Cul5 (cullin 5) - Rat Genome Database

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Gene: Cul5 (cullin 5) Rattus norvegicus
Analyze
Symbol: Cul5
Name: cullin 5
RGD ID: 621742
Description: Predicted to enable ubiquitin ligase complex scaffold activity and ubiquitin protein ligase binding activity. Involved in regulation of cytosolic calcium ion concentration. Predicted to be located in site of DNA damage. Predicted to be part of Cul5-RING ubiquitin ligase complex and SCF ubiquitin ligase complex. Predicted to be active in nucleus. Orthologous to human CUL5 (cullin 5); PARTICIPATES IN neddylation pathway; proteasome degradation pathway involving cullin-dependent ubiquitin ligases; ubiquitin/proteasome degradation pathway; INTERACTS WITH 2,4-dinitrotoluene; acetamide; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CUL-5; cullin-5; VACM-1; vasopressin-activated calcium-mobilizing receptor 1; vasopressin-activated calcium-mobilizing receptor protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8862,909,150 - 62,974,641 (-)NCBIGRCr8
mRatBN7.2854,012,963 - 54,066,751 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl854,016,006 - 54,066,666 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx859,541,355 - 59,591,763 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0857,820,377 - 57,870,785 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0855,684,618 - 55,735,030 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0858,199,992 - 58,255,149 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl858,202,821 - 58,253,688 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0856,782,444 - 56,837,338 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4857,080,787 - 57,132,486 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1857,099,840 - 57,151,540 (-)NCBI
Celera853,506,656 - 53,557,091 (-)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Expression of VACM-1/cul5 mutant in endothelial cells induces MAPK phosphorylation and maspin degradation and converts cells to the angiogenic phenotype. Buchwalter A, etal., Microvasc Res. 2008 Mar;75(2):155-68. Epub 2007 Sep 4.
2. Expression of VACM-1 protein in cultured rat adrenal endothelial cells is linked to the cell cycle. Burnatowska-Hledin, etal., Endothelium. 2001;8(1):49-63.
3. Vasopressin-activated calcium-mobilizing (VACM-1) receptor mRNA is present in peripheral organs and the central nervous system of the laboratory rat. Ceremuga TE, etal., Endocr Res 2001 Nov;27(4):433-45.
4. Alterations of cullin-5 mRNA levels in the rat central nervous system following hemorrhagic shock. Ceremuga TE, etal., Neurol Res. 2003 Mar;25(2):211-6.
5. Cullin-5 is ubiquitous in the rat brain. Ceremuga TE, etal., Neurosci Lett 2003 Jul 17;345(2):121-5.
6. Osmotic stress increases cullin-5 (cul-5) mRNA in the rat cerebral cortex, hypothalamus and kidney. Ceremuga TE, etal., Neurosci Res 2003 Mar;45(3):305-11.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Expression of the genes encoding the vasopressin-activated calcium-mobilizing receptor and the dual angiotensin II/vasopressin receptor in the rat central nervous system. Hurbin A, etal., J Neuroendocrinol 2000 Jul;12(7):677-84.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Nedd8 on cullin: building an expressway to protein destruction. Pan ZQ, etal., Oncogene. 2004 Mar 15;23(11):1985-97.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Cullin 5 gene expression in the rat cerebral cortex and hippocampus following traumatic brain injury (TBI). Yao XL, etal., Neurosci Lett. 2006 Nov 27;409(1):65-9. Epub 2006 Sep 28.
