Isl1 (ISL1 transcription factor, LIM/homeodomain) - Rat Genome Database

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Gene: Isl1 (ISL1 transcription factor, LIM/homeodomain) Mus musculus
Analyze
Symbol: Isl1
Name: ISL1 transcription factor, LIM/homeodomain
RGD ID: 62250
MGI Page MGI
Description: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; promoter-specific chromatin binding activity; and transcription cis-regulatory region binding activity. Involved in several processes, including heart development; nervous system development; and positive regulation of cytokine production. Acts upstream of or within several processes, including heart development; neuron differentiation; and positive regulation of nitrogen compound metabolic process. Located in nucleus. Part of chromatin. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and heart and pericardium. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus and type 2 diabetes mellitus. Orthologous to human ISL1 (ISL LIM homeobox 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: insulin gene enhancer protein ISL-1; insulin related protein; Islet 1; islet-1; Lim-homeodomain protein Islet1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913116,434,806 - 116,446,224 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13116,434,817 - 116,446,225 (-)EnsemblGRCm39 Ensembl
GRCm3813116,298,270 - 116,309,688 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13116,298,281 - 116,309,689 (-)EnsemblGRCm38mm10GRCm38
MGSCv3713117,088,478 - 117,099,896 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613117,418,963 - 117,430,370 (-)NCBIMGSCv36mm8
Celera13120,696,034 - 120,707,388 (-)NCBICelera
Cytogenetic Map13D2.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
atrial septum morphogenesis  (IGI)
axon regeneration  (ISO)
axonogenesis  (IBA)
canonical Wnt signaling pathway  (IGI)
cardiac cell fate determination  (IMP,ISO)
cardiac muscle cell myoblast differentiation  (IMP)
cardiac right ventricle morphogenesis  (IGI)
cell differentiation  (IEA)
cell population proliferation  (IDA)
cellular response to glucocorticoid stimulus  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
endocardial cushion morphogenesis  (IGI)
heart development  (IMP)
heart morphogenesis  (IGI)
innervation  (IMP)
mesenchymal cell differentiation  (IMP)
negative regulation of canonical Wnt signaling pathway  (IGI)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of inflammatory response  (IMP)
negative regulation of intracellular estrogen receptor signaling pathway  (ISO)
negative regulation of mesenchymal cell proliferation  (ISO)
negative regulation of neuron apoptotic process  (IMP)
negative regulation of neuron differentiation  (IGI)
negative regulation of protein-containing complex assembly  (ISO)
negative regulation of transcription by RNA polymerase II  (IMP)
neural crest cell migration  (IGI)
neuron differentiation  (IGI,IMP)
neuron fate commitment  (IGI)
neuron fate specification  (IBA,IMP)
outflow tract morphogenesis  (IGI)
outflow tract septum morphogenesis  (IGI)
pancreas development  (IMP)
peripheral nervous system neuron axonogenesis  (IMP)
peripheral nervous system neuron development  (IGI)
pharyngeal system development  (IGI)
pituitary gland development  (IMP)
positive regulation of angiogenesis  (IMP)
positive regulation of calcium ion import  (ISO)
positive regulation of cell differentiation  (IMP)
positive regulation of cell population proliferation  (IDA)
positive regulation of DNA binding  (IDA)
positive regulation of epithelial to mesenchymal transition  (ISO)
positive regulation of granulocyte colony-stimulating factor production  (IDA)
positive regulation of granulocyte macrophage colony-stimulating factor production  (IDA)
positive regulation of insulin secretion  (ISO)
positive regulation of interleukin-1 alpha production  (IDA)
positive regulation of interleukin-1 beta production  (IDA)
positive regulation of interleukin-12 production  (IDA)
positive regulation of interleukin-6 production  (IDA)
positive regulation of macrophage colony-stimulating factor production  (IDA)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of smoothened signaling pathway  (ISO)
positive regulation of transcription by RNA polymerase II  (IBA,IDA,IGI,IMP,ISO)
positive regulation of tumor necrosis factor production  (IDA)
