Per2 (period circadian clock 2) - Rat Genome Database

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Gene: Per2 (period circadian clock 2) Mus musculus
Analyze
Symbol: Per2
Name: period circadian clock 2
RGD ID: 62238
MGI Page MGI
Description: Enables several functions, including enzyme binding activity; nucleic acid binding activity; and transcription corepressor binding activity. Involved in several processes, including gluconeogenesis; monocarboxylic acid metabolic process; and regulation of gene expression. Acts upstream of or within circadian rhythm and negative regulation of transcription by RNA polymerase II. Located in nucleus and perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study advanced sleep phase syndrome 1. Human ortholog(s) of this gene implicated in advanced sleep phase syndrome; advanced sleep phase syndrome 1; and cocaine dependence. Orthologous to human PER2 (period circadian regulator 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: circadian clock protein PERIOD 2; mKIAA0347; mPe; mPer2; period 2; period circadian protein homolog 2; period homolog 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39191,343,699 - 91,387,028 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl191,343,704 - 91,387,046 (-)EnsemblGRCm39 Ensembl
GRCm38191,415,977 - 91,459,351 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl191,415,982 - 91,459,324 (-)EnsemblGRCm38mm10GRCm38
MGSCv37193,312,559 - 93,355,905 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36193,246,388 - 93,289,702 (-)NCBIMGSCv36mm8
Celera194,353,350 - 94,396,834 (-)NCBICelera
Cytogenetic Map1DNCBI
cM Map146.13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-epicatechin-3-O-gallate  (ISO)
(+)-schisandrin B  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-noradrenaline  (EXP)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP)
5-fluorouracil  (EXP)
6-propyl-2-thiouracil  (ISO)
acamprosate  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (EXP)
ammonium chloride  (ISO)
amphetamine  (ISO)
Ampullosporin  (ISO)
antirheumatic drug  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (ISO)
butanal  (ISO)
C60 fullerene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
capsaicin  (ISO)
carbon nanotube  (EXP)
carnosic acid  (EXP)
CGP 52608  (ISO)
CGS-21680  (ISO)
chloroprene  (EXP,ISO)
choline  (EXP)
chromium(6+)  (ISO)
chrysene  (EXP)
cocaine  (EXP)
cocaine hydrochloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cyanocob(III)alamin  (EXP)
cyclosporin A  (ISO)
deoxynivalenol  (EXP)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (EXP)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
diethyl maleate  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
epoxiconazole  (EXP)
Erionite  (EXP)
ethanol  (EXP,ISO)
ferric oxide  (EXP)
flavonoids  (ISO)
fluoranthene  (EXP)
fluoxetine  (EXP)
folic acid  (EXP)
formaldehyde  (ISO)
furan  (ISO)
gallic acid  (ISO)
gallocatechin  (ISO)
gamma-hexachlorocyclohexane  (ISO)
gentamycin  (ISO)
glycine betaine  (EXP)
glyphosate  (EXP)
hydrogen peroxide  (ISO)
indometacin  (ISO)
ketamine  (ISO)
L-methionine  (EXP)
lead diacetate  (ISO)
leflunomide  (ISO)
linsidomine  (EXP)
manganese(II) chloride  (ISO)
melatonin  (ISO)
menadione  (ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (ISO)
methotrexate  (EXP,ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
milrinone  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
morphine  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
orphenadrine  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentanal  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
phenformin  (ISO)
phenobarbital  (EXP,ISO)
phenol  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
plumbagin  (EXP)
potassium chromate  (ISO)
potassium dichromate  (EXP)
prednisolone  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP,ISO)
propanal  (ISO)
quercetin  (ISO)
raloxifene  (EXP)
resveratrol  (EXP)
rotenone  (ISO)
SB 431542  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
sevoflurane  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (EXP)
Soman  (ISO)
styrene  (EXP)
sulforaphane  (EXP)
sunitinib  (ISO)
