Dapk3 (death-associated protein kinase 3) - Rat Genome Database

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Gene: Dapk3 (death-associated protein kinase 3) Rattus norvegicus
Analyze
Symbol: Dapk3
Name: death-associated protein kinase 3
RGD ID: 621766
Description: Enables ATP binding activity; DNA-binding transcription factor binding activity; and protein serine/threonine kinase activity. Involved in several processes, including intracellular signal transduction; neuron differentiation; and positive regulation of extrinsic apoptotic signaling pathway in absence of ligand. Located in actin filament; membrane raft; and nucleus. Orthologous to human DAPK3 (death associated protein kinase 3); PARTICIPATES IN urinary bladder cancer pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: DAP kinase 3; DAP-like kinase; Dapkl; Death-associated like kinase; dlk; MYPT1 kinase; ZIP-kinase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr879,174,903 - 9,183,272 (-)NCBIGRCr8
mRatBN7.278,524,182 - 8,532,552 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,524,183 - 8,532,558 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx711,409,265 - 11,417,634 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0713,284,751 - 13,293,120 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0711,151,188 - 11,159,566 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0711,392,436 - 11,400,855 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,392,437 - 11,400,805 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0711,559,842 - 11,568,242 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4710,007,997 - 10,016,365 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1710,007,996 - 10,016,365 (-)NCBI
Celera76,712,067 - 6,720,435 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
amenorrhea  (ISO)
RASopathy  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-lapachone  (ISO)
bexarotene  (EXP)
bisphenol A  (EXP)
bisphenol F  (EXP,ISO)
butan-1-ol  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
cannabidiol  (EXP)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium atom  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
diazinon  (EXP)
Dibutyl phosphate  (ISO)
dioxygen  (ISO)
elemental selenium  (ISO)
ethanol  (EXP,ISO)
fenthion  (ISO)
flutamide  (EXP)
folic acid  (ISO)
furan  (EXP)
gentamycin  (EXP)
glycidol  (EXP)
hydrogen cyanide  (ISO)
isobutanol  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methotrexate  (ISO)
methoxyacetic acid  (EXP)
methylphenidate  (ISO)
motexafin gadolinium  (ISO)
oxybenzone  (EXP)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
PhIP  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium cyanide  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
quercetin  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
Tributyltin oxide  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
zinc acetate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
actin filament  (IDA)
chromosome, centromeric region  (ISO,ISS)
cytoplasm  (IBA)
cytosol  (IEA,ISO)
membrane raft  (IDA)
microtubule organizing center  (IEA)
midbody  (ISO,ISS)
nucleoplasm  (ISO)
nucleus  (IBA,IDA,ISO)
PML body  (IEA,ISO)
spindle  (ISO,ISS)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. DAP-like kinase interacts with the rat homolog of Schizosaccharomyces pombe CDC5 protein, a factor involved in pre-mRNA splicing and required for G2/M phase transition. Engemann H, etal., Nucleic Acids Res 2002 Mar 15;30(6):1408-17.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. The dependence receptor UNC5H2/B triggers apoptosis via PP2A-mediated dephosphorylation of DAP kinase. Guenebeaud C, etal., Mol Cell. 2010 Dec 22;40(6):863-76. doi: 10.1016/j.molcel.2010.11.021.
5. Expression of death-associated protein kinase and recruitment to the tumor necrosis factor signaling pathway following brief seizures. Henshall DC, etal., J Neurochem 2003 Sep;86(5):1260-70.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. AATF, a novel transcription factor that interacts with Dlk/ZIP kinase and interferes with apoptosis. Page G, etal., FEBS Lett 1999 Nov 26;462(1-2):187-91.
9. Interaction partners of Dlk/ZIP kinase: co-expression of Dlk/ZIP kinase and Par-4 results in cytoplasmic retention and apoptosis. Page G, etal., Oncogene. 1999 Dec 2;18(51):7265-73.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. DAPK catalytic activity in the hippocampus increases during the recovery phase in an animal model of brain hypoxic-ischemic injury. Schumacher AM, etal., Biochim Biophys Acta 2002 Nov 4;1600(1-2):128-37.
15. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
16. The association of death-associated protein kinase hypermethylation with early recurrence in superficial bladder cancers. Tada Y, etal., Cancer Res 2002 Jul 15;62(14):4048-53.
