Tnni1 (troponin I1, slow skeletal type) - Rat Genome Database

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Gene: Tnni1 (troponin I1, slow skeletal type) Rattus norvegicus
Analyze
Symbol: Tnni1
Name: troponin I1, slow skeletal type
RGD ID: 621765
Description: Predicted to have actin binding activity and metal ion binding activity. Involved in regulation of muscle contraction. Localizes to troponin complex. Orthologous to human TNNI1 (troponin I1, slow skeletal type); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: troponin I skeletal slow 1; troponin I type 1 (skeletal, slow); troponin I, skeletal, slow 1; Troponin I, slow isoform; troponin I, slow skeletal muscle; troponin I, slow-twitch isoform
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21347,229,217 - 47,241,640 (+)NCBI
Rnor_6.0 Ensembl1352,624,878 - 52,637,297 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01352,624,856 - 52,637,297 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01357,672,816 - 57,685,255 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41348,830,442 - 48,841,258 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11348,844,484 - 48,855,301 (+)NCBI
Celera1347,546,945 - 47,557,674 (+)NCBICelera
Cytogenetic Map13q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
troponin complex  (IDA,IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway  (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

Additional References at PubMed
PMID:9915769   PMID:12551900   PMID:12815045   PMID:14726477   PMID:15601779   PMID:16679402   PMID:17602701   PMID:18423659   PMID:18550549   PMID:18850076   PMID:18978355   PMID:19184367  
PMID:19507043   PMID:26391394   PMID:28864299   PMID:30820991   PMID:31505169   PMID:31981571  


Genomics

Comparative Map Data
Tnni1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21347,229,217 - 47,241,640 (+)NCBI
Rnor_6.0 Ensembl1352,624,878 - 52,637,297 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01352,624,856 - 52,637,297 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01357,672,816 - 57,685,255 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41348,830,442 - 48,841,258 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11348,844,484 - 48,855,301 (+)NCBI
Celera1347,546,945 - 47,557,674 (+)NCBICelera
Cytogenetic Map13q13NCBI
TNNI1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1201,403,768 - 201,429,866 (-)EnsemblGRCh38hg38GRCh38
GRCh381201,403,784 - 201,421,730 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371201,372,912 - 201,390,858 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361199,639,518 - 199,657,497 (-)NCBINCBI36hg18NCBI36
Build 341198,104,552 - 198,122,531NCBI
Celera1174,496,762 - 174,514,748 (-)NCBI
Cytogenetic Map1q32.1NCBI
HuRef1172,538,919 - 172,556,905 (-)NCBIHuRef
CHM1_11202,795,059 - 202,813,037 (-)NCBICHM1_1
Tnni1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391135,709,252 - 135,738,727 (+)NCBIGRCm39mm39
GRCm39 Ensembl1135,707,172 - 135,738,727 (+)Ensembl
GRCm381135,783,033 - 135,810,989 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1135,779,434 - 135,810,989 (+)EnsemblGRCm38mm10GRCm38
MGSCv371137,695,998 - 137,707,566 (+)NCBIGRCm37mm9NCBIm37
MGSCv361137,616,244 - 137,627,387 (+)NCBImm8
Celera1138,433,849 - 138,445,388 (+)NCBICelera
Cytogenetic Map1E4NCBI
cM Map159.28NCBI
Tnni1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540637,534,453 - 37,554,868 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540637,535,397 - 37,554,868 (-)NCBIChiLan1.0ChiLan1.0
TNNI1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11181,308,154 - 181,329,486 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1181,309,609 - 181,314,889 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01177,006,262 - 177,054,525 (-)NCBIMhudiblu_PPA_v0panPan3
TNNI1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.171,647,138 - 1,658,648 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl71,647,377 - 1,658,724 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha71,521,941 - 1,533,380 (+)NCBI
ROS_Cfam_1.071,478,422 - 1,490,139 (+)NCBI
UMICH_Zoey_3.171,466,030 - 1,477,462 (+)NCBI
UNSW_CanFamBas_1.071,545,747 - 1,585,433 (+)NCBI
UU_Cfam_GSD_1.071,598,424 - 1,609,860 (+)NCBI
Tnni1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934473,761,666 - 73,790,461 (+)NCBI
SpeTri2.0NW_0049365673,013,359 - 3,025,137 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNNI1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1023,788,279 - 23,804,083 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11023,788,279 - 23,800,554 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21028,197,736 - 28,209,608 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TNNI1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12527,989,743 - 28,009,234 (+)NCBI
ChlSab1.1 Ensembl2527,997,709 - 28,002,646 (+)Ensembl
Tnni1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248079,295,121 - 9,306,368 (+)NCBI

