Kcnk3 (potassium channel, subfamily K, member 3)

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Gene: Kcnk3 (potassium channel, subfamily K, member 3) Mus musculus

Analyze

Symbol:

Kcnk3

Name:

potassium channel, subfamily K, member 3

RGD ID:

62289

MGI Page

MGI

Description:

Predicted to enable S100 protein binding activity; open rectifier potassium channel activity; and potassium ion leak channel activity. Predicted to be involved in several processes, including positive regulation of voltage-gated potassium channel activity; regulation of resting membrane potential; and stabilization of membrane potential. Predicted to act upstream of or within monoatomic ion transport. Predicted to be located in plasma membrane. Is expressed in early conceptus; heart; and secondary oocyte. Human ortholog(s) of this gene implicated in primary pulmonary hypertension. Orthologous to human KCNK3 (potassium two pore domain channel subfamily K member 3).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

acid-sensitive potassium channel protein TASK-1; cardiac two pore background K(+) channel; cTBAK-; cTBAK-1; potassium channel subfamily K member 3; TASK; Task-1; TWIK-related acid-sensitive K(+) channel 1; two pore K(+) channel KT3.1; two pore potassium channel KT3.1

RGD Orthologs

Human

Rat

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	30,745,514 - 30,782,614 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	30,745,514 - 30,782,615 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	30,588,170 - 30,625,270 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	30,588,170 - 30,625,271 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	30,890,543 - 30,927,643 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	30,864,751 - 30,901,851 (+)	NCBI		MGSCv36	mm8
Celera	5	28,066,527 - 28,103,716 (+)	NCBI		Celera
Cytogenetic Map	5	B1	NCBI
cM Map	5	16.68	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autism spectrum disorder (ISO)

Deafness (ISO)

genetic disease (ISO)

Gliosis (ISO)

primary pulmonary hypertension (ISO)

Primary Pulmonary Hypertension, 1 (ISO)

Primary Pulmonary Hypertension, 4 (ISO)

Pulmonary Arterial Hypertension (ISO)

pulmonary hypertension (ISO)

pulmonary venoocclusive disease (ISO)

short-rib thoracic dysplasia 10 with or without polydactyly (ISO)

status epilepticus (ISO)

Stroke (ISO)

Tatton-Brown-Rahman syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (EXP)

17alpha-ethynylestradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

3-isobutyl-1-methyl-7H-xanthine (EXP)

4,4'-diaminodiphenylmethane (EXP)

4,4'-sulfonyldiphenol (EXP,ISO)

4-hydroxyphenyl retinamide (EXP)

6-propyl-2-thiouracil (ISO)

aflatoxin B1 (ISO)

alpha-Sanshool (ISO)

ammonium chloride (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

atrazine (ISO)

barium chloride (ISO)

benzo[a]pyrene (ISO)

bisphenol A (ISO)

bisphenol F (EXP,ISO)

butanal (ISO)

cadmium dichloride (EXP)

calcitriol (ISO)

carvedilol (ISO)

chlordecone (EXP)

cyclosporin A (ISO)

dexamethasone (EXP)

doxorubicin (ISO)

folic acid (EXP,ISO)

Licochalcone B (ISO)

mercury dichloride (ISO)

N,N-diethyl-m-toluamide (ISO)

N-methyl-4-phenylpyridinium (ISO)

ozone (EXP)

paclitaxel (ISO)

paracetamol (ISO)

paraquat (ISO)

permethrin (ISO)

potassium atom (ISO)

potassium dichromate (EXP)

progesterone (ISO)

riociguat (ISO)

serotonin (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sodium hydroxide (ISO)

sunitinib (ISO)

testosterone (EXP)

tetrachloromethane (ISO)

thioacetamide (ISO)

titanium dioxide (EXP)

toluene (ISO)

tributylstannane (EXP)

trichloroethene (ISO)

triptonide (EXP)

valproic acid (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

brain development (ISO)

cellular response to hypoxia (ISO)

cellular response to zinc ion (ISO)

cochlea development (ISO)

monoatomic ion transmembrane transport (ISO)

monoatomic ion transport (IEA)

negative regulation of cytosolic calcium ion concentration (ISO)

positive regulation of voltage-gated potassium channel activity (ISO)

potassium ion transmembrane transport (IBA)

potassium ion transport (ISO)

regulation of resting membrane potential (ISO)

response to xenobiotic stimulus (ISO)

stabilization of membrane potential (IBA)