Additional References at PubMed
PMID:9488481   PMID:9840928   PMID:10356987   PMID:12917339   PMID:15096528   PMID:15489334   PMID:17087515   PMID:18239682   PMID:18310078   PMID:18505470   PMID:18995835   PMID:19373133  
PMID:19541925   PMID:20038585   PMID:21454679   PMID:21487036   PMID:21880706   PMID:22235829   PMID:23071094   PMID:23454120   PMID:25931508   PMID:26111663   PMID:30851272   PMID:37084168  


Genomics

Comparative Map Data
Dapk3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr879,174,903 - 9,183,272 (-)NCBIGRCr8
mRatBN7.278,524,182 - 8,532,552 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,524,183 - 8,532,558 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx711,409,265 - 11,417,634 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0713,284,751 - 13,293,120 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0711,151,188 - 11,159,566 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0711,392,436 - 11,400,855 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,392,437 - 11,400,805 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0711,559,842 - 11,568,242 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4710,007,997 - 10,016,365 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1710,007,996 - 10,016,365 (-)NCBI
Celera76,712,067 - 6,720,435 (-)NCBICelera
Cytogenetic Map7q11NCBI
DAPK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38193,958,453 - 3,971,099 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl193,958,453 - 3,971,123 (-)EnsemblGRCh38hg38GRCh38
GRCh37193,958,451 - 3,971,097 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36193,909,452 - 3,920,826 (-)NCBINCBI36Build 36hg18NCBI36
Build 34193,909,451 - 3,920,826NCBI
Celera193,895,592 - 3,906,968 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef193,721,681 - 3,733,014 (-)NCBIHuRef
CHM1_1193,958,113 - 3,969,502 (-)NCBICHM1_1
T2T-CHM13v2.0193,937,706 - 3,950,355 (-)NCBIT2T-CHM13v2.0
Dapk3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391081,018,821 - 81,029,031 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1081,018,839 - 81,029,031 (+)EnsemblGRCm39 Ensembl
GRCm381081,182,987 - 81,193,197 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1081,183,005 - 81,193,197 (+)EnsemblGRCm38mm10GRCm38
MGSCv371080,645,752 - 80,655,942 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361080,587,134 - 80,596,127 (+)NCBIMGSCv36mm8
Celera1082,203,364 - 82,213,553 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Dapk3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554954,810,474 - 4,823,259 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554954,809,475 - 4,822,210 (+)NCBIChiLan1.0ChiLan1.0
DAPK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2208,357,518 - 8,369,504 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1197,589,027 - 7,601,004 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0192,984,806 - 2,996,782 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1193,934,496 - 3,946,011 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl193,934,496 - 3,946,011 (-)Ensemblpanpan1.1panPan2
DAPK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12055,590,199 - 55,603,883 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2055,590,223 - 55,602,682 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2055,315,718 - 55,329,927 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02056,250,289 - 56,264,535 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2056,250,314 - 56,263,999 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12055,306,274 - 55,320,466 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02055,788,043 - 55,802,254 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02055,986,748 - 56,000,993 (+)NCBIUU_Cfam_GSD_1.0
Dapk3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118215,576,995 - 215,590,047 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365882,244,708 - 2,257,779 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365882,246,142 - 2,257,733 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DAPK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl274,759,004 - 74,775,330 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1274,758,962 - 74,776,355 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2275,303,427 - 75,320,026 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DAPK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.163,713,179 - 3,729,223 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl63,712,170 - 3,727,929 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660814,517,737 - 4,535,148 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dapk3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248285,621,696 - 5,625,601 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248285,616,839 - 5,626,849 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dapk3
50 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:55
Count of miRNA genes:53
Interacting mature miRNAs:54
Transcripts:ENSRNOT00000027634
Prediction methods:Microtar, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat

Markers in Region
RH127807  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.278,524,183 - 8,524,363 (+)MAPPERmRatBN7.2
Rnor_6.0711,392,438 - 11,392,617NCBIRnor6.0
Rnor_5.0711,559,844 - 11,560,023UniSTSRnor5.0
