Ehd3 (EH-domain containing 3) - Rat Genome Database

Name: Ehd3
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Ehd3 (EH-domain containing 3) Rattus norvegicus

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Symbol:

Ehd3

Name:

EH-domain containing 3

RGD ID:

621762

Description:

Predicted to enable ATP binding activity; GTP binding activity; and calcium ion binding activity. Predicted to be involved in several processes, including cytosolic transport; positive regulation of voltage-gated calcium channel activity; and regulation of heart contraction. Predicted to act upstream of or within regulation of cardiac muscle cell membrane potential. Predicted to be located in ciliary pocket membrane. Predicted to be active in cytoplasmic vesicle; perinuclear region of cytoplasm; and plasma membrane. Orthologous to human EHD3 (EH domain containing 3); PARTICIPATES IN endocytosis pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-methoxyethanol; 3,7-dihydropurine-6-thione.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

EH domain-containing protein 3; Ehd2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	EHD3 (EH domain containing 3)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Ehd3 (EH-domain containing 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ehd3 (EH domain containing 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	EHD3 (EH domain containing 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	EHD3 (EH domain containing 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ehd3 (EH domain containing 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	EHD3 (EH domain containing 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	EHD3 (EH domain containing 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ehd3 (EH domain containing 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	EHD1 (EH domain containing 1)	HGNC	OrthoDB
Homo sapiens (human):	GDPGP1 (GDP-D-glucose phosphorylase 1)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	EHD3 (EH domain containing 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Ehd3 (EH-domain containing 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ehd3 (EH-domain containing 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Past1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	rme-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	IRS4	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	SLA1	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	ehd3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	27,392,709 - 27,417,445 (-)	NCBI		GRCr8
mRatBN7.2	6	21,640,861 - 21,665,601 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	21,639,290 - 21,665,236 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	21,969,572 - 21,994,301 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	22,285,418 - 22,310,143 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	21,765,853 - 21,790,578 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	25,076,012 - 25,102,457 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	25,074,955 - 25,100,977 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	34,923,729 - 34,949,869 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	21,638,705 - 21,686,023 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	21,641,657 - 21,688,976 (-)	NCBI
Celera	6	21,191,963 - 21,214,991 (-)	NCBI		Celera
Cytogenetic Map	6	q14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute myeloid leukemia (ISO)

hepatocellular carcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-hydroxypropanoic acid (ISO)

2-methoxyethanol (EXP)

3,3',4,4',5-pentachlorobiphenyl (ISO)

3,7-dihydropurine-6-thione (EXP)

3-methylcholanthrene (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (EXP)

4-hydroxyphenyl retinamide (ISO)

4-phenylbutyric acid (ISO)

5-aza-2'-deoxycytidine (ISO)

Aflatoxin B2 alpha (ISO)

aldehydo-D-glucose (EXP)

ammonium chloride (EXP)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP)

C60 fullerene (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chloroprene (EXP)

choline (ISO)

cisplatin (ISO)

D-glucose (EXP)

dexamethasone (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (EXP)

dimethylarsinic acid (ISO)

dioxygen (EXP)

doxorubicin (ISO)

endosulfan (EXP)

epoxiconazole (ISO)

ethanol (ISO)

fluoranthene (ISO)

folic acid (ISO)

gentamycin (EXP)

glucose (EXP)

hydrogen sulfide (ISO)

L-methionine (ISO)

lead(0) (ISO)

mercaptopurine (EXP)

methidathion (ISO)

nimesulide (EXP)

ozone (ISO)

paracetamol (EXP,ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

propiconazole (ISO)

purine-6-thiol (EXP)

rac-lactic acid (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

starch (EXP)

tamoxifen (ISO)

tetrachloromethane (ISO)

trichostatin A (ISO)

triclosan (ISO)

triphenyl phosphate (ISO)

valproic acid (ISO)

vorinostat (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cilium assembly (IBA,IEA,ISO,ISS)

early endosome to Golgi transport (IEA,ISO)

endocytic recycling (IBA,IEA,ISO,ISS)

endocytosis (IBA)