Cellular Component

membrane (IEA)

plasma membrane (ISO)

Molecular Function

monoatomic ion channel activity (ISO)

open rectifier potassium channel activity (ISO)

potassium channel activity (IEA)

potassium ion leak channel activity (IBA,ISO)

protein binding (ISO)

S100 protein binding (ISO)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal action potential (IAGP)

abnormal adrenal gland physiology (IAGP)

abnormal channel response (IAGP)

abnormal motor coordination/balance (IAGP)

decreased circulating renin level (IAGP)

decreased heart rate (IAGP)

hypertension (IAGP)

hypokalemia (IAGP)

increased circulating aldosterone level (IAGP)

no abnormal phenotype detected (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Deafness associated changes in two-pore domain potassium channels in the rat inferior colliculus.	Cui YL, etal., Neuroscience. 2007 Oct 26;149(2):421-33. Epub 2007 Jul 17.
2.	Region-specific alterations in astroglial TWIK-related acid-sensitive K+-1 channel immunoreactivity in the rat hippocampal complex following pilocarpine-induced status epilepticus.	Kim JE, etal., J Comp Neurol. 2008 Oct 10;510(5):463-74.
3.	Characterization of Kcnk3-Mutated Rat, a Novel Model of Pulmonary Hypertension.	Lambert M, etal., Circ Res. 2019 Sep 13;125(7):678-695. doi: 10.1161/CIRCRESAHA.119.314793. Epub 2019 Jul 26.
4.	Comparison of Human and Experimental Pulmonary Veno-Occlusive Disease.	Manaud G, etal., Am J Respir Cell Mol Biol. 2020 Jul;63(1):118-131. doi: 10.1165/rcmb.2019-0015OC.
5.	Electronic Transfer of Homolog Data	MGD and Homologene mouse data transfer
6.	MGDs mouse GO annotations	MGD data from the GO Consortium
7.	Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.	Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
8.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
9.	Mouse MP Annotation Import Pipeline	RGD automated import pipeline
10.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:8889548	PMID:9312005	PMID:9506712	PMID:9806851	PMID:10349636	PMID:10575216	PMID:10748056	PMID:10843805	PMID:10899153	PMID:11042159	PMID:11076861	PMID:11217851
PMID:12477932	PMID:12634929	PMID:15184378	PMID:16141072	PMID:16141073	PMID:16145663	PMID:16339039	PMID:16424077	PMID:16837582	PMID:16985003	PMID:17541788	PMID:17967808
PMID:18034154	PMID:18094244	PMID:18250325	PMID:18753386	PMID:18799693	PMID:18930826	PMID:19188660	PMID:19244527	PMID:19508695	PMID:19805135	PMID:20167264	PMID:20410120
PMID:20452469	PMID:20519544	PMID:20705896	PMID:20978771	PMID:21111026	PMID:21486782	PMID:21575593	PMID:21865850	PMID:21873635	PMID:22253765	PMID:22419831	PMID:22813543
PMID:22918120	PMID:23473320	PMID:23567653	PMID:24042502	PMID:24848104	PMID:24932805	PMID:25556792	PMID:25849724	PMID:26378152	PMID:26446210	PMID:26527067	PMID:26549439
PMID:26678830	PMID:27838333	PMID:27930725	PMID:27997827	PMID:28276488	PMID:28301582	PMID:28673876	PMID:28714121	PMID:28988768	PMID:29881975	PMID:30001168	PMID:30580687
PMID:30623969	PMID:31439839	PMID:31824340	PMID:31977249	PMID:32492036	PMID:34065088	PMID:35526370

