Pde11a (phosphodiesterase 11A) - Rat Genome Database

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Gene: Pde11a (phosphodiesterase 11A) Rattus norvegicus
Analyze
Symbol: Pde11a (Ensembl: Cyct)
Name: phosphodiesterase 11A (Ensembl:cytochrome c, testis)
RGD ID: 621793
Description: Enables cyclic-nucleotide phosphodiesterase activity. Involved in negative regulation of cAMP-mediated signaling and negative regulation of cGMP-mediated signaling. Located in perikaryon. Human ortholog(s) of this gene implicated in primary pigmented nodular adrenocortical disease. Orthologous to human PDE11A (phosphodiesterase 11A); PARTICIPATES IN protein kinase A (PKA) signaling pathway; purine metabolic pathway; INTERACTS WITH 6-propyl-2-thiouracil; all-trans-retinoic acid; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cAMP and cGMP phosphodiesterase 11A; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A; Pde11A2; Pde11A3; Pde11A4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Pde11a_v3   Pde11a_v2   Pde11a_v1  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8381,320,822 - 81,704,397 (-)NCBIGRCr8
mRatBN7.2360,913,562 - 61,297,154 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl360,913,562 - 61,297,158 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx364,287,040 - 64,657,493 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0372,870,673 - 73,241,149 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0370,638,029 - 71,008,278 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0362,818,502 - 63,211,843 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl362,818,502 - 63,211,845 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0369,363,100 - 69,784,930 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4358,659,595 - 59,049,869 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1358,555,966 - 58,922,151 (-)NCBI
Celera360,413,273 - 60,785,139 (-)NCBICelera
Cytogenetic Map3q23-q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IEA)
perikaryon  (IDA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling. Conti M and Beavo J, Annu Rev Biochem. 2007;76:481-511.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. PDE9A, PDE10A, and PDE11A expression in rat trigeminovascular pain signalling system. Kruse LS, etal., Brain Res. 2009 Jul 24;1281:25-34. Epub 2009 May 13.
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Identification of rat cyclic nucleotide phosphodiesterase 11A (PDE11A): comparison of rat and human PDE11A splicing variants. Yuasa K, etal., Eur J Biochem 2001 Aug;268(16):4440-8.
Additional References at PubMed
PMID:2834389   PMID:17696499   PMID:19689430   PMID:31904090  


