Ptafr (platelet-activating factor receptor) - Rat Genome Database

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Gene: Ptafr (platelet-activating factor receptor) Mus musculus
Analyze
Symbol: Ptafr
Name: platelet-activating factor receptor
RGD ID: 62190
MGI Page MGI
Description: Enables lipopolysaccharide binding activity and lipopolysaccharide immune receptor activity. Acts upstream of or within inflammatory response; inositol trisphosphate biosynthetic process; and response to lipopolysaccharide. Predicted to be located in plasma membrane. Is expressed in blood; early conceptus; and liver. Orthologous to human PTAFR (platelet activating factor receptor).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: P; PAF receptor; PAF-R; PAFR
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394132,291,378 - 132,309,994 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4132,291,378 - 132,309,994 (+)EnsemblGRCm39 Ensembl
GRCm384132,564,067 - 132,582,683 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4132,564,067 - 132,582,683 (+)EnsemblGRCm38mm10GRCm38
MGSCv374132,119,982 - 132,136,781 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364131,836,143 - 131,852,942 (+)NCBIMGSCv36mm8
Celera4130,724,940 - 130,741,731 (+)NCBICelera
Cytogenetic Map4D2.3NCBI
cM Map465.56NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1-naphthyl isothiocyanate  (ISO)
1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
2-naphthylamine  (ISO)
acetamide  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
albuterol  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (EXP,ISO)
alpha-pinene  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
antirheumatic drug  (ISO)
Apafant  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
asbestos  (ISO)
avobenzone  (ISO)
Azoxymethane  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (ISO)
bleomycin A2  (EXP)
cadmium atom  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
camptothecin  (ISO)
cannabidiol  (EXP)
carbon nanotube  (EXP)
carvedilol  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (EXP)
cisplatin  (ISO)
Cuprizon  (ISO)
D-glucose  (EXP)
dexamethasone  (ISO)
dextran sulfate  (EXP)
dichlorine  (ISO)
elemental selenium  (ISO)
ethanol  (EXP)
ethyl methanesulfonate  (ISO)
fenvalerate  (ISO)
flavonoids  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
fructose  (EXP)
gentamycin  (ISO)
ginsenoside Re  (EXP)
glucose  (EXP)
glyphosate  (EXP)
indometacin  (ISO)
ivermectin  (ISO)
L-arginine  (ISO)
L-methionine  (EXP)
lipopolysaccharide  (ISO)
lipoxin A4  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
monosodium L-glutamate  (EXP)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (ISO)
N-nitrosodimethylamine  (ISO)
nickel atom  (ISO)
nicotine  (ISO)
Nutlin-3  (ISO)
o-anisidine  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
potassium chromate  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
selenium atom  (ISO)
sevoflurane  (EXP)
silicon dioxide  (EXP,ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
triphenyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
vincristine  (ISO)
zileuton  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine  (IEA,ISO)
cellular response to cAMP  (IEA,ISO)
cellular response to fatty acid  (IEA,ISO)
cellular response to gravity  (IEA,ISO)
chemotaxis  (IEA)
G protein-coupled receptor signaling pathway  (IBA,ISO)
inflammatory response  (IMP)
inositol trisphosphate biosynthetic process  (IMP)
lipopolysaccharide-mediated signaling pathway  (IEA)
negative regulation of blood pressure  (IEA,ISO)
parturition  (IEA,ISO)
phospholipase C-activating G protein-coupled receptor signaling pathway  (IEA,ISO)
positive regulation of cellular extravasation  (IEA,ISO)
positive regulation of gastro-intestinal system smooth muscle contraction  (IEA,ISO)
positive regulation of inositol phosphate biosynthetic process  (IEA,ISO)
positive regulation of interleukin-6 production  (IEA,ISO)
positive regulation of leukocyte cell-cell adhesion  (ISO)
positive regulation of leukocyte tethering or rolling  (IEA,ISO)
positive regulation of maternal process involved in parturition  (IEA,ISO)
positive regulation of neutrophil degranulation  (IEA,ISO)
positive regulation of smooth muscle cell proliferation  (IEA,ISO)
positive regulation of smooth muscle contraction  (ISO)
positive regulation of transcytosis  (IEA,ISO)
positive regulation of translation  (IEA,ISO)
positive regulation of tumor necrosis factor production  (IEA,ISO)
positive regulation of voltage-gated chloride channel activity  (ISO)
regulation of transcription by RNA polymerase II  (IEA,ISO)
response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine  (ISO)
response to dexamethasone  (IEA,ISO)
response to lipopolysaccharide  (IMP,ISO)
response to organophosphorus  (ISO)
response to symbiotic bacterium  (IEA,ISO)
transcytosis  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Platelet-activating factor in vasoobliteration of oxygen-induced retinopathy. Beauchamp MH, etal., Invest Ophthalmol Vis Sci. 2002 Oct;43(10):3327-37.
