Pggt1b (protein geranylgeranyltransferase type I subunit beta) - Rat Genome Database

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Gene: Pggt1b (protein geranylgeranyltransferase type I subunit beta) Rattus norvegicus
Analyze
Symbol: Pggt1b
Name: protein geranylgeranyltransferase type I subunit beta
RGD ID: 621754
Description: Enables heterocyclic compound binding activity. Contributes to CAAX-protein geranylgeranyltransferase activity; peptide binding activity; and zinc ion binding activity. Involved in several processes, including negative regulation of nitric-oxide synthase biosynthetic process; positive regulation of cell cycle; and positive regulation of cell population proliferation. Part of CAAX-protein geranylgeranyltransferase complex. Orthologous to human PGGT1B (protein geranylgeranyltransferase type I subunit beta); INTERACTS WITH (+)-schisandrin B; ammonium chloride; amphetamine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: geranylgeranyl transferase type I subunit beta; geranylgeranyl transferase type-1 subunit beta; geranylgeranyltransferase type 1 beta; geranylgeranyltransferase type I (GGTase-I); GGTase-I-beta; protein geranylgeranyltransferase type 1 subunit beta; protein geranylgeranyltransferase type I, beta subunit; type I protein geranyl-geranyltransferase subunit beta
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81841,138,536 - 41,182,145 (-)NCBIGRCr8
mRatBN7.21838,952,147 - 38,995,656 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1838,952,914 - 38,995,503 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1840,986,574 - 41,028,748 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01841,688,793 - 41,730,969 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01839,481,904 - 39,524,080 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01840,173,236 - 40,218,225 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1840,175,951 - 40,218,225 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01839,826,667 - 39,871,483 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41840,410,055 - 40,452,883 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11840,447,595 - 40,490,419 (-)NCBI
Celera1837,212,291 - 37,254,465 (-)NCBICelera
Cytogenetic Map18q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Inhibition of protein geranylgeranylation causes a superinduction of nitric-oxide synthase-2 by interleukin-1beta in vascular smooth muscle cells. Finder JD, etal., J Biol Chem. 1997 May 23;272(21):13484-8.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
5. Combination of the novel farnesyltransferase inhibitor RPR130401 and the geranylgeranyltransferase-1 inhibitor GGTI-298 disrupts MAP kinase activation and G(1)-S transition in Ki-Ras-overexpressing transformed adrenocortical cells. Mazet JL, etal., FEBS Lett. 1999 Oct 29;460(2):235-40.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. Crystallographic analysis reveals that anticancer clinical candidate L-778,123 inhibits protein farnesyltransferase and geranylgeranyltransferase-I by different binding modes. Reid TS, etal., Biochemistry. 2004 Jul 20;43(28):9000-8.
9. Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity. Reid TS, etal., J Mol Biol. 2004 Oct 15;343(2):417-33.
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Role of the carboxyterminal residue in peptide binding to protein farnesyltransferase and protein geranylgeranyltransferase. Roskoski R Jr and Ritchie P, Arch Biochem Biophys. 1998 Aug 15;356(2):167-76.
14. Structure of mammalian protein geranylgeranyltransferase type-I. Taylor JS, etal., EMBO J. 2003 Nov 17;22(22):5963-74.
15. cDNA cloning and expression of rat and human protein geranylgeranyltransferase type-I. Zhang FL, etal., J Biol Chem 1994 Feb 4;269(5):3175-80.
16. Properties and kinetic mechanism of recombinant mammalian protein geranylgeranyltransferase type I. Zhang FL, etal., J Biol Chem. 1994 Sep 23;269(38):23465-70.
17. TrkB-mediated activation of geranylgeranyltransferase I promotes dendritic morphogenesis. Zhou XP, etal., Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):17181-6. Epub 2008 Oct 28.