Additional References at PubMed
PMID:17636018   PMID:19917606   PMID:22405651   PMID:22581383   PMID:22709582   PMID:22871113   PMID:23171819   PMID:24210661   PMID:28292928  


Genomics

Comparative Map Data
Cul5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8862,909,150 - 62,974,641 (-)NCBIGRCr8
mRatBN7.2854,012,963 - 54,066,751 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl854,016,006 - 54,066,666 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx859,541,355 - 59,591,763 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0857,820,377 - 57,870,785 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0855,684,618 - 55,735,030 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0858,199,992 - 58,255,149 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl858,202,821 - 58,253,688 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0856,782,444 - 56,837,338 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4857,080,787 - 57,132,486 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1857,099,840 - 57,151,540 (-)NCBI
Celera853,506,656 - 53,557,091 (-)NCBICelera
Cytogenetic Map8q24NCBI
CUL5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811108,008,898 - 108,107,761 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11108,008,898 - 108,107,761 (+)EnsemblGRCh38hg38GRCh38
GRCh3711107,879,624 - 107,978,488 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611107,384,618 - 107,483,698 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411107,384,854 - 107,482,773NCBI
Celera11105,033,798 - 105,132,859 (+)NCBICelera
Cytogenetic Map11q22.3NCBI
HuRef11103,804,481 - 103,903,597 (+)NCBIHuRef
CHM1_111107,762,661 - 107,861,678 (+)NCBICHM1_1
T2T-CHM13v2.011108,015,935 - 108,114,778 (+)NCBIT2T-CHM13v2.0
Cul5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39953,525,881 - 53,578,807 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl953,525,882 - 53,581,314 (-)EnsemblGRCm39 Ensembl
GRCm38953,614,581 - 53,667,507 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl953,614,582 - 53,670,014 (-)EnsemblGRCm38mm10GRCm38
MGSCv37953,422,687 - 53,475,612 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36953,379,265 - 53,429,872 (-)NCBIMGSCv36mm8
Celera950,874,391 - 50,927,173 (-)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map929.12NCBI
Cul5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541210,256,381 - 10,336,156 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541210,266,072 - 10,336,156 (+)NCBIChiLan1.0ChiLan1.0
CUL5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29108,752,165 - 108,852,631 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111109,846,019 - 109,945,548 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011102,895,611 - 102,994,447 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111106,371,759 - 106,469,989 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11106,371,759 - 106,469,989 (+)Ensemblpanpan1.1panPan2
CUL5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1524,393,692 - 24,477,595 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl524,396,823 - 24,488,043 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha524,319,399 - 24,414,613 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0524,422,828 - 24,518,010 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl524,422,832 - 24,518,012 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1524,470,110 - 24,565,387 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0524,371,684 - 24,467,023 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0524,429,854 - 24,525,492 (-)NCBIUU_Cfam_GSD_1.0
Cul5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494790,811,798 - 90,894,693 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936551641,463 - 724,711 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936551641,469 - 724,706 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CUL5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl936,419,881 - 36,507,667 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1936,419,806 - 36,507,681 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2940,496,564 - 40,584,016 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CUL5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1199,432,034 - 99,538,296 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl199,432,706 - 99,534,888 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604326,419,221 - 26,524,597 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cul5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247842,736,490 - 2,820,564 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247842,736,462 - 2,822,854 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cul5
226 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:159
Count of miRNA genes:130
Interacting mature miRNAs:139
Transcripts:ENSRNOT00000010956
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83084815461290444Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85009524982460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)82950266570386295Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)84186687675097878Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815458482492Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)84186701070386132Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85009524982460899Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)851351728107062046Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85009524982460899Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)85404374498968765Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)82720571554998217Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82613018771130187Rat
2303570Gluco48Glucose level QTL 482blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)84980583194805831Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)82613018771130187Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat

Markers in Region
