Park7 (Parkinsonism associated deglycase) - Rat Genome Database

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Gene: Park7 (Parkinsonism associated deglycase) Rattus norvegicus
Analyze
Symbol: Park7
Name: Parkinsonism associated deglycase
RGD ID: 621808
Description: Predicted to enable several functions, including enzyme activator activity; enzyme binding activity; and transition metal ion binding activity. Involved in several processes, including negative regulation of NMDA glutamate receptor activity; negative regulation of vascular associated smooth muscle cell proliferation; and positive regulation of fertilization. Located in several cellular components, including endoplasmic reticulum; mitochondrion; and sperm head. Used to study Parkinson's disease and Parkinsonism. Biomarker of Parkinsonism. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 7; Parkinsonism; cerebral infarction; and middle cerebral artery infarction. Orthologous to human PARK7 (Parkinsonism associated deglycase); PARTICIPATES IN transforming growth factor-beta signaling pathway; Parkinson's disease pathway; INTERACTS WITH 1-bromopropane; 15-deoxy-Delta(12,14)-prostaglandin J2; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CAP1; contraception-associated protein 1; DJ-1; Dj1; fertility protein SP22; maillard deglycase; Parkinson disease (autosomal recessive, early onset) 7; parkinson disease protein 7 homolog; parkinson protein 7; protein/nucleic acid deglycase DJ-1; SP22
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Park7-ps1   Park7-ps2   Park7-ps3  
Allele / Splice: Park7em1Sage  
Genetic Models: LE-Park7em1Sage-/- LE-Park7em1Sage
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25161,353,718 - 161,376,993 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5161,353,719 - 161,376,970 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5164,071,138 - 164,094,398 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.05165,887,564 - 165,910,960 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.05165,849,775 - 165,873,035 (-)NCBIRnor_WKY
Rnor_6.05167,982,438 - 168,004,724 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5167,982,439 - 168,004,724 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05171,559,202 - 171,582,476 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45168,050,149 - 168,061,616 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15168,060,336 - 168,071,804 (-)NCBI
Celera5159,607,648 - 159,630,713 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-bromopropane  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
3-chloropropane-1,2-diol  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-phenylbutyric acid  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
amiodarone  (ISO)
ammonium chloride  (EXP)
amphetamine  (ISO)
arsenite(3-)  (ISO)
astemizole  (EXP)
benzene  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
butyric acid  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
CCCP  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
chromium trinitrate  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP,ISO)
dexamethasone  (ISO)
diazinon  (EXP)
dibenziodolium  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
fenazaquin  (ISO)
fenpyroximate  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
glutathione  (ISO)
glyphosate  (ISO)
haloperidol  (ISO)
heparin  (EXP)
hydralazine  (ISO)
hydrogen peroxide  (EXP,ISO)
inulin  (ISO)
isoniazide  (ISO)
ivermectin  (ISO)
lactacystin  (ISO)
lipopolysaccharide  (ISO)
lutein  (ISO)
LY294002  (EXP)
maneb  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
meloxicam  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosomorpholine  (EXP)
nicotine  (ISO)
ouabain  (ISO)
oxidopamine  (EXP,ISO)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorododecanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP)
phlorizin  (ISO)
potassium chromate  (ISO)
prostaglandin E2  (ISO)
pyridaben  (ISO)
Pyridostigmine bromide  (EXP)