testosterone  (EXP,ISO)
tetrachloroethene  (EXP)
tetrachloromethane  (EXP,ISO)
tetraphene  (EXP)
thapsigargin  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP,ISO)
torcetrapib  (ISO)
tributylstannane  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
trovafloxacin  (EXP)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vorinostat  (EXP,ISO)
zalcitabine  (ISO)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IDA)
cytosol  (ISO,TAS)
nucleoplasm  (ISO,TAS)
nucleus  (IBA,IDA,IPI,ISO)
perinuclear region of cytoplasm  (IDA)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal basal metabolism  (IAGP)
abnormal blood vessel morphology  (IAGP)
abnormal body weight  (IAGP)
abnormal bone marrow cell morphology/development  (IAGP)
abnormal bone mineralization  (IEA)
abnormal brain wave pattern  (IAGP)
abnormal circadian behavior  (IEA)
abnormal circadian behavior period  (IAGP)
abnormal circadian behavior phase  (IAGP)
abnormal circadian sleep/wake cycle  (IAGP)
abnormal circadian temperature homeostasis  (IAGP)
abnormal circardian behavior entrainment  (IAGP)
abnormal coat/hair pigmentation  (IEA)
abnormal eye physiology  (IAGP)
abnormal fibroblast physiology  (IAGP)
abnormal food intake  (IAGP)
abnormal food preference  (IAGP)
abnormal hematopoietic stem cell physiology  (IAGP)
abnormal hypothalamus physiology  (IAGP)
abnormal liver physiology  (IAGP)
abnormal locomotor circadian rhythm  (IAGP)
abnormal male preputial gland morphology  (IAGP)
abnormal maternal behavior  (IAGP)
abnormal nervous system morphology  (IAGP)
abnormal pregnancy  (IAGP)
abnormal retina morphology  (IAGP)
abnormal retina vasculature morphology  (IAGP)
abnormal skeleton development  (IAGP)
abnormal sleep pattern  (IAGP)
abnormal urine catecholamine level  (IAGP)
absent estrous cycle  (IAGP)
arrhythmic circadian behavior persistence  (IAGP)
decreased bone ossification  (IAGP)
decreased cellular sensitivity to gamma-irradiation  (IAGP)
decreased hematopoietic stem cell proliferation  (IAGP)
decreased litter size  (IAGP)
decreased osteoblast cell number  (IAGP)
delayed circadian behavior phase  (IEA)
early reproductive senescence  (IAGP)
enhanced behavioral response to cocaine  (IAGP)
enhanced conditioned place preference behavior  (IAGP)
impaired wound healing  (IAGP)
improved glucose tolerance  (IAGP)
increased body weight  (IAGP)
increased bone mass  (IAGP)
increased bone ossification  (IAGP)
increased bone volume  (IAGP)
increased circulating alkaline phosphatase level  (IEA)
increased circulating leptin level  (IAGP)
increased hematopoietic stem cell number  (IAGP)
increased incidence of tumors by ionizing radiation induction  (IAGP)
increased lymphoma incidence  (IAGP)
increased mortality induced by gamma-irradiation  (IAGP)
increased osteoblast cell number  (IAGP)
increased osteoblast proliferation  (IAGP)
increased salivary gland tumor incidence  (IAGP)
no abnormal phenotype detected  (IAGP)
premature death  (IAGP)
prolonged circadian behavior period  (IAGP)
prolonged estrous cycle  (IAGP)
pup cannibalization  (IAGP)
reduced female fertility  (IAGP)
salivary gland epithelial hyperplasia  (IAGP)
shortened circadian behavior period  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Prenatal ethanol exposure alters the expression of period genes governing the circadian function of beta-endorphin neurons in the hypothalamus. Chen CP, etal., J Neurochem. 2006 May;97(4):1026-33. doi: 10.1111/j.1471-4159.2006.03839.x.
2. Role for intestinal CYP2E1 in alcohol-induced circadian gene-mediated intestinal hyperpermeability. Forsyth CB, etal., Am J Physiol Gastrointest Liver Physiol. 2013 Jul 15;305(2):G185-95. doi: 10.1152/ajpgi.00354.2012. Epub 2013 May 9.
3. Hypermethylation of Proopiomelanocortin and Period 2 Genes in Blood Are Associated with Greater Subjective and Behavioral Motivation for Alcohol in Humans. Gangisetty O, etal., Alcohol Clin Exp Res. 2019 Feb;43(2):212-220. doi: 10.1111/acer.13932. Epub 2018 Dec 31.
4. Reduced expression of circadian clock genes in male alcoholic patients. Huang MC, etal., Alcohol Clin Exp Res. 2010 Nov;34(11):1899-904. doi: 10.1111/j.1530-0277.2010.01278.x. Epub 2010 Aug 24.
5. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
6. MGDs mouse GO annotations MGD data from the GO Consortium
7. MGD IEA MGD IEA
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. Development of morphine-induced tolerance and withdrawal: involvement of the clock gene mPer2. Perreau-Lenz S, etal., Eur Neuropsychopharmacol. 2010 Jul;20(7):509-17. doi: 10.1016/j.euroneuro.2010.03.006.
10. Mouse MP Annotation Import Pipeline RGD automated import pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Persistent Changes in Stress-Regulatory Genes in Pregnant Women or Children Exposed Prenatally to Alcohol. Sarkar DK, etal., Alcohol Clin Exp Res. 2019 Sep;43(9):1887-1897. doi: 10.1111/acer.14148. Epub 2019 Aug 6.
14. Repeat variation in the human PER2 gene as a new genetic marker associated with cocaine addiction and brain dopamine D2 receptor availability. Shumay E, etal., Transl Psychiatry. 2012 Mar 6;2(3):e86. doi: 10.1038/tp.2012.11.
15. A light-independent oscillatory gene mPer3 in mouse SCN and OVLT. Takumi T, etal., EMBO J 1998 Aug 17;17(16):4753-9.
16. An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome. Toh KL, etal., Science. 2001 Feb 9;291(5506):1040-3.
17. Effect of fluoxetine and cocaine on the expression of clock genes in the mouse hippocampus and striatum. Uz T, etal., Neuroscience. 2005;134(4):1309-16. doi: 10.1016/j.neuroscience.2005.05.003.
Additional References at PubMed
PMID:9427249   PMID:9428527   PMID:9582067   PMID:9619629   PMID:9856465   PMID:9856466   PMID:9920673   PMID:9988221   PMID:9989497   PMID:10077321   PMID:10208599   PMID:10349636  
PMID:10408444   PMID:10428031   PMID:10487202   PMID:10508692   PMID:10617474   PMID:10807566   PMID:10837028   PMID:10848614   PMID:10891604   PMID:10899319   PMID:11042159   PMID:11042357  
PMID:11076861   PMID:11207804   PMID:11217851   PMID:11389837   PMID:11395012   PMID:11591712   PMID:11865049   PMID:11889036   PMID:11959112   PMID:12024206   PMID:12032351   PMID:12054191  
PMID:12084940   PMID:12150932   PMID:12372028   PMID:12372299   PMID:12374857   PMID:12381662   PMID:12383239   PMID:12466851   PMID:12477932   PMID:12531511   PMID:12622829   PMID:12693553  
PMID:12693867   PMID:12738229   PMID:12775559   PMID:12824769   PMID:12843397   PMID:12897057   PMID:12916720   PMID:14522008   PMID:14645221   PMID:14657179   PMID:14681479   PMID:14701732  
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PMID:19222558   PMID:19299560   PMID:19327139   PMID:19402751   PMID:19414365   PMID:19414593   PMID:19477955   PMID:19523042   PMID:19587447   PMID:19605937   PMID:19698763   PMID:19718444  
PMID:19738906   PMID:19740747   PMID:19741146   PMID:19786732   PMID:19805059   PMID:19805326   PMID:19829696   PMID:19840112   PMID:19917250   PMID:19926610   PMID:19926612   PMID:19926812  
PMID:19948962   PMID:20030538   PMID:20043880   PMID:20053965   PMID:20059953   PMID:20061537   PMID:20072700   PMID:20075296   PMID:20159955   PMID:20180860   PMID:20211142   PMID:20236181  
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PMID:20696890   PMID:20826680   PMID:20829506   PMID:20832105   PMID:20840750   PMID:20887817   PMID:20932939   PMID:20944004   PMID:20947768   PMID:20967239   PMID:21035761   PMID:21113167  
PMID:21151601   PMID:21156215   PMID:21179498   PMID:21186050   PMID:21267068   PMID:21285316   PMID:21324900   PMID:21366728   PMID:21382453   PMID:21392557   PMID:21458659   PMID:21488990  
PMID:21549097   PMID:21559484   PMID:21613214   PMID:21624349   PMID:21628550   PMID:21655193   PMID:21680841   PMID:21703244   PMID:21768648   PMID:21773940   PMID:21793695   PMID:21818120  
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PMID:22362755   PMID:22405069   PMID:22460952   PMID:22504074   PMID:22504483   PMID:22558277   PMID:22723262   PMID:22734566   PMID:22745491   PMID:22764243   PMID:22767893   PMID:22823489  
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PMID:25514904   PMID:25525750   PMID:25573753   PMID:25581923   PMID:25660546   PMID:25689298   PMID:25741729   PMID:25741730   PMID:25756610   PMID:25779967   PMID:25821984   PMID:25846207  