positive regulation of type B pancreatic cell apoptotic process  (ISO)
positive regulation of type II interferon production  (IDA)
positive regulation of tyrosine phosphorylation of STAT protein  (IDA)
positive regulation of vascular endothelial growth factor production  (IDA)
regulation of DNA-templated transcription  (ISO)
regulation of gene expression  (IMP)
regulation of heart rate by cardiac conduction  (IMP)
regulation of secondary heart field cardioblast proliferation  (IMP)
retinal ganglion cell axon guidance  (IMP)
secondary heart field specification  (ISO)
sensory system development  (IMP)
sinoatrial node cell development  (IMP)
spinal cord motor neuron cell fate specification  (IGI)
spinal cord motor neuron differentiation  (IMP)
stem cell differentiation  (IMP)
transcription by RNA polymerase II  (IDA)
trigeminal nerve development  (IMP)
ventricular cardiac muscle tissue morphogenesis  (IGI)
visceral motor neuron differentiation  (IGI)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
aberrant origin of the right subclavian artery  (IAGP)
abnormal abducens nerve morphology  (IAGP)
abnormal aortic arch morphology  (IAGP)
abnormal auditory bulla morphology  (IAGP)
abnormal axon extension  (IAGP)
abnormal axon morphology  (IAGP)
abnormal blood circulation  (IAGP)
abnormal brain development  (IAGP)
abnormal cardiac epithelial to mesenchymal transition  (IAGP)
abnormal cardiac neural crest cell migration  (IAGP)
abnormal cardiac outflow tract development  (IAGP)
abnormal cardiomyocyte apoptosis  (IAGP)
abnormal cerebral cortex morphology  (IAGP)
abnormal coat/ hair morphology  (IAGP)
abnormal common carotid artery morphology  (IAGP)
abnormal conotruncal ridge morphology  (IAGP)
abnormal dorsal aorta morphology  (IAGP)
abnormal dorsal root ganglion morphology  (IAGP)
abnormal embryonic cloaca development  (IAGP)
abnormal external female genitalia morphology  (IAGP)
abnormal fetal cardiomyocyte proliferation  (IAGP)
abnormal fibula morphology  (IAGP)
abnormal heart atrium morphology  (IAGP)
abnormal heart development  (IAGP)
abnormal heart right ventricle morphology  (IAGP)
abnormal heart shape  (IAGP)
abnormal hindlimb bud morphology  (IAGP)
abnormal hindlimb morphology  (IAGP)
abnormal hindlimb zeugopod morphology  (IAGP)
abnormal hyoid bone greater horn morphology  (IAGP)
abnormal hyoid bone lesser horn morphology  (IAGP)
abnormal hyoid bone morphology  (IAGP)
abnormal inferior horn of thyroid cartilage morphology  (IAGP)
abnormal innervation  (IAGP)
abnormal interatrial septum morphology  (IAGP)
abnormal ischium morphology  (IAGP)
abnormal limb development  (IAGP)
abnormal malleus morphology  (IAGP)
abnormal Meissner's corpuscle morphology  (IAGP)
abnormal motor neuron innervation pattern  (IAGP)
abnormal motor neuron morphology  (IAGP)
abnormal muscle spindle morphology  (IAGP)
abnormal myocardial trabeculae morphology  (IAGP)
abnormal nervous system electrophysiology  (IAGP)
abnormal neuron differentiation  (IAGP)
abnormal neuron physiology  (IAGP)
abnormal optic nerve innervation  (IAGP)
abnormal optic nerve morphology  (IAGP)
abnormal optic tract morphology  (IAGP)
abnormal pacinian corpuscle morphology  (IAGP)
abnormal pancreas mesenchyme morphology  (IAGP)
abnormal pancreas morphology  (IAGP)
abnormal pancreatic acinar cell morphology  (IAGP)
abnormal pancreatic islet morphology  (IAGP)
abnormal pharyngeal arch morphology  (IAGP)
abnormal proprioceptive neuron morphology  (IAGP)
abnormal pterygopalatine ganglion morphology  (IAGP)
abnormal Rathke's pouch development  (IAGP)
abnormal renal/urinary system morphology  (IAGP)
abnormal retina bipolar cell morphology  (IAGP)
abnormal retina ganglion cell morphology  (IAGP)
abnormal retina outer plexiform layer morphology  (IAGP)
abnormal sensory neuron innervation pattern  (IAGP)
abnormal sensory neuron morphology  (IAGP)
abnormal sixth pharyngeal arch artery morphology  (IAGP)
abnormal spinal cord interneuron morphology  (IAGP)
abnormal splanchnic mesoderm morphology  (IAGP)
abnormal superior horn of thyroid cartilage morphology  (IAGP)
abnormal trigeminal ganglion morphology  (IAGP)
abnormal truncus arteriosus septation  (IAGP)
abnormal tympanic membrane morphology  (IAGP)
abnormal vascular endothelial cell morphology  (IAGP)
absent cardiac outflow tract  (IAGP)
absent gastric milk in neonates  (IAGP)