pyrimidifen  (ISO)
quercetin  (EXP)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
rotenone  (EXP,ISO)
rutin  (EXP)
sarin  (EXP,ISO)
SB 203580  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
superoxide  (ISO)
T-2 toxin  (EXP)
tetrachloromethane  (EXP)
thapsigargin  (EXP)
thioacetamide  (EXP)
toluene  (EXP)
trans-piceid  (ISO)
Tributyltin oxide  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult locomotory behavior  (ISO)
autophagy  (IEA)
cellular detoxification of aldehyde  (ISO,ISS)
cellular detoxification of methylglyoxal  (ISO,ISS)
cellular response to glyoxal  (ISO,ISS)
cellular response to hypoxia  (IEP)
cellular response to lipopolysaccharide  (IEP)
cellular response to oxidative stress  (ISO,ISS)
cellular response to reactive oxygen species  (ISO)
detection of oxidative stress  (ISO)
detoxification of copper ion  (ISO,ISS)
detoxification of hydrogen peroxide  (ISO,ISS)
detoxification of mercury ion  (ISO,ISS)
DNA repair  (ISO,ISS)
dopamine uptake involved in synaptic transmission  (ISO)
fertilization  (TAS)
glucose homeostasis  (ISO,ISS)
glutathione deglycation  (ISO)
glycolate biosynthetic process  (IBA,ISO,ISS)
glyoxal catabolic process  (IEA)
glyoxal metabolic process  (IBA,ISO)
guanine deglycation  (ISO,ISS)
guanine deglycation, glyoxal removal  (ISO,ISS)
guanine deglycation, methylglyoxal removal  (ISO,ISS)
hydrogen peroxide metabolic process  (ISO,ISS)
inflammatory response  (IEA)
insulin secretion  (ISO,ISS)
lactate biosynthetic process  (ISO)
maternal process involved in female pregnancy  (IEP)
membrane depolarization  (ISO)
membrane hyperpolarization  (ISO)
methylglyoxal catabolic process to lactate  (ISO,ISS)
methylglyoxal metabolic process  (ISO,ISS)
mitochondrion organization  (ISO,ISS)
negative regulation of cellular process  (IMP)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway  (ISO,ISS)
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (ISO)
negative regulation of extrinsic apoptotic signaling pathway  (ISO,ISS)
negative regulation of gene expression  (ISO)
negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway  (ISO)
negative regulation of neuron apoptotic process  (ISO,ISS)
negative regulation of neuron death  (IBA,ISO)
negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway  (ISO)
negative regulation of NMDA glutamate receptor activity  (IMP)
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  (ISO)
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  (ISO,ISS)
negative regulation of proteasomal ubiquitin-dependent protein catabolic process  (ISO)
negative regulation of protein acetylation  (ISO,ISS)
negative regulation of protein binding  (ISO,ISS)
negative regulation of protein catabolic process  (ISO)
negative regulation of protein export from nucleus  (ISO,ISS)
negative regulation of protein K48-linked deubiquitination  (ISO,ISS)
negative regulation of protein kinase activity  (ISO,ISS)
negative regulation of protein phosphorylation  (ISO,ISS)
negative regulation of protein sumoylation  (ISO,ISS)
negative regulation of protein ubiquitination  (ISO,ISS)
negative regulation of reactive oxygen species biosynthetic process  (ISO,ISS)
negative regulation of smooth muscle cell migration  (IDA)
negative regulation of TRAIL-activated apoptotic signaling pathway  (ISO,ISS)
negative regulation of ubiquitin-protein transferase activity  (ISO)
negative regulation of ubiquitin-specific protease activity  (ISO,ISS)
negative regulation of vascular associated smooth muscle cell proliferation  (IDA)
obsolete negative regulation of cell death  (ISO)
obsolete negative regulation of hydrogen peroxide-induced cell death  (ISO)
obsolete negative regulation of hydrogen peroxide-induced neuron death  (ISO)
obsolete negative regulation of oxidative stress-induced cell death  (ISO)
peptidyl-arginine deglycation  (ISO,ISS)
peptidyl-cysteine deglycation  (ISO)
peptidyl-lysine deglycation  (ISO)
positive regulation of acute inflammatory response to antigenic stimulus  (ISO,ISS)