Genomics

Comparative Map Data
Pde11a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8381,320,822 - 81,704,397 (-)NCBIGRCr8
mRatBN7.2360,913,562 - 61,297,154 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl360,913,562 - 61,297,158 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx364,287,040 - 64,657,493 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0372,870,673 - 73,241,149 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0370,638,029 - 71,008,278 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0362,818,502 - 63,211,843 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl362,818,502 - 63,211,845 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0369,363,100 - 69,784,930 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4358,659,595 - 59,049,869 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1358,555,966 - 58,922,151 (-)NCBI
Celera360,413,273 - 60,785,139 (-)NCBICelera
Cytogenetic Map3q23-q24NCBI
PDE11A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382177,623,244 - 178,108,339 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2177,623,244 - 178,108,339 (-)EnsemblGRCh38hg38GRCh38
GRCh372178,487,972 - 178,973,066 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362178,196,223 - 178,681,312 (-)NCBINCBI36Build 36hg18NCBI36
Build 342178,318,318 - 178,762,989NCBI
Celera2172,090,836 - 172,575,966 (-)NCBICelera
Cytogenetic Map2q31.2NCBI
HuRef2170,359,035 - 170,843,555 (-)NCBIHuRef
CHM1_12178,493,788 - 178,979,175 (-)NCBICHM1_1
T2T-CHM13v2.02178,105,555 - 178,591,096 (-)NCBIT2T-CHM13v2.0
Pde11a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39275,816,152 - 76,169,501 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl275,819,485 - 76,169,118 (-)EnsemblGRCm39 Ensembl
GRCm38275,985,808 - 76,339,145 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl275,989,141 - 76,338,774 (-)EnsemblGRCm38mm10GRCm38
MGSCv37275,829,189 - 76,176,710 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36275,791,561 - 76,139,492 (-)NCBIMGSCv36mm8
Celera277,652,941 - 78,004,820 (-)NCBICelera
Cytogenetic Map2C3NCBI
cM Map244.8NCBI
Pde11a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540318,804,789 - 19,180,612 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540318,804,789 - 19,180,612 (+)NCBIChiLan1.0ChiLan1.0
LOC100982736
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21380,289,127 - 80,564,300 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B80,307,862 - 80,579,274 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B64,903,170 - 65,332,922 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B182,605,628 - 183,038,353 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B182,611,762 - 183,038,353 (-)Ensemblpanpan1.1panPan2
PDE11A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13621,347,171 - 21,701,976 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3621,326,346 - 21,702,268 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3621,359,186 - 21,721,039 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03621,484,502 - 21,846,241 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3621,484,429 - 21,846,383 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13621,554,639 - 21,921,057 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03621,556,642 - 21,918,772 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03621,671,753 - 22,033,167 (-)NCBIUU_Cfam_GSD_1.0
Pde11a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303138,389,843 - 138,768,230 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365096,948,710 - 7,322,156 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365096,943,758 - 7,322,192 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDE11A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1583,365,723 - 83,757,934 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11583,366,082 - 83,784,266 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21593,138,914 - 93,295,087 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PDE11A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11063,183,716 - 63,649,030 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1063,185,043 - 63,614,749 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040136,120,068 - 136,395,287 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pde11a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478714,743,831 - 15,238,020 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478714,742,890 - 15,238,349 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pde11a
1848 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)32824968773249687Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35378111291609953Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)36113434889115068Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)33068464275684642Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)32824968773249687Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
1582249Bw77Body weight QTL 773.20.0025epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)35318459364655484Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
12879868Am6Aortic mass QTL 60.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)33142640370668733Rat
11565451Bw177Body weight QTL 1770.002body mass (VT:0001259)body weight (CMO:0000012)33142640370668733Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
11565452Kidm57Kidney mass QTL 570.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)33142640370668733Rat
12879866Cm94Cardiac mass QTL 940.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)33142640370668733Rat
12879867Cm95Cardiac mass QTL 950.047heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)33142640370668733Rat
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34382736490905114Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)35318469289878207Rat
2302055Pia30Pristane induced arthritis QTL 303.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)32793691972936919Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)33945463789115240Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)33370334778196190Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)32846857173468571Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)32846857173468571Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)33945463789115240Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)33068464275684642Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33370334761017857Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2302276Bw82Body weight QTL 824.32body mass (VT:0001259)body weight (CMO:0000012)33945463762951183Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)33851780383517803Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32824968773249687Rat
10450804Scl70Serum cholesterol level QTL 704.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)32824968773249687Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)31695470861954708Rat
10450794Scl69Serum cholesterol level QTL 696.30.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)32824968773249687Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
2301400Cm68Cardiac mass QTL 680.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)33142640370668733Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat

Markers in Region
D3Rat38  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2361,134,216 - 61,134,348 (+)MAPPERmRatBN7.2
Rnor_6.0363,048,919 - 63,049,050NCBIRnor6.0
Rnor_5.0369,593,794 - 69,593,925UniSTSRnor5.0
RGSC_v3.4358,882,845 - 58,882,977RGDRGSC3.4
RGSC_v3.4358,882,846 - 58,882,977UniSTSRGSC3.4
RGSC_v3.1358,779,217 - 58,779,349RGD
Celera360,631,503 - 60,631,634UniSTS
SHRSP x BN Map338.3398UniSTS
SHRSP x BN Map338.3398RGD
Cytogenetic Map3q23UniSTS
D3Rat180  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2361,017,749 - 61,017,857 (+)MAPPERmRatBN7.2
Rnor_6.0362,922,868 - 62,922,975NCBIRnor6.0
Rnor_5.0369,467,333 - 69,467,440UniSTSRnor5.0
RGSC_v3.4358,764,506 - 58,764,827RGDRGSC3.4
RGSC_v3.4358,764,514 - 58,764,621UniSTSRGSC3.4
RGSC_v3.1358,660,878 - 58,661,199RGD
Celera360,517,624 - 60,517,731UniSTS
SHRSP x BN Map338.3798UniSTS
SHRSP x BN Map338.3798RGD
Cytogenetic Map3q23UniSTS
AU049636  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2361,283,491 - 61,283,674 (+)MAPPERmRatBN7.2
Rnor_6.0363,198,181 - 63,198,363NCBIRnor6.0
Rnor_5.0369,737,516 - 69,737,698UniSTSRnor5.0
RGSC_v3.4359,036,207 - 59,036,389UniSTSRGSC3.4
Celera360,771,474 - 60,771,659UniSTS
Cytogenetic Map3q23UniSTS
AU048155  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2361,130,022 - 61,130,228 (+)MAPPERmRatBN7.2
Rnor_6.0363,044,725 - 63,044,930NCBIRnor6.0
Rnor_5.0369,589,600 - 69,589,805UniSTSRnor5.0
RGSC_v3.4358,878,652 - 58,878,857UniSTSRGSC3.4
Celera360,627,309 - 60,627,514UniSTS
Cytogenetic Map3q23UniSTS
AU047925  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2862,837,571 - 62,837,827 (+)MAPPERmRatBN7.2
Rnor_6.0867,304,185 - 67,304,440NCBIRnor6.0
Rnor_5.0867,038,196 - 67,038,451UniSTSRnor5.0
Rnor_5.0369,754,081 - 69,754,336UniSTSRnor5.0
RGSC_v3.4866,497,088 - 66,497,343UniSTSRGSC3.4
Celera862,255,430 - 62,255,685UniSTS
Cytogenetic Map8q24UniSTS
Cytogenetic Map3q23UniSTS
ANP32C__4314  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2361,291,940 - 61,292,660 (+)MAPPERmRatBN7.2
Rnor_6.0363,206,630 - 63,207,349NCBIRnor6.0
RGSC_v3.4359,044,656 - 59,045,375UniSTSRGSC3.4
Celera360,779,926 - 60,780,645UniSTS
Cytogenetic Map3q23UniSTS
Cytogenetic Map8q24UniSTS


