Grn (granulin) - Rat Genome Database

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Gene: Grn (granulin) Mus musculus
Analyze
Symbol: Grn
Name: granulin
RGD ID: 62275
MGI Page MGI
Description: Predicted to enable protein-folding chaperone binding activity. Involved in several processes, including glial cell activation; positive regulation of cellular component organization; and regulation of defense response. Acts upstream of or within several processes, including blastocyst hatching; locomotory exploration behavior; and positive regulation of cell population proliferation. Located in several cellular components, including endoplasmic reticulum; lysosome; and trans-Golgi network. Is active in cerebellar climbing fiber to Purkinje cell synapse. Is expressed in several structures, including brain; early conceptus; gonad; placenta; and skin. Used to study Grn-related frontotemporal lobar degeneration with Tdp43 inclusions and nephrogenic diabetes insipidus. Human ortholog(s) of this gene implicated in dementia (multiple); neurodegenerative disease (multiple); neuronal ceroid lipofuscinosis 11; and primary progressive multiple sclerosis. Orthologous to human GRN (granulin precursor).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: acrogranin; acrogranulin; epit; epithelin; epithelin/granulin; glycoprotein 88; glycoprotein of 88 Kda; GP88; granulins; P; PC cell-derived growth factor; PCDGF; PEPI; Pgrn; pr; proepithelin; progranulin
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911102,321,333 - 102,327,635 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11102,321,141 - 102,327,874 (+)EnsemblGRCm39 Ensembl
GRCm3811102,430,507 - 102,436,809 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11102,430,315 - 102,437,048 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711102,291,636 - 102,298,123 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611102,246,597 - 102,252,895 (+)NCBIMGSCv36mm8
Celera11114,140,482 - 114,146,970 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1166.29NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
3',5'-cyclic AMP  (ISO)
3-chloropropane-1,2-diol  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (ISO)
alpha-pinene  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
antirheumatic drug  (ISO)
Aroclor 1254  (EXP)
arsenous acid  (ISO)
astaxanthin  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) adipate  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
butan-1-ol  (ISO)
butyric acid  (ISO)
carbon nanotube  (EXP)
carmustine  (ISO)
carnosic acid  (EXP)
chlorogenic acid  (ISO)
chloropicrin  (ISO)
ciguatoxin CTX1B  (EXP)
cisplatin  (EXP,ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
coumestrol  (ISO)
CU-O LINKAGE  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (ISO)
cypermethrin  (ISO)
cyproconazole  (EXP)
DDE  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (ISO)
diquat  (EXP)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP)
ethyl methanesulfonate  (ISO)
felbamate  (ISO)
fenamidone  (EXP)
fenthion  (EXP)
fenvalerate  (ISO)
flavonoids  (ISO)
flutamide  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
fumonisin B1  (EXP)
gentamycin  (ISO)
hydrogen peroxide  (ISO)
hypochlorous acid  (EXP)
inulin  (EXP)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (EXP,ISO)
lidocaine  (ISO)
lipopolysaccharide  (EXP)
lithium chloride  (ISO)
LY294002  (ISO)
menadione  (ISO)
methimazole  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
N-nitrosodimethylamine  (ISO)
nickel dichloride  (ISO)
nimesulide  (ISO)
nitrates  (EXP)
nitroglycerin  (ISO)
Osajin  (ISO)
oxybenzone  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pinostrobin  (ISO)
pirinixic acid  (EXP)
piroxicam  (ISO)
Pomiferin  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
propiconazole  (EXP)
pyrethrins  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
senecionine  (EXP)
sodium arsenite  (ISO)
Soman  (ISO)
sulfadimethoxine  (ISO)
sulindac  (ISO)
sulindac sulfide  (ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (EXP)
tamibarotene  (ISO)
tamoxifen  (EXP)
tetrachloromethane  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP)
triphenyl phosphate  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (EXP)
vitamin E  (ISO)
vorinostat  (EXP,ISO)
wortmannin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
astrocyte activation involved in immune response  (IMP)
blastocyst hatching  (IDA)
chondrocyte proliferation  (ISO)
embryo implantation  (IDA)
epithelial cell proliferation  (IDA)
locomotory exploration behavior  (IMP)
lysosomal lumen acidification  (ISO,ISS)
lysosomal protein catabolic process  (IMP)
lysosomal transport  (IMP,ISO,ISS)
lysosome organization  (IMP)
maintenance of synapse structure  (IDA,IMP)
male mating behavior  (ISO)
microglial cell activation involved in immune response  (IMP)
negative regulation of hydrolase activity  (IMP)
negative regulation of inflammatory response  (IMP)
negative regulation of innate immune response  (IMP)
negative regulation of microglial cell activation  (IMP)
negative regulation of neuron apoptotic process  (ISO,ISS)
negative regulation of neutrophil activation  (ISO,ISS)
negative regulation of respiratory burst involved in inflammatory response  (ISO,ISS)