positive regulation of androgen receptor activity  (ISO,ISS)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of dopamine biosynthetic process  (ISO,ISS)
positive regulation of fertilization  (IMP)
positive regulation of gene expression  (ISO)
positive regulation of interleukin-8 production  (ISO,ISS)
positive regulation of L-dopa biosynthetic process  (ISO,ISS)
positive regulation of L-dopa decarboxylase activity  (ISO,ISS)
positive regulation of mitochondrial electron transport, NADH to ubiquinone  (ISO,ISS)
positive regulation of NAD(P)H oxidase activity  (ISO,ISS)
positive regulation of oxidative phosphorylation uncoupler activity  (ISO,ISS)
positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of protein localization to nucleus  (ISO,ISS)
positive regulation of protein-containing complex assembly  (ISO,ISS)
positive regulation of pyrroline-5-carboxylate reductase activity  (ISO,ISS)
positive regulation of reactive oxygen species biosynthetic process  (ISO)
positive regulation of superoxide dismutase activity  (ISO,ISS)
positive regulation of transcription by RNA polymerase II  (ISO,ISS)
positive regulation of transcription regulatory region DNA binding  (ISO)
positive regulation of tyrosine 3-monooxygenase activity  (ISO,ISS)
protein deglycation, glyoxal removal  (ISO)
protein deglycation, methylglyoxal removal  (ISO,ISS)
protein deglycosylation  (ISO,ISS)
protein stabilization  (ISO,ISS)
proteolysis  (IEA)
regulation of androgen receptor signaling pathway  (ISO,ISS)
regulation of inflammatory response  (ISO,ISS)
regulation of mitochondrial membrane potential  (ISO,ISS)
regulation of neuron apoptotic process  (ISO,ISS)
regulation of TRAIL production  (ISO)
response to hydrogen peroxide  (ISO)
response to oxidative stress  (IBA,IMP,ISO,ISS)
response to xenobiotic stimulus  (IEP)
single fertilization  (IEA)
spermatogenesis  (IEP)
synaptic transmission, dopaminergic  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The Parkinson's disease gene DJ-1 is also a key regulator of stroke-induced damage. Aleyasin H, etal., Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18748-53. doi: 10.1073/pnas.0709379104. Epub 2007 Nov 14.
2. Neuroprotective function of DJ-1 in Parkinson's disease. Ariga H, etal., Oxid Med Cell Longev. 2013;2013:683920. doi: 10.1155/2013/683920. Epub 2013 May 16.
3. The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease. Bandopadhyay R, etal., Brain. 2004 Feb;127(Pt 2):420-30. Epub 2003 Dec 8.
4. Localization of fertility factor SP22 to specific cell types within the anterior pituitary gland. Benoit AM, etal., Exp Biol Med (Maywood). 2005 Nov;230(10):721-30.
5. Expression of sperm protein 22 (SP22) in the rat ovary during different reproductive states. Benoit AM, etal., Exp Biol Med (Maywood). 2007 Jul;232(7):910-20.
6. Life-time expression of the proteins peroxiredoxin, beta-synuclein, PARK7/DJ-1, and stathmin in the primary visual and primary somatosensory cortices in rats. Böhm MR, etal., Front Neuroanat. 2015 Mar 4;9:16. doi: 10.3389/fnana.2015.00016. eCollection 2015.
7. Differential regulation of NMDA receptor function by DJ-1 and PINK1. Chang N, etal., Aging Cell. 2010 Oct;9(5):837-50. doi: 10.1111/j.1474-9726.2010.00615.x.
8. Phenotypic characterization of recessive gene knockout rat models of Parkinson's disease. Dave KD, etal., Neurobiol Dis. 2014 Oct;70:190-203. doi: 10.1016/j.nbd.2014.06.009. Epub 2014 Jun 24.
9. Up-regulation of caveolin-1 by DJ-1 attenuates rat pulmonary arterial hypertension by inhibiting TGFβ/Smad signaling pathway. Gao W, etal., Exp Cell Res. 2017 Dec 1;361(1):192-198. doi: 10.1016/j.yexcr.2017.10.019. Epub 2017 Oct 22.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Protection against dopaminergic neurodegeneration in Parkinson's disease-model animals by a modulator of the oxidized form of DJ-1, a wild-type of familial Parkinson's disease-linked PARK7. Inden M, etal., J Pharmacol Sci. 2011;117(3):189-203. Epub 2011 Oct 29.