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PMID:26617050   PMID:26652002   PMID:26657859   PMID:26776516   PMID:26781276   PMID:26838474   PMID:26862173   PMID:26895328   PMID:26903623   PMID:26926165   PMID:26930624   PMID:26966234  
PMID:27021954   PMID:27054331   PMID:27058663   PMID:27088856   PMID:27113500   PMID:27168152   PMID:27271267   PMID:27346580   PMID:27374340   PMID:27383066   PMID:27459195   PMID:27476975  
PMID:27494874   PMID:27529127   PMID:27609640   PMID:27657167   PMID:27662578   PMID:27690690   PMID:27773697   PMID:27791392   PMID:27796320   PMID:27875243   PMID:27879317   PMID:27889186  
PMID:27893733   PMID:27912059   PMID:27923220   PMID:28017605   PMID:28065650   PMID:28112045   PMID:28134247   PMID:28213822   PMID:28232786   PMID:28259547   PMID:28285822   PMID:28286126  
PMID:28326909   PMID:28401936   PMID:28402850   PMID:28423315   PMID:28439257   PMID:28448534   PMID:28484984   PMID:28486525   PMID:28499924   PMID:28556462   PMID:28560311   PMID:28576728  
PMID:28602615   PMID:28607147   PMID:28634329   PMID:28683290   PMID:28687372   PMID:28689605   PMID:28698388   PMID:28710114   PMID:28821839   PMID:28827343   PMID:28828400   PMID:28883509  
PMID:28886335   PMID:28973913   PMID:29054877   PMID:29138421   PMID:29186676   PMID:29199069   PMID:29227248   PMID:29269828   PMID:29293562   PMID:29302035   PMID:29339832   PMID:29362450  
PMID:29386573   PMID:29447160   PMID:29463694   PMID:29463714   PMID:29478834   PMID:29481323   PMID:29490985   PMID:29491349   PMID:29518531   PMID:29533925   PMID:29540683   PMID:29555746  
PMID:29561690   PMID:29610316   PMID:29626648   PMID:29688375   PMID:29750810   PMID:29760192   PMID:29784789   PMID:29899468   PMID:29931690   PMID:29937374   PMID:29965797   PMID:29982483  
PMID:30017392   PMID:30031683   PMID:30242505   PMID:30283092   PMID:30287844   PMID:30321360   PMID:30321586   PMID:30429219   PMID:30452546   PMID:30487216   PMID:30527742   PMID:30612576  
PMID:30630934   PMID:30710088   PMID:30744968   PMID:30773466   PMID:30782483   PMID:30794439   PMID:30822304   PMID:30884411   PMID:31006590   PMID:31030999   PMID:31136603   PMID:31138685  
PMID:31189119   PMID:31189882   PMID:31211910   PMID:31260634   PMID:31263776   PMID:31296902   PMID:31308426   PMID:31353184   PMID:31358797   PMID:31390562   PMID:31398249   PMID:31420455  
PMID:31428688   PMID:31522764   PMID:31607531   PMID:31687929   PMID:31746738   PMID:31797953   PMID:31822134   PMID:31847374   PMID:31848250   PMID:31875550   PMID:31879343   PMID:31907414  
PMID:31914667   PMID:31919902   PMID:31930968   PMID:32182332   PMID:32245954   PMID:32325033   PMID:32348614   PMID:32354999   PMID:32369735   PMID:32385329   PMID:32433970   PMID:32455427  
PMID:32543667   PMID:32555162   PMID:32555251   PMID:32613762   PMID:32615095   PMID:32644041   PMID:32681096   PMID:32768389   PMID:32796949   PMID:32864176   PMID:32888430   PMID:32896721  
PMID:32968200   PMID:32981454   PMID:33053337   PMID:33086741   PMID:33123539   PMID:33135952   PMID:33202247   PMID:33207207   PMID:33234609   PMID:33382840   PMID:33443219   PMID:33491228  
PMID:33526663   PMID:33554778   PMID:33606281   PMID:33621249   PMID:33913482   PMID:34009269   PMID:34011974   PMID:34048425   PMID:34112905   PMID:34160105   PMID:34426495   PMID:34487375  
PMID:34529765   PMID:34584158   PMID:34632336   PMID:34661529   PMID:34695438   PMID:34702951   PMID:34705514   PMID:34732735   PMID:34741086   PMID:34851661   PMID:34887762   PMID:34895464  
PMID:34927581   PMID:34968386   PMID:34974160   PMID:35023384   PMID:35046033   PMID:35172136   PMID:35272486   PMID:35386071   PMID:35401134   PMID:35418126   PMID:35443162   PMID:35460695  
PMID:35486444   PMID:35584682   PMID:35606517   PMID:35755440   PMID:35806403   PMID:35810166   PMID:35902736   PMID:35910841   PMID:35933488   PMID:36194579   PMID:36213234   PMID:36285301  
PMID:36350921   PMID:36361751   PMID:36450499   PMID:36465103   PMID:36638184   PMID:36724252   PMID:36764158   PMID:36871756   PMID:36882059   PMID:37031230   PMID:37056311   PMID:37092429  
PMID:37117756   PMID:37141987   PMID:37162693   PMID:37215573   PMID:37349305   PMID:37365376   PMID:37621713   PMID:37643163   PMID:37657440   PMID:37769257   PMID:37951213   PMID:37951214  