Genomics

Comparative Map Data

Kcnk3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	30,745,514 - 30,782,614 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	30,745,514 - 30,782,615 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	30,588,170 - 30,625,270 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	30,588,170 - 30,625,271 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	30,890,543 - 30,927,643 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	30,864,751 - 30,901,851 (+)	NCBI		MGSCv36	mm8
Celera	5	28,066,527 - 28,103,716 (+)	NCBI		Celera
Cytogenetic Map	5	B1	NCBI
cM Map	5	16.68	NCBI

KCNK3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	26,692,722 - 26,733,420 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	2	26,692,722 - 26,733,420 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	26,915,590 - 26,956,288 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	26,769,123 - 26,806,222 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	26,827,269 - 26,864,354	NCBI
Celera	2	26,759,188 - 26,800,097 (+)	NCBI		Celera
Cytogenetic Map	2	p23.3	NCBI
HuRef	2	26,654,995 - 26,695,894 (+)	NCBI		HuRef
CHM1_1	2	26,845,436 - 26,883,789 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	26,731,837 - 26,774,979 (+)	NCBI		T2T-CHM13v2.0

Kcnk3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	6	25,761,487 - 25,799,153 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	25,763,228 - 25,799,153 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	26,055,862 - 26,091,832 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	6	26,371,748 - 26,407,719 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	6	25,851,418 - 25,887,323 (-)	NCBI	Rnor_WKY
Rnor_6.0	6	27,154,274 - 27,190,209 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	27,151,612 - 27,190,132 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	36,969,843 - 37,005,778 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	25,745,923 - 25,782,144 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	25,748,881 - 25,785,097 (-)	NCBI
Celera	6	25,246,393 - 25,282,199 (-)	NCBI		Celera
Cytogenetic Map	6	q14	NCBI

Kcnk3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955469	8,709,999 - 8,747,467 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955469	8,710,749 - 8,744,423 (+)	NCBI	ChiLan1.0	ChiLan1.0

KCNK3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	2A	26,780,475 - 26,819,123 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	26,780,475 - 26,819,123 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	2A	26,688,938 - 26,729,860 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

KCNK3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	20,732,779 - 20,771,104 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	20,732,819 - 20,768,730 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	20,626,715 - 20,665,014 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	21,054,044 - 21,092,326 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	21,054,082 - 21,089,962 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	20,740,930 - 20,779,204 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	20,752,294 - 20,790,552 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	20,798,295 - 20,836,548 (+)	NCBI		UU_Cfam_GSD_1.0

Kcnk3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	65,067,699 - 65,071,786 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936493	5,770,103 - 5,772,326 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936493	5,767,779 - 5,772,043 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

KCNK3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	112,322,446 - 112,359,212 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	112,322,446 - 112,359,212 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	119,337,496 - 119,340,759 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

KCNK3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	80,905,168 - 80,945,972 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	80,906,608 - 80,945,806 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	31,201,565 - 31,245,180 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Kcnk3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624738	8,813,644 - 8,848,783 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624738	8,813,683 - 8,850,744 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	1194
Count of miRNA genes:	544
Interacting mature miRNAs:	686
Transcripts:	ENSMUST00000066295
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10401122	Pgia41_m	proteoglycan induced arthritis 41 (mouse)			Not determined		5	823144	34823280	Mouse
15039371	Nmrs21_m	NAFLD-associated magnetic resonance shift 21 (mouse)					5	3504823	37504823	Mouse
1301806	Actd2_m	activity-distance traveled 2 (mouse)			Not determined		5	5384520	39384652	Mouse
4141207	Imrfq1_m	immune response to Factor IX QTL 1 (mouse)			Not determined		5	8124117	42124239	Mouse
7394748	Mom5_m	modifier of Min 5 (mouse)			Not determined		5	8847672	33475637	Mouse
1301693	Sle6_m	systemic lupus erythematosus susceptibility 6 (mouse)			Not determined		5	8890693	87841837	Mouse
1357478	Kdnw1_m	kidney weight 1 (mouse)			Not determined		5	8915949	40529869	Mouse
14696730	Kidlq1_m	kidney weight, left QTL 1 (mouse)					5	13563152	47563152	Mouse
1301685	Estq2_m	estradiol regulated response QTL 2 (mouse)			Not determined		5	15634084	49634190	Mouse
1300719	Iba5_m	induction of brown adipocytes 5 (mouse)			Not determined		5	20686993	54687134	Mouse
1301776	Skts3_m	skin tumor susceptibility 3 (mouse)			Not determined		5	21667295	55667403	Mouse
11537368	Hmtb10_m	hemostasis and thrombosis 10 (mouse)					5	22100823	54500318	Mouse
11537367	Hmtb11_m	hemostasis and thrombosis 11 (mouse)					5	22100823	64806579	Mouse
11341716	Rvfs3_m	Rift Valley fever susceptibility 3 (mouse)					5	26441234	138455402	Mouse
1300701	Cd8ts1_m	CD8 T cell subset 1 (mouse)			Not determined		5	27215348	61215451	Mouse