neural precursor cell proliferation  (ISO)
positive regulation of angiogenesis  (IDA)
positive regulation of aspartic-type peptidase activity  (IMP,ISO,ISS)
positive regulation of axon regeneration  (IMP)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (IDA)
positive regulation of defense response to bacterium  (IMP)
positive regulation of dendritic spine development  (ISO)
positive regulation of endothelial cell migration  (IDA)
positive regulation of epithelial cell proliferation  (IDA,ISO)
positive regulation of inflammatory response to wounding  (IDA)
positive regulation of lysosome organization  (IDA,ISO)
positive regulation of neuron apoptotic process  (IMP)
positive regulation of neuron projection development  (ISO)
positive regulation of protein folding  (IMP)
positive regulation of trophectodermal cell proliferation  (IDA)
protein stabilization  (ISO,ISS)
regulation of inflammatory response  (IBA)
regulation of lysosome organization  (IMP)
response to estradiol  (ISO)
retina development in camera-type eye  (IMP)
signal transduction  (IEA)
synaptic vesicle endocytosis  (ISO)
trophectodermal cell proliferation  (IDA)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal body weight  (IAGP)
abnormal brain morphology  (IAGP)
abnormal cell cycle checkpoint function  (IAGP)
abnormal cerebral cortex morphology  (IAGP)
abnormal chemokine secretion  (IAGP)
abnormal circulating hormone level  (IAGP)
abnormal cone electrophysiology  (IAGP)
abnormal dendrite morphology  (IAGP)
abnormal ejaculation  (IAGP)
abnormal endoplasmic reticulum morphology  (IAGP)
abnormal excitatory postsynaptic potential  (IAGP)
abnormal frontal lobe morphology  (IAGP)
abnormal hepatocyte morphology  (IAGP)
abnormal hepatocyte physiology  (IAGP)
abnormal hippocampus morphology  (IAGP)
abnormal hypothalamus morphology  (IAGP)
abnormal hypothalamus secretion  (IAGP)
abnormal kidney physiology  (IAGP)
abnormal liver morphology  (IAGP)
abnormal liver parenchyma morphology  (IAGP)
abnormal long-term spatial reference memory  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal microglial cell physiology  (IAGP)
abnormal midbrain morphology  (IAGP)
abnormal nervous system physiology  (IAGP)
abnormal neurite morphology  (IAGP)
abnormal neuron physiology  (IAGP)
abnormal paraventricular hypothalamic nucleus morphology  (IAGP)
abnormal primary motor cortex morphology  (IAGP)
abnormal renal water homeostasis  (IAGP)
abnormal response to novel object  (IAGP)
abnormal retina ganglion cell morphology  (IAGP)
abnormal retina nerve fiber layer morphology  (IAGP)
abnormal retrosplenial region morphology  (IAGP)
abnormal social investigation  (IAGP)
abnormal spatial learning  (IAGP)
abnormal supraoptic nucleus morphology  (IAGP)
abnormal synapse morphology  (IAGP)
abnormal thalamus morphology  (IAGP)
abnormal thalamus neuron morphology  (IAGP)
abnormal zinc homeostasis  (IAGP)
astrocytosis  (IAGP)
cellular necrosis  (IAGP)
decreased a-wave amplitude  (IAGP)
decreased aggression towards male mice  (IAGP)
decreased b-wave amplitude  (IAGP)
decreased body weight  (IAGP)
decreased brain weight  (IAGP)
decreased dendritic spine density  (IAGP)
decreased grooming behavior  (IAGP)
decreased survivor rate  (IAGP)
decreased urine creatinine level  (IAGP)
decreased urine magnesium level  (IAGP)
decreased urine osmolality  (IAGP)
decreased urine potassium level  (IAGP)
dilated kidney collecting duct  (IAGP)
dilated renal tubule  (IAGP)
enlarged kidney  (IAGP)
impaired contextual conditioning behavior  (IAGP)
impaired coordination  (IAGP)
impaired spatial learning  (IAGP)
impaired synaptic plasticity  (IAGP)
increased aggression towards male mice  (IAGP)
increased anxiety-related response  (IAGP)
increased body weight  (IAGP)
increased circulating antidiuretic hormone level  (IAGP)
increased circulating ghrelin level  (IAGP)
increased fluid intake  (IAGP)
increased food intake  (IAGP)
increased grooming behavior  (IAGP)
increased hepatocyte karyomegaly  (IAGP)
increased interleukin-1 beta secretion  (IAGP)
increased interleukin-10 secretion  (IAGP)
increased interleukin-12 secretion  (IAGP)
increased interleukin-6 secretion  (IAGP)
increased kidney weight  (IAGP)
increased liver weight  (IAGP)
increased mean platelet volume  (IEA)
increased susceptibility to bacterial infection  (IAGP)
increased susceptibility to dopaminergic neuron neurotoxicity  (IAGP)
increased susceptibility to injury  (IAGP)
increased thigmotaxis  (IAGP)
increased tumor necrosis factor secretion  (IAGP)
kidney inflammation  (IAGP)
lipofuscinosis  (IAGP)
loss of dopaminergic neurons  (IAGP)
microgliosis  (IAGP)
nervous system inclusion bodies  (IAGP)
neurodegeneration  (IAGP)
neuronal cytoplasmic inclusions  (IAGP)
polydipsia  (IAGP)
polyuria  (IAGP)
premature death  (IAGP)
reduced long-term potentiation  (IAGP)
retina ganglion cell degeneration  (IAGP)
skin lesions  (IAGP)
tau protein deposits  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Low plasma progranulin levels in children with autism. Al-Ayadhi LY and Mostafa GA, J Neuroinflammation. 2011 Sep 5;8:111.
2. Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17. Baker M, etal., Nature. 2006 Aug 24;442(7105):916-9. Epub 2006 Jul 16.
3. Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Brady KP, etal., Genome Res 1997 Nov;7(11):1085-93.
4. Progranulin mutations in Dutch familial frontotemporal lobar degeneration. Bronner IF, etal., Eur J Hum Genet. 2007 Mar;15(3):369-74. Epub 2007 Jan 17.
5. Genetic variability in progranulin contributes to risk for clinically diagnosed Alzheimer disease. Brouwers N, etal., Neurology. 2008 Aug 26;71(9):656-64. Epub 2008 Jun 18.
6. Brain progranulin expression in GRN-associated frontotemporal lobar degeneration. Chen-Plotkin AS, etal., Acta Neuropathol. 2010 Jan;119(1):111-22. Epub 2009 Aug 2.
7. Progranulin mutation causes frontotemporal dementia in the Swedish Karolinska family. Chiang HH, etal., Alzheimers Dement. 2008 Nov;4(6):414-20.
8. Association of TMEM106B gene polymorphism with age at onset in granulin mutation carriers and plasma granulin protein levels. Cruchaga C, etal., Arch Neurol. 2011 May;68(5):581-6. Epub 2011 Jan 10.
9. Common variant in GRN is a genetic risk factor for hippocampal sclerosis in the elderly. Dickson DW, etal., Neurodegener Dis. 2010;7(1-3):170-4. Epub 2010 Mar 3.
10. The growth factor progranulin attenuates neuronal injury induced by cerebral ischemia-reperfusion through the suppression of neutrophil recruitment. Egashira Y, etal., J Neuroinflammation. 2013 Aug 23;10:105. doi: 10.1186/1742-2094-10-105.
11. Progranulin gene variability increases the risk for primary progressive multiple sclerosis in males. Fenoglio C, etal., Genes Immun. 2010 Sep;11(6):497-503. Epub 2010 May 13.
12. Plasma progranulin levels predict progranulin mutation status in frontotemporal dementia patients and asymptomatic family members. Finch N, etal., Brain. 2009 Mar;132(Pt 3):583-91. doi: 10.1093/brain/awn352. Epub 2009 Jan 21.
13. Progranulin gene (GRN) promoter methylation is increased in patients with sporadic frontotemporal lobar degeneration. Galimberti D, etal., Neurol Sci. 2013 Jun;34(6):899-903. doi: 10.1007/s10072-012-1151-5. Epub 2012 Jul 14.
14. Core features of frontotemporal dementia recapitulated in progranulin knockout mice. Ghoshal N, etal., Neurobiol Dis. 2011 Sep 10.
15. GRN 3'UTR+78 C>T is not associated with risk for Parkinson's disease. Jasinska-Myga B, etal., Eur J Neurol. 2009 Aug;16(8):909-11. doi: 10.1111/j.1468-1331.2009.02621.x. Epub 2009 Mar 31.
16. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
17. Alzheimer disease-like phenotype associated with the c.154delA mutation in progranulin. Kelley BJ, etal., Arch Neurol. 2010 Feb;67(2):171-7.
18. Further evidence for plasma progranulin as a biomarker in bipolar disorder. Kittel-Schneider S, etal., J Affect Disord. 2014 Mar;157:87-91. doi: 10.1016/j.jad.2014.01.006. Epub 2014 Jan 25.
19. Structural analysis and chromosomal localization of the mouse Psmb5 gene coding for the constitutively expressed beta-type proteasome subunit. Kohda K, etal., Immunogenetics 1997;47(1):77-87.
20. Progranulin expression in advanced human atherosclerotic plaque. Kojima Y, etal., Atherosclerosis. 2009 Sep;206(1):102-8. Epub 2009 Feb 23.
21. Identification of candidate lung cancer susceptibility genes in mouse using oligonucleotide arrays. Lemon WJ, etal., J Med Genet 2002 Sep;39(9):644-55.
22. Mutations in progranulin gene: clinical, pathological, and ribonucleic acid expression findings. Lopez de Munain A, etal., Biol Psychiatry. 2008 May 15;63(10):946-52. Epub 2007 Oct 22.
23. Reduced serum progranulin level might be associated with Parkinson's disease risk. Mateo I, etal., Eur J Neurol. 2013 Dec;20(12):1571-3. doi: 10.1111/ene.12090. Epub 2013 Feb 9.
24. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
25. MGDs mouse GO annotations MGD data from the GO Consortium
26. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, etal., Cell 2003 Nov 26;115(5):629-40.
27. HDDD2 is a familial frontotemporal lobar degeneration with ubiquitin-positive, tau-negative inclusions caused by a missense mutation in the signal peptide of progranulin. Mukherjee O, etal., Ann Neurol. 2006 Sep;60(3):314-22.
28. Progranulin expression is upregulated after spinal contusion in mice. Naphade SB, etal., Acta Neuropathol. 2010 Jan;119(1):123-33. Epub 2009 Nov 28.
29. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
30. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
31. Progranulin expression correlates with dense-core amyloid plaque burden in Alzheimer disease mouse models. Pereson S, etal., J Pathol. 2009 Oct;219(2):173-81.
32. Microglial upregulation of progranulin as a marker of motor neuron degeneration. Philips T, etal., J Neuropathol Exp Neurol. 2010 Dec;69(12):1191-200.