Additional References at PubMed
PMID:15131129   PMID:16893176   PMID:20540740  


Genomics

Comparative Map Data
Pggt1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81841,138,536 - 41,182,145 (-)NCBIGRCr8
mRatBN7.21838,952,147 - 38,995,656 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1838,952,914 - 38,995,503 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1840,986,574 - 41,028,748 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01841,688,793 - 41,730,969 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01839,481,904 - 39,524,080 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01840,173,236 - 40,218,225 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1840,175,951 - 40,218,225 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01839,826,667 - 39,871,483 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41840,410,055 - 40,452,883 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11840,447,595 - 40,490,419 (-)NCBI
Celera1837,212,291 - 37,254,465 (-)NCBICelera
Cytogenetic Map18q11NCBI
PGGT1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385115,204,012 - 115,262,877 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5115,204,012 - 115,262,877 (-)EnsemblGRCh38hg38GRCh38
GRCh375114,539,709 - 114,598,574 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365114,575,476 - 114,626,449 (-)NCBINCBI36Build 36hg18NCBI36
Build 345114,575,475 - 114,626,449NCBI
Celera5110,494,046 - 110,546,088 (-)NCBICelera
Cytogenetic Map5q22.3NCBI
HuRef5109,728,848 - 109,780,942 (-)NCBIHuRef
CHM1_15113,979,258 - 114,031,277 (-)NCBICHM1_1
T2T-CHM13v2.05115,713,562 - 115,776,201 (-)NCBIT2T-CHM13v2.0
Pggt1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391846,368,411 - 46,414,173 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1846,368,418 - 46,414,060 (-)EnsemblGRCm39 Ensembl
GRCm381846,235,344 - 46,281,089 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1846,235,351 - 46,280,993 (-)EnsemblGRCm38mm10GRCm38
MGSCv371846,399,603 - 46,440,504 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361846,365,280 - 46,406,181 (-)NCBIMGSCv36mm8
Celera1847,599,910 - 47,646,046 (-)NCBICelera
Cytogenetic Map18CNCBI
cM Map1824.45NCBI
Pggt1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540834,994,545 - 35,049,037 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540834,994,545 - 35,049,037 (-)NCBIChiLan1.0ChiLan1.0
PGGT1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24110,459,853 - 110,511,951 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15108,613,523 - 108,665,713 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05110,558,684 - 110,622,175 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15116,360,149 - 116,419,069 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5116,366,984 - 116,419,069 (-)Ensemblpanpan1.1panPan2
PGGT1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1114,967,504 - 5,020,491 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl114,880,404 - 5,020,473 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha115,099,400 - 5,171,320 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0114,940,644 - 5,012,576 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl114,953,486 - 5,012,560 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1114,896,291 - 4,968,192 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0114,977,938 - 5,037,052 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0115,218,691 - 5,290,606 (-)NCBIUU_Cfam_GSD_1.0
Pggt1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213127,692,328 - 127,749,907 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936742395,073 - 450,860 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936742394,061 - 450,717 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PGGT1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2119,383,387 - 119,440,322 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12119,386,692 - 119,440,834 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22124,200,641 - 124,235,373 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PGGT1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12318,462,750 - 18,517,193 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2318,464,827 - 18,517,176 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603459,882,912 - 59,945,051 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pggt1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247336,683,080 - 6,761,038 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247336,682,123 - 6,766,359 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pggt1b
95 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:244
Count of miRNA genes:171
Interacting mature miRNAs:199
Transcripts:ENSRNOT00000004723
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9589153Insul31Insulin level QTL 317.150.05blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)18142547119Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18420794160377792Rat
2312568Glom21Glomerulus QTL 2120.005kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)18518585840503530Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181179151863636873Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
61375Bp41Blood pressure QTL 412.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)181194429941122201Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194429952293055Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)181194429959330563Rat
6903359Bp355Blood pressure QTL 3553.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194454459796478Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181495133759951337Rat
1358193Emca2Estrogen-induced mammary cancer QTL 21.6mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)181800759963571040Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
1641923Colcr8Colorectal carcinoma resistance QTL 83.10.0014intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)182206624252293055Rat
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182557098570570985Rat
12904673Cm127Cardiac mass QTL 1270.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)182654808246969551Rat
12904675Am19Aortic mass QTL 190.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)182654808246969551Rat
12904677Kidm72Kidney mass QTL 720.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)182654808246969551Rat
12904668Bw188Body weight QTL 1880.03body mass (VT:0001259)body weight (CMO:0000012)182654808246969551Rat
12904669Cm125Cardiac mass QTL 1250.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)182654808246969551Rat
12904670Cm126Cardiac mass QTL 1260.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)182654808246969551Rat
2301413Bp318Blood pressure QTL 3180.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182654808246969551Rat
2293704Bss35Bone structure and strength QTL 354.590.0002femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)182896485373964853Rat
