc5ac PhenoGen
PROSITE CTCK_1 UniProtKB/TrEMBL
  CTCK_2 UniProtKB/TrEMBL
  PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
  VWFC_1 UniProtKB/TrEMBL
  VWFC_2 UniProtKB/TrEMBL
  VWFD UniProtKB/TrEMBL
SMART SM00041 UniProtKB/TrEMBL
  SM00832 UniProtKB/TrEMBL
  VWC UniProtKB/TrEMBL
  VWC_out UniProtKB/TrEMBL
  VWD UniProtKB/TrEMBL
Superfamily-SCOP Cysrich_TIL UniProtKB/TrEMBL
  FnI-like domain UniProtKB/TrEMBL
UniProt E9PWB6_MOUSE UniProtKB/TrEMBL
  E9QAQ8 ENTREZGENE, UniProtKB/TrEMBL
  O88715_MOUSE UniProtKB/TrEMBL
  Q61916_MOUSE UniProtKB/TrEMBL
  Q9CVD4_MOUSE UniProtKB/TrEMBL