Markers in Region

AB013345

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	5	30,623,349 - 30,623,452	UniSTS	GRCm38
MGSCv37	5	30,925,722 - 30,925,825	UniSTS	GRCm37
Celera	5	28,101,795 - 28,101,898	UniSTS
Cytogenetic Map	5	B	UniSTS
cM Map	5	18.0	UniSTS
Whitehead/MRC_RH	5	386.1	UniSTS

D5Jcs302

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	5	30,592,069 - 30,592,268	UniSTS	GRCm38
MGSCv37	5	30,894,442 - 30,894,641	UniSTS	GRCm37
Celera	5	28,070,426 - 28,070,625	UniSTS
Cytogenetic Map	5	B	UniSTS
cM Map	5		UniSTS

PMC16288P1

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	5	30,622,263 - 30,622,386	UniSTS	GRCm38
MGSCv37	5	30,924,636 - 30,924,759	UniSTS	GRCm37
Celera	5	28,100,709 - 28,100,832	UniSTS
Cytogenetic Map	5	B	UniSTS
cM Map	5	18.0	UniSTS

Kcnk3

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	5	30,623,195 - 30,623,371	UniSTS	GRCm38
MGSCv37	5	30,925,568 - 30,925,744	UniSTS	GRCm37
Celera	5	28,101,641 - 28,101,817	UniSTS
Cytogenetic Map	5	B	UniSTS
cM Map	5	18.0	UniSTS

PMC16288P2

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	5	30,622,263 - 30,622,625	UniSTS	GRCm38
MGSCv37	5	30,924,636 - 30,924,998	UniSTS	GRCm37
Celera	5	28,100,709 - 28,101,071	UniSTS
Cytogenetic Map	5	B	UniSTS
cM Map	5	18.0	UniSTS

Kcnk3

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	5	B	UniSTS

Kcnk3

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	5	B	UniSTS
Cytogenetic Map	2	H3	UniSTS

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_010608	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB008537	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB013345	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC105298	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC120408	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AEKQ02160270	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF006824	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF022821	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF065162	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AH009585	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AI325858	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK032542	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK084790	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC032047	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466524	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSMUST00000066295 ⟹ ENSMUSP00000098987

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	5	30,745,514 - 30,782,615 (+)	Ensembl
GRCm38.p6 Ensembl	5	30,588,170 - 30,625,271 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000197428

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	5	30,778,717 - 30,779,576 (+)	Ensembl
GRCm38.p6 Ensembl	5	30,621,373 - 30,622,232 (+)	Ensembl

RefSeq Acc Id:

NM_010608 ⟹ NP_034738

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	5	30,745,514 - 30,782,614 (+)	NCBI
GRCm38	5	30,588,170 - 30,625,270 (+)	ENTREZGENE
MGSCv37	5	30,890,543 - 30,927,643 (+)	RGD
Celera	5	28,066,527 - 28,103,716 (+)	RGD
cM Map	5		ENTREZGENE

