Ptprn2 (protein tyrosine phosphatase receptor type N polypeptide 2) - Rat Genome Database

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Gene: Ptprn2 (protein tyrosine phosphatase receptor type N polypeptide 2) Mus musculus
Analyze
Symbol: Ptprn2
Name: protein tyrosine phosphatase receptor type N polypeptide 2
RGD ID: 62197
MGI Page MGI
Description: Predicted to enable histone H2AXY142 phosphatase activity; non-membrane spanning protein tyrosine phosphatase activity; and protein tyrosine phosphatase activity, metal-dependent. Involved in insulin secretion involved in cellular response to glucose stimulus and neurotransmitter secretion. Located in secretory granule membrane and synaptic vesicle membrane. Is expressed in several structures, including foregut-midgut junction; midgut endoderm; and nervous system. Used to study type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in prediabetes syndrome and type 1 diabetes mellitus. Orthologous to human PTPRN2 (protein tyrosine phosphatase receptor type N2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 4930425H11Rik; IA-2 beta; IA-2b; IA2beta; KIAA0387; mKIAA0387; ph; phogrin; phogrin-like; Phol; protein tyrosine phosphatase-NP; PT; PTP IA-2beta; PTP-NP; R-PTP-N2; receptor-type tyrosine-protein phosphatase N2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912116,449,316 - 117,241,787 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12116,449,340 - 117,240,469 (+)EnsemblGRCm39 Ensembl
GRCm3812116,485,695 - 117,278,167 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12116,485,720 - 117,276,849 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712117,724,193 - 118,516,640 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612110,685,719 - 111,477,358 (+)NCBIMGSCv36mm8
MGSCv3612116,927,842 - 117,718,802 (+)NCBIMGSCv36mm8
Cytogenetic Map12F2NCBI
cM Map1262.65NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
cefaloridine  (ISO)
cisplatin  (ISO)
crocidolite asbestos  (ISO)
DDE  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dorsomorphin  (ISO)
ellagic acid  (ISO)
ethanol  (EXP)
ethyl methanesulfonate  (ISO)
ethylparaben  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
gentamycin  (ISO)
iron dichloride  (ISO)
lead(0)  (ISO)
methapyrilene  (ISO)
methimazole  (ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
PCB138  (EXP)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
thapsigargin  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Autoantibodies to IA-2beta improve diabetes risk assessment in high-risk relatives. Achenbach P, etal., Diabetologia. 2008 Mar;51(3):488-92. Epub 2008 Jan 9.
2. Spontaneous peripheral T-cell responses to the IA-2beta (phogrin) autoantigen in young nonobese diabetic mice. Achenbach P, etal., J Autoimmun. 2002 Nov;19(3):111-6.
3. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
4. HLA-DQ8-associated T cell responses to the diabetes autoantigen phogrin (IA-2 beta) in human prediabetes. Kelemen K, etal., J Immunol. 2004 Mar 15;172(6):3955-62.
5. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
6. MGDs mouse GO annotations MGD data from the GO Consortium
7. MGD IEA MGD IEA
8. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. Mouse MP Annotation Import Pipeline RGD automated import pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8637868   PMID:8663434   PMID:8681804   PMID:8878534   PMID:8954911   PMID:9341252   PMID:9383296   PMID:9858807   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11206415  
PMID:11387227   PMID:12364328   PMID:12477932   PMID:12636919   PMID:14610273   PMID:15220191   PMID:15485654   PMID:15788565   PMID:15882444   PMID:16141072   PMID:16141073   PMID:16269463  
PMID:16306340   PMID:16418280   PMID:18310453   PMID:19019914   PMID:19073770   PMID:19361477   PMID:19433624   PMID:21267068   PMID:21732083   PMID:21873635   PMID:22372950   PMID:22785238  
PMID:23016632   PMID:23382219   PMID:23595248   PMID:24662847   PMID:25861885   PMID:26141787   PMID:26148972   PMID:28671696   PMID:29483197   PMID:32325033   PMID:32581705   PMID:34474245  
PMID:36611058   PMID:38150052  