Position Markers
D13Wox16  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21347,227,783 - 47,228,023 (+)MAPPER
Rnor_6.01352,623,446 - 52,623,685NCBIRnor6.0
Rnor_5.01357,671,404 - 57,671,643UniSTSRnor5.0
RGSC_v3.41348,828,447 - 48,828,686UniSTSRGSC3.4
Celera1347,544,962 - 47,545,189UniSTS
Cytogenetic Map13q13UniSTS
RH133325  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21347,240,297 - 47,241,401 (+)MAPPER
Rnor_6.01352,635,956 - 52,637,059NCBIRnor6.0
Rnor_5.01357,683,914 - 57,685,017UniSTSRnor5.0
RGSC_v3.41348,840,957 - 48,842,060UniSTSRGSC3.4
Celera1347,557,373 - 47,558,476UniSTS
RH 3.4 Map13128.2UniSTS
Cytogenetic Map13q13UniSTS
RH142414  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21347,241,382 - 47,241,591 (+)MAPPER
Rnor_6.01352,637,041 - 52,637,249NCBIRnor6.0
Rnor_5.01357,684,999 - 57,685,207UniSTSRnor5.0
RGSC_v3.41348,842,042 - 48,842,250UniSTSRGSC3.4
Celera1347,558,458 - 47,558,666UniSTS
Cytogenetic Map13q13UniSTS
RH137504  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21347,241,386 - 47,241,612 (+)MAPPER
Rnor_6.01352,637,045 - 52,637,270NCBIRnor6.0
Rnor_5.01357,685,003 - 57,685,228UniSTSRnor5.0
RGSC_v3.41348,842,046 - 48,842,271UniSTSRGSC3.4
Celera1347,558,462 - 47,558,687UniSTS
Cytogenetic Map13q13UniSTS
TNNI1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21347,239,328 - 47,240,318 (+)MAPPER
Rnor_6.01352,634,987 - 52,635,976NCBIRnor6.0
Rnor_5.01357,682,945 - 57,683,934UniSTSRnor5.0
RGSC_v3.41348,839,988 - 48,840,977UniSTSRGSC3.4
Celera1347,556,404 - 47,557,393UniSTS
Cytogenetic Map13q13UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131107975663Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131107975663Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131107975663Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13901690682995569Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13901690682995569Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1312193394108478121Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)131409633059096330Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)131409633059096330Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131462463159624631Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131462463159624631Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131981081464810814Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)132005247765052477Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)132148248158537177Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1324502279108770533Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132800833873008338Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132858445273584452Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132907693474076934Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132907693474076934Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1335301263107975663Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133614753364868393Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133614753399968921Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133614753399968921Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133614753399968921Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133614753399968921Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133734634882346348Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133937292784372927Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133950130093652524Rat
4889861Pur29Proteinuria QTL 2913.80.005total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)134231074486833540Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)134231074487310744Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)134250834587508345Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)134250834587508345Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134357571788575717Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134567662990676629Rat
4145117Mcs27Mammary carcinoma susceptibility QTL 270.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)134877665553264877Rat
6893344Cm79Cardiac mass QTL 791.50.04heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)134905850767207219Rat
12879472Bp399Blood pressure QTL 399arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)135060922853264877Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)135108098996080989Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)135156924896569248Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)135157782490675199Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:44
Count of miRNA genes:39
Interacting mature miRNAs:43
Transcripts:ENSRNOT00000012095
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 26
Medium 4 12 12 1 12 8 10 12 14 7 8
Low 1 13 26 15 18 15 1 5 19 25 2
Below cutoff 2 8 3 3 30 4 2 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_017184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249864 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249866 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598771 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC096932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217411 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J04993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000242 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000012095   ⟹   ENSRNOP00000012096
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1352,625,441 - 52,636,257 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000076054   ⟹   ENSRNOP00000067933
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1352,624,878 - 52,637,297 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000076299   ⟹   ENSRNOP00000068337
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1352,624,905 - 52,636,258 (+)Ensembl
RefSeq Acc Id: NM_017184   ⟹   NP_058880
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21347,229,779 - 47,240,599 (+)NCBI
Rnor_6.01352,625,441 - 52,636,257 (+)NCBI
Rnor_5.01357,672,816 - 57,685,255 (+)NCBI
RGSC_v3.41348,830,442 - 48,841,258 (+)RGD
Celera1347,546,945 - 47,557,674 (+)RGD
Sequence:
RefSeq Acc Id: XM_006249862   ⟹   XP_006249924
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21347,235,158 - 47,241,640 (+)NCBI
Rnor_6.01352,629,428 - 52,637,297 (+)NCBI
Rnor_5.01357,672,816 - 57,685,255 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006249864   ⟹   XP_006249926
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01352,629,429 - 52,637,297 (+)NCBI
Rnor_5.01357,672,816 - 57,685,255 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006249865   ⟹   XP_006249927
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21347,229,217 - 47,241,640 (+)NCBI
Rnor_6.01352,624,856 - 52,637,297 (+)NCBI
Rnor_5.01357,672,816 - 57,685,255 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006249866   ⟹   XP_006249928
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21347,229,322 - 47,241,640 (+)NCBI
Rnor_6.01352,624,973 - 52,637,297 (+)NCBI
Rnor_5.01357,672,816 - 57,685,255 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006249868   ⟹   XP_006249930
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01352,624,856 - 52,637,297 (+)NCBI
Rnor_5.01357,672,816 - 57,685,255 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006249869   ⟹   XP_006249931
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01352,624,982 - 52,637,297 (+)NCBI
Rnor_5.01357,672,816 - 57,685,255 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017598771   ⟹   XP_017454260
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01352,629,427 - 52,636,258 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_058880   ⟸   NM_017184
- Sequence:
RefSeq Acc Id: XP_006249927   ⟸   XM_006249865
- Peptide Label: isoform X2
- UniProtKB: A0A096MIZ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249930   ⟸   XM_006249868
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_006249928   ⟸   XM_006249866
- Peptide Label: isoform X2
- UniProtKB: A0A096MIZ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249931   ⟸   XM_006249869
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_006249924   ⟸   XM_006249862
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006249926   ⟸   XM_006249864
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017454260   ⟸   XM_017598771
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000012096   ⟸   ENSRNOT00000012095
RefSeq Acc Id: ENSRNOP00000068337   ⟸   ENSRNOT00000076299
RefSeq Acc Id: ENSRNOP00000067933   ⟸   ENSRNOT00000076054