33. Frequency and clinical characteristics of progranulin mutation carriers in the Manchester frontotemporal lobar degeneration cohort: comparison with patients with MAPT and no known mutations. Pickering-Brown SM, etal., Brain. 2008 Mar;131(Pt 3):721-31. doi: 10.1093/brain/awm331. Epub 2008 Jan 11.
34. Mouse MP Annotation Import Pipeline RGD automated import pipeline
35. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
36. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
37. The genomic organization of type I keratin genes in mice. Sato H, etal., Genomics 1999 Mar 15;56(3):303-9.
38. Frontotemporal dementia in a large Swedish family is caused by a progranulin null mutation. Skoglund L, etal., Neurogenetics. 2009 Feb;10(1):27-34. Epub 2008 Oct 15.
39. Progranulin genetic variability contributes to amyotrophic lateral sclerosis. Sleegers K, etal., Neurology. 2008 Jul 22;71(4):253-9. Epub 2008 Jan 9.
40. The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice. Tang W, etal., Science. 2011 Apr 22;332(6028):478-84. Epub 2011 Mar 10.
41. Progranulin expression in brain tissue and cerebrospinal fluid levels in multiple sclerosis. Vercellino M, etal., Mult Scler. 2011 Oct;17(10):1194-201. Epub 2011 May 25.
42. An association study between granulin gene polymorphisms and Alzheimer's disease in Finnish population. Viswanathan J, etal., Am J Med Genet B Neuropsychiatr Genet. 2009 Jul 5;150B(5):747-50. doi: 10.1002/ajmg.b.30889.
43. Large-scale screen for genes involved in gonad development. Wertz K and Herrmann BG, Mech Dev 2000 Nov;98(1-2):51-70.
44. Progranulin promotes activation of microglia/macrophage after pilocarpine-induced status epilepticus. Zhu S, etal., Brain Res. 2013 Sep 12;1530:54-65. doi: 10.1016/j.brainres.2013.07.023. Epub 2013 Jul 22.
Additional References at PubMed
PMID:1618805   PMID:8471244   PMID:8482392   PMID:8496151   PMID:8703129   PMID:8889548   PMID:9096121   PMID:9218537   PMID:9434940   PMID:10349636   PMID:10625564   PMID:10725249  
PMID:11042159   PMID:11076861   PMID:12477932   PMID:12524533   PMID:12526812   PMID:12588988   PMID:12889069   PMID:15569995   PMID:15782199   PMID:15901638   PMID:16141072   PMID:16141073  
PMID:16533762   PMID:16602821   PMID:16857791   PMID:17203169   PMID:17261172   PMID:17307734   PMID:17764761   PMID:19046946   PMID:19091514   PMID:19487464   PMID:19550107   PMID:19860916  
PMID:20026663   PMID:20054825   PMID:20368287   PMID:20489155   PMID:20522652   PMID:20667979   PMID:20731760   PMID:20737593   PMID:20962456   PMID:21092856   PMID:21152114   PMID:21224065  
PMID:21267068   PMID:21368173   PMID:21497117   PMID:21538739   PMID:21540081   PMID:21645236   PMID:21677750   PMID:21873635   PMID:21933869   PMID:21934540   PMID:21943601   PMID:22028881  
PMID:22062772   PMID:22179841   PMID:22194816   PMID:22225875   PMID:22608501   PMID:22733568   PMID:22781549   PMID:22967900   PMID:23041626   PMID:23201826   PMID:23364791   PMID:23516300  
PMID:23608112   PMID:23669357   PMID:23699531   PMID:23702345   PMID:23741441   PMID:23746860   PMID:23755248   PMID:23774650   PMID:23830905   PMID:23847387   PMID:24006456   PMID:24070898  
PMID:24233842   PMID:24319417   PMID:24336722   PMID:24383743   PMID:24457600   PMID:24652679   PMID:24703938   PMID:25022663   PMID:25155018   PMID:25234724   PMID:25261995   PMID:25387791  
PMID:25393765   PMID:25575133   PMID:25607110   PMID:25626394   PMID:25777988   PMID:25838514   PMID:26039714   PMID:26206194   PMID:26245842   PMID:26297947   PMID:26302163   PMID:26361634  
PMID:26370502   PMID:26495792   PMID:26701296   PMID:26757107   PMID:26864916   PMID:26892362   PMID:27030285   PMID:27075243   PMID:27088855   PMID:27114033   PMID:27213486   PMID:27215202  
PMID:27220888   PMID:27356620   PMID:27367257   PMID:27440553   PMID:27497155   PMID:27515686   PMID:27619993   PMID:27629805   PMID:27778404   PMID:27789271   PMID:28011648   PMID:28069809  
PMID:28070672   PMID:28073925   PMID:28273689   PMID:28379303   PMID:28404863   PMID:28438992   PMID:28453791   PMID:28479389   PMID:28493053   PMID:28541286   PMID:28640985   PMID:28647554  
PMID:28720486   PMID:28728022   PMID:28778989   PMID:28835281   PMID:28837568   PMID:28845019   PMID:28899992   PMID:28903038   PMID:29031143   PMID:29096020   PMID:29378861   PMID:29382817  
PMID:29396296   PMID:29398357   PMID:29511098   PMID:29625085   PMID:29789416   PMID:29929528   PMID:30090016   PMID:30196744   PMID:30212683   PMID:30271659   PMID:30341570   PMID:30448285  
PMID:30550785   PMID:30561754   PMID:30562941   PMID:30619312   PMID:30635627   PMID:30696728   PMID:30713523   PMID:31086348   PMID:31122931   PMID:31237618   PMID:31285425   PMID:31291241  
PMID:31391467   PMID:31454754   PMID:31467413   PMID:31484831   PMID:31491449   PMID:31519865   PMID:31550482   PMID:31591383   PMID:31639062   PMID:31679689   PMID:31758561   PMID:31775776  
PMID:31866375   PMID:31959936   PMID:31990656   PMID:32025182   PMID:32079660   PMID:32168097   PMID:32247641   PMID:32290105   PMID:32761777   PMID:32792571   PMID:32852886   PMID:32866962  
PMID:32929860   PMID:32945448   PMID:32985120   PMID:33028409   PMID:33157500   PMID:33181174   PMID:33441916   PMID:33636385   PMID:33795008   PMID:33796852   PMID:34103390   PMID:34130995  
PMID:34304733   PMID:34385591   PMID:34450028   PMID:34480901   PMID:34618685   PMID:34768987   PMID:35019161   PMID:35054815   PMID:35338960   PMID:35362178   PMID:35933009   PMID:36121866  