Genomics

Comparative Map Data
Ptprn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912116,449,316 - 117,241,787 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12116,449,340 - 117,240,469 (+)EnsemblGRCm39 Ensembl
GRCm3812116,485,695 - 117,278,167 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12116,485,720 - 117,276,849 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712117,724,193 - 118,516,640 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612110,685,719 - 111,477,358 (+)NCBIMGSCv36mm8
MGSCv3612116,927,842 - 117,718,802 (+)NCBIMGSCv36mm8
Cytogenetic Map12F2NCBI
cM Map1262.65NCBI
PTPRN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387157,539,056 - 158,587,823 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7157,539,056 - 158,587,823 (-)EnsemblGRCh38hg38GRCh38
GRCh377157,331,750 - 158,380,515 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367157,024,516 - 158,073,179 (-)NCBINCBI36Build 36hg18NCBI36
Build 347156,831,230 - 157,879,894NCBI
Celera7151,758,421 - 152,708,128 (-)NCBICelera
Cytogenetic Map7q36.3NCBI
HuRef7151,062,797 - 152,022,430 (-)NCBIHuRef
CHM1_17157,340,603 - 158,388,873 (-)NCBICHM1_1
T2T-CHM13v2.07158,727,687 - 159,797,184 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27156,563,177 - 157,584,848 (-)NCBI
Ptprn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86143,582,568 - 144,334,573 (+)NCBIGRCr8
mRatBN7.26137,439,572 - 138,191,575 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6137,439,540 - 138,191,575 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6140,874,866 - 141,626,022 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06137,499,335 - 138,243,617 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06138,047,241 - 138,799,129 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06144,384,773 - 145,133,042 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6144,384,773 - 145,133,042 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06153,312,968 - 154,056,676 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46143,787,884 - 144,549,042 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16143,794,070 - 144,555,221 (+)NCBI
Celera6135,102,182 - 135,845,915 (+)NCBICelera
Cytogenetic Map6q33NCBI
Ptprn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955579364,748 - 833,729 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955579366,441 - 862,837 (-)NCBIChiLan1.0ChiLan1.0
PTPRN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26193,988,298 - 195,067,961 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1745,998,563 - 47,078,226 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07149,158,513 - 150,390,077 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17160,850,042 - 161,756,328 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7160,851,703 - 161,756,325 (-)Ensemblpanpan1.1panPan2
PTPRN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11619,904,468 - 20,562,585 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1619,905,473 - 20,602,680 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1620,472,150 - 21,134,670 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01621,636,514 - 22,361,137 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11620,003,354 - 20,728,392 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01620,586,565 - 21,312,677 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01620,639,115 - 21,366,802 (-)NCBIUU_Cfam_GSD_1.0
Ptprn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118752,917 - 1,422,817 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493679755,217 - 151,201 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTPRN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl18721,131 - 1,389,607 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.118721,125 - 1,389,609 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2181,081,388 - 1,085,384 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTPRN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121125,655,787 - 126,622,503 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607221,894,122 - 23,016,772 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptprn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624800648,264 - 1,117,312 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624800501,884 - 1,116,795 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ptprn2
28806 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:505
Count of miRNA genes:357
Interacting mature miRNAs:408
Transcripts:ENSMUST00000070733
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300883Ath21_matherosclerosis 21 (mouse)Not determined1285961579119961683Mouse
12910532Nrq10a_mnoise-induced hearing loss resistant QTL 10a (mouse)1292750025120092757Mouse
12910533Nrq10_mnoise-induced hearing loss resistant QTL 10 (mouse)1292750025120092757Mouse
1357463Vtbt14_mvertebral trabecular bone trait 14 (mouse)Not determined1292936097120092757Mouse
1301269Sluc12_msusceptibility to lung cancer 12 (mouse)Not determined1296860337120092757Mouse
4142007Chlq17_mcirculating hormone level QTL 17 (mouse)Not determined1288052874120092757Mouse
15092086Igly3_mIgG glycosylation 3, GP16 (mouse)12114429496117830647Mouse
15092087Igly4_mIgG glycosylation 4, GP17a (mouse)12114429496118423781Mouse
1300545Lifespan3_mlife span 3 (mouse)Not determined1288052874120092757Mouse
15092084Igly1_mIgG glycosylation 1, GP1 (mouse)12114429496117830647Mouse
15092085Igly2_mIgG glycosylation 2, GP14 (mouse)12111737297119992757Mouse
15092083Igly5_mIgG glycosylation 5, GP20 (mouse)12113373605117830647Mouse
1301836Heal5_mwound healing/regeneration 5 (mouse)Not determined1289939031120092757Mouse
13524846Ppiq11_mprepulse inhibition QTL 11 (mouse)1282666396116666396Mouse
1301879Insq10_minsulin QTL 10 (mouse)Not determined1283532075117532224Mouse
10402491Dipa4_mdrug induced psychomotor activation 4 (mouse)Not determined1291222515120092757Mouse
1301492Dbsty3_mdiabesity 3 (mouse)Not determined1283532075117532224Mouse
5491194Mobq3_mmultigenic obesity QTL 3 (mouse)Not determined1289664071120092757Mouse
1302138Im6_mimmunoregulatory 6 (mouse)Not determined1296860337120092757Mouse
1301308Prdt4_mprion disease incubation time 4 (mouse)Not determined1288308354120092757Mouse
1301922Bbaa6_mB.burgdorferi-associated arthritis 6 (mouse)Not determined1290308268120092757Mouse
1302177Dps2_mdelta power in slow-wave sleep 2 (mouse)Not determined1294146064120092757Mouse
10412075Nils1_mneointima lesion size 1 (mouse)Not determined12102024665120092757Mouse
1558957Igan4_mIgA nephropathy 4 (mouse)Not determined12109750025119024949Mouse
1300973Abmm_mantibody mediated myocarditis (mouse)Not determined1293264461120092757Mouse