12. PARK7 DJ-1 protects against degeneration of nigral dopaminergic neurons in Parkinson's disease rat model. Inden M, etal., Neurobiol Dis. 2006 Oct;24(1):144-58. Epub 2006 Jul 24.
13. Identification of novel proteins associated with both alpha-synuclein and DJ-1. Jin J, etal., Mol Cell Proteomics. 2007 May;6(5):845-59. Epub 2006 Jul 18.
14. DJ-1 associates with lipid rafts by palmitoylation and regulates lipid rafts-dependent endocytosis in astrocytes. Kim KS, etal., Hum Mol Genet. 2013 Dec 1;22(23):4805-17. doi: 10.1093/hmg/ddt332. Epub 2013 Jul 11.
15. Localization of the sperm protein SP22 and inhibition of fertility in vivo and in vitro. Klinefelter GR, etal., J Androl. 2002 Jan-Feb;23(1):48-63.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system. Miller DW, etal., J Biol Chem. 2003 Sep 19;278(38):36588-95. Epub 2003 Jul 8.
18. DJ-1-binding compounds prevent oxidative stress-induced cell death and movement defect in Parkinson's disease model rats. Miyazaki S, etal., J Neurochem. 2008 Jun 1;105(6):2418-34. doi: 10.1111/j.1471-4159.2008.05327.x.
19. Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis. Moutaoufik MT, etal., iScience. 2019 Sep 27;19:1114-1132. doi: 10.1016/j.isci.2019.08.057. Epub 2019 Sep 4.
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
22. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
23. GOA pipeline RGD automated data pipeline
24. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Comprehensive gene review and curation RGD comprehensive gene curation
27. Rotenone-induced parkinsonism elicits behavioral impairments and differential expression of parkin, heat shock proteins and caspases in the rat. Sonia Angeline M, etal., Neuroscience. 2012 Sep 18;220:291-301. doi: 10.1016/j.neuroscience.2012.06.021. Epub 2012 Jun 16.
28. Regulation of dopamine presynaptic markers and receptors in the striatum of DJ-1 and Pink1 knockout rats. Sun J, etal., Neurosci Lett. 2013 Dec 17;557 Pt B:123-8. doi: 10.1016/j.neulet.2013.10.034. Epub 2013 Oct 22.
29. Molecular cloning and expression of rat contraception associated protein 1 (CAP1), a protein putatively involved in fertilization. Wagenfeld A, etal., Biochem Biophys Res Commun 1998 Oct 20;251(2):545-9.
30. SP22: a novel fertility protein from a highly conserved gene family. Welch JE, etal., J Androl 1998 Jul-Aug;19(4):385-93.
31. Differential transport and local translation of cytoskeletal, injury-response, and neurodegeneration protein mRNAs in axons. Willis D, etal., J Neurosci. 2005 Jan 26;25(4):778-91.
32. Distribution of DJ-1, Parkinson's disease-related protein PARK7, and its alteration in 6-hydroxydopamine-treated hemiparkinsonian rat brain. Yanagida T, etal., J Pharmacol Sci. 2006 Oct;102(2):243-7. Epub 2006 Oct 12.
33. DJ-1 protects against neurodegeneration caused by focal cerebral ischemia and reperfusion in rats. Yanagisawa D, etal., J Cereb Blood Flow Metab. 2008 Mar;28(3):563-78. doi: 10.1038/sj.jcbfm.9600553. Epub 2007 Sep 19.
34. DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T alpha-synuclein toxicity. Zhou W and Freed CR, J Biol Chem. 2005 Dec 30;280(52):43150-8. Epub 2005 Oct 14.
35. Daxx inhibits stress-induced apoptosis in cardiac myocytes. Zobalova R, etal., Redox Rep. 2008;13(6):263-70. doi: 10.1179/135100008X308975.