PMID:36207292   PMID:36233357   PMID:36514959   PMID:36574647   PMID:36602862   PMID:36618392   PMID:36707901   PMID:36822087   PMID:37105261   PMID:37118844   PMID:37120788   PMID:37329998  
PMID:37519899   PMID:37581395   PMID:37810172   PMID:37838007   PMID:37897724   PMID:37965143   PMID:37974165   PMID:38039836   PMID:38057339   PMID:38103296   PMID:38355776   PMID:38355793  
PMID:38365048   PMID:38365772   PMID:38369347   PMID:38499658   PMID:38573860   PMID:38678021   PMID:38838131   PMID:39101473   PMID:39141257   PMID:39252120   PMID:39390556   PMID:39565694  


Genomics

Comparative Map Data
Grn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911102,321,333 - 102,327,635 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11102,321,141 - 102,327,874 (+)EnsemblGRCm39 Ensembl
GRCm3811102,430,507 - 102,436,809 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11102,430,315 - 102,437,048 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711102,291,636 - 102,298,123 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611102,246,597 - 102,252,895 (+)NCBIMGSCv36mm8
Celera11114,140,482 - 114,146,970 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1166.29NCBI
GRN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381744,345,302 - 44,353,106 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1744,345,246 - 44,353,106 (+)EnsemblGRCh38hg38GRCh38
GRCh371742,422,670 - 42,430,474 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361739,778,017 - 39,785,996 (+)NCBINCBI36Build 36hg18NCBI36
Build 341739,778,016 - 39,785,996NCBI
Celera1739,132,112 - 39,140,095 (+)NCBICelera
Cytogenetic Map17q21.31NCBI
HuRef1738,186,768 - 38,194,753 (+)NCBIHuRef
CHM1_11742,658,166 - 42,666,146 (+)NCBICHM1_1
T2T-CHM13v2.01745,199,297 - 45,207,105 (+)NCBIT2T-CHM13v2.0
Grn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81087,887,834 - 87,893,938 (+)NCBIGRCr8
mRatBN7.21087,387,672 - 87,393,777 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1087,387,638 - 87,393,775 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1092,424,835 - 92,430,942 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01091,890,037 - 91,896,139 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01087,283,370 - 87,289,472 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01090,377,103 - 90,383,207 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1090,376,933 - 90,383,205 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01090,165,634 - 90,171,738 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41091,536,135 - 91,542,239 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11091,552,883 - 91,556,599 (+)NCBI
Celera1086,096,583 - 86,102,687 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
Grn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545117,368,428 - 17,372,377 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545117,368,600 - 17,371,981 (+)NCBIChiLan1.0ChiLan1.0
GRN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21920,557,091 - 20,565,084 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11722,521,447 - 22,529,431 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01713,046,329 - 13,054,236 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11713,211,784 - 13,219,793 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1713,211,784 - 13,219,609 (-)Ensemblpanpan1.1panPan2
GRN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1919,077,430 - 19,085,443 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl919,077,427 - 19,082,268 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha918,467,174 - 18,474,620 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0919,771,801 - 19,779,240 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl919,771,806 - 19,779,115 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1918,625,608 - 18,633,045 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0918,808,582 - 18,816,025 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0918,952,849 - 18,960,290 (-)NCBIUU_Cfam_GSD_1.0
Grn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560218,390,156 - 18,401,106 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936541793,523 - 800,217 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936541793,548 - 800,271 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1218,893,770 - 18,900,446 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11218,893,772 - 18,900,444 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21219,212,414 - 19,216,283 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GRN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11662,037,344 - 62,045,765 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1662,036,412 - 62,045,614 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607732,804,031 - 32,812,724 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624795704,252 - 707,165 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624795704,066 - 708,721 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Grn
264 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1800
Count of miRNA genes:652
Interacting mature miRNAs:826
Transcripts:ENSMUST00000049460, ENSMUST00000123500, ENSMUST00000125819, ENSMUST00000127530, ENSMUST00000129997, ENSMUST00000135517, ENSMUST00000138451, ENSMUST00000148580, ENSMUST00000176953, ENSMUST00000177428
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191604608121973369Mouse