absent heart right ventricle  (IAGP)
absent hindlimb  (IAGP)
absent pancreatic alpha cells  (IAGP)
absent petrosal ganglion  (IAGP)
absent pinna reflex  (IAGP)
absent pubis  (IAGP)
absent urinary bladder  (IAGP)
anal stenosis  (IAGP)
atrial septal defect  (IAGP)
atrioventricular septal defect  (IAGP)
axon degeneration  (IAGP)
blood vessel atresia  (IAGP)
blood vessel congestion  (IAGP)
bradykinesia  (IAGP)
craniofacial phenotype  (IAGP)
cyanosis  (IAGP)
decreased amacrine cell number  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased cell proliferation  (IAGP)
decreased chemical nociceptive threshold  (IAGP)
decreased embryo size  (IAGP)
decreased embryonic neuroepithelium thickness  (IAGP)
decreased heart right ventricle size  (IAGP)
decreased mitotic index  (IAGP)
decreased motor neuron number  (IAGP)
decreased muscle spindle number  (IAGP)
decreased nerve conduction velocity  (IAGP)
decreased pacinian corpuscle number  (IAGP)
decreased retina ganglion cell number  (IAGP)
decreased retina inner nuclear layer thickness  (IAGP)
decreased Schwann cell number  (IAGP)
dorsal root ganglion hypoplasia  (IAGP)
double outlet right ventricle  (IAGP)
ectopic thymus  (IAGP)
embryo tissue necrosis  (IAGP)
embryonic growth arrest  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
excessive cerumen  (IAGP)
external male genitalia hypoplasia  (IAGP)
failure of heart looping  (IAGP)
fusion of middle ear ossicles  (IAGP)
heart right ventricle hypoplasia  (IAGP)
impaired coordination  (IAGP)
impaired hearing  (IAGP)
increased apoptosis  (IAGP)
increased gastrointestinal tumor incidence  (IAGP)
increased or absent threshold for auditory brainstem response  (IAGP)
increased retina apoptosis  (IAGP)
increased susceptibility to otitis media  (IAGP)
interrupted aortic arch  (IAGP)
lethality throughout fetal growth and development  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
microphthalmia  (IAGP)
middle ear effusion  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
oligodactyly  (IAGP)
optic nerve degeneration  (IAGP)
optic nerve hypoplasia  (IAGP)
pericardial edema  (IAGP)
perimembraneous ventricular septal defect  (IAGP)
perinatal lethality  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
persistent truncus arteriosis  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
preaxial polydactyly  (IAGP)
premature death  (IAGP)
preweaning lethality, complete penetrance  (IAGP)
preweaning lethality, incomplete penetrance  (IAGP)
renal hypoplasia  (IAGP)
retina ganglion cell degeneration  (IAGP)
right aortic arch  (IAGP)
sirenomelia  (IAGP)
small pacinian corpuscles  (IAGP)
small pharyngeal arch  (IAGP)
small Rathke's pouch  (IAGP)
syndactyly  (IAGP)
thin cerebral cortex  (IAGP)
thin myocardium  (IAGP)
thin retina inner plexiform layer  (IAGP)
thymus hypoplasia  (IAGP)
transposition of great arteries  (IAGP)
ventricular septal defect  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Positional candidate gene analysis of Lim domain homeobox gene (Isl-1) on chromosome 5q11-q13 in a French morbidly obese population suggests indication for association with type 2 diabetes. Barat-Houari M, etal., Diabetes. 2002 May;51(5):1640-3.
2. Islet-1 gene delivery improves myocardial performance after experimental infarction. Barzelay A, etal., Atherosclerosis. 2012 Aug;223(2):284-90. doi: 10.1016/j.atherosclerosis.2012.05.025. Epub 2012 May 30.
3. ISL1 Is Necessary for Maximal Thyrotrope Response to Hypothyroidism. Castinetti F, etal., Mol Endocrinol. 2015 Oct;29(10):1510-21. doi: 10.1210/me.2015-1192. Epub 2015 Aug 21.
4. Lack of association of the 3'-UTR polymorphism (rs1017) in the ISL1 gene and risk of congenital heart disease in the white population. Cresci M, etal., Pediatr Cardiol. 2013 Apr;34(4):938-41. doi: 10.1007/s00246-012-0578-z. Epub 2012 Nov 15.
5. Interaction and association analysis of a type 1 diabetes susceptibility locus on chromosome 5q11-q13 and the 7q32 chromosomal region in Scandinavian families. Holm P, etal., Diabetes. 2004 Jun;53(6):1584-91.
6. Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo- and a Cys-His domain. Karlsson O, etal., Nature 1990 Apr 26;344(6269):879-82.
7. Association between ISL1 variants and susceptibility to ventricular septal defect in a Chinese cohort. Lang J, etal., Mol Diagn Ther. 2013 Apr;17(2):101-6. doi: 10.1007/s40291-013-0033-8.