Additional References at PubMed
PMID:10022524   PMID:11477070   PMID:12446870   PMID:12477932   PMID:14652021   PMID:14749723   PMID:14752510   PMID:15502874   PMID:15721235   PMID:15784737   PMID:15790595   PMID:15799973  
PMID:15944198   PMID:15983381   PMID:16047164   PMID:16624565   PMID:16632486   PMID:16731528   PMID:17015834   PMID:17510388   PMID:17599367   PMID:17766438   PMID:18614015   PMID:18626009  
PMID:18711745   PMID:19056867   PMID:19199708   PMID:19229105   PMID:19276172   PMID:19703902   PMID:19822128   PMID:20186336   PMID:20304780   PMID:20458337   PMID:20969476   PMID:21068725  
PMID:21097510   PMID:21426932   PMID:21630459   PMID:21785459   PMID:22132160   PMID:22492997   PMID:22511790   PMID:22523093   PMID:22555455   PMID:22611253   PMID:22613231   PMID:22683601  
PMID:22878563   PMID:23376485   PMID:23533145   PMID:23743200   PMID:23792957   PMID:24144264   PMID:24303086   PMID:24567322   PMID:24899725   PMID:24947010   PMID:25037998   PMID:25416785  
PMID:25468996   PMID:25726699   PMID:25915512   PMID:26021615   PMID:26081287   PMID:26873851   PMID:26913805   PMID:26945066   PMID:26995087   PMID:27171370   PMID:27430285   PMID:27903648  
PMID:28035392   PMID:28245986   PMID:28596309   PMID:28941803   PMID:28993701   PMID:29109055   PMID:29287203   PMID:29431188   PMID:29476059   PMID:29649621   PMID:29791076   PMID:30150385  
PMID:30506316   PMID:30894531   PMID:31034784   PMID:31250274   PMID:31593688   PMID:31653696   PMID:31734455   PMID:31878239   PMID:32051471   PMID:32061171   PMID:32151250   PMID:32157145  
PMID:35835217   PMID:36042578   PMID:36167256   PMID:36410277  


Genomics

Comparative Map Data
Park7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25161,353,718 - 161,376,993 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5161,353,719 - 161,376,970 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5164,071,138 - 164,094,398 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.05165,887,564 - 165,910,960 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.05165,849,775 - 165,873,035 (-)NCBIRnor_WKY
Rnor_6.05167,982,438 - 168,004,724 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5167,982,439 - 168,004,724 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05171,559,202 - 171,582,476 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45168,050,149 - 168,061,616 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15168,060,336 - 168,071,804 (-)NCBI
Celera5159,607,648 - 159,630,713 (-)NCBICelera
Cytogenetic Map5q36NCBI
PARK7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3817,961,711 - 7,985,505 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl17,954,291 - 7,985,505 (+)EnsemblGRCh38hg38GRCh38
GRCh3718,021,771 - 8,045,565 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3617,944,380 - 7,967,926 (+)NCBINCBI36Build 36hg18NCBI36
Build 3417,956,058 - 7,979,602NCBI
Celera17,128,771 - 7,152,398 (+)NCBICelera
Cytogenetic Map1p36.23NCBI
HuRef17,169,316 - 7,193,163 (+)NCBIHuRef
CHM1_118,009,469 - 8,033,097 (+)NCBICHM1_1
T2T-CHM13v2.017,492,675 - 7,516,444 (+)NCBIT2T-CHM13v2.0
Park7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394150,981,590 - 150,994,378 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4150,981,590 - 150,998,894 (-)EnsemblGRCm39 Ensembl
GRCm384150,897,133 - 150,909,921 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4150,897,133 - 150,914,437 (-)EnsemblGRCm38mm10GRCm38
MGSCv374150,271,242 - 150,284,030 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364149,740,942 - 149,753,650 (-)NCBIMGSCv36mm8
Celera4153,174,297 - 153,187,100 (-)NCBICelera
Cytogenetic Map4E2NCBI
Park7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554864,969,497 - 4,985,885 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554864,974,130 - 4,985,927 (-)NCBIChiLan1.0ChiLan1.0
PARK7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11218,884,515 - 218,908,146 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v016,722,260 - 6,745,915 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.117,969,265 - 7,993,271 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl17,969,280 - 7,993,271 (+)Ensemblpanpan1.1panPan2
PARK7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1561,576,219 - 61,592,325 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl561,576,069 - 61,592,303 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha561,584,413 - 61,601,125 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0561,791,984 - 61,808,701 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl561,792,439 - 61,808,700 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1561,791,244 - 61,807,961 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0561,656,017 - 61,672,730 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0562,059,399 - 62,076,120 (+)NCBIUU_Cfam_GSD_1.0
