Pten (phosphatase and tensin homolog)

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Gene: Pten (phosphatase and tensin homolog) Mus musculus

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Symbol:

Pten

Name:

phosphatase and tensin homolog

RGD ID:

62287

MGI Page

MGI

Description:

Enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity and protein kinase binding activity. Involved in several processes, including modulation of chemical synaptic transmission; negative regulation of neuron projection development; and nervous system development. Acts upstream of or within several processes, including circulatory system development; negative regulation of cell population proliferation; and regulation of apoptotic process. Located in several cellular components, including Schmidt-Lanterman incisure; myelin sheath adaxonal region; and neuron projection. Is expressed in several structures, including alimentary system; central nervous system; egg cylinder; genitourinary system; and integumental system. Used to study several diseases, including Cowden syndrome (multiple); carcinoma (multiple); macrocephaly-autism syndrome; persistent fetal circulation syndrome; and reproductive organ cancer (multiple). Human ortholog(s) of this gene implicated in several diseases, including PTEN hamartoma tumor syndrome (multiple); breast cancer (multiple); macrocephaly-autism syndrome; nervous system cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human PTEN (phosphatase and tensin homolog).

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

2310035O07Rik; A130070J02Rik; AI463227; B430203M17Rik; inositol polyphosphate 3-phosphatase; MGC183880; mitochondrial PTENalpha; MMAC; MMAC1; mutated in multiple advanced cancers 1; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; PTENbeta; PTENepsilon; RIKEN cDNA B430203M17 gene; TEP; TEP1

RGD Orthologs

Alliance Orthologs

More Info

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More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PTEN (phosphatase and tensin homolog)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Pten (phosphatase and tensin homolog)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Pten (phosphatase and tensin homolog)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PTEN (phosphatase and tensin homolog)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PTEN (phosphatase and tensin homolog)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Pten (phosphatase and tensin homolog)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PTEN (phosphatase and tensin homolog)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PTEN (phosphatase and tensin homolog)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Pten (phosphatase and tensin homolog)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Pten (phosphatase and tensin homolog)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	PTEN (phosphatase and tensin homolog)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ptena (phosphatase and tensin homolog A)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid\|ZFIN)
Danio rerio (zebrafish):	ptenb (phosphatase and tensin homolog B)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid\|ZFIN)
Caenorhabditis elegans (roundworm):	daf-18	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Pten	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	TEP1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	pten	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	32,734,977 - 32,803,560 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	32,734,897 - 32,803,560 (+)	Ensembl		GRCm39 Ensembl
GRCm38	19	32,757,577 - 32,826,160 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	32,757,497 - 32,826,160 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	19	32,832,067 - 32,900,650 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	19	32,823,574 - 32,892,157 (+)	NCBI		MGSCv36	mm8
Celera	19	33,541,182 - 33,610,051 (+)	NCBI		Celera
Cytogenetic Map	19	C1	NCBI
cM Map	19	28.14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIA

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

Mammalian Phenotype

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