8. Statin downregulation of miR-652-3p protects endothelium from dyslipidemia by promoting ISL1 expression. Liang L, etal., Metabolism. 2020 Jun;107:154226. doi: 10.1016/j.metabol.2020.154226. Epub 2020 Apr 8.
9. Genetic variations of ISL1 associated with human congenital heart disease in Chinese Han people. Luo ZL, etal., Genet Mol Res. 2014 Feb 28;13(1):1329-38. doi: 10.4238/2014.February.28.5.
10. ISL1 loss-of-function mutation contributes to congenital heart defects. Ma L, etal., Heart Vessels. 2019 Apr;34(4):658-668. doi: 10.1007/s00380-018-1289-z. Epub 2018 Nov 2.
11. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
12. MGDs mouse GO annotations MGD data from the GO Consortium
13. MGD IEA MGD IEA
14. Mouse MP Annotation Import Pipeline RGD automated import pipeline
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Common variation in ISL1 confers genetic susceptibility for human congenital heart disease. Stevens KN, etal.
17. MiR-128-3p accelerates cardiovascular calcification and insulin resistance through ISL1-dependent Wnt pathway in type 2 diabetes mellitus rats. Wang XY, etal., J Cell Physiol. 2019 Apr;234(4):4997-5010. doi: 10.1002/jcp.27300. Epub 2018 Oct 20.
18. A New ISL1 Loss-of-Function Mutation Predisposes to Congenital Double Outlet Right Ventricle. Wang Z, etal., Int Heart J. 2019 Sep 27;60(5):1113-1122. doi: 10.1536/ihj.18-685. Epub 2019 Sep 4.
19. ISL1 loss-of-function variation causes familial atrial fibrillation. Wu SH, etal., Eur J Med Genet. 2020 Nov;63(11):104029. doi: 10.1016/j.ejmg.2020.104029. Epub 2020 Aug 6.
20. ISL1 overexpression enhances the survival of transplanted human mesenchymal stem cells in a murine myocardial infarction model. Xiang Q, etal., Stem Cell Res Ther. 2018 Feb 26;9(1):51. doi: 10.1186/s13287-018-0803-7.
21. Identification and Functional Characterization of an ISL1 Mutation Predisposing to Dilated Cardiomyopathy. Xu YJ, etal., J Cardiovasc Transl Res. 2019 Jun;12(3):257-267. doi: 10.1007/s12265-018-9851-8. Epub 2018 Dec 10.
Additional References at PubMed
PMID:1764243   PMID:7720556   PMID:8050356   PMID:8069910   PMID:8221886   PMID:8224007   PMID:8543157   PMID:8555108   PMID:8565076   PMID:8744440   PMID:8756299   PMID:8812059  
PMID:8817562   PMID:8837770   PMID:8876198   PMID:8889548   PMID:8903354   PMID:8922421   PMID:8951074   PMID:8951795   PMID:8955272   PMID:8967950   PMID:8978605   PMID:9000074  
PMID:9100133   PMID:9102308   PMID:9118797   PMID:9192866   PMID:9230312   PMID:9242412   PMID:9272948   PMID:9315901   PMID:9353119   PMID:9374403   PMID:9389446   PMID:9463347  
PMID:9486801   PMID:9490412   PMID:9507132   PMID:9584121   PMID:9585504   PMID:9603426   PMID:9620855   PMID:9636069   PMID:9655799   PMID:9664688   PMID:9767163   PMID:9806916  
PMID:9806931   PMID:9828088   PMID:9851981   PMID:9865699   PMID:9895316   PMID:9915576   PMID:9988216   PMID:10049363   PMID:10075844   PMID:10079519   PMID:10217145   PMID:10349636  
PMID:10357893   PMID:10367888   PMID:10395791   PMID:10419687   PMID:10419695   PMID:10431247   PMID:10471501   PMID:10476967   PMID:10477289   PMID:10482234   PMID:10482235   PMID:10499586  
PMID:10529422   PMID:10536059   PMID:10585298   PMID:10588713   PMID:10615124   PMID:10625551   PMID:10640277   PMID:10642437   PMID:10677261   PMID:10677506   PMID:10693795   PMID:10704382  
PMID:10707974   PMID:10712625   PMID:10725236   PMID:10725250   PMID:10825208   PMID:10850491   PMID:10862153   PMID:10864955   PMID:10864957   PMID:10864958   PMID:10868931   PMID:10887087  
PMID:10903178   PMID:10906467   PMID:10921901   PMID:10932192   PMID:10934027   PMID:11003836   PMID:11042159   PMID:11066097   PMID:11071781   PMID:11076752   PMID:11076756   PMID:11076772  
PMID:11076861   PMID:11152636   PMID:11156606   PMID:11161479   PMID:11165475   PMID:11180952   PMID:11217851   PMID:11222142   PMID:11239429   PMID:11239430   PMID:11299042   PMID:11306624  
PMID:11312598   PMID:11390667   PMID:11395002   PMID:11395003   PMID:11449277   PMID:11466434   PMID:11472850   PMID:11493524   PMID:11500980   PMID:11502253   PMID:11502254   PMID:11511541  
PMID:11566099   PMID:11567614   PMID:11684651   PMID:11731238   PMID:11731257   PMID:11731457   PMID:11748146   PMID:11748151   PMID:11749040   PMID:11784004   PMID:11784021   PMID:11784044  