Sequence:

show sequence

CCCCGGGGTGCGGAGCTGGTGCCCGGCGTGGAGATCCGCGAGCGCAGCCATGCCCCAGGCCGCC
TCCGGGGCAGCAGCGGCGGCGGCGGCCGGGGCCGGGGCGCGGGCCGGAGACGCCGGAGGGCCGG
CGAGGACCCGGGAGGGACGATGAAGCGGCAGAATGTGCGCACGTTGGCTCTCATCGTGTGCACC
TTCACCTACCTGCTGGTGGGCGCCGCGGTGTTCGACGCACTGGAGTCGGAGCCGGAGATGATCG
AGCGGCAGCGGCTGGAGCTGCGGCAGCTGGAGCTGCGGGCGCGCTACAACCTCAGCGAGGGCGG
CTACGAGGAGCTGGAGCGCGTCGTGCTGCGCCTCAAGCCGCACAAGGCCGGCGTGCAGTGGCGC
TTCGCCGGCTCCTTCTACTTCGCCATCACCGTCATCACCACCATCGGCTATGGTCATGCGGCGC
CCAGCACGGACGGAGGCAAGGTGTTCTGCATGTTCTACGCGCTGCTGGGCATCCCGCTCACACT
AGTCATGTTCCAGAGCCTGGGTGAACGCATCAACACCTTCGTGAGGTACCTGCTGCACCGTGCC
AAGAGGGGGCTGGGCATGCGGCACGCCGAGGTGTCCATGGCCAACATGGTGCTCATCGGTTTCG
TGTCGTGCATCAGCACGCTGTGCATCGGCGCAGCTGCCTTCTCCTACTACGAGCGCTGGACTTT
CTTCCAGGCCTATTACTACTGCTTCATCACCCTCACCACCATCGGCTTCGGCGACTATGTGGCG
CTGCAGAAGGACCAGGCGCTGCAGACGCAGCCGCAGTATGTGGCCTTCAGCTTCGTGTACATCC
TCACGGGCCTCACGGTCATCGGCGCCTTCCTCAACCTCGTGGTGCTGCGATTCATGACCATGAA
CGCCGAGGACGAGAAGCGTGATGCGGAGCACCGCGCCCTGCTCACGCACAACGGCCAGGCTGTC
GGCCTGGGTGGCCTGAGCTGCCTGAGCGGTAGCCTGGGCGACGGCGTGCGTCCCCGCGACCCAG
TCACATGCGCTGCGGCCGCGGGAGGCGTGGGCGTGGGCGTCGGTGGCAGCGGCTTCCGCAACGT
CTATGCCGAGGTGCTGCACTTCCAGTCCATGTGCTCGTGCCTCTGGTACAAGAGCCGCGAGAAG
CTGCAGTACTCCATCCCCATGATCATCCCGCGGGACCTCTCCACGTCCGACACCTGCGTGGAGC
ACAGCCACTCGTCGCCGGGAGGCGGCGGCCGCTACAGCGACACGCCCTCACACCCCTGCCTGTG
CAGCGGGACGCAGCGCTCGGCCATCAGCTCGGTGTCCACGGGCCTGCACAGCCTGGCTGCCTTC
CGCGGCCTCATGAAGCGCAGGAGCTCGGTGTGAACCACAGCCAGACCTGGAGCACCTGTGAGCC
AGAGGGGTAGGGGACCTGCCTGCAGAAGCCGCAGGAGTTGGCCAGAAGGCCCCCCAAAGACGCC
TTCGGGCCCCATGGGAAGTCCCCAGCCCATCACCACCACCACCACCTCTACTCTTCCCCAGCCC
CTAAATCTCCAACTGTGCAGGCTATCACTAGCCAGCAGGAGGCGGGGCTCTGAGGACCCCTGGA
GCCCCCATCGGAGCCGAAGAATTCCGAGAAATGTGAAACTTAGGGGGTGGGGAGCCCGGAAAGC
AGCCACGGGGAGCTGCTGAGAAGCCCCCAGTCCTCAGAGGCCCTACGGGGGCCCCAGACCCCTC
ACCTCCGGAGGGAACTAATGTTCTCGGGTTTTGTTTTCTGTTTTCTGTTTTGGTTTGGTTCTCT
CTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCCCTCCCTCCCTCCCTCCTTCTCTCTCT