1301012Vispl_mvisual placing (mouse)Not determined11101022590121973369Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170691198104691366Mouse
1301535Pas5b_mpulmonary adenoma susceptibility 5b (mouse)Not determined1196176465108806384Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181574481115574636Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172019649106019734Mouse
12910539Sstapa3_msuseptibility to Staphylococcus aureus infection 3 (mouse)1196897693110603991Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
14747003Mancz9_mmandible centroid size 9 (mouse)1185844911119844911Mouse
1301640Lore4_mloss of righting induced by ethanol 4 (mouse)Not determined1179156009107616472Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181810267115810267Mouse
11251723Ewc5_methanol withdrawal and consumption 5 (mouse)1189869251121973369Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170691198104691366Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170691198104691366Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177770978111771099Mouse
4141465Dbm2_mdiabetes modifier 2 (mouse)Not determined94437183118022724Mouse
10045617Heal26_mwound healing/regeneration 26 (mouse)Not determined1192939373112544554Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177437183111437322Mouse
1357631Motr1_mmodifier of tubby retinal degeneration 1 (mouse)Not determined1187691198103274115Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172726125106726289Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172818615106818733Mouse
11341721Rvfs2_mRift Valley fever susceptibility 2 (mouse)11100254186120887165Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177437183111437322Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170691198104691366Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181574481115574636Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187490826121873369Mouse
14746970Manh71_mmandible shape 71 (mouse)1179416257113416257Mouse
10043865T2dm5sa_mtype 2 diabetes mellitus 5 in SMXA RI mice (mouse)Not determined1179813759104502698Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172818615106818733Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182377698116377820Mouse
1300944Alcp20_malcohol preference locus 20 (mouse)Not determined1195403965121973369Mouse
4141939Pregq2_mpregnancy QTL 2 (mouse)Not determined1194063779118022724Mouse
1301983Berr2_mberghei resistance locus 2 (mouse)Not determined1198352609121973369Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177063779111063918Mouse
10043976Obq33_mobesity QTL 33 (mouse)Not determined1198500469121973369Mouse
1301057Nidd4_mnon-insulin-dependent diabetes mellitus 4 (mouse)Not determined1196810136121973369Mouse
1301958Alcp18_malcohol preference locus 18 (mouse)Not determined1195403965121973369Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186608320120608320Mouse
15039374Adip29_madiposity 29 (mouse)1186608320120608320Mouse
1300962Cd8mts4_mCD8 memory T cell subset 4 (mouse)Not determined1196137674121973369Mouse
1301095El6_mepilepsy 6 (mouse)Not determined1193229183121973369Mouse
27226731Tibmd4_mtibia midshaft diameter 4, 10 week (mouse)1194190826118890826Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186608320120608320Mouse
14700693Ppiq12_mprepulse inhibition QTL 12 (mouse)11101504820114472363Mouse
1558753Ath19_matherosclerosis 19 (mouse)Not determined1191604608121973369Mouse
14700694Ppiq13_mprepulse inhibition QTL 13 (mouse)11101504820114472363Mouse
14700695Ppiq14_mprepulse inhibition QTL 14 (mouse)11101504820114472363Mouse
10044001Alcw8_malcohol withdrawal 8 (mouse)Not determined1199254187121973369Mouse
14700696Ppiq15_mprepulse inhibition QTL 15 (mouse)11101504820114472363Mouse
11553867Stmm5_mskin tumor modifier of MSM 5 (mouse)11100058103121973369Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187502600121502698Mouse

Markers in Region
D16195  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811102,436,639 - 102,436,804UniSTSGRCm38
MGSCv3711102,297,953 - 102,298,118UniSTSGRCm37
Celera11114,146,800 - 114,146,965UniSTS
Cytogenetic Map11DUniSTS
cM Map1160.0UniSTS
Whitehead_YAC11 UniSTS
UniSTS:236740  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811102,436,500 - 102,436,703UniSTSGRCm38
MGSCv3711102,297,814 - 102,298,017UniSTSGRCm37
Celera11114,146,661 - 114,146,864UniSTS
Cytogenetic Map11DUniSTS
cM Map1160.0UniSTS
Grn  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv3711102,297,834 - 102,298,068UniSTSGRCm37
MGSCv3711102,297,724 - 102,298,055UniSTSGRCm37
MGSCv3711102,297,724 - 102,298,054UniSTSGRCm37
MGSCv3711102,298,095 - 102,298,368UniSTSGRCm37
Celera11114,146,681 - 114,146,915UniSTS
Celera11114,146,571 - 114,146,902UniSTS
Celera11114,146,942 - 114,147,211UniSTS
Celera11114,146,571 - 114,146,901UniSTS
Cytogenetic Map11DUniSTS
cM Map1160.0UniSTS
cM Map1160.0UniSTS
Grn  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811102,436,410 - 102,436,741UniSTSGRCm38
MGSCv3711102,297,724 - 102,298,055UniSTSGRCm37
Celera11114,146,571 - 114,146,902UniSTS
Cytogenetic Map11DUniSTS
Grn  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811102,436,520 - 102,436,754UniSTSGRCm38
MGSCv3711102,297,834 - 102,298,068UniSTSGRCm37
Celera11114,146,681 - 114,146,915UniSTS
Cytogenetic Map11DUniSTS
cM Map1160.0UniSTS
Grn  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811102,436,781 - 102,437,054UniSTSGRCm38