PMID:11784060   PMID:11825874   PMID:11877374   PMID:11880356   PMID:11886853   PMID:11912494   PMID:11944941   PMID:11955448   PMID:11960711   PMID:11988168   PMID:12019323   PMID:12023301  
PMID:12040030   PMID:12062038   PMID:12062039   PMID:12112475   PMID:12118260   PMID:12135932   PMID:12139922   PMID:12183375   PMID:12186854   PMID:12189445   PMID:12209838   PMID:12351199  
PMID:12354395   PMID:12361967   PMID:12372284   PMID:12404118   PMID:12410312   PMID:12412008   PMID:12421714   PMID:12421716   PMID:12435629   PMID:12466851   PMID:12477932   PMID:12485625  
PMID:12490199   PMID:12495620   PMID:12514213   PMID:12559489   PMID:12571103   PMID:12571110   PMID:12575949   PMID:12619134   PMID:12624426   PMID:12651891   PMID:12666204   PMID:12681500  
PMID:12687699   PMID:12730604   PMID:12741988   PMID:12787506   PMID:12797958   PMID:12799141   PMID:12805300   PMID:12812795   PMID:12842915   PMID:12855770   PMID:12874134   PMID:12900460  
PMID:12917290   PMID:12921747   PMID:12933680   PMID:12948444   PMID:12954718   PMID:12971893   PMID:12971989   PMID:13678579   PMID:14499653   PMID:14517283   PMID:14517990   PMID:14522873  
PMID:14534138   PMID:14551230   PMID:14623245   PMID:14627641   PMID:14627719   PMID:14643678   PMID:14643685   PMID:14664703   PMID:14667410   PMID:14681479   PMID:14702043   PMID:14723851  
PMID:14729487   PMID:14736744   PMID:14766174   PMID:14960494   PMID:15031110   PMID:15037319   PMID:15071095   PMID:15075292   PMID:15105370   PMID:15148302   PMID:15150159   PMID:15163631  
PMID:15198977   PMID:15215207   PMID:15229603   PMID:15240886   PMID:15326611   PMID:15329346   PMID:15329890   PMID:15339983   PMID:15363409   PMID:15459098   PMID:15469980   PMID:15509772  
PMID:15525990   PMID:15528197   PMID:15541311   PMID:15545635   PMID:15548576   PMID:15576400   PMID:15590934   PMID:15604100   PMID:15618518   PMID:15653467   PMID:15659653   PMID:15668393  
PMID:15673567   PMID:15689381   PMID:15691760   PMID:15703280   PMID:15703750   PMID:15728558   PMID:15729571   PMID:15733084   PMID:15733660   PMID:15739225   PMID:15753214   PMID:15769945  
PMID:15788454   PMID:15804564   PMID:15817220   PMID:15820692   PMID:15834955   PMID:15836427   PMID:15843409   PMID:15843414   PMID:15870291   PMID:15880651   PMID:15901662   PMID:15901664  
PMID:15922675   PMID:15930101   PMID:15936012   PMID:15944193   PMID:15976074   PMID:16020526   PMID:16026391   PMID:16026781   PMID:16038893   PMID:16055717   PMID:16099729   PMID:16116448  
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PMID:30917309   PMID:30940539   PMID:30951706   PMID:30959515   PMID:30995485   PMID:31024170   PMID:31064784   PMID:31112136   PMID:31112709   PMID:31152445   PMID:31171666   PMID:31175693  
PMID:31186351   PMID:31196952   PMID:31201155   PMID:31201182   PMID:31206334   PMID:31211835   PMID:31221018   PMID:31235634   PMID:31235635   PMID:31249377   PMID:31305241   PMID:31320323  
PMID:31341279   PMID:31356769   PMID:31371378   PMID:31399471   PMID:31412026   PMID:31427287   PMID:31461644   PMID:31488563   PMID:31491374   PMID:31515492   PMID:31526806   PMID:31535973  
PMID:31558700   PMID:31578231   PMID:31597102   PMID:31609468   PMID:31614382   PMID:31655130   PMID:31749685   PMID:31787878   PMID:31811168   PMID:31812516   PMID:31813798   PMID:31822965  
PMID:31875546   PMID:31882119   PMID:31918020   PMID:31928974   PMID:31944180   PMID:31969659   PMID:31988190   PMID:31995756   PMID:32019948   PMID:32027825   PMID:32060653   PMID:32083082  
PMID:32096760   PMID:32105214   PMID:32150249   PMID:32170006   PMID:32180559   PMID:32215989   PMID:32244588   PMID:32398354   PMID:32414840   PMID:32420617   PMID:32453714   PMID:32471461  
PMID:32499648   PMID:32511952   PMID:32521266   PMID:32546759   PMID:32561725   PMID:32597756   PMID:32692983   PMID:32717817   PMID:32744119   PMID:32778568   PMID:32783938   PMID:32792525  
PMID:32803714   PMID:32804075   PMID:32817515   PMID:32826903   PMID:32857951   PMID:32880858   PMID:32901292   PMID:32937136   PMID:32938678   PMID:32943498   PMID:32986815   PMID:33044128  
