Imported Disease Annotations - ClinVarTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | genetic disease | | ISO | RGD:1348499 | 8554872 | ClinVar Annotator: match by term: Inborn genetic diseases | ClinVar | | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Imported Disease Annotations - CTD
Gene-Chemical Interaction Annotations Click to see Annotation Detail View
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Molecular Pathway Annotations
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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | Altered expression and subcellular distribution of GRK subtypes in the dopamine-depleted rat basal ganglia is not normalized by l-DOPA treatment. | Ahmed MR, etal., J Neurochem. 2008 Mar;104(6):1622-36. Epub 2007 Nov 7. |
| 2. | Impaired neutrophil chemotaxis in sepsis associates with GRK expression and inhibition of actin assembly and tyrosine phosphorylation. | Arraes SM, etal., Blood. 2006 Nov 1;108(9):2906-13. Epub 2006 Jul 18. |
| 3. | The physiology, signaling, and pharmacology of dopamine receptors. | Beaulieu JM and Gainetdinov RR, Pharmacol Rev. 2011 Mar;63(1):182-217. doi: 10.1124/pr.110.002642. Epub 2011 Feb 8. |
| 4. | Arrestins and two receptor kinases are upregulated in Parkinson's disease with dementia. | Bychkov ER, etal., Neurobiol Aging. 2008 Mar;29(3):379-96. Epub 2006 Nov 27. |
| 5. | GRK mythology: G-protein receptor kinases in cardiovascular disease. | Dorn GW 2nd J Mol Med (Berl). 2009 May;87(5):455-63. Epub 2009 Feb 20. |
| 6. | Beta-adrenergic stimulation and myocardial function in the failing heart. | El-Armouche A and Eschenhagen T, Heart Fail Rev. 2009 Dec;14(4):225-41. |
| 7. | Defective lymphocyte chemotaxis in beta-arrestin2- and GRK6-deficient mice. | Fong AM, etal., Proc Natl Acad Sci U S A 2002 May 28;99(11):7478-83. |
| 8. | GRK5 deficiency exaggerates inflammatory changes in TgAPPsw mice. | Li L, etal., J Neuroinflammation. 2008 Jun 3;5:24. |
| 9. | GRK5 deficiency leads to reduced hippocampal acetylcholine level via impaired presynaptic M2/M4 autoreceptor desensitization. | Liu J, etal., J Biol Chem. 2009 Jul 17;284(29):19564-71. doi: 10.1074/jbc.M109.005959. Epub 2009 May 28. |
| 10. | Decreased expression and activity of G-protein-coupled receptor kinases in peripheral blood mononuclear cells of patients with rheumatoid arthritis. | Lombardi MS, etal., FASEB J. 1999 Apr;13(6):715-25. |
| 11. | Electronic Transfer of Homolog Data | MGD and Homologene mouse data transfer |
| 12. | MGDs mouse GO annotations | MGD data from the GO Consortium |
| 13. | MGD IEA | MGD IEA |
| 14. | beta2- and beta1-Adrenoceptor Expression Exhibits a Common Regulatory Pattern With GRK2 and GRK5 in Human and Animal Models of Cardiovascular Diseases. | Monto F, etal., J Cardiovasc Pharmacol. 2015 Nov;66(5):478-86. doi: 10.1097/FJC.0000000000000299. |
| 15. | Different expression of adrenoceptors and GRKs in the human myocardium depends on heart failure etiology and correlates to clinical variables. | Montó F, etal., Am J Physiol Heart Circ Physiol. 2012 Aug 1;303(3):H368-76. doi: 10.1152/ajpheart.01061.2011. Epub 2012 Jun 8. |
| 16. | Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. | Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73. |
| 17. | G-protein coupled receptor kinase 5 mediates lipopolysaccharide-induced NFkappaB activation in primary macrophages and modulates inflammation in vivo in mice. | Patial S, etal., J Cell Physiol. 2011 May;226(5):1323-33. doi: 10.1002/jcp.22460. |
| 18. | KEGG Annotation Import Pipeline | Pipeline to import KEGG annotations from KEGG into RGD |