CTCTTCTACTTACACCTCCTCTGGGTTCTCCAAAGCCCAAGGTGTTTTTGTCCAGGTCACCCCC
ACTCAGTCCCACCTGGCTCTCATCCCCAGCCATGTCTCCCAGCCTTCCACTACCTTACGTGTCC
ACTCCCTTCTGTTTTTTGCATGGCTATGCAGTTATGGAAGAAAAAAAAAAAAAAGGAAACCCCA
GCAGCCCCTAAAGCTAGTCCCCAGAGGGCAAGATAAAAAAGAAAGAAAGAAAAAAAAAAAAAAG
AAGAAGAAAAAAAAAGGGCAGGCCACAGATGTTAGAGCAGAGTGTGTGCAGAAACTGTGGCTTC
CACCTCTGCGGGGTGGACATCTGTAGGTGAGCCACCTGGAGTCTGGGAACATTCTCAGGGGCTC
CTGAGAGACTCCAGCCTTCAGGACTGCCCTTGGAATCTAAAACATGGACTCCCCTTTGCTGTCC
CTGGCTGCAGCTGCTCATTCACTCGTCCATAGGTTGTTTTTTTTTGTTTGTTTGTTTTTTTGTT
TTTTGTTTTTTTGTCCCAGAAACCCTGTGCCACCTCCGTATTCATTTGAGTGTAATAACACTCT
AGTTAAGTCACCTGGGCAGTTCTTATGGCCATTTTTCAGAAGAGGAAAACAGGTAAAAAAAAAA
AAATTTTTTTTTTTACTTGCCCGGGGTGTCTTGAAGGGGAACAGCCTGCCGGCTTGTTCCCAGC
CCAAGTGCTCTTTCTTCAGGCTCAGCCTGCCCTCAGAAGCGAAGCCCCTGCAGGCAACACCCCA
GCTTTGTGTAGGCAGCTGGGGTTTAAACCAGAATCAAAAGCCCCAGCCTGAGCCACTGCCAGGG
CTCTGCCTCTGGTACTCTTTAGCCCAGAGACTGAGGCTCTAAATGGACCCTTGTCTCTGTTCAC
AAGCAGGGAAGTCCTTGGGACCAAGGTAAGAAGGACTGAGTCTCATGGACTACAAGCCAGCAGT
TGGCACTCTTGAGAGTTCAGGGACTGGGCAGAGCAGCCCAGACAGCTGACAGGTATATCCTGGG
ACGTTTTCCCTGGCCTAGAAGCCAGGATAAATGCATCCTAAGTTGCTAGAGTAACTTCCACTGC
AGCCAGGAACACCCCTCTGGAGGGAAGGAGGTATTGGGCCTGCTATGCCTTCTACCTCCTCTAC
CTGCAACCCAGTGGAGGGTGGCTTGCTACTGGGGACAAGCTGGAGGTGGAAACCAGGACAACAG
AAGGGTATGTGTGGGGCTATGGGTATAGCCCCAAGTTTTATTCCCAGTACCATGAAAAGGGAAA
CCTTTCCCCTGCAGAGCTGCCTTCTGCTCACTGTTCCCAGGCCTAGCTCCATACTGCTGAGTAA
GGCCAATGTGACCATTTGGGGAGGTAGAGAGAGAGCCCCACCATGTCCTCCAGGTCCTGGGAAA
TCCTTAGGTGGAAGGAATCTGGCCTGTGTGTATCCCATGTCCGTGTGGAGGAGCTGGCCCCTGT
GTCAAGGGGGAATGGAACCCAGCAGCTGGAGAGGTGCTGTCTGTGTTTATGTTGGGCTGGAGGC
AGTGCTGGCTGCCTCTGTCCTGTGTGTGACCCTGCCCTCGAGGGGTCAAGTCCCGTCAGATCCG
AGGGAGCCACAACCAAAGTTACAGAGAGGGTGGGGAAGGCAGCAGAGTGGCCCTAGGGTCTAAG
CATGGGGGACTGCTGGTCTCCTGTAGGGTCTTTGCCTAGGGAACTAGAAGGCCACTGTCACTTC
CTGTCTCACCCCCTCCCATGCAGGCAGCCTTTCTGCTTCCCCAATGCCTTATGCCTGGGCACAC
TGCCACAGAATATGCAATATGTGTGGGTGACATCCCCACACCCACCCGGGCAGCCCCTAAGTCC
CCAGGCTGTGGCTGCCCTGGCCCCCTTTTCAGCAGCTCCTGCCCATCTGTCTTCACACTGAGAA
TGGCGCCTAATAAATGCTGTCCATGGAGACCAGG