2. Scorpion venom-induced neutrophilia is inhibited by a PAF receptor antagonist in the rat. Borges CM, etal., J Leukoc Biol. 2000 Apr;67(4):515-9.
3. Platelet-activating factor (PAF) mediation of rat anaphylactic responses to soluble immune complexes. Studies with PAF receptor antagonist L-652,731. Doebber TW, etal., J Immunol. 1986 Jun 15;136(12):4659-68.
4. Platelet activating factor receptor antagonist improves survival and attenuates eicosanoid release in severe endotoxemia. Fletcher JR, etal., Ann Surg. 1990 Mar;211(3):312-6.
5. Mechanisms of glomerular injury in experimental immune nephritis. II. Effect of a platelet activating factor receptor antagonist in an autologous nephritis model. Hruby ZW, etal., Arch Immunol Ther Exp (Warsz). 1991;39(5-6):575-86.
6. Mechanism and dose-effect of Ginkgolide B on severe acute pancreatitis of rats. Ji RL, etal., World J Gastroenterol. 2011 May 7;17(17):2241-7. doi: 10.3748/wjg.v17.i17.2241.
7. Beneficial actions of BN 50739, a new PAF receptor antagonist, in murine traumatic shock. Karasawa A, etal., Methods Find Exp Clin Pharmacol. 1990 May;12(4):231-7.
8. Antiinflammatory and antiallodynic actions of the lignan niranthin isolated from Phyllanthus amarus. Evidence for interaction with platelet activating factor receptor. Kassuya CA, etal., Eur J Pharmacol. 2006 Sep 28;546(1-3):182-8. Epub 2006 Jul 22.
9. Polyunsaturated fatty acid supplementation alters proinflammatory gene expression and reduces the incidence of necrotizing enterocolitis in a neonatal rat model. Lu J, etal., Pediatr Res. 2007 Apr;61(4):427-32.
10. Interference of the PAF receptor antagonist, PCA 4248, with the rat pleurisy evoked by inflammatory mediators or allergen. Martins MA, etal., Eur J Pharmacol. 1993 Jun 11;237(1):17-22.
11. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
12. MGDs mouse GO annotations MGD data from the GO Consortium
13. MGD IEA MGD IEA
14. Role of PAF in acute liver injury after extended hepatectomy: overexpression of PAF receptor mRNA in Kupffer cells. Mizuno S, etal., Dig Dis Sci. 2001 Jun;46(6):1299-304.
15. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
16. Up-regulation of platelet-activating factor synthases and its receptor in spinal cord contribute to development of neuropathic pain following peripheral nerve injury. Okubo M, etal., Mol Pain. 2012 Feb 2;8:8. doi: 10.1186/1744-8069-8-8.
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. Mouse MP Annotation Import Pipeline RGD automated import pipeline
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Effects of the PAF receptor antagonist UK74505 on local and remote reperfusion injuries following ischaemia of the superior mesenteric artery in the rat. Souza DG, etal., Br J Pharmacol. 2000 Dec;131(8):1800-8.
21. Role of PAF receptors during intestinal ischemia and reperfusion injury. A comparative study between PAF receptor-deficient mice and PAF receptor antagonist treatment. Souza DG, etal., Br J Pharmacol. 2003 Jun;139(4):733-40.
22. Effect of the platelet-activating factor antagonist BN 50739 and its diluents on mitochondrial respiration and membrane lipids during and following cerebral ischemia. Sun D and Gilboe DD, J Neurochem. 1994 May;62(5):1929-38.
23. Role of platelet activating factor in endotoxemic acute renal failure in the male rat. Tolins JP, etal., J Lab Clin Med. 1989 Mar;113(3):316-24.
24. Protective effects of a PAF receptor antagonist and a neutrophil elastase inhibitor on multiple organ failure induced by cerulein plus lipopolysaccharide in rats. Yamano M, etal., Naunyn Schmiedebergs Arch Pharmacol. 1998 Aug;358(2):253-63.
