Flt4 (Fms related receptor tyrosine kinase 4) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Flt4 (Fms related receptor tyrosine kinase 4) Rattus norvegicus
Analyze
Symbol: Flt4
Name: Fms related receptor tyrosine kinase 4
RGD ID: 621737
Description: Enables growth factor binding activity and vascular endothelial growth factor receptor activity. Involved in positive regulation of cell growth and vascular endothelial growth factor receptor signaling pathway. Predicted to be located in cytoplasm and nucleus. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in hereditary lymphedema IA. Orthologous to human FLT4 (fms related receptor tyrosine kinase 4); PARTICIPATES IN vascular endothelial growth factor signaling pathway; altered vascular endothelial growth factor signaling pathway; altered vascular endothelial growth factor signaling pathway involving the main players; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: FLT-4; FMS-like tyrosine kinase 4; fms-related tyrosine kinase 4; LOC360235; tyrosine-protein kinase receptor FLT4; vascular endothelial growth factor receptor 3; VEGFR-3; Vegfr3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81034,414,834 - 34,455,878 (+)NCBIGRCr8
GRCr8 Ensembl1034,414,733 - 34,456,645 (+)EnsemblGRCr8 Ensembl
mRatBN7.21033,913,725 - 33,954,770 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1033,913,608 - 33,954,770 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1038,589,263 - 38,630,365 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0107,127,669 - 7,168,775 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01033,582,919 - 33,624,021 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01035,078,782 - 35,120,296 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1035,078,726 - 35,121,599 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01034,850,707 - 34,892,141 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41035,071,002 - 35,112,006 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1033,270,535 - 33,311,432 (+)NCBICelera
RGSC_v3.11035,072,050 - 35,113,055NCBI
Cytogenetic Map10q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
membrane  (IEA)
nucleus  (IEA)
plasma membrane  (IBA,IEA,ISO)
receptor complex  (IBA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Biochemical characterization of two isoforms of FLT4, a VEGF receptor-related tyrosine kinase. Borg JP, etal., Oncogene 1995 Mar 2;10(5):973-84.
2. Meta-analysis of contribution of genetic polymorphisms in drug-metabolizing enzymes or transporters to axitinib pharmacokinetics. Brennan M, etal., Eur J Clin Pharmacol. 2012 May;68(5):645-55. Epub 2011 Dec 15.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Expression pattern of VEGFR-1, -2, -3 and D2-40 protein in the skin of patients with systemic sclerosis. Higashi-Kuwata N, etal., Eur J Dermatol. 2011 Jul-Aug;21(4):490-4. doi: 10.1684/ejd.2011.1284.
6. Characterization of indolinones which preferentially inhibit VEGF-C- and VEGF-D-induced activation of VEGFR-3 rather than VEGFR-2. Kirkin V, etal., Eur J Biochem 2001 Nov;268(21):5530-40.
7. Molecular regulation of the VEGF family -- inducers of angiogenesis and lymphangiogenesis. McColl BK, etal., APMIS 2004 Jul-Aug;112(7-8):463-80.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. Elevated expression of VEGFR-3 in lymphatic endothelial cells from lymphangiomas. Norgall S, etal., BMC Cancer. 2007 Jun 21;7:105.
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Nine Genes Mediate the Therapeutic Effects of Iodine-131 Radiotherapy in Thyroid Carcinoma Patients. Shuwen H, etal., Dis Markers. 2020 Jun 16;2020:9369341. doi: 10.1155/2020/9369341. eCollection 2020.