Golgi to lysosome transport (IEA,ISO)

positive regulation of voltage-gated calcium channel activity (ISO)

protein homooligomerization (IEA,ISO,ISS)

protein localization to plasma membrane (IBA,IEA,ISO)

protein transport (IEA)

receptor recycling (IEA,ISO)

regulation of cardiac conduction (IEA,ISO)

regulation of cardiac muscle cell membrane potential (IEA,ISO)

regulation of cardiac muscle contraction (IEA,ISO)

regulation of Golgi organization (IEA,ISO)

Cellular Component

ciliary pocket membrane (IEA,ISO,ISS)

cytoplasm (IBA,ISO,ISS)

cytosol (IEA)

early endosome (IBA)

endocytic vesicle (IBA,IEA,ISO)

perinuclear region of cytoplasm (IBA,IEA,ISO)

plasma membrane (IBA)

recycling endosome membrane (IBA,IEA,ISO,ISS)

Molecular Function

ATP binding (IEA)

calcium ion binding (IEA)

GTP binding (IEA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

endocytosis pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	EHD3: a protein that resides in recycling tubular and vesicular membrane structures and interacts with EHD1.	Galperin E, etal., Traffic 2002 Aug;3(8):575-89.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
5.	EHD2 interacts with the insulin-responsive glucose transporter (GLUT4) in rat adipocytes and may participate in insulin-induced GLUT4 recruitment.	Park SY, etal., Biochemistry 2004 Jun 15;43(23):7552-62.
6.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
7.	GOA pipeline	RGD automated data pipeline
8.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:11423532	PMID:17233914	PMID:17251388	PMID:17634366	PMID:19139087	PMID:20489164	PMID:21423176	PMID:21791287	PMID:25686250	PMID:25825486	PMID:29476059

Genomics

Comparative Map Data

Ehd3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	27,392,709 - 27,417,445 (-)	NCBI		GRCr8
mRatBN7.2	6	21,640,861 - 21,665,601 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	21,639,290 - 21,665,236 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	21,969,572 - 21,994,301 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	22,285,418 - 22,310,143 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	21,765,853 - 21,790,578 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	25,076,012 - 25,102,457 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	25,074,955 - 25,100,977 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	34,923,729 - 34,949,869 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	21,638,705 - 21,686,023 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	21,641,657 - 21,688,976 (-)	NCBI
Celera	6	21,191,963 - 21,214,991 (-)	NCBI		Celera
Cytogenetic Map	6	q14	NCBI

EHD3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	31,234,152 - 31,269,451 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	31,234,152 - 31,269,451 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	31,457,018 - 31,492,317 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	31,310,707 - 31,344,764 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	31,368,853 - 31,402,911	NCBI
Celera	2	31,299,596 - 31,333,966 (+)	NCBI		Celera
Cytogenetic Map	2	p23.1	NCBI
HuRef	2	31,194,543 - 31,228,913 (+)	NCBI		HuRef
CHM1_1	2	31,387,489 - 31,421,882 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	31,278,316 - 31,313,593 (+)	NCBI		T2T-CHM13v2.0

Ehd3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	74,111,836 - 74,139,088 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	74,111,129 - 74,139,089 (+)	Ensembl		GRCm39 Ensembl
GRCm38	17	73,804,841 - 73,832,093 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	73,804,134 - 73,832,094 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	74,154,181 - 74,181,433 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	73,709,754 - 73,736,970 (+)	NCBI		MGSCv36	mm8
Celera	17	78,096,325 - 78,123,512 (+)	NCBI		Celera
Cytogenetic Map	17	E2	NCBI
cM Map	17	45.2	NCBI

Ehd3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955469	12,953,645 - 12,984,430 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955469	12,953,800 - 12,984,296 (+)	NCBI	ChiLan1.0	ChiLan1.0

EHD3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	95,230,506 - 95,265,388 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	95,234,481 - 95,269,366 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	31,245,908 - 31,280,485 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	31,317,432 - 31,353,312 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	31,317,432 - 31,353,312 (+)	Ensembl	panpan1.1		panPan2