2300157Bmd66Bone mineral density QTL 6613.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
2300177Bmd65Bone mineral density QTL 6519.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)182979296574792965Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)182979296574792965Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)182979296574792965Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182979296574792965Rat
738005Anxrr11Anxiety related response QTL 113.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)183003981375039813Rat
61383Bp47Blood pressure QTL 4717.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)183127168160377755Rat
1331742Bp228Blood pressure QTL 2283.88752arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
1331774Bp226Blood pressure QTL 2264.41065arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
1331776Bp225Blood pressure QTL 2252.829arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)183135940859796643Rat
1331798Bp224Blood pressure QTL 2243.53873arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
1331727Bp237Blood pressure QTL 2373.053arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940861698465Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183135940870263868Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183135940883218561Rat
6903347Bp350Blood pressure QTL 3504.4arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135953059796478Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183139332077209694Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183587072380870723Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183819245583192455Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 36 40 24 19 24 8 8 74 32 36 11 8
Low 7 17 17 17 3 3 5
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000004723   ⟹   ENSRNOP00000004723
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1838,952,917 - 38,995,503 (-)Ensembl
Rnor_6.0 Ensembl1840,175,951 - 40,218,225 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000097524   ⟹   ENSRNOP00000087553
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1838,952,917 - 38,995,503 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000103699   ⟹   ENSRNOP00000095779
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1838,952,914 - 38,995,491 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000116864   ⟹   ENSRNOP00000087099
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1838,952,917 - 38,995,281 (-)Ensembl
RefSeq Acc Id: NM_031082   ⟹   NP_112344
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81841,139,965 - 41,182,139 (-)NCBI
mRatBN7.21838,953,329 - 38,995,507 (-)NCBI
Rnor_6.01840,175,951 - 40,218,225 (-)NCBI
Rnor_5.01839,826,667 - 39,871,483 (-)NCBI
RGSC_v3.41840,410,055 - 40,452,883 (-)RGD
Celera1837,212,291 - 37,254,465 (-)RGD
Sequence:
RefSeq Acc Id: XM_008772177   ⟹   XP_008770399
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81841,138,536 - 41,182,046 (-)NCBI
mRatBN7.21838,953,360 - 38,995,498 (-)NCBI
Rnor_6.01840,173,236 - 40,218,167 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039097140   ⟹   XP_038953068
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81841,138,536 - 41,177,311 (-)NCBI
mRatBN7.21838,952,147 - 38,995,520 (-)NCBI
RefSeq Acc Id: XM_039097141   ⟹   XP_038953069
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81841,147,688 - 41,182,145 (-)NCBI
mRatBN7.21838,961,058 - 38,995,656 (-)NCBI
RefSeq Acc Id: NP_112344   ⟸   NM_031082
- UniProtKB: P53610 (UniProtKB/Swiss-Prot),   A6IWV1 (UniProtKB/TrEMBL),   A0A8I6A578 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008770399   ⟸   XM_008772177
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A578 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000004723   ⟸   ENSRNOT00000004723
RefSeq Acc Id: XP_038953068   ⟸   XM_039097140
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038953069   ⟸   XM_039097141
- Peptide Label: isoform X3
RefSeq Acc Id: ENSRNOP00000095779   ⟸   ENSRNOT00000103699
RefSeq Acc Id: ENSRNOP00000087099   ⟸   ENSRNOT00000116864
RefSeq Acc Id: ENSRNOP00000087553   ⟸   ENSRNOT00000097524

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P53610-F1-model_v2 AlphaFold P53610 1-377 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700760
Promoter ID:EPDNEW_R11284
Type:multiple initiation site
Name:Pggt1b_1
Description:protein geranylgeranyltransferase type 1 subunit beta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01840,218,228 - 40,218,288EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621754 AgrOrtholog
BioCyc Gene G2FUF-7635 BioCyc
Ensembl Genes ENSRNOG00000003541 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055017993 UniProtKB/Swiss-Prot
  ENSRNOG00060012113 UniProtKB/Swiss-Prot
  ENSRNOG00065019185 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000004723 ENTREZGENE
  ENSRNOT00000004723.4 UniProtKB/Swiss-Prot
  ENSRNOT00000097524.1 UniProtKB/TrEMBL
  ENSRNOT00000103699.1 UniProtKB/TrEMBL
  ENSRNOT00000116864.1 UniProtKB/TrEMBL
  ENSRNOT00055030494 UniProtKB/Swiss-Prot
  ENSRNOT00060020564 UniProtKB/Swiss-Prot
  ENSRNOT00065032279 UniProtKB/Swiss-Prot
Gene3D-CATH 1.50.10.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GGTase_I_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PFTB_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PGGT1B-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Terpenoid_cyclase/PrenylTrfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81746 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 81746 ENTREZGENE
PANTHER GERANYLGERANYL TRANSFERASE TYPE-1 SUBUNIT BETA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11774 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Prenyltrans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pggt1b PhenoGen
RatGTEx ENSRNOG00000003541 RatGTEx
  ENSRNOG00055017993 RatGTEx
  ENSRNOG00060012113 RatGTEx
  ENSRNOG00065019185 RatGTEx
Superfamily-SCOP SSF48239 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A578 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AGS5_RAT UniProtKB/TrEMBL
  A0A8I6GLB2_RAT UniProtKB/TrEMBL
  A6IWV1 ENTREZGENE, UniProtKB/TrEMBL
  P53610 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-08 Pggt1b  protein geranylgeranyltransferase type I subunit beta  Pggt1b  protein geranylgeranyltransferase type 1 subunit beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-03 Pggt1b  protein geranylgeranyltransferase type 1 subunit beta  Pggt1b  protein geranylgeranyltransferase type I, beta subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Pggt1b  protein geranylgeranyltransferase type I, beta subunit    geranylgeranyltransferase type I (GGTase-I)  Name updated 1299863 APPROVED
2002-08-07 Pggt1b  geranylgeranyltransferase type I (GGTase-I)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_product beta subunit of geranylgeranyltransferase type I 729447