25. Down-regulation of platelet-activating factor receptor gene expression during focal reversible cerebral ischemia in rats. Zhang X, etal., Neurochem Res. 2007 Mar;32(3):451-6.
26. Direct action of platelet activating factor (PAF) induces eosinophil accumulation and enhances expression of PAF receptors in conjunctivitis. Zinchuk O, etal., Mol Vis. 2005 Feb 9;11:114-23.
Additional References at PubMed
PMID:8670084   PMID:9009274   PMID:9013981   PMID:9282993   PMID:9607919   PMID:10026115   PMID:10103126   PMID:10349636   PMID:10525045   PMID:10729607   PMID:11042159   PMID:11076861  
PMID:11152738   PMID:11217851   PMID:11350972   PMID:11673526   PMID:11786559   PMID:11805144   PMID:11958508   PMID:11984592   PMID:12107726   PMID:12477932   PMID:12850205   PMID:12911752  
PMID:14610273   PMID:14742561   PMID:14767826   PMID:15020683   PMID:15030403   PMID:15087283   PMID:15153532   PMID:15232615   PMID:15234672   PMID:15485633   PMID:15545826   PMID:15791001  
PMID:16100290   PMID:16115894   PMID:16141072   PMID:16141073   PMID:16172262   PMID:16184199   PMID:16299272   PMID:16365452   PMID:16369019   PMID:16602821   PMID:16651609   PMID:16818786  
PMID:16982922   PMID:17056547   PMID:17230418   PMID:17662046   PMID:17852951   PMID:17928889   PMID:18200048   PMID:18292528   PMID:18292561   PMID:18292574   PMID:18441203   PMID:18483284  
PMID:18550892   PMID:18580961   PMID:19234179   PMID:19666557   PMID:20032301   PMID:20421642   PMID:20454616   PMID:20465821   PMID:21079759   PMID:21109237   PMID:21183738   PMID:21248291  
PMID:21267068   PMID:21338585   PMID:21677750   PMID:21873635   PMID:22079430   PMID:22131343   PMID:22223848   PMID:22301794   PMID:22542595   PMID:22570511   PMID:22577252   PMID:23260771  
PMID:23355733   PMID:23708969   PMID:23743065   PMID:23964117   PMID:24002061   PMID:24009177   PMID:24086643   PMID:24100020   PMID:24120121   PMID:24339378   PMID:24347838   PMID:24492283  
PMID:24612488   PMID:24841255   PMID:25050596   PMID:25304264   PMID:25375862   PMID:25577975   PMID:26003521   PMID:26013469   PMID:26084439   PMID:26785675   PMID:26962947   PMID:27098179  
PMID:27554194   PMID:28094295   PMID:28667161   PMID:29278700   PMID:29354667   PMID:29445756   PMID:29695417   PMID:29857067   PMID:30970255   PMID:30976089   PMID:31558613   PMID:32140075  
PMID:32206714   PMID:32434939   PMID:32661728   PMID:34493775   PMID:38355793   PMID:38572071   PMID:38715939   PMID:39332666  


Genomics

Comparative Map Data
Ptafr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394132,291,378 - 132,309,994 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4132,291,378 - 132,309,994 (+)EnsemblGRCm39 Ensembl
GRCm384132,564,067 - 132,582,683 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4132,564,067 - 132,582,683 (+)EnsemblGRCm38mm10GRCm38
MGSCv374132,119,982 - 132,136,781 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364131,836,143 - 131,852,942 (+)NCBIMGSCv36mm8
Celera4130,724,940 - 130,741,731 (+)NCBICelera
Cytogenetic Map4D2.3NCBI
cM Map465.56NCBI
PTAFR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38128,147,166 - 28,193,856 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl128,147,166 - 28,193,936 (-)EnsemblGRCh38hg38GRCh38
GRCh37128,473,677 - 28,520,367 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36128,348,425 - 28,375,778 (-)NCBINCBI36Build 36hg18NCBI36
Build 34128,160,005 - 28,187,333NCBI
Celera126,869,321 - 26,916,090 (-)NCBICelera
Cytogenetic Map1p35.3NCBI
HuRef126,730,992 - 26,777,615 (-)NCBIHuRef
CHM1_1128,589,192 - 28,635,951 (-)NCBICHM1_1
T2T-CHM13v2.0127,988,997 - 28,035,686 (-)NCBIT2T-CHM13v2.0
Ptafr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85150,049,322 - 150,079,060 (+)NCBIGRCr8
mRatBN7.25144,765,770 - 144,795,057 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5144,765,976 - 144,795,251 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5147,473,683 - 147,495,127 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05149,243,260 - 149,264,707 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05149,231,360 - 149,253,019 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05150,746,284 - 150,775,675 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5150,754,021 - 150,775,672 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05154,414,542 - 154,443,798 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45152,565,687 - 152,587,342 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15152,575,728 - 152,597,381 (-)NCBI
