Gsr (glutathione-disulfide reductase) - Rat Genome Database

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Gene: Gsr (glutathione-disulfide reductase) Rattus norvegicus
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Symbol: Gsr
Name: glutathione-disulfide reductase
RGD ID: 621747
Description: Enables several functions, including glutathione binding activity; glutathione-disulfide reductase (NADPH) activity; and nucleotide binding activity. Involved in several processes, including response to iron(III) ion; response to ischemia; and response to vitamin A. Predicted to be located in external side of plasma membrane. Predicted to be active in cytosol and mitochondrion. Used to study cataract and transient cerebral ischemia. Biomarker of several diseases, including acute kidney failure (multiple); artery disease (multiple); hemorrhagic cystitis; myoglobinuria; and neurodegenerative disease (multiple). Human ortholog(s) of this gene implicated in macular degeneration. Orthologous to human GSR (glutathione-disulfide reductase); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; glutamic acid/glutamate metabolic pathway; glutathione metabolic pathway; INTERACTS WITH (+)-catechin; (+)-schisandrin B; (+)-sesamin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: glutathione reductase; glutathione reductase, mitochondrial; GR; GRase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81665,185,574 - 65,228,742 (-)NCBIGRCr8
mRatBN7.21658,482,209 - 58,525,256 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1658,482,505 - 58,525,661 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1663,820,015 - 63,862,474 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01667,233,692 - 67,276,139 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01662,454,254 - 62,496,705 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01662,197,617 - 62,239,987 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1662,197,617 - 62,241,361 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01661,859,601 - 61,901,971 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41662,255,562 - 62,298,458 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11662,255,636 - 62,298,530 (-)NCBI
Celera1656,518,556 - 56,560,956 (-)NCBICelera
Cytogenetic Map16q12.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model