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698851
Promoter ID:EPDNEW_R9372
Type:initiation region
Name:Tnni1_1
Description:troponin I1, slow skeletal type
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01352,624,905 - 52,624,965EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621765 AgrOrtholog
Ensembl Genes ENSRNOG00000009073 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000012096 UniProtKB/TrEMBL
  ENSRNOP00000067933 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000068337 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012095 UniProtKB/TrEMBL
  ENSRNOT00000076054 UniProtKB/TrEMBL
  ENSRNOT00000076299 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Troponin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Troponin_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29388 UniProtKB/Swiss-Prot
NCBI Gene 29388 ENTREZGENE
Pfam Troponin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tnni1 PhenoGen
Superfamily-SCOP SSF90250 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A096MIZ5 ENTREZGENE, UniProtKB/TrEMBL
  F1LMC6_RAT UniProtKB/TrEMBL
  P13413 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-24 Tnni1  troponin I1, slow skeletal type  Tnni1  troponin I type 1 (skeletal, slow)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-23 Tnni1  troponin I type 1 (skeletal, slow)  Tnni1  troponin I, skeletal, slow 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Tnni1  troponin I, skeletal, slow 1    Troponin I, slow isoform  Name updated 1299863 APPROVED
2002-08-07 Tnni1        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression different isoforms are expressed in the various classes of vertebrate striated muscle cells 729969