Celera5143,199,712 - 143,221,168 (+)NCBICelera
Cytogenetic Map5q36NCBI
Ptafr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554527,311,901 - 7,312,929 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554527,309,854 - 7,345,579 (-)NCBIChiLan1.0ChiLan1.0
PTAFR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21198,678,044 - 198,707,889 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11197,792,619 - 197,829,135 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0127,405,880 - 27,436,184 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1128,447,178 - 28,474,623 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl128,447,833 - 28,448,861 (-)Ensemblpanpan1.1panPan2
PTAFR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1272,225,386 - 72,256,353 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl272,225,386 - 72,256,352 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha268,803,234 - 68,834,141 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0272,785,522 - 72,816,261 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl272,785,522 - 72,816,261 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1269,612,919 - 69,643,905 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0270,622,939 - 70,654,206 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0271,619,611 - 71,650,615 (+)NCBIUU_Cfam_GSD_1.0
Ptafr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505846,509,123 - 46,540,460 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647412,336,071 - 12,337,099 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647412,333,905 - 12,337,140 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTAFR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl685,235,394 - 85,261,760 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1685,235,390 - 85,272,360 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2684,789,514 - 84,851,193 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PTAFR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120104,627,591 - 104,658,840 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20104,657,179 - 104,658,207 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603311,819,318 - 11,850,460 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptafr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476411,998,657 - 11,999,685 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476411,996,454 - 12,025,751 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ptafr
1234 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1000
Count of miRNA genes:543
Interacting mature miRNAs:664
Transcripts:ENSMUST00000070690
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142139Adip12_madiposity 12 (mouse)Not determined4124621281156860686Mouse
25394567Skmw55_mskeletal muscle weight 55, gastroc (mouse)4131437804133710576Mouse
10047132Albq19_malbuminuria QTL 19 (mouse)Not determined4112824389146824389Mouse
1301525Lmb1_mlupus in MRL and B6 F2 cross (mouse)Not determined4124264957150676858Mouse
14746982Manh56_mmandible shape 56 (mouse)4117815917151815917Mouse
4141623W6q13_mweight 6 weeks QTL 13 (mouse)Not determined88982069140468203Mouse
12910797Pwgrq4_mpre-weaning growth rate QTL 4 (mouse)4105835310141433838Mouse
14696808Rbcn1_mrod bipolar cell number 1 (mouse)4131947311134047311Mouse
25314312Syncl2_msynaptonemal complex length 2 (mouse)465718237146584457Mouse
25394568Skmw56_mskeletal muscle weight 56, EDL (mouse)4129859344133710576Mouse
12904009Cfq9_mconditioned fear QTL 9 (mouse)4130036287133772722Mouse
12910794Pwbwq8_mpost-weaning body weight QTL 8 (mouse)4105835310141433838Mouse
1300743Skull6_mskull morphology 6 (mouse)Not determined4111009051145009280Mouse
1301382Arvm2_mautoimmune renal vasculitis 2 (mouse)Not determined4107791564141791756Mouse