Additional References at PubMed
PMID:7675451   PMID:9012504   PMID:9247316   PMID:9435229   PMID:9794766   PMID:10878616   PMID:11532940   PMID:11574540   PMID:16076871   PMID:18594512   PMID:19196316   PMID:19779139  
PMID:19901262   PMID:19903896   PMID:19963036   PMID:20127810   PMID:20439428   PMID:20572782   PMID:20692049   PMID:20697430   PMID:20826270   PMID:21072582   PMID:21703344   PMID:22771250  
PMID:22818386   PMID:22959907   PMID:22983493   PMID:23382219   PMID:23878260   PMID:24379135   PMID:24733830   PMID:25943477   PMID:31757960   PMID:38728943  


Genomics

Comparative Map Data
Flt4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81034,414,834 - 34,455,878 (+)NCBIGRCr8
GRCr8 Ensembl1034,414,733 - 34,456,645 (+)EnsemblGRCr8 Ensembl
mRatBN7.21033,913,725 - 33,954,770 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1033,913,608 - 33,954,770 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1038,589,263 - 38,630,365 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0107,127,669 - 7,168,775 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01033,582,919 - 33,624,021 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01035,078,782 - 35,120,296 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1035,078,726 - 35,121,599 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01034,850,707 - 34,892,141 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41035,071,002 - 35,112,006 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1033,270,535 - 33,311,432 (+)NCBICelera
RGSC_v3.11035,072,050 - 35,113,055NCBI
Cytogenetic Map10q21NCBI
FLT4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385180,601,506 - 180,650,298 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5180,601,506 - 180,649,624 (-)EnsemblGRCh38hg38GRCh38
GRCh375180,028,506 - 180,076,600 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365179,961,112 - 180,009,206 (-)NCBINCBI36Build 36hg18NCBI36
Build 345179,962,147 - 180,009,171NCBI
Celera5175,651,089 - 175,699,841 (-)NCBICelera
Cytogenetic Map5q35.3NCBI
HuRef5174,752,484 - 174,782,989 (-)NCBIHuRef
CHM1_15179,460,942 - 179,509,118 (-)NCBICHM1_1
T2T-CHM13v2.05181,157,398 - 181,206,988 (-)NCBIT2T-CHM13v2.0
Flt4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391149,500,506 - 49,543,566 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1149,500,090 - 49,543,566 (+)EnsemblGRCm39 Ensembl
GRCm381149,609,679 - 49,652,739 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1149,609,263 - 49,652,739 (+)EnsemblGRCm38mm10GRCm38
MGSCv371149,423,181 - 49,466,241 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361149,453,150 - 49,495,652 (+)NCBIMGSCv36mm8
Celera1154,171,357 - 54,214,402 (+)NCBICelera
Cytogenetic Map11B1.2NCBI
cM Map1129.69NCBI
Flt4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955408107,056 - 140,056 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540898,995 - 137,922 (+)NCBIChiLan1.0ChiLan1.0
FLT4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24175,624,976 - 175,674,118 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15173,789,056 - 173,838,198 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05175,804,728 - 175,852,703 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15183,114,166 - 183,148,518 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5183,115,856 - 183,149,006 (-)Ensemblpanpan1.1panPan2
FLT4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1111,145,643 - 1,184,097 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl111,145,585 - 1,185,165 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha111,205,492 - 1,245,028 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0111,114,649 - 1,154,193 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl111,114,656 - 1,154,194 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1111,067,618 - 1,107,139 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0111,165,705 - 1,205,208 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0111,405,676 - 1,445,228 (+)NCBIUU_Cfam_GSD_1.0
Flt4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213119,026,753 - 119,071,689 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936739236,510 - 281,729 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936739240,572 - 281,925 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FLT4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl278,076,080 - 78,115,126 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1278,076,008 - 78,115,137 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2279,479,951 - 79,504,057 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FLT4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12382,328,257 - 82,373,785 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2382,328,258 - 82,357,044 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607513,749,531 - 13,795,003 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Flt4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473343,204,651 - 43,238,674 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473343,203,311 - 43,238,664 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Flt4