MGSCv3711102,298,095 - 102,298,368UniSTSGRCm37
Celera11114,146,942 - 114,147,211UniSTS
Cytogenetic Map11DUniSTS
cM Map1160.0UniSTS
Grn  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811102,436,410 - 102,436,740UniSTSGRCm38
MGSCv3711102,297,724 - 102,298,054UniSTSGRCm37
Celera11114,146,571 - 114,146,901UniSTS
Cytogenetic Map11DUniSTS
cM Map1160.0UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_008175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK013678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK018744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150881 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152944 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154492 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159428 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK160022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK160033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK160074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK179088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK181447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK182648 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK184964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK185467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK187351 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK193719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK196399 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK204596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK204598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK205747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK211032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK213315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK213410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK217383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK219696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL596258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW456643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC037047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC049943 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC129849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC129850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY275129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D16195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M86736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X62321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000049460   ⟹   ENSMUSP00000046340
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11102,321,148 - 102,327,633 (+)Ensembl
GRCm38.p6 Ensembl11102,430,322 - 102,436,807 (+)Ensembl
Ensembl Acc Id: ENSMUST00000123500
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11102,325,544 - 102,326,770 (+)Ensembl
GRCm38.p6 Ensembl11102,434,718 - 102,435,944 (+)Ensembl
Ensembl Acc Id: ENSMUST00000125819   ⟹   ENSMUSP00000134948
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11102,326,111 - 102,327,399 (+)Ensembl
GRCm38.p6 Ensembl11102,435,285 - 102,436,573 (+)Ensembl
Ensembl Acc Id: ENSMUST00000127530
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11102,326,132 - 102,326,890 (+)Ensembl
GRCm38.p6 Ensembl11102,435,306 - 102,436,064 (+)Ensembl
Ensembl Acc Id: ENSMUST00000129997   ⟹   ENSMUSP00000135739
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11102,321,344 - 102,325,272 (+)Ensembl
GRCm38.p6 Ensembl11102,430,518 - 102,434,446 (+)Ensembl
Ensembl Acc Id: ENSMUST00000135517
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11102,323,611 - 102,325,083 (+)Ensembl
GRCm38.p6 Ensembl11102,432,785 - 102,434,257 (+)Ensembl
Ensembl Acc Id: ENSMUST00000138451
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11102,324,928 - 102,325,717 (+)Ensembl
GRCm38.p6 Ensembl11102,434,102 - 102,434,891 (+)Ensembl
Ensembl Acc Id: ENSMUST00000148580
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11102,324,758 - 102,325,419 (+)Ensembl
GRCm38.p6 Ensembl11102,433,932 - 102,434,593 (+)Ensembl
Ensembl Acc Id: ENSMUST00000176953
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11102,324,925 - 102,326,088 (+)Ensembl
GRCm38.p6 Ensembl11102,434,099 - 102,435,262 (+)Ensembl
Ensembl Acc Id: ENSMUST00000177428   ⟹   ENSMUSP00000134893
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11102,326,242 - 102,327,874 (+)Ensembl
GRCm38.p6 Ensembl11102,435,416 - 102,437,048 (+)Ensembl
Ensembl Acc Id: ENSMUST00000239431   ⟹   ENSMUSP00000159379
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11102,321,141 - 102,327,635 (+)Ensembl
GRCm38.p6 Ensembl11102,430,315 - 102,436,809 (+)Ensembl
RefSeq Acc Id: NM_008175   ⟹   NP_032201
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911102,321,333 - 102,327,635 (+)NCBI
GRCm3811102,430,507 - 102,436,809 (+)NCBI
MGSCv3711102,291,636 - 102,298,123 (+)RGD
Celera11114,140,482 - 114,146,970 (+)RGD
cM Map11 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_032201 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA37191 (Get FASTA)   NCBI Sequence Viewer  
  AAI29850 (Get FASTA)   NCBI Sequence Viewer  
  AAI29851 (Get FASTA)   NCBI Sequence Viewer  
  BAA03736 (Get FASTA)   NCBI Sequence Viewer  
  BAB28951 (Get FASTA)   NCBI Sequence Viewer  
  BAB31384 (Get FASTA)   NCBI Sequence Viewer  
  BAE29325 (Get FASTA)   NCBI Sequence Viewer  