EHD3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	24,828,289 - 24,854,990 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	24,828,372 - 24,853,400 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	24,622,571 - 24,649,257 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	25,392,047 - 25,418,779 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	25,392,095 - 25,417,697 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	24,695,316 - 24,722,054 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	24,757,373 - 24,784,106 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	24,857,360 - 24,884,084 (+)	NCBI		UU_Cfam_GSD_1.0

Ehd3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	68,943,443 - 68,974,729 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936493	1,864,755 - 1,896,097 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936493	1,864,836 - 1,896,079 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

EHD3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	108,100,401 - 108,134,906 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	108,103,631 - 108,135,161 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

EHD3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	76,237,345 - 76,271,557 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	76,236,246 - 76,271,546 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	35,801,161 - 35,835,035 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ehd3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624738	13,032,604 - 13,062,795 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624738	13,033,491 - 13,062,795 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Ehd3
134 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	32
Count of miRNA genes:	32
Interacting mature miRNAs:	32
Transcripts:	ENSRNOT00000010419
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
8552962	Pigfal16	Plasma insulin-like growth factor 1 level QTL 16	9.4		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	6	1	41223769	Rat
1549905	Stresp10	Stress response QTL 10	6.83	0.0066	stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	6	1	27574569	Rat
8693645	Alc31	Alcohol consumption QTL 31	3.7	0.038	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	6	17532521	24011952	Rat
10401812	Kidm54	Kidney mass QTL 54			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	6	14368788	59368788	Rat
1331743	Uae28	Urinary albumin excretion QTL 28	4.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	6	1	34235784	Rat
2292589	Emca10	Estrogen-induced mammary cancer QTL 10		0.048	mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	6	16536140	61536140	Rat
10401800	Kidm49	Kidney mass QTL 49			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	6	14368788	59368788	Rat
1300164	Rf15	Renal function QTL 15	3.12		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	5074497	54641141	Rat
9589129	Insul24	Insulin level QTL 24	19.06	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	6	1	41223769	Rat
1578758	Tcas9	Tongue tumor susceptibility QTL 9	3.29		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	6	1	37618905	Rat
4145119	Mcs25	Mammary carcinoma susceptibility QTL 25		0.0001	mammary gland integrity trait (VT:0010552)	ratio of deaths to total study population during a period of time (CMO:0001023)	6	10894415	110548006	Rat
7411603	Foco13	Food consumption QTL 13	5.5	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	6	1	41223769	Rat
738024	Sach5	Saccharine consumption QTL 5	3.9	0.00039	consumption behavior trait (VT:0002069)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	6	1	43394190	Rat
1598843	Cm63	Cardiac mass QTL 63	2.6		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	6	1	39036266	Rat
7411542	Bw127	Body weight QTL 127	5.5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	1	41223769	Rat
9589048	Scfw3	Subcutaneous fat weight QTL 3	4.57	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	6	1	41223769	Rat
2293839	Kiddil2	Kidney dilation QTL 2	4.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	20866422	81133036	Rat
738023	Alc17	Alcohol consumption QTL 17	3.1	0.003	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	6	1	27574569	Rat
1354616	Despr12	Despair related QTL 12		0.0012	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	6	1	27574569	Rat
1576309	Emca7	Estrogen-induced mammary cancer QTL 7	4		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	6	15107216	107351382	Rat
2293709	Bss23	Bone structure and strength QTL 23	5.18	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	6	1	42487980	Rat
2293650	Bss31	Bone structure and strength QTL 31	5.05	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	6	1	42487980	Rat
1578665	Bss16	Bone structure and strength QTL 16	4.4		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	6	11735669	72593685	Rat
7411584	Foco4	Food consumption QTL 4	4.3	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	6	1	42838846	Rat
2293841	Kiddil4	Kidney dilation QTL 4	4.4		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	20866422	81133036	Rat
1641898	Colcr4	Colorectal carcinoma resistance QTL4	3.71	0.0007	intestine integrity trait (VT:0010554)	well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)	6	20338777	62613667	Rat
2300176	Bmd51	Bone mineral density QTL 51	11.7	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	6	1	27574569	Rat
1300128	Rf16	Renal function QTL 16	3.89		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	5074497	34434305	Rat
1578668	Bmd14	Bone mineral density QTL 14	3.8		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	6	11735669	72593685	Rat
2301972	Bp325	Blood pressure QTL 325	4.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	1	72227641	Rat
2293656	Bss28	Bone structure and strength QTL 28	6.79	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	6	1	42487980	Rat
1359023	Bp272	Blood pressure QTL 272	2.5		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	6	16536140	27261739	Rat
1354664	Slep2	Serum leptin concentration QTL 2	4.49		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	6	16536140	71636405	Rat
2300190	Bmd52	Bone mineral density QTL 52	11.2	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	6	1	27574569	Rat