hide sequence

Protein Sequences


Protein RefSeqs	NP_034738	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC53367	(Get FASTA)	NCBI Sequence Viewer
	AAD09338	(Get FASTA)	NCBI Sequence Viewer
	AAF81418	(Get FASTA)	NCBI Sequence Viewer
	AAG29339	(Get FASTA)	NCBI Sequence Viewer
	BAA25436	(Get FASTA)	NCBI Sequence Viewer
	BAA28349	(Get FASTA)	NCBI Sequence Viewer
	EDL37281	(Get FASTA)	NCBI Sequence Viewer
	O35111	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_034738 ⟸ NM_010608

- UniProtKB:

O35163 (UniProtKB/Swiss-Prot), O35111 (UniProtKB/Swiss-Prot), A0A6P5PQ65 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MKRQNVRTLALIVCTFTYLLVGAAVFDALESEPEMIERQRLELRQLELRARYNLSEGGYEELER
VVLRLKPHKAGVQWRFAGSFYFAITVITTIGYGHAAPSTDGGKVFCMFYALLGIPLTLVMFQSL
GERINTFVRYLLHRAKRGLGMRHAEVSMANMVLIGFVSCISTLCIGAAAFSYYERWTFFQAYYY
CFITLTTIGFGDYVALQKDQALQTQPQYVAFSFVYILTGLTVIGAFLNLVVLRFMTMNAEDEKR
DAEHRALLTHNGQAVGLGGLSCLSGSLGDGVRPRDPVTCAAAAGGVGVGVGGSGFRNVYAEVLH
FQSMCSCLWYKSREKLQYSIPMIIPRDLSTSDTCVEHSHSSPGGGGRYSDTPSHPCLCSGTQRS
AISSVSTGLHSLAAFRGLMKRRSSV

hide sequence

RefSeq Acc Id:

ENSMUSP00000098987 ⟸ ENSMUST00000066295

Protein Domains

Potassium channel

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O35111-F1-model_v2	AlphaFold	O35111	1-409	view protein structure

Promoters

RGD ID:

6886290

Promoter ID:

EPDNEW_M6596

Type:

initiation region

Name:

Kcnk3_1

Description:

Mus musculus potassium channel, subfamily K, member 3 , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	5	30,588,138 - 30,588,198	EPDNEW

RGD ID:

6837756

Promoter ID:

MM_KWN:41765

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

3T3L1_Day4

Transcripts:

NM_010608

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	5	30,889,871 - 30,890,371 (+)	MPROMDB

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:1100509	AgrOrtholog
Ensembl Genes	ENSMUSG00000049265	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein	ENSMUSP00000098987	ENTREZGENE
	ENSMUSP00000098987.2	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSMUST00000066295	ENTREZGENE
	ENSMUST00000066295.5	UniProtKB/Swiss-Prot
Gene3D-CATH	1.10.287.70	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	2pore_dom_K_chnl	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	2pore_dom_K_chnl_TASK	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	K_chnl_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	KCNK3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:16527	UniProtKB/Swiss-Prot
MGD	MGI:1100509	ENTREZGENE
NCBI Gene	16527	ENTREZGENE
PANTHER	PTHR11003	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR11003:SF138	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Ion_trans_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB	KCNK3	RGD
PhenoGen	Kcnk3	PhenoGen
PIRSF	K_channel_subfamily_K_type	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS	2POREKCHANEL	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TASK1CHANNEL	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TASKCHANNEL	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	Voltage-gated potassium channels	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A6P5PQ65	ENTREZGENE
	KCNK3_MOUSE	UniProtKB/Swiss-Prot, ENTREZGENE
	O35163	ENTREZGENE
	Q9QX34_MOUSE	UniProtKB/TrEMBL
UniProt Secondary	O35163	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Mammalian Phenotype

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