  BAE29376 (Get FASTA)   NCBI Sequence Viewer  
  BAE29480 (Get FASTA)   NCBI Sequence Viewer  
  BAE29544 (Get FASTA)   NCBI Sequence Viewer  
  BAE29795 (Get FASTA)   NCBI Sequence Viewer  
  BAE30030 (Get FASTA)   NCBI Sequence Viewer  
  BAE30321 (Get FASTA)   NCBI Sequence Viewer  
  BAE30632 (Get FASTA)   NCBI Sequence Viewer  
  BAE30664 (Get FASTA)   NCBI Sequence Viewer  
  BAE30904 (Get FASTA)   NCBI Sequence Viewer  
  BAE30937 (Get FASTA)   NCBI Sequence Viewer  
  BAE30962 (Get FASTA)   NCBI Sequence Viewer  
  BAE31041 (Get FASTA)   NCBI Sequence Viewer  
  BAE31433 (Get FASTA)   NCBI Sequence Viewer  
  BAE31478 (Get FASTA)   NCBI Sequence Viewer  
  BAE31615 (Get FASTA)   NCBI Sequence Viewer  
  BAE31872 (Get FASTA)   NCBI Sequence Viewer  
  BAE31978 (Get FASTA)   NCBI Sequence Viewer  
  BAE32021 (Get FASTA)   NCBI Sequence Viewer  
  BAE32624 (Get FASTA)   NCBI Sequence Viewer  
  BAE35050 (Get FASTA)   NCBI Sequence Viewer  
  BAE35075 (Get FASTA)   NCBI Sequence Viewer  
  BAE35182 (Get FASTA)   NCBI Sequence Viewer  
  BAE35389 (Get FASTA)   NCBI Sequence Viewer  
  BAE35565 (Get FASTA)   NCBI Sequence Viewer  
  BAE35576 (Get FASTA)   NCBI Sequence Viewer  
  BAE35608 (Get FASTA)   NCBI Sequence Viewer  
  CAA44197 (Get FASTA)   NCBI Sequence Viewer  
  EDL34129 (Get FASTA)   NCBI Sequence Viewer  
  EDL34130 (Get FASTA)   NCBI Sequence Viewer  
  EDL34131 (Get FASTA)   NCBI Sequence Viewer  
  EDL34132 (Get FASTA)   NCBI Sequence Viewer  
  EDL34133 (Get FASTA)   NCBI Sequence Viewer  
  EDL34134 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000046340.5
  ENSMUSP00000134893.2
  ENSMUSP00000134948.2
  ENSMUSP00000135739.2
  ENSMUSP00000159379
  ENSMUSP00000159379.2
GenBank Protein P28798 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_032201   ⟸   NM_008175
- Peptide Label: precursor
- UniProtKB: P28798 (UniProtKB/Swiss-Prot),   Q544Y8 (UniProtKB/TrEMBL),   Q3TWT4 (UniProtKB/TrEMBL),   Q3TX66 (UniProtKB/TrEMBL),   Q3UC19 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000134948   ⟸   ENSMUST00000125819
Ensembl Acc Id: ENSMUSP00000134893   ⟸   ENSMUST00000177428
Ensembl Acc Id: ENSMUSP00000046340   ⟸   ENSMUST00000049460
Ensembl Acc Id: ENSMUSP00000159379   ⟸   ENSMUST00000239431
Ensembl Acc Id: ENSMUSP00000135739   ⟸   ENSMUST00000129997
Protein Domains
GRANULINS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P28798-F1-model_v2 AlphaFold P28798 1-589 view protein structure

Promoters
RGD ID:6821030
Promoter ID:MM_KWN:9984
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000005699,   OTTMUST00000005700,   OTTMUST00000005783
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3611102,290,781 - 102,291,917 (+)MPROMDB
RGD ID:6821031
Promoter ID:MM_KWN:9985
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Liver,   Spleen
Transcripts:OTTMUST00000005701
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3611102,293,646 - 102,294,312 (+)MPROMDB
RGD ID:6821032
Promoter ID:MM_KWN:9986
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Lung
Transcripts:OTTMUST00000005702,   OTTMUST00000005784,   OTTMUST00000005785
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3611102,294,576 - 102,295,627 (+)MPROMDB
RGD ID:6821033
Promoter ID:MM_KWN:9987
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Liver,   Spleen
Transcripts:OTTMUST00000005786
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3611102,295,741 - 102,297,147 (+)MPROMDB
RGD ID:8676896
Promoter ID:EPDNEW_M16478
Type:initiation region
Name:Grn_1
Description:Mus musculus granulin , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3811102,430,507 - 102,430,567EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:95832 AgrOrtholog
Ensembl Genes ENSMUSG00000034708 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000049460.12 UniProtKB/TrEMBL
  ENSMUST00000125819.9 UniProtKB/TrEMBL
  ENSMUST00000129997.2 UniProtKB/TrEMBL
  ENSMUST00000177428.2 UniProtKB/TrEMBL
  ENSMUST00000239431 ENTREZGENE
  ENSMUST00000239431.2 UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.25.160 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Granulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Granulin_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Granulin_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14824 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:95832 ENTREZGENE
NCBI Gene 14824 ENTREZGENE
PANTHER PROGRANULIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12274 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Granulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Grn PhenoGen
PROSITE GRANULINS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART GRAN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Granulin repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt GRN_MOUSE UniProtKB/Swiss-Prot
  H3BJ90_MOUSE UniProtKB/TrEMBL
  H3BJE0_MOUSE UniProtKB/TrEMBL
  H3BLC9_MOUSE UniProtKB/TrEMBL
  P28798 ENTREZGENE
  Q3TVQ3_MOUSE UniProtKB/TrEMBL
  Q3TW77_MOUSE UniProtKB/TrEMBL
  Q3TWT4 ENTREZGENE, UniProtKB/TrEMBL
  Q3TX66 ENTREZGENE, UniProtKB/TrEMBL
  Q3U5Q6_MOUSE UniProtKB/TrEMBL
  Q3U8W3_MOUSE UniProtKB/TrEMBL
  Q3U9K2_MOUSE UniProtKB/TrEMBL
  Q3U9N4_MOUSE UniProtKB/TrEMBL
  Q3UAJ3_MOUSE UniProtKB/TrEMBL
  Q3UC19 ENTREZGENE, UniProtKB/TrEMBL
  Q3UD85_MOUSE UniProtKB/TrEMBL
  Q3UDD6_MOUSE UniProtKB/TrEMBL
  Q544Y8 ENTREZGENE, UniProtKB/TrEMBL
  Q9D2V3_MOUSE UniProtKB/TrEMBL