PMID:33096050   PMID:33187539   PMID:33192618   PMID:33238113   PMID:33414188   PMID:33431871   PMID:33443158   PMID:33510480   PMID:33547135   PMID:33567267   PMID:33575260   PMID:33585465  
PMID:33674582   PMID:33711282   PMID:33712461   PMID:33712552   PMID:33727334   PMID:33731940   PMID:33775695   PMID:33787491   PMID:33789102   PMID:33833454   PMID:33869166   PMID:33887179  
PMID:33892704   PMID:33899511   PMID:34003106   PMID:34169071   PMID:34171285   PMID:34201511   PMID:34228108   PMID:34248495   PMID:34329593   PMID:34374463   PMID:34423345   PMID:34494344  
PMID:34518365   PMID:34547456   PMID:34564702   PMID:34571841   PMID:34615475   PMID:34672258   PMID:34687812   PMID:34713362   PMID:34782793   PMID:34789765   PMID:34851821   PMID:34906895  
PMID:34974536   PMID:34994686   PMID:35100965   PMID:35105870   PMID:35156680   PMID:35177643   PMID:35210288   PMID:35237793   PMID:35252209   PMID:35273083   PMID:35315772   PMID:35358427  
PMID:35377797   PMID:35401124   PMID:35676931   PMID:35690356   PMID:35700056   PMID:35713404   PMID:35736367   PMID:35790771   PMID:35815410   PMID:35817979   PMID:35831318   PMID:35831953  
PMID:35946435   PMID:36028102   PMID:36039295   PMID:36074819   PMID:36081908   PMID:36082581   PMID:36178196   PMID:36196625   PMID:36196867   PMID:36197846   PMID:36240771   PMID:36260685  
PMID:36321865   PMID:36326727   PMID:36333314   PMID:36353228   PMID:36395107   PMID:36418415   PMID:36476860   PMID:36521641   PMID:36529318   PMID:36537573   PMID:36542664   PMID:36549270  
PMID:36596776   PMID:36596814   PMID:36736300   PMID:36899442   PMID:36916392   PMID:36941249   PMID:36943865   PMID:37019373   PMID:37060937  


Genomics

Comparative Map Data
Isl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913116,434,806 - 116,446,224 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13116,434,817 - 116,446,225 (-)EnsemblGRCm39 Ensembl
GRCm3813116,298,270 - 116,309,688 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13116,298,281 - 116,309,689 (-)EnsemblGRCm38mm10GRCm38
MGSCv3713117,088,478 - 117,099,896 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613117,418,963 - 117,430,370 (-)NCBIMGSCv36mm8
Celera13120,696,034 - 120,707,388 (-)NCBICelera
Cytogenetic Map13D2.2NCBI
ISL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38551,383,448 - 51,394,730 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl551,383,448 - 51,394,730 (+)EnsemblGRCh38hg38GRCh38
GRCh37550,679,282 - 50,690,564 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36550,714,715 - 50,726,321 (+)NCBINCBI36Build 36hg18NCBI36
Build 34550,715,025 - 50,726,310NCBI
Celera547,625,609 - 47,637,216 (+)NCBICelera
Cytogenetic Map5q11.1NCBI
HuRef547,642,569 - 47,654,183 (+)NCBIHuRef
CHM1_1550,681,961 - 50,693,557 (+)NCBICHM1_1
T2T-CHM13v2.0552,202,628 - 52,213,920 (+)NCBIT2T-CHM13v2.0
Isl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2248,079,412 - 48,090,704 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl248,080,522 - 48,095,584 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx255,203,901 - 55,213,771 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0253,262,535 - 53,272,409 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0248,114,441 - 48,124,280 (-)NCBIRnor_WKY
Rnor_6.0248,488,911 - 48,501,217 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl248,487,736 - 48,501,436 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0266,871,790 - 66,883,936 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4248,050,124 - 48,060,394 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1247,978,356 - 47,988,627 (-)NCBI
Celera243,808,350 - 43,818,250 (-)NCBICelera
Cytogenetic Map2q14NCBI
Isl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544615,824,035 - 15,835,046 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544615,824,956 - 15,835,000 (-)NCBIChiLan1.0ChiLan1.0
ISL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1560,700,147 - 60,717,845 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0562,635,095 - 62,650,141 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1564,253,037 - 64,264,674 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl564,252,715 - 64,264,674 (-)Ensemblpanpan1.1panPan2