1302149Tlsr2_mthymic lymphoma suppressor region 2 (mouse)Not determined4124264957142230960Mouse
12910813Pwbwq4_mpre-weaning body weight QTL 4 (mouse)4105835310141433838Mouse
4141093W3q17_mweight 3 weeks QTL 17 (mouse)Not determined88982069140468203Mouse
27226757Femd1_mfemur midshaft diameter 1, 5 week (mouse)4123993793144326570Mouse
12910808Pwbwq9_mpost-weaning body weight QTL 9 (mouse)4105835310141433838Mouse
1300621Tpnr1_mthermal pain response 1 (mouse)Not determined4125230872156860686Mouse
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
4142493Femwf13_mfemur work to failure 13 (mouse)Not determined116154678150154782Mouse
1301815Sles2_msystemic lupus erythmatosus suppressor 2 (mouse)Not determined494957579150676858Mouse
1300663Start2_mstartle response 2 (mouse)Not determined4107264957141265153Mouse
1300917Gasa1_mgastritis type A susceptibility locus 1 (mouse)Not determined4124055093142438020Mouse
1301823Bmd7_mbone mineral density 7 (mouse)Not determined488982069151654550Mouse
10412210Cypr6_mcytokine production 6 (mouse)Not determined4120617848154617995Mouse
1302078Sluc21_msusceptibility to lung cancer 21 (mouse)Not determined4117401141151401275Mouse
10045620Heal22_mwound healing/regeneration 22 (mouse)Not determined4125230872156860686Mouse
4142481Gct1_mgranulosa cell tumorigenesis 1 (mouse)Not determined4127784226156860686Mouse
1301793Tlsr3_mthymic lymphoma suppressor region 3 (mouse)Not determined4129465811136864536Mouse
10412072Ssen1_msuseptibility to Sendai virus 1 (mouse)Not determined4109658132133154782Mouse
4141065Shali2_msurvival time to hyperoxic acute lung injury 2 (mouse)Not determined124055093141572792Mouse
13503348Bntq18_mbone traits QTL 18 (mouse)4120617848154617995Mouse
13208562Wght7_mweight 7 (mouse)490888237148084457Mouse
1300781Lith8_mlithogenic gene 8 (mouse)Not determined4107264957141265153Mouse
39128212Lwq21_mliver weight QTL 21 (mouse)488982069140468203Mouse
4141180Ssic1_msusceptibility to small intestinal cancer 1 (mouse)Not determined120674005154674151Mouse
1301584Lrdg2_mlight induced retinal degeneration 2 (mouse)Not determined4129465811151654550Mouse
1301847Fecq2_mfecundity QTL 2 (mouse)Not determined4100071971134072206Mouse
1302102Bis1_mbeta-carboline-induced seizures 1 (mouse)Not determined4119864433153864536Mouse
10043996Gct5_mgranulosa cell tumorigenesis 5 (mouse)Not determined4127784226156860686Mouse
26884445Sklq7_mskull length QTL 7, 10 week (mouse)468018237150884457Mouse
10043985Stheal12_msoft tissue heal 12 (mouse)Not determined4121342649155342753Mouse
1301982Pltiq1_mphospholipid transfer protein inducibility QTL 1 (mouse)Not determined4124621281156860686Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155684457Mouse
1300803Sluc6_msusceptibility to lung cancer 6 (mouse)Not determined4120674005154674151Mouse
4141549W10q10_mweight 10 weeks QTL 10 (mouse)Not determined88982069140468203Mouse
4142061Chlq16_mcirculating hormone level QTL 16 (mouse)Not determined4121342649155342753Mouse
1357895Ctrcts_mcataract severity (mouse)Not determined445709925138342753Mouse
1300933Cdcs9_mcytokine deficiency colitis susceptibility 9 (mouse)Not determined4125230872156860686Mouse
1300809Ccrs2_mcorpus callosum hemisphere surface size 2 (mouse)Not determined4107264957141265153Mouse
4141154Nba1_mNew Zealand Black autoimmunity 1 (mouse)Not determined131650724140879275Mouse
1301964Bw8q2_mbody weight at 8 weeks QTL 2 (mouse)Not determined4119864433153864536Mouse
1301452Elsgp1_melevated serum gp70 1 (mouse)Not determined4121342649155342753Mouse
1301106Skts7_mskin tumor susceptibility 7 (mouse)Not determined4100071971134072206Mouse
10755520Rbc1_mred blood cell count 1 (mouse)4108477692142477692Mouse
10755521Hct1_mhematocrit 1 (mouse)4108477692142477692Mouse
10755522Hgb1_mhemoglobin 1 (mouse)4108477692142477692Mouse
1300858Tafat_mtally ho associated mesenteric fat pad weight (mouse)Not determined4124621281156860686Mouse
10755531Lymph3_mlymphocyte differential 3 (mouse)4124553483156860686Mouse
15039382Ltgq7_mliver triglyceride QTL 7 (mouse)4105705794139705794Mouse
11533916Mts1_mmammary tumor susceptibility 1 (mouse)4125289325156860686Mouse