Park7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505831,937,508 - 31,951,577 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366232,422,833 - 2,436,817 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049366232,422,780 - 2,436,817 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PARK7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl668,629,214 - 68,645,516 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1668,629,327 - 68,645,147 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2663,023,779 - 63,033,855 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PARK7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120123,776,084 - 123,808,031 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20123,776,297 - 123,798,434 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605427,810,002 - 27,834,129 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Park7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248183,900,917 - 3,911,042 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248183,900,917 - 3,915,457 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Park7
160 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5151113452164465185Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5151113452166875058Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5154828214166875058Rat

Markers in Region
RH142283  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map21059.6UniSTS
Cytogenetic Map5q36UniSTS


Genetic Models
This gene Park7 is modified in the following models/strains

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001277249 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001277250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001277251 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001277252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001277253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_057143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC115172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF157511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF157512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ007291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC091128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM055257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM061417 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM069664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GN087054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GN087057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GN087058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000024711   ⟹   ENSRNOP00000024711
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5161,360,664 - 161,376,970 (-)Ensembl
Rnor_6.0 Ensembl5167,988,385 - 168,004,724 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000087402   ⟹   ENSRNOP00000072068
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5161,360,666 - 161,372,093 (-)Ensembl
Rnor_6.0 Ensembl5167,988,385 - 167,999,853 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000091206   ⟹   ENSRNOP00000074942
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5161,353,719 - 161,372,352 (-)Ensembl
Rnor_6.0 Ensembl5167,982,439 - 168,000,083 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000119817   ⟹   ENSRNOP00000085313
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5161,360,728 - 161,372,339 (-)Ensembl
RefSeq Acc Id: NM_001277249   ⟹   NP_001264178
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25161,353,718 - 161,372,352 (-)NCBI
Rnor_6.05167,982,438 - 168,000,083 (-)NCBI
Rnor_5.05171,559,202 - 171,582,476 (-)NCBI
Celera5159,607,648 - 159,626,072 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001277250   ⟹   NP_001264179
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25161,360,654 - 161,372,352 (-)NCBI
Rnor_6.05167,988,385 - 168,000,083 (-)NCBI
Rnor_5.05171,559,202 - 171,582,476 (-)NCBI
Celera5159,614,374 - 159,626,072 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001277251   ⟹   NP_001264180
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25161,360,654 - 161,372,352 (-)NCBI
Rnor_6.05167,988,385 - 168,000,083 (-)NCBI
Rnor_5.05171,559,202 - 171,582,476 (-)NCBI
Celera5159,614,374 - 159,626,072 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001277252   ⟹   NP_001264181