| 19. | The GRK4 subfamily of G protein-coupled receptor kinases. Alternative splicing, gene organization, and sequence conservation. | Premont RT, etal., J Biol Chem 1999 Oct 8;274(41):29381-9. |
| 20. | Mouse MP Annotation Import Pipeline | RGD automated import pipeline |
| 21. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 22. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
| 23. | Angiotensin II-stimulated signaling through G proteins and beta-arrestin. | Shenoy SK and Lefkowitz RJ, Sci STKE. 2005 Nov 22;2005(311):cm14. |
| 24. | Potential genetic risk factors for chronic TMD: genetic associations from the OPPERA case control study. | Smith SB, etal., J Pain. 2011 Nov;12(11 Suppl):T92-101. |
| 25. | Lack of association between G-protein coupled receptor kinase 5 gene and Parkinson's disease. | Tarantino P, etal., Am J Med Genet B Neuropsychiatr Genet. 2011 Jan;156B(1):104-7. doi: 10.1002/ajmg.b.31129. Epub 2010 Nov 2. |
| 26. | Granulocyte chemotaxis and disease expression are differentially regulated by GRK subtype in an acute inflammatory arthritis model (K/BxN). | Tarrant TK, etal., Clin Immunol. 2008 Oct;129(1):115-22. Epub 2008 Jul 26. |
| 27. | G protein-coupled receptor kinase 5 regulates airway responses induced by muscarinic receptor activation. | Walker JK, etal., Am J Physiol Lung Cell Mol Physiol. 2004 Feb;286(2):L312-9. Epub 2003 Oct 17. |
| 28. | Dysregulation of cannabinoid CB1 receptor and associated signaling networks in brains of cocaine addicts and cocaine-treated rodents. | Álvaro-Bartolomé M and García-Sevilla JA, Neuroscience. 2013 Sep 5;247:294-308. doi: 10.1016/j.neuroscience.2013.05.035. Epub 2013 May 29. |
Additional References at PubMed
| PMID:8889548 | PMID:8917529 | PMID:10338466 | PMID:10349636 | PMID:10624964 | PMID:10922068 | PMID:11042159 | PMID:11076861 | PMID:11217851 | PMID:12477932 | PMID:14610273 | PMID:15489334 |
| PMID:16103237 | PMID:16141072 | PMID:16141073 | PMID:17011668 | PMID:17018529 | PMID:17060617 | PMID:17786238 | PMID:18180038 | PMID:18711143 | PMID:18955119 | PMID:19796012 | PMID:19801552 |
| PMID:20124405 | PMID:20530803 | PMID:21041302 | PMID:21267068 | PMID:21677750 | PMID:21873635 | PMID:21930777 | PMID:22078319 | PMID:22095977 | PMID:22507984 | PMID:22859683 | PMID:22888001 |
| PMID:23111327 | PMID:23485819 | PMID:24174526 | PMID:24194600 | PMID:24629717 | PMID:25332207 | PMID:26515328 | PMID:26778781 | PMID:26975990 | PMID:27193825 | PMID:27565865 | PMID:27626380 |
| PMID:28334166 | PMID:29627294 | PMID:29969579 | PMID:30196744 | PMID:30511419 | PMID:31040226 | PMID:32507058 | PMID:33500351 | PMID:33560342 | PMID:33785612 | PMID:36451830 | PMID:36584571 |
| PMID:36633120 | PMID:37520700 |
Genomics
Comparative Map Data
| Grk5 (Mus musculus - house mouse) |
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| GRK5 (Homo sapiens - human) |
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| Grk5 (Rattus norvegicus - Norway rat) |
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| Grk5 (Chinchilla lanigera - long-tailed chinchilla) |
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| GRK5 (Pan paniscus - bonobo/pygmy chimpanzee) |
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| GRK5 (Canis lupus familiaris - dog) |
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| Grk5 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| GRK5 (Sus scrofa - pig) |
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| GRK5 (Chlorocebus sabaeus - green monkey) |
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| Grk5 (Heterocephalus glaber - naked mole-rat) |
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Variants
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Variants in Grk5
4860 total Variants 
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