D8Rat111  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2854,043,744 - 54,043,840 (+)MAPPERmRatBN7.2
Rnor_6.0858,230,766 - 58,230,861NCBIRnor6.0
Rnor_5.0856,813,094 - 56,813,189UniSTSRnor5.0
RGSC_v3.4857,109,012 - 57,109,108RGDRGSC3.4
RGSC_v3.4857,109,013 - 57,109,108UniSTSRGSC3.4
RGSC_v3.1857,128,066 - 57,128,162RGD
Celera853,534,460 - 53,534,573UniSTS
SHRSP x BN Map839.17UniSTS
SHRSP x BN Map839.17RGD
FHH x ACI Map847.98RGD
Cytogenetic Map8q24UniSTS
RH130898  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2854,067,033 - 54,067,230 (+)MAPPERmRatBN7.2
Rnor_6.0858,254,052 - 58,254,248NCBIRnor6.0
Rnor_5.0856,836,218 - 56,836,414UniSTSRnor5.0
RGSC_v3.4857,133,137 - 57,133,333UniSTSRGSC3.4
Celera853,557,742 - 53,557,938UniSTS
RH 3.4 Map8594.8UniSTS
Cytogenetic Map8q24UniSTS
BF397556  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2854,015,664 - 54,015,844 (+)MAPPERmRatBN7.2
Rnor_6.0858,202,694 - 58,202,873NCBIRnor6.0
Rnor_5.0856,785,146 - 56,785,325UniSTSRnor5.0
RGSC_v3.4857,080,446 - 57,080,625UniSTSRGSC3.4
Celera853,506,315 - 53,506,494UniSTS
RH 3.4 Map8594.8UniSTS
Cytogenetic Map8q24UniSTS
RH141279  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2854,047,157 - 54,047,360 (+)MAPPERmRatBN7.2
Rnor_6.0858,234,179 - 58,234,381NCBIRnor6.0
Rnor_5.0856,816,507 - 56,816,709UniSTSRnor5.0
RGSC_v3.4857,112,426 - 57,112,628UniSTSRGSC3.4
Celera853,537,891 - 53,538,093UniSTS
RH 3.4 Map8593.6UniSTS
Cytogenetic Map8q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000010956   ⟹   ENSRNOP00000010956
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl854,016,006 - 54,066,666 (-)Ensembl
Rnor_6.0 Ensembl858,202,821 - 58,253,688 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099521   ⟹   ENSRNOP00000089198
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl854,016,006 - 54,056,518 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114900   ⟹   ENSRNOP00000097338
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl854,016,006 - 54,066,666 (-)Ensembl
RefSeq Acc Id: NM_022683   ⟹   NP_073174
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8862,912,193 - 62,962,571 (-)NCBI
mRatBN7.2854,016,006 - 54,066,383 (-)NCBI
Rnor_6.0858,203,035 - 58,253,401 (-)NCBI
Rnor_5.0856,782,444 - 56,837,338 (-)NCBI
RGSC_v3.4857,080,787 - 57,132,486 (-)RGD
Celera853,506,656 - 53,557,091 (-)RGD
Sequence:
RefSeq Acc Id: XM_006243090   ⟹   XP_006243152
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8862,909,150 - 62,974,641 (-)NCBI
mRatBN7.2854,012,963 - 54,066,751 (-)NCBI
Rnor_6.0858,199,992 - 58,255,149 (-)NCBI
Rnor_5.0856,782,444 - 56,837,338 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_073174 (Get FASTA)   NCBI Sequence Viewer  
  XP_006243152 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF61416 (Get FASTA)   NCBI Sequence Viewer  
  EDL95521 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000010956.4
  ENSRNOP00000089198.1
  ENSRNOP00000097338.1
GenBank Protein Q9JJ31 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_073174   ⟸   NM_022683
- UniProtKB: Q9JJ31 (UniProtKB/Swiss-Prot),   A0A8I6A7N3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243152   ⟸   XM_006243090
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ASH3 (UniProtKB/TrEMBL),   A0A0H2UHG3 (UniProtKB/TrEMBL),   A6J4J8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010956   ⟸   ENSRNOT00000010956
Ensembl Acc Id: ENSRNOP00000097338   ⟸   ENSRNOT00000114900
Ensembl Acc Id: ENSRNOP00000089198   ⟸   ENSRNOT00000099521
Protein Domains
Cullin family profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JJ31-F1-model_v2 AlphaFold Q9JJ31 1-780 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695972
Promoter ID:EPDNEW_R6497
Type:initiation region
Name:Cul5_1
Description:cullin 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0858,253,684 - 58,253,744EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621742 AgrOrtholog
BioCyc Gene G2FUF-30430 BioCyc
Ensembl Genes ENSRNOG00000008039 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000010956.5 UniProtKB/TrEMBL
  ENSRNOT00000099521.1 UniProtKB/TrEMBL
  ENSRNOT00000114900.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cullin Repeats UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cullin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cullin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cullin_homology UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cullin_homology_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cullin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cullin_neddylation_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cullin_repeat-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64624 UniProtKB/Swiss-Prot
NCBI Gene 64624 ENTREZGENE
PANTHER CULLIN-5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11932 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cullin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cullin_Nedd8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cul5 PhenoGen
PROSITE CULLIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CULLIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008039 RatGTEx
SMART CULLIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cullin_Nedd8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF74788 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF75632 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0H2UHG3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A7N3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ASH3 ENTREZGENE, UniProtKB/TrEMBL
  A6J4J8 ENTREZGENE, UniProtKB/TrEMBL
  CUL5_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Cul5  cullin 5    vasopressin-activated calcium-mobilizing receptor protein  Name updated 1299863 APPROVED
2002-08-07 Cul5  vasopressin-activated calcium-mobilizing receptor protein      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in all tissues examined 632581
gene_product member of the cullin gene family 632581