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25161,360,654 - 161,372,352 (-)NCBI
Rnor_6.05167,988,385 - 168,000,083 (-)NCBI
Rnor_5.05171,559,202 - 171,582,476 (-)NCBI
Celera5159,614,374 - 159,626,072 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001277253   ⟹   NP_001264182
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25161,360,654 - 161,376,993 (-)NCBI
Rnor_6.05167,988,385 - 168,004,724 (-)NCBI
Rnor_5.05171,559,202 - 171,582,476 (-)NCBI
Celera5159,614,374 - 159,630,713 (-)NCBI
Sequence:
RefSeq Acc Id: NM_057143   ⟹   NP_476484
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25161,360,654 - 161,372,122 (-)NCBI
Rnor_6.05167,988,385 - 167,999,853 (-)NCBI
Rnor_5.05171,559,202 - 171,582,476 (-)NCBI
RGSC_v3.45168,050,149 - 168,061,616 (-)RGD
Celera5159,614,374 - 159,625,842 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_476484   ⟸   NM_057143
- Peptide Label: isoform 2
- UniProtKB: O88767 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001264178   ⟸   NM_001277249
- Peptide Label: isoform 1
- UniProtKB: Q5BKC3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001264182   ⟸   NM_001277253
- Peptide Label: isoform 2
- UniProtKB: O88767 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001264181   ⟸   NM_001277252
- Peptide Label: isoform 2
- UniProtKB: O88767 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001264179   ⟸   NM_001277250
- Peptide Label: isoform 2
- UniProtKB: O88767 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001264180   ⟸   NM_001277251
- Peptide Label: isoform 2
- UniProtKB: O88767 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000024711   ⟸   ENSRNOT00000024711
RefSeq Acc Id: ENSRNOP00000072068   ⟸   ENSRNOT00000087402
RefSeq Acc Id: ENSRNOP00000074942   ⟸   ENSRNOT00000091206
RefSeq Acc Id: ENSRNOP00000085313   ⟸   ENSRNOT00000119817
Protein Domains
DJ-1/PfpI

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88767-F1-model_v2 AlphaFold O88767 1-189 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694284
Promoter ID:EPDNEW_R4809
Type:initiation region
Name:Park7_1
Description:Parkinsonism associated deglycase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R4810  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05168,000,070 - 168,000,130EPDNEW
RGD ID:13694285
Promoter ID:EPDNEW_R4810
Type:initiation region
Name:Park7_2
Description:Parkinsonism associated deglycase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R4809  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05168,004,692 - 168,004,752EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621808 AgrOrtholog
BioCyc Gene G2FUF-39052 BioCyc
Ensembl Genes ENSRNOG00000018289 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000024711.3 UniProtKB/TrEMBL
  ENSRNOP00000072068 ENTREZGENE
  ENSRNOP00000072068.1 UniProtKB/Swiss-Prot
  ENSRNOP00000074942 ENTREZGENE
  ENSRNOP00000074942.1 UniProtKB/TrEMBL
  ENSRNOP00000085313.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000024711.6 UniProtKB/TrEMBL
  ENSRNOT00000087402 ENTREZGENE
  ENSRNOT00000087402.2 UniProtKB/Swiss-Prot
  ENSRNOT00000091206 ENTREZGENE
  ENSRNOT00000091206.2 UniProtKB/TrEMBL
  ENSRNOT00000119817.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.880 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7376914 IMAGE-MGC_LOAD
InterPro Class_I_gatase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DJ-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DJ-1/PfpI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117287 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108615 IMAGE-MGC_LOAD
NCBI Gene 117287 ENTREZGENE
PANTHER PARKINSON DISEASE PROTEIN 7 HOMOLOG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DJ-1_PfpI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Park7 PhenoGen
Superfamily-SCOP SSF52317 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs not_thiJ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6GCY6_RAT UniProtKB/TrEMBL
  A0A8L2QD92_RAT UniProtKB/TrEMBL
  O88767 ENTREZGENE, UniProtKB/Swiss-Prot
  Q5BKC3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Park7  parkinson protein 7  Park7  Parkinson disease (autosomal recessive, early onset) 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Park7  Parkinson disease (autosomal recessive, early onset) 7    fertility protein SP22  Name updated 1299863 APPROVED
2004-09-10 Park7  fertility protein SP22  SP22    Symbol and Name updated 1299863 APPROVED
2002-08-07 SP22  fertility protein SP22      Symbol and Name status set to provisional 70820 PROVISIONAL