ISL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1463,638,009 - 63,648,492 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl463,637,443 - 63,648,183 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha463,397,586 - 63,408,606 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0464,141,344 - 64,152,383 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl464,141,331 - 64,152,087 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1463,906,232 - 63,917,266 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0464,028,384 - 64,039,422 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0464,567,747 - 64,578,778 (-)NCBIUU_Cfam_GSD_1.0
Isl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213206,869,998 - 206,881,359 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648015,805,247 - 15,817,854 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493648015,805,259 - 15,817,854 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ISL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1630,963,000 - 30,973,907 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11630,962,994 - 30,974,201 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21632,548,015 - 32,559,227 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ISL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1447,665,861 - 47,678,631 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl447,666,536 - 47,677,552 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660823,504,978 - 3,526,896 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Isl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247597,994,242 - 8,006,311 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247597,996,177 - 8,006,281 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Isl1
492 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:636
Count of miRNA genes:438
Interacting mature miRNAs:484
Transcripts:ENSMUST00000036060, ENSMUST00000176044, ENSMUST00000176444, ENSMUST00000176812, ENSMUST00000177469
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558741Ses10_msalmonella enteritidis susceptibility 10 (mouse)Not determined1382739968116740106Mouse
4142465Pbwg17_mpostnatal body weight growth 17 (mouse)Not determined1383876060117876256Mouse
14700691Cisaq1_mcoxsackieviral infection serum ALT QTL 1 (mouse)1386148119120461536Mouse
4140995Fbtq6_mfemoral bone trait QTL 6 (mouse)Not determined1386341617120341758Mouse
1300939Hrtfm6_mheart failure modifier 6 (mouse)Not determined1391383692120883175Mouse
1300876Tanidd2_mtally ho associated non-insulin dependednt diabetes mellitus 2 (mouse)Not determined1391965303120883175Mouse
1301142Heal2_mwound healing/regeneration 2 (mouse)Not determined1393875267120883175Mouse
4142338Skmw18_mskeletal muscle weight 18 (mouse)Not determined1394528399120883175Mouse
1558763Gct9_mgranulosa cell tumorigenesis 9 (mouse)Not determined1395036824120883175Mouse
1357468Rplag_mreduced platelet aggregation (mouse)Not determined1395502130120883175Mouse
14746974Manh75_mmandible shape 75 (mouse)1399386647120883175Mouse
12879496Fexq2_mfear expression QTL 2 (mouse)13100741519120883175Mouse
4142400Tgq24_mtriglyceride QTL 24 (mouse)Not determined102602630120883175Mouse
4141826Tbqt5_mtibia bone quality traits 5 (mouse)Not determined13103341617117043216Mouse
4142334Svtms_msurvival time modifier of Sod2 (mouse)Not determined13107613580119476372Mouse
4141704Hipq1_mhyperinsulin production QTL 1 (mouse)Not determined110409487119476372Mouse

Markers in Region
Isl1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv3713117,088,780 - 117,088,847UniSTSGRCm37
MGSCv3713117,089,527 - 117,089,720UniSTSGRCm37
MGSCv3713117,091,928 - 117,093,348UniSTSGRCm37
Celera13120,696,338 - 120,696,405UniSTS
Celera13120,699,469 - 120,700,888UniSTS
Celera13120,697,085 - 120,697,278UniSTS
Cytogenetic Map13D2.3UniSTS
cM Map13 UniSTS
PMC186328P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3813116,305,251 - 116,305,437UniSTSGRCm38
MGSCv3713117,095,459 - 117,095,645UniSTSGRCm37
Celera13120,702,951 - 120,703,137UniSTS
Cytogenetic Map13D2.3UniSTS
Isl1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3813116,298,572 - 116,298,639UniSTSGRCm38
MGSCv3713117,088,780 - 117,088,847UniSTSGRCm37
Celera13120,696,338 - 120,696,405UniSTS
Cytogenetic Map13D2.3UniSTS
Isl1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3813116,299,319 - 116,299,512UniSTSGRCm38