PMID:38205198   PMID:38221535   PMID:38229522   PMID:38355793   PMID:38585660   PMID:38625943   PMID:38805270  


Genomics

Comparative Map Data
Per2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39191,343,699 - 91,387,028 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl191,343,704 - 91,387,046 (-)EnsemblGRCm39 Ensembl
GRCm38191,415,977 - 91,459,351 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl191,415,982 - 91,459,324 (-)EnsemblGRCm38mm10GRCm38
MGSCv37193,312,559 - 93,355,905 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36193,246,388 - 93,289,702 (-)NCBIMGSCv36mm8
Celera194,353,350 - 94,396,834 (-)NCBICelera
Cytogenetic Map1DNCBI
cM Map146.13NCBI
PER2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382238,244,044 - 238,300,065 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2238,244,044 - 238,290,102 (-)EnsemblGRCh38hg38GRCh38
GRCh372239,152,685 - 239,197,251 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362238,817,418 - 238,861,946 (-)NCBINCBI36Build 36hg18NCBI36
Build 342238,934,685 - 238,979,092NCBI
Celera2232,865,233 - 232,909,762 (-)NCBICelera
Cytogenetic Map2q37.3NCBI
HuRef2230,943,837 - 230,988,232 (-)NCBIHuRef
CHM1_12239,158,528 - 239,203,056 (-)NCBICHM1_1
T2T-CHM13v2.02238,733,782 - 238,779,869 (-)NCBIT2T-CHM13v2.0
Per2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8999,454,828 - 99,497,069 (-)NCBIGRCr8
mRatBN7.2992,007,289 - 92,049,551 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl992,007,296 - 92,049,459 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9100,434,053 - 100,476,216 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09105,569,813 - 105,611,980 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09103,933,398 - 103,975,592 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0998,555,154 - 98,597,362 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl998,555,169 - 98,597,359 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0998,231,202 - 98,273,371 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4990,645,342 - 90,687,509 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1990,850,110 - 90,892,278 (-)NCBI
Celera989,548,336 - 89,590,505 (-)NCBICelera
Cytogenetic Map9q36NCBI
Per2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555422,338,099 - 2,371,274 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555422,331,547 - 2,369,011 (+)NCBIChiLan1.0ChiLan1.0
PER2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213140,876,886 - 140,921,469 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B140,891,847 - 140,936,401 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B125,477,021 - 125,521,577 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B244,328,122 - 244,371,040 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B244,328,122 - 244,371,040 (-)Ensemblpanpan1.1panPan2
PER2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12548,716,499 - 48,761,617 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2548,717,173 - 48,758,755 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2549,211,912 - 49,257,033 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02549,102,140 - 49,147,315 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2549,102,151 - 49,143,375 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12548,977,242 - 49,022,398 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02548,765,877 - 48,806,293 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02548,998,242 - 49,043,270 (-)NCBIUU_Cfam_GSD_1.0
Per2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303190,676,406 - 190,718,243 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936525221,510 - 263,295 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936525221,601 - 263,284 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PER2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15137,793,422 - 137,837,070 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115137,793,419 - 137,837,854 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215152,264,819 - 152,284,153 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PER2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110124,270,917 - 124,316,031 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10124,269,543 - 124,315,904 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604075,104,175 - 75,149,164 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Per2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248473,361,170 - 3,390,405 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248473,359,174 - 3,399,584 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Per2