Markers in Region

RH142835

Rat Assembly	Chr	Position (strand)	Source	JBrowse
RH 3.4 Map	8	212.2	UniSTS
Cytogenetic Map	6	q13	UniSTS

RH141270

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	21,640,510 - 21,640,702 (-)	MAPPER	mRatBN7.2
Rnor_6.0	6	25,101,042 - 25,101,233	NCBI	Rnor6.0
Rnor_5.0	6	34,948,457 - 34,948,648	UniSTS	Rnor5.0
RGSC_v3.4	6	21,638,355 - 21,638,546	UniSTS	RGSC3.4
Celera	6	21,191,613 - 21,191,804	UniSTS
Cytogenetic Map	6	q13	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_138890	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006239774	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC135695	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF494093	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473947	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000010419 ⟹ ENSRNOP00000010419

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	21,639,290 - 21,665,236 (-)	Ensembl
Rnor_6.0 Ensembl	6	25,076,147 - 25,100,883 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000084773 ⟹ ENSRNOP00000068716

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	21,639,290 - 21,665,206 (-)	Ensembl
Rnor_6.0 Ensembl	6	25,074,955 - 25,100,977 (+)	Ensembl

RefSeq Acc Id:

NM_138890 ⟹ NP_620245

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	27,392,709 - 27,417,445 (-)	NCBI
mRatBN7.2	6	21,640,861 - 21,665,601 (-)	NCBI
Rnor_6.0	6	25,076,147 - 25,100,883 (+)	NCBI
Rnor_5.0	6	34,923,729 - 34,949,869 (+)	NCBI
RGSC_v3.4	6	21,638,705 - 21,686,023 (-)	RGD
Celera	6	21,191,963 - 21,214,991 (-)	RGD

Sequence:

show sequence

TCCTGCACGTCTAGCATTTAAACGAGCGCCGGGGGCGGCGGGATGCTGCTGCGGATGCGGAGCT
GTGTGCGCCTCCACCTACTCCCAGCAGCCTGGACACCGCAGCAGCGGGGCTCCAGAATCCTTTA
GCCACCTAACTGGGGAGACCCAGAACTCATGCTTCGGCTTCCCGGCAGGTTCGTCTTTAATTTC
CAAGGTTGCAGTTCTCCTGACACGATCCGCAGCATCCTCTTCCCCCAACCCCGCTGTGGATGAA
GCTGGGGCTGGACTGGATCCAGCAGCTGGGGCAGCCCCGGCCATGGTGTATCTGAGCCCCGAGC
TCTGGTAAGGCAGCTGTGGCGGCGTGGTTCGAGCTAGGCGGGTGCCACTCCCGGGAGCCTTCTT
CCAGCTGCCACAATGTTCAGCTGGCTGGGTAACGATGATCGCCGCAAGAAGGACCCTGAGGTCT
TCCAGACCGTGAGCGAGGGGCTCAAGAAACTCTACAAGACCAAGCTGCTGCCTCTGGAAGAGTA
TTACCGCTTCCACGAGTTCCACTCGCCGGCCTTGGAGGATGCTGATTTCGACAACAAGCCCATG
GTCCTGTTGGTGGGCCAATACTCTACTGGCAAGACCACCTTCATCAGGTACCTGCTGGAACAGG
ATTTTCCAGGCATGAGGATTGGGCCTGAGCCAACCACTGATTCCTTCATAGCAGTGATGCAGGG
AGATGTGGAGGGGATCATCCCTGGGAACGCCCTGGTGGTGGATCCGAAGAAACCCTTCAGAAAG
CTCAACGCCTTCGGCAATGCCTTCTTGAACAGGTTTGTGTGTGCGCAGCTGCCCAACGCTGTTC
TAGAAAGTATCAGTGTCATCGACACACCGGGGATCCTCTCTGGTGAGAAACAGAGGATCAGCCG
AGGGTATGATTTTGCTGCTGTCCTCGAATGGTTTGCTGAGCGGGTGGACCGAATCATCCTGCTC
TTTGACGCCCACAAGCTTGACATCTCTGATGAGTTCTCAGAAGTCATCAAGGCCCTCAAGAACC
ACGAGGACAAGATGCGAGTGGTGTTGAACAAGGCTGACCAGATTGAGACCCAGCAGCTGATGCG
GGTGTATGGGGCCCTCATGTGGTCCCTGGGGAAGATTGTGAACACACCAGAGGTGATCCGGGTC
TACATTGGCTCCTTCTGGTCCCACCCTCTCCTCATTCCTGACAACAGGAAGCTCTTTGAAGCTG
AAGAGCAAGACTTGTTCAAAGACATTCAGAGTCTACCCCGTAATGCTGCTCTTCGAAAGCTCAA
TGATCTCATCAAGAGAGCCCGGCTGGCCAAGGTCCATGCCTATATCATCAGCTCCCTAAAAAAG
GAGATGCCCTCAGTGTTTGGGAAGGACACCAAAAAGAAAGAGCTGGTGAACAACCTGGCTGAGA
TCTATGGCCGGATTGAGCGAGAACACCAGATATCCCCTGGGGACTTCCCCAACCTGAAGAGGAT
GCAGGATCAGCTGCAGGCCCAGGACTTCAGCAAATTCCAACCACTGAAGAGCAAGCTGCTAGAA
GTGGTTGATGACATGCTGGCCCATGACATTGCCCAGCTCATGGTGCTGGTACGCCAGGAAGAGA
CCCAGCGGCCTGTTCAGATGGTGAAGGGTGGAGCATTTGAGGGAACCCTCCAAGGGCCCTTCGG
GCATGGCTATGGAGAGGGAGCTGGGGAGGGCATTGATGATGCCGAGTGGGTGGTGGCCCGGGAC
AAGCCTATGTATGATGAAATCTTCTACACCTTATCCCCGGTGGATGGCAAGATTACGGGCGCCA
ATGCCAAAAAGGAGATGGTGCGCTCCAAGTTGCCCAACAGCGTCCTGGGGAAGATCTGGAAGCT
AGCCGACATTGACAAGGATGGCATGTTGGATGATGAGGAGTTTGCCCTGGCCAACCACCTTATC
AAAGTCAAGCTAGAGGGGCATGAGCTGCCCAGTGAGCTGCCTGCCCATCTCCTCCCTCCATCTA
AGAGGAAAGTAGCGGAGTGAGAGAGCCAGGCAGCTTCAGACAGACAGTGTCAAAAGAGAGGATA
GACGTGATGACCACACACACACACACACACACACACACACACACACACACACACACACAC

hide sequence

Protein Sequences


Protein RefSeqs	NP_620245	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAM14604	(Get FASTA)	NCBI Sequence Viewer
	EDM02853	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000010419.3
	ENSRNOP00000068716.1
	ENSRNOP00055029128
	ENSRNOP00060017334
	ENSRNOP00065028250
GenBank Protein	Q8R491	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_620245 ⟸ NM_138890

- UniProtKB:

Q8R491 (UniProtKB/Swiss-Prot), A6H9Z8 (UniProtKB/TrEMBL), A0A0G2JTH6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MFSWLGNDDRRKKDPEVFQTVSEGLKKLYKTKLLPLEEYYRFHEFHSPALEDADFDNKPMVLLV
GQYSTGKTTFIRYLLEQDFPGMRIGPEPTTDSFIAVMQGDVEGIIPGNALVVDPKKPFRKLNAF
GNAFLNRFVCAQLPNAVLESISVIDTPGILSGEKQRISRGYDFAAVLEWFAERVDRIILLFDAH
KLDISDEFSEVIKALKNHEDKMRVVLNKADQIETQQLMRVYGALMWSLGKIVNTPEVIRVYIGS
FWSHPLLIPDNRKLFEAEEQDLFKDIQSLPRNAALRKLNDLIKRARLAKVHAYIISSLKKEMPS
VFGKDTKKKELVNNLAEIYGRIEREHQISPGDFPNLKRMQDQLQAQDFSKFQPLKSKLLEVVDD
MLAHDIAQLMVLVRQEETQRPVQMVKGGAFEGTLQGPFGHGYGEGAGEGIDDAEWVVARDKPMY
DEIFYTLSPVDGKITGANAKKEMVRSKLPNSVLGKIWKLADIDKDGMLDDEEFALANHLIKVKL
EGHELPSELPAHLLPPSKRKVAE

hide sequence

Ensembl Acc Id:

ENSRNOP00000068716 ⟸ ENSRNOT00000084773

Ensembl Acc Id:

ENSRNOP00000010419 ⟸ ENSRNOT00000010419

Protein Domains

Dynamin-type G EF-hand EH

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q8R491-F1-model_v2	AlphaFold	Q8R491	1-535	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13694424

Promoter ID:

EPDNEW_R4949

Type:

initiation region

Name:

Ehd3_1

Description:

EH-domain containing 3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	6	25,076,191 - 25,076,251	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621762	AgrOrtholog
BioCyc Gene	G2FUF-38425	BioCyc
Ensembl Genes	ENSRNOG00000007744	Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSRNOG00055020999	UniProtKB/Swiss-Prot
	ENSRNOG00060012878	UniProtKB/Swiss-Prot
	ENSRNOG00065020714	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000010419.4	UniProtKB/Swiss-Prot
	ENSRNOT00000084773.2	UniProtKB/TrEMBL
	ENSRNOT00055035871	UniProtKB/Swiss-Prot
	ENSRNOT00060021912	UniProtKB/Swiss-Prot
	ENSRNOT00065035132	UniProtKB/Swiss-Prot
Gene3D-CATH	1.10.268.20	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.40.50.300	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EF-hand	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	DUF5600	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Dynamin_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EF-hand-dom_pair	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EF_Hand_1_Ca_BS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EF_hand_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EH_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EHD_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	G_DYNAMIN_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:192249	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	192249	ENTREZGENE
PANTHER	EH DOMAIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EPIDERMAL GROWTH FACTOR RECEPTOR PATHWAY SUBSTRATE CLONE 15, ISOFORM A	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	DUF5600	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Dynamin_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EF-hand_4	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EHD_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Ehd3	PhenoGen
PROSITE	EF_HAND_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EF_HAND_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	G_DYNAMIN_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PS50031	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000007744	RatGTEx
	ENSRNOG00055020999	RatGTEx
	ENSRNOG00060012878	RatGTEx
	ENSRNOG00065020714	RatGTEx
SMART	SM00027	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF47473	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF52540	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0G2JTH6	ENTREZGENE, UniProtKB/TrEMBL
	A6H9Z8	ENTREZGENE, UniProtKB/TrEMBL
	EHD3_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-09-10	Ehd3	EH-domain containing 3			Symbol and Name status set to approved	1299863	APPROVED
2002-08-07	Ehd3	EH-domain containing 3			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_function	interacts with GLUT4 in rat adipocytes	1304334

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)