Markers in Region
G20053  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3812116,823,575 - 116,823,699UniSTSGRCm38
MGSCv3712118,062,048 - 118,062,172UniSTSGRCm37
Cytogenetic Map12FUniSTS
cM Map1260.0UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_011215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011244019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC159625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC159645 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC159648 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC160634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC161242 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC164641 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC169503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AEKQ02180644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF357439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ583055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK015197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK030534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK081267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK083776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK138655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK220255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC048570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC133678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BN000293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BN000294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BN000295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BN000296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BN000297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BN000298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BN000299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BN000300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BN000301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BN000302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BN000303 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BN000304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BN000305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BN000306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BN000307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BN000308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BN000309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BN000310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BN000311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BN000312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BN000313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BN000314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BN000315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U57345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U82439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000070733   ⟹   ENSMUSP00000064046
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12116,449,453 - 117,240,413 (+)Ensembl
GRCm38.p6 Ensembl12116,485,833 - 117,276,793 (+)Ensembl
Ensembl Acc Id: ENSMUST00000185505
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12116,449,340 - 116,736,950 (+)Ensembl
GRCm38.p6 Ensembl12116,485,720 - 116,773,330 (+)Ensembl
Ensembl Acc Id: ENSMUST00000189009
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12116,449,349 - 117,087,087 (+)Ensembl
GRCm38.p6 Ensembl12116,485,729 - 117,123,467 (+)Ensembl
Ensembl Acc Id: ENSMUST00000190247   ⟹   ENSMUSP00000139978
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12116,449,349 - 117,240,469 (+)Ensembl
GRCm38.p6 Ensembl12116,485,729 - 117,276,849 (+)Ensembl
Ensembl Acc Id: ENSMUST00000191106
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12116,449,390 - 116,808,609 (+)Ensembl
GRCm38.p6 Ensembl12116,485,770 - 116,844,989 (+)Ensembl
RefSeq Acc Id: NM_011215   ⟹   NP_035345
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912116,449,340 - 117,241,787 (+)NCBI
GRCm3812116,485,720 - 117,278,167 (+)NCBI
MGSCv3712117,724,193 - 118,516,640 (+)RGD
cM Map12 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011244019   ⟹   XP_011242321
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912116,449,316 - 117,241,121 (+)NCBI
GRCm3812116,485,695 - 117,277,501 (+)NCBI
Sequence:
RefSeq Acc Id: NP_035345   ⟸   NM_011215
- Peptide Label: precursor
- UniProtKB: P70328 (UniProtKB/Swiss-Prot),   O09134 (UniProtKB/Swiss-Prot),   Q1RLJ1 (UniProtKB/Swiss-Prot),   P80560 (UniProtKB/Swiss-Prot),   A3KN68 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011242321   ⟸   XM_011244019
- Peptide Label: isoform X1
- UniProtKB: A3KN68 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000064046   ⟸   ENSMUST00000070733
Ensembl Acc Id: ENSMUSP00000139978   ⟸   ENSMUST00000190247
Protein Domains
Protein-tyrosine phosphatase receptor IA-2   Tyrosine specific protein phosphatases   Tyrosine-protein phosphatase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P80560-F1-model_v2 AlphaFold P80560 1-1001 view protein structure

Promoters
RGD ID:8679466
Promoter ID:EPDNEW_M17763
Type:initiation region
Name:Ptprn2_1
Description:Mus musculus protein tyrosine phosphatase, receptor type, N polypeptide2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3812116,485,756 - 116,485,816EPDNEW
RGD ID:6823190
Promoter ID:MM_KWN:13084
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:NM_011215,   UC007PHV.1,   UC007PHW.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3612117,724,026 - 117,724,526 (+)MPROMDB
RGD ID:6847001
Promoter ID:MM_ACW:12278
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:PTPRN2.ESEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3612118,392,381 - 118,392,881 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:107418 AgrOrtholog
Ensembl Genes ENSMUSG00000056553 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000070733 ENTREZGENE
  ENSMUST00000070733.9 UniProtKB/Swiss-Prot
  ENSMUST00000190247.7 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.2470 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.190.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro IA-2/IA-2_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPase_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Receptor_IA-2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Receptor_IA-2_ectodomain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:19276 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:107418 ENTREZGENE
NCBI Gene 19276 ENTREZGENE
PANTHER PTHR46106 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE N2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Receptor_IA-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Y_phosphatase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ptprn2 PhenoGen
PRINTS PRTYPHPHTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TYR_PHOSPHATASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_PTP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PTPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPc_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RESP18 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52799 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A3KN68 ENTREZGENE, UniProtKB/TrEMBL
  O09134 ENTREZGENE
  P70328 ENTREZGENE
  P80560 ENTREZGENE, UniProtKB/Swiss-Prot
  Q1RLJ1 ENTREZGENE
  Q3UU93_MOUSE UniProtKB/TrEMBL
  Q571D4_MOUSE UniProtKB/TrEMBL
  Q70FG5_MOUSE UniProtKB/TrEMBL
  Q8C8Z6_MOUSE UniProtKB/TrEMBL
UniProt Secondary O09134 UniProtKB/Swiss-Prot
  P70328 UniProtKB/Swiss-Prot
  Q1RLJ1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-05-09 Ptprn2  protein tyrosine phosphatase receptor type N polypeptide 2  Ptprn2  protein tyrosine phosphatase, receptor type, N polypeptide 2  Symbol and/or name change 5135510 APPROVED