MGSCv3713117,089,527 - 117,089,720UniSTSGRCm37
Celera13120,697,085 - 120,697,278UniSTS
Cytogenetic Map13D2.3UniSTS
Isl1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3813116,301,720 - 116,303,140UniSTSGRCm38
MGSCv3713117,091,928 - 117,093,348UniSTSGRCm37
Celera13120,699,469 - 120,700,888UniSTS
Cytogenetic Map13D2.3UniSTS
Isl1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13D2.3UniSTS
Isl1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13D2.3UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000036060   ⟹   ENSMUSP00000044879
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl13116,434,817 - 116,446,225 (-)Ensembl
GRCm38.p6 Ensembl13116,298,281 - 116,309,689 (-)Ensembl
RefSeq Acc Id: ENSMUST00000176044   ⟹   ENSMUSP00000135567
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl13116,435,799 - 116,445,958 (-)Ensembl
GRCm38.p6 Ensembl13116,299,263 - 116,309,422 (-)Ensembl
RefSeq Acc Id: ENSMUST00000176444
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl13116,435,931 - 116,439,887 (-)Ensembl
GRCm38.p6 Ensembl13116,299,395 - 116,303,351 (-)Ensembl
RefSeq Acc Id: ENSMUST00000176812
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl13116,439,582 - 116,442,933 (-)Ensembl
GRCm38.p6 Ensembl13116,303,046 - 116,306,397 (-)Ensembl
RefSeq Acc Id: ENSMUST00000177469
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl13116,443,427 - 116,446,221 (-)Ensembl
GRCm38.p6 Ensembl13116,306,891 - 116,309,685 (-)Ensembl
RefSeq Acc Id: NM_021459   ⟹   NP_067434
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3913116,434,806 - 116,446,224 (-)NCBI
GRCm3813116,298,270 - 116,309,688 (-)NCBI
MGSCv3713117,088,478 - 117,099,896 (-)RGD
Celera13120,696,034 - 120,707,388 (-)RGD
cM Map13 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_067434   ⟸   NM_021459
- UniProtKB: Q812D8 (UniProtKB/Swiss-Prot),   P61372 (UniProtKB/Swiss-Prot),   A2RSV5 (UniProtKB/TrEMBL),   Q8BTH7 (UniProtKB/TrEMBL),   A0A6P5R399 (UniProtKB/TrEMBL),   A0A8C6G4H3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000044879   ⟸   ENSMUST00000036060
RefSeq Acc Id: ENSMUSP00000135567   ⟸   ENSMUST00000176044
Protein Domains
Homeobox   LIM zinc-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P61372-F1-model_v2 AlphaFold P61372 1-349 view protein structure

Promoters
RGD ID:8681362
Promoter ID:EPDNEW_M18712
Type:initiation region
Name:Isl1_1
Description:Mus musculus ISL1 transcription factor, LIM/homeodomain , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3813116,309,647 - 116,309,707EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:101791 AgrOrtholog
Ensembl Genes ENSMUSG00000042258 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000044879 ENTREZGENE
  ENSMUSP00000044879.7 UniProtKB/Swiss-Prot
  ENSMUSP00000135567.2 UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000036060 ENTREZGENE
  ENSMUST00000036060.13 UniProtKB/Swiss-Prot
  ENSMUST00000176044.3 UniProtKB/Swiss-Prot
Gene3D-CATH Cysteine Rich Protein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeodomain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ISL1/2-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ISL1/2-like_LIM1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_LIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16392 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:101791 ENTREZGENE
NCBI Gene 16392 ENTREZGENE
PANTHER INSULIN GENE ENHANCER PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INSULIN GENE ENHANCER PROTEIN ISL-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Homeodomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Isl1 PhenoGen
PROSITE HOMEOBOX_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIM_DOMAIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIM_DOMAIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF46689 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A6P5R399 ENTREZGENE
  A0A8C6G4H3 ENTREZGENE
  A2RSV5 ENTREZGENE, UniProtKB/TrEMBL
  B2ZUN4_MOUSE UniProtKB/TrEMBL
  ISL1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q812D8 ENTREZGENE
  Q8BTH7 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary P20663 UniProtKB/Swiss-Prot
  P47894 UniProtKB/Swiss-Prot
  Q812D8 UniProtKB/Swiss-Prot