Expression


Sequence


RefSeq Acc Id: ENSRNOT00000008301   ⟹   ENSRNOP00000008300
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl360,913,571 - 61,273,339 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000008371   ⟹   ENSRNOP00000008371
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl361,290,090 - 61,297,158 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000045862   ⟹   ENSRNOP00000048657
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl360,913,562 - 61,179,487 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000050355   ⟹   ENSRNOP00000051289
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl360,913,562 - 61,297,156 (-)Ensembl
RefSeq Acc Id: NM_001127480   ⟹   NP_001120952
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8381,320,822 - 81,704,397 (-)NCBI
mRatBN7.2360,913,562 - 61,297,154 (-)NCBI
Rnor_6.0362,818,502 - 63,211,843 (-)NCBI
Rnor_5.0369,363,100 - 69,784,930 (-)NCBI
RGSC_v3.4358,659,595 - 59,049,869 (-)RGD
Celera360,413,273 - 60,785,139 (-)RGD
Sequence:
RefSeq Acc Id: NM_001127481   ⟹   NP_001120953
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8381,320,822 - 81,587,090 (-)NCBI
mRatBN7.2360,913,562 - 61,179,844 (-)NCBI
Rnor_6.0362,818,502 - 63,094,534 (-)NCBI
Rnor_5.0369,363,100 - 69,784,930 (-)NCBI
RGSC_v3.4358,659,595 - 59,049,869 (-)RGD
Celera360,413,273 - 60,677,634 (-)NCBI
Sequence:
RefSeq Acc Id: NM_080893   ⟹   NP_543169
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8381,320,822 - 81,680,612 (-)NCBI
mRatBN7.2360,913,562 - 61,273,369 (-)NCBI
Rnor_6.0362,818,502 - 63,188,028 (-)NCBI
Rnor_5.0369,363,100 - 69,784,930 (-)NCBI
RGSC_v3.4358,659,595 - 59,049,869 (-)RGD
Celera360,413,273 - 60,761,181 (-)NCBI
Sequence:
RefSeq Acc Id: NP_543169   ⟸   NM_080893
- Peptide Label: isoform 4
- UniProtKB: Q8VID7 (UniProtKB/Swiss-Prot),   Q8VID8 (UniProtKB/Swiss-Prot),   Q8VID6 (UniProtKB/Swiss-Prot),   A0A8L2Q3C3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001120952   ⟸   NM_001127480
- Peptide Label: isoform 3
- UniProtKB: Q8VID6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001120953   ⟸   NM_001127481
- Peptide Label: isoform 2
- UniProtKB: Q8VID6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000051289   ⟸   ENSRNOT00000050355
RefSeq Acc Id: ENSRNOP00000008300   ⟸   ENSRNOT00000008301
RefSeq Acc Id: ENSRNOP00000008371   ⟸   ENSRNOT00000008371
RefSeq Acc Id: ENSRNOP00000048657   ⟸   ENSRNOT00000045862
Protein Domains
GAF   PDEase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VID6-F1-model_v2 AlphaFold Q8VID6 1-935 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621793 AgrOrtholog
BioCyc Gene G2FUF-49293 BioCyc
Ensembl Genes ENSRNOG00000024457 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00065017777 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000008301 ENTREZGENE
  ENSRNOT00000008301.7 UniProtKB/TrEMBL
  ENSRNOT00000045862 ENTREZGENE
  ENSRNOT00000045862.3 UniProtKB/Swiss-Prot
  ENSRNOT00000050355 ENTREZGENE
  ENSRNOT00000050355.4 UniProtKB/Swiss-Prot
  ENSRNOT00065029752 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.1300.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.450.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GAF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GAF-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HD/PDEase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDEase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDEase_catalytic_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDEase_catalytic_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDEase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:140928 UniProtKB/Swiss-Prot
NCBI Gene 140928 ENTREZGENE
PANTHER CYCLIC NUCLEOTIDE PHOSPHODIESTERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUAL 3',5'-CYCLIC-AMP AND -GMP PHOSPHODIESTERASE 11A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GAF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDEase_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pde11a PhenoGen
PRINTS PDIESTERASE1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PDEASE_I_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDEASE_I_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000024457 RatGTEx
  ENSRNOG00065017777 RatGTEx
SMART GAF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HDc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP GAF domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HD-domain/PDEase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2Q3C3 ENTREZGENE, UniProtKB/TrEMBL
  PDE11_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q8VID7 ENTREZGENE
  Q8VID8 ENTREZGENE
UniProt Secondary Q8VID7 UniProtKB/Swiss-Prot
  Q8VID8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Pde11a  phosphodiesterase 11A      Symbol and Name status set to approved 1299863 APPROVED
2004-12-14 Pde11a  phosphodiesterase 11A      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Pde11a  phosphodiesterase 11A      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
null has several splice variant products which exhibit differences in cyclic nucleotide phosphodiesterase activity toward cAMP and cGMP characterized as similar Km values but differing Vmax values  
gene_function has several splice variant products which exhibit differences in cyclic nucleotide phosphodiesterase activity toward cAMP and cGMP characterized as similar Km values but differing Vmax values 633590