15039377Bw45_mbody weight QTL 45 (mouse)4105705794139705794Mouse
1300839Dyscalc2_mdystrophic cardiac calcinosis 2 (mouse)Not determined4111009051145009280Mouse
12880433Fgf23lq1_mFGF23 serum level QTL 1 (mouse)4101157197135157197Mouse
4141001Tgq17_mtriglyceride QTL 17 (mouse)Not determined112523489146523489Mouse
15039378Adip30_madiposity 30 (mouse)4105705794139705794Mouse
1357800Tgq3_mtriglyceride QTL 3 (mouse)Not determined4107055093141055180Mouse
15039385Mvlq3_mmacrovesicular liver lesion QTL 3 (mouse)4112182386146182386Mouse

Markers in Region
Ptafr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384132,579,793 - 132,580,027UniSTSGRCm38
MGSCv374132,135,708 - 132,135,942UniSTSGRCm37
Celera4130,740,657 - 130,740,891UniSTS
Cytogenetic Map4D2.2UniSTS
cM Map462.4UniSTS
Ptafr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384132,579,585 - 132,580,119UniSTSGRCm38
MGSCv374132,135,500 - 132,136,034UniSTSGRCm37
Celera4130,740,449 - 130,740,983UniSTS
Cytogenetic Map4D2.2UniSTS
cM Map462.4UniSTS
UniSTS:484979  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384132,579,281 - 132,580,658UniSTSGRCm38
MGSCv374132,135,196 - 132,136,573UniSTSGRCm37
Celera4130,740,145 - 130,741,523UniSTS
Cytogenetic Map4D2.2UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000070690   ⟹   ENSMUSP00000070925
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4132,291,378 - 132,309,994 (+)Ensembl
GRCm38.p6 Ensembl4132,564,067 - 132,582,683 (+)Ensembl
RefSeq Acc Id: NM_001081211   ⟹   NP_001074680
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394132,291,378 - 132,309,994 (+)NCBI
GRCm384132,564,067 - 132,582,683 (+)NCBI
MGSCv374132,119,982 - 132,136,781 (+)RGD
Celera4130,724,940 - 130,741,731 (+)RGD
cM Map4 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001074680 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC53357 (Get FASTA)   NCBI Sequence Viewer  
  BAA09468 (Get FASTA)   NCBI Sequence Viewer  
  BAC27919 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000070925
  ENSMUSP00000070925.8
GenBank Protein Q62035 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001074680   ⟸   NM_001081211
- UniProtKB: B1B170 (UniProtKB/Swiss-Prot),   Q8C017 (UniProtKB/Swiss-Prot),   Q62035 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000070925   ⟸   ENSMUST00000070690

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62035-F1-model_v2 AlphaFold Q62035 1-341 view protein structure

Promoters
RGD ID:6835999
Promoter ID:MM_KWN:39963
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Spleen
Transcripts:OTTMUST00000022676
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364132,119,441 - 132,120,167 (+)MPROMDB
RGD ID:6884902
Promoter ID:EPDNEW_M5902
Type:initiation region
Name:Ptafr_2
Description:Mus musculus platelet-activating factor receptor , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M5903  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384132,564,067 - 132,564,127EPDNEW
RGD ID:6884904
Promoter ID:EPDNEW_M5903
Type:initiation region
Name:Ptafr_1
Description:Mus musculus platelet-activating factor receptor , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M5902  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384132,564,185 - 132,564,245EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:106066 AgrOrtholog
Ensembl Genes ENSMUSG00000056529 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000070690 ENTREZGENE
  ENSMUST00000070690.8 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  PAF_rcpt UniProtKB/Swiss-Prot
KEGG Report mmu:19204 UniProtKB/Swiss-Prot
MGD MGI:106066 ENTREZGENE
NCBI Gene 19204 ENTREZGENE
PANTHER P2Y PURINOCEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot
  PLATELET-ACTIVATING FACTOR RECEPTOR UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Ptafr PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot
  PAFRECEPTOR UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt B1B170 ENTREZGENE
  O35159_MOUSE UniProtKB/TrEMBL
  PTAFR_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q8C017 ENTREZGENE
UniProt Secondary B1B170 UniProtKB/Swiss-Prot
  Q8C017 UniProtKB/Swiss-Prot