1288 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:775
Count of miRNA genes:470
Interacting mature miRNAs:559
Transcripts:ENSMUST00000069620
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
15039333Nmrs1_mNAFLD-associated magnetic resonance shift 1 (mouse)189786512123786512Mouse
1357847Jckm2_mjuvenile cystic kidney modifier 2 (mouse)Not determined174991977133290937Mouse
4142394Mssq1_mmandible size and shape QTL 1 (mouse)Not determined73615692107615830Mouse
1300821Lore1_mloss of righting induced by ethanol 1 (mouse)Not determined17554919192941077Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
1558928Mord2_mmodifier of retinal degeneration 2 (mouse)Not determined177123115110536075Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
14697706Stsl3a_mSalmonella typhimurium susceptibility locus 3a (mouse)17747663795827725Mouse
12790991Aath1_maortic arch atherosclerosis 1 (mouse)186483929120483929Mouse
1357721Sle17_msystematic lupus erythematosus susceptibility 17 (mouse)Not determined139132808126445310Mouse
10412238Alpq5_malcohol preference QTL 5 (mouse)Not determined182832635116832635Mouse
1302146Cocrb1_mcocaine related behavior 1 (mouse)Not determined170133533104139557Mouse
14746998Mancz1_mmandible centroid size 1 (mouse)15794135191941351Mouse
1301444Alcw5_malcohol withdrawal 5 (mouse)Not determined15854919192549443Mouse
1300746Skl1_mskeletal size (tail length) 1 (mouse)Not determined15799197791992080Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134760138150193871Mouse
12791004Aath7_maortic arch atherosclerosis 7 (mouse)182832635116832635Mouse
14747009Manh49_mmandible shape 49 (mouse)15794135191941351Mouse
4141725Wbcq4_mwhite blood cell quantitative locus 4 (mouse)Not determined179858683113858791Mouse
12050069Nabq1_mnasal bone morphology QTL 1 (mouse)179858683113858791Mouse
1300976Bmd19_mbone mineral density 19 (mouse)Not determined173266214108838414Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134760138150193871Mouse
4141914Gcsfis_mG-CSF induced splenomegaly (mouse)Not determined74516235148715579Mouse
27095928Pglq6_mpelvic girdle length QTL 6, 10 week (mouse)175976637148775742Mouse
27095931Pglq1_mpelvic girdle length QTL 1, 5 week (mouse)175976637128527737Mouse
13452395Leusq2_mleucocytosis susceptibility QTL 2 (mouse)180245593126386517Mouse
1301748Abbp1_mA/J and C57BL/6 blood pressure 1 (mouse)Not determined162946755120529678Mouse
1301304Hrq3_mheart rate quantitative locus 3 (mouse)Not determined173615692107615830Mouse
1357439Popoa_mpremature ovulation and primary oocyte arrest (mouse)Not determined182643189135615379Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52457737182250592Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134760138150193871Mouse
1300989Lrdg1_mlight induced retinal degeneration 1 (mouse)Not determined173755175147125370Mouse
4141329Mleu1_mmyeloid leukemia survival 1 (mouse)Not determined89786512123786512Mouse
1301667Lxw5_mlupus BXSB x NZW 5 (mouse)Not determined15854919192549443Mouse
11667074Led2_mlate embryonic death 2 (mouse)185696027117195081Mouse
27095918Ulnl1_mulna length 1, 5 week (mouse)167339159129727737Mouse
1301350Nidd4k_mNidd4 on KK-A (mouse)Not determined782291982147125370Mouse
1301162Skull1_mskull morphology 1 (mouse)Not determined15799197791992080Mouse
1300841Ssial1_msusceptibility to sialadenitis 1 (mouse)Not determined163920002153557562Mouse
26884448Sklq1_mskull length QTL 1, 5 week (mouse)175976637181327565Mouse
1357679Egrm1_mearly growth rate, maternal effect 1 (mouse)Not determined15799197791992080Mouse

Markers in Region
PMC124275P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38191,417,344 - 91,417,845UniSTSGRCm38
MGSCv37193,313,921 - 93,314,422UniSTSGRCm37