RGSC_v3.4710,007,998 - 10,008,177UniSTSRGSC3.4
Celera76,712,068 - 6,712,247UniSTS
Cytogenetic Map7q11UniSTS
RH139169  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.278,525,035 - 8,525,172 (+)MAPPERmRatBN7.2
Rnor_6.0711,393,290 - 11,393,426NCBIRnor6.0
Rnor_5.0711,560,696 - 11,560,832UniSTSRnor5.0
RGSC_v3.4710,008,850 - 10,008,986UniSTSRGSC3.4
Celera76,712,920 - 6,713,056UniSTS
RH 3.4 Map2880.3UniSTS
Cytogenetic Map7q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000027634   ⟹   ENSRNOP00000027634
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl78,524,183 - 8,532,552 (-)Ensembl
Rnor_6.0 Ensembl711,392,437 - 11,400,805 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096134   ⟹   ENSRNOP00000081984
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl78,524,183 - 8,532,558 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113082   ⟹   ENSRNOP00000094423
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl78,524,237 - 8,532,552 (-)Ensembl
RefSeq Acc Id: NM_022546   ⟹   NP_071991
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,174,904 - 9,183,272 (-)NCBI
mRatBN7.278,524,183 - 8,532,552 (-)NCBI
Rnor_6.0711,392,437 - 11,400,805 (-)NCBI
Rnor_5.0711,559,842 - 11,568,242 (-)NCBI
RGSC_v3.4710,007,997 - 10,016,365 (-)RGD
Celera76,712,067 - 6,720,435 (-)RGD
Sequence:
RefSeq Acc Id: XM_006240991   ⟹   XP_006241053
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,174,903 - 9,183,202 (-)NCBI
mRatBN7.278,524,182 - 8,532,451 (-)NCBI
Rnor_6.0711,392,436 - 11,400,722 (-)NCBI
Rnor_5.0711,559,842 - 11,568,242 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006240993   ⟹   XP_006241055
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,174,903 - 9,183,024 (-)NCBI
mRatBN7.278,524,182 - 8,532,295 (-)NCBI
Rnor_6.0711,392,436 - 11,400,722 (-)NCBI
Rnor_5.0711,559,842 - 11,568,242 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017595099   ⟹   XP_017450588
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,174,903 - 9,183,133 (-)NCBI
mRatBN7.278,524,182 - 8,532,539 (-)NCBI
Rnor_6.0711,392,436 - 11,400,721 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039079856   ⟹   XP_038935784
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,174,903 - 9,182,777 (-)NCBI
mRatBN7.278,524,182 - 8,532,436 (-)NCBI
RefSeq Acc Id: NP_071991   ⟸   NM_022546
- UniProtKB: O88764 (UniProtKB/Swiss-Prot),   A6K8B5 (UniProtKB/TrEMBL),   A0A8I6GL62 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241053   ⟸   XM_006240991
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GL62 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241055   ⟸   XM_006240993
- Peptide Label: isoform X2
- UniProtKB: O88764 (UniProtKB/Swiss-Prot),   A6K8B5 (UniProtKB/TrEMBL),   A0A8I6GL62 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450588   ⟸   XM_017595099
- Peptide Label: isoform X2
- UniProtKB: O88764 (UniProtKB/Swiss-Prot),   A6K8B5 (UniProtKB/TrEMBL),   A0A8I6GL62 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000027634   ⟸   ENSRNOT00000027634
RefSeq Acc Id: XP_038935784   ⟸   XM_039079856
- Peptide Label: isoform X2
- UniProtKB: O88764 (UniProtKB/Swiss-Prot),   A6K8B5 (UniProtKB/TrEMBL),   A0A8I6GL62 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000081984   ⟸   ENSRNOT00000096134
Ensembl Acc Id: ENSRNOP00000094423   ⟸   ENSRNOT00000113082
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88764-F1-model_v2 AlphaFold O88764 1-448 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694985
Promoter ID:EPDNEW_R5509
Type:initiation region
Name:Dapk3_1
Description:death-associated protein kinase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0711,400,796 - 11,400,856EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621766 AgrOrtholog
BioCyc Gene G2FUF-35005 BioCyc
Ensembl Genes ENSRNOG00000020383 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055032768 UniProtKB/Swiss-Prot
  ENSRNOG00060030872 UniProtKB/Swiss-Prot
  ENSRNOG00065022007 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000027634.5 UniProtKB/Swiss-Prot
  ENSRNOT00000096134.1 UniProtKB/TrEMBL
  ENSRNOT00000113082.1 UniProtKB/TrEMBL
  ENSRNOT00055056655 UniProtKB/Swiss-Prot
  ENSRNOT00060053652 UniProtKB/Swiss-Prot
  ENSRNOT00065037526 UniProtKB/Swiss-Prot
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5599435 IMAGE-MGC_LOAD
InterPro DAPK3_STKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
KEGG Report rno:64391 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72441 IMAGE-MGC_LOAD
NCBI Gene 64391 ENTREZGENE
PANTHER DEATH-ASSOCIATED PROTEIN KINASE 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE 17 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dapk3 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020383 RatGTEx
  ENSRNOG00055032768 RatGTEx
  ENSRNOG00060030872 RatGTEx
  ENSRNOG00065022007 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZTC3_RAT UniProtKB/TrEMBL
  A0A8I6GL62 ENTREZGENE, UniProtKB/TrEMBL
  A6K8B5 ENTREZGENE, UniProtKB/TrEMBL
  DAPK3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Dapk3  Death-associated protein kinase 3  Dapkl  Death-associated like kinase  Symbol and Name updated 1299863 APPROVED
2002-08-07 Dapkl  Death-associated like kinase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation catalytic activity and protein levels increase after nerve growth factor (NGF)-induced differentiation 632627