Celera194,354,712 - 94,355,213UniSTS
Cytogenetic Map1C5UniSTS
Per2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1C5UniSTS
cM Map146.13UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000069620   ⟹   ENSMUSP00000066620
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl191,343,704 - 91,387,046 (-)Ensembl
GRCm38.p6 Ensembl191,415,982 - 91,459,324 (-)Ensembl
Ensembl Acc Id: ENSMUST00000185298
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl191,375,444 - 91,377,587 (-)Ensembl
GRCm38.p6 Ensembl191,447,722 - 91,449,865 (-)Ensembl
RefSeq Acc Id: NM_001420881   ⟹   NP_001407810
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39191,343,704 - 91,387,028 (-)NCBI
RefSeq Acc Id: NM_011066   ⟹   NP_035196
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39191,343,704 - 91,387,028 (-)NCBI
GRCm38191,415,982 - 91,459,328 (-)NCBI
MGSCv37193,312,559 - 93,355,905 (-)RGD
Celera194,353,350 - 94,396,834 (-)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_185210
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39191,343,704 - 91,387,028 (-)NCBI
RefSeq Acc Id: XM_006529250   ⟹   XP_006529313
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39191,343,699 - 91,373,833 (-)NCBI
GRCm38191,415,977 - 91,446,017 (-)NCBI
Sequence:
RefSeq Acc Id: NP_035196   ⟸   NM_011066
- Peptide Label: isoform 1
- UniProtKB: A0A0R4J0U3 (UniProtKB/TrEMBL),   Q3TN36 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006529313   ⟸   XM_006529250
- Peptide Label: isoform X2
- UniProtKB: Q3TN36 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000066620   ⟸   ENSMUST00000069620
RefSeq Acc Id: NP_001407810   ⟸   NM_001420881
- Peptide Label: isoform 2
- UniProtKB: Q3TN36 (UniProtKB/TrEMBL)
Protein Domains
PAC   PAS   Period circadian-like C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O54943-F1-model_v2 AlphaFold O54943 1-1257 view protein structure

Promoters
RGD ID:6874488
Promoter ID:EPDNEW_M695
Type:initiation region
Name:Per2_1
Description:Mus musculus period circadian clock 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38191,459,306 - 91,459,366EPDNEW
RGD ID:6846632
Promoter ID:MM_ACW:1727
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Spleen
Transcripts:PER2.FSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36193,320,491 - 93,320,991 (-)MPROMDB
RGD ID:6818226
Promoter ID:MM_KWN:1632
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung,   Spleen
Transcripts:ENSMUST00000069620,   UC007CAW.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36193,355,631 - 93,356,131 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1195265 AgrOrtholog
Ensembl Genes ENSMUSG00000055866 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000069620 ENTREZGENE
  ENSMUST00000069620.10 UniProtKB/TrEMBL
Gene3D-CATH PAS domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro PAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS_fold_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Per1-3_PAS-A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Period_circadian-like_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Period_circadian_regulator UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18627 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1195265 ENTREZGENE
NCBI Gene 18627 ENTREZGENE
PANTHER PERIOD CIRCADIAN PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PERIOD CIRCADIAN PROTEIN HOMOLOG 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PAS_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Per3-like_PAS-A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Period_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Per2 PhenoGen
PROSITE PAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF55785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0R4J0U3 ENTREZGENE, UniProtKB/TrEMBL
  O54943 ENTREZGENE, UniProtKB/Swiss-Prot
  Q3TN36 ENTREZGENE, UniProtKB/TrEMBL
  Q3TW41_MOUSE UniProtKB/TrEMBL
  Q7TMG5_MOUSE UniProtKB/TrEMBL
  Q8C8R0_MOUSE UniProtKB/TrEMBL
UniProt Secondary O54954 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-01-08 Per2  period circadian clock 2    period homolog 2 (Drosophila)  Symbol and/or name change 5135510 APPROVED