140 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:108
Count of miRNA genes:77
Interacting mature miRNAs:86
Transcripts:ENSRNOT00000003519, ENSRNOT00000059341
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135730538Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102980091064653589Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10666111835509383Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102937704652699134Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 11 49 113 91 90 59 25 59 6 218 97 10 93 45 60 31 13 13

Sequence


Ensembl Acc Id: ENSRNOT00000003519   ⟹   ENSRNOP00000003519
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1034,414,733 - 34,456,645 (+)Ensembl
mRatBN7.2 Ensembl1033,913,608 - 33,954,770 (+)Ensembl
Rnor_6.0 Ensembl1035,078,726 - 35,121,599 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103659   ⟹   ENSRNOP00000093550
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1034,414,737 - 34,456,645 (+)Ensembl
mRatBN7.2 Ensembl1033,928,505 - 33,954,770 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108197   ⟹   ENSRNOP00000095638
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1034,428,936 - 34,456,645 (+)Ensembl
mRatBN7.2 Ensembl1033,927,827 - 33,954,770 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000157416   ⟹   ENSRNOP00000106424
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1034,414,733 - 34,446,536 (+)Ensembl
RefSeq Acc Id: NM_053652   ⟹   NP_446104
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81034,414,834 - 34,455,878 (+)NCBI
mRatBN7.21033,913,725 - 33,954,770 (+)NCBI
Rnor_6.01035,078,782 - 35,120,296 (+)NCBI
Rnor_5.01034,850,707 - 34,892,141 (+)NCBI
RGSC_v3.41035,071,002 - 35,112,006 (+)RGD
Celera1033,270,535 - 33,311,432 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_446104 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB63249 (Get FASTA)   NCBI Sequence Viewer  
  AAL13269 (Get FASTA)   NCBI Sequence Viewer  
  AAL13270 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000003519
GenBank Protein Q91ZT1 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446104   ⟸   NM_053652
- Peptide Label: precursor
- UniProtKB: Q91ZT1 (UniProtKB/Swiss-Prot),   Q91ZT0 (UniProtKB/Swiss-Prot),   O35755 (UniProtKB/Swiss-Prot),   G3V6B7 (UniProtKB/TrEMBL),   A6HDW9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000003519   ⟸   ENSRNOT00000003519
Ensembl Acc Id: ENSRNOP00000093550   ⟸   ENSRNOT00000103659
Ensembl Acc Id: ENSRNOP00000095638   ⟸   ENSRNOT00000108197
Ensembl Acc Id: ENSRNOP00000106424   ⟸   ENSRNOT00000157416
Protein Domains
Ig-like   Ig-like C2-type   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q91ZT1-F1-model_v2 AlphaFold Q91ZT1 1-1363 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697143
Promoter ID:EPDNEW_R7668
Type:multiple initiation site
Name:Flt4_1
Description:fms-related tyrosine kinase 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01035,078,727 - 35,078,787EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621737 AgrOrtholog
BioCyc Gene G2FUF-25281 BioCyc
Ensembl Genes ENSRNOG00000002511 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000003519 ENTREZGENE
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro Ig-like_dom UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_I-set UniProtKB/Swiss-Prot
  Ig_sub UniProtKB/Swiss-Prot
  Ig_sub2 UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  RTK UniProtKB/Swiss-Prot
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  Tyr_kinase_AS UniProtKB/Swiss-Prot
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  Tyr_kinase_rcpt_3_CS UniProtKB/Swiss-Prot
  VEGFR-2_TMD UniProtKB/Swiss-Prot
  VEGFR1-3_5th UniProtKB/Swiss-Prot
  VEGFR1-3_N_Ig-like UniProtKB/Swiss-Prot
KEGG Report rno:114110 UniProtKB/Swiss-Prot
NCBI Gene 114110 ENTREZGENE
PANTHER TYROSINE-PROTEIN KINASE RECEPTOR UniProtKB/Swiss-Prot
  VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 3 UniProtKB/Swiss-Prot
Pfam I-set UniProtKB/Swiss-Prot
  Ig_3 UniProtKB/Swiss-Prot
  Pkinase_Tyr UniProtKB/Swiss-Prot
  VEGFR-1-like_5th UniProtKB/Swiss-Prot
  VEGFR-1-like_Ig-like UniProtKB/Swiss-Prot
  VEGFR-2_TMD UniProtKB/Swiss-Prot
  VEGFR1-3_N_Ig-like UniProtKB/Swiss-Prot
PhenoGen Flt4 PhenoGen
PIRSF TyrPK_CSF1-R UniProtKB/Swiss-Prot
PRINTS VEGFRECEPTOR UniProtKB/Swiss-Prot
  VEGFRECEPTR3 UniProtKB/Swiss-Prot
PROSITE IG_LIKE UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot
  RECEPTOR_TYR_KIN_III UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002511 RatGTEx
SMART IGc2 UniProtKB/Swiss-Prot
  SM00409 UniProtKB/Swiss-Prot
  TyrKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
UniProt A0A8I6AX70_RAT UniProtKB/TrEMBL
  A0A8I6GL85_RAT UniProtKB/TrEMBL
  A6HDW9 ENTREZGENE, UniProtKB/TrEMBL
  G3V6B7 ENTREZGENE, UniProtKB/TrEMBL
  O35755 ENTREZGENE
  Q91ZT0 ENTREZGENE
  Q91ZT1 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary O35755 UniProtKB/Swiss-Prot
  Q91ZT0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-01-03 Flt4  Fms related receptor tyrosine kinase 4  Flt4  fms-related tyrosine kinase 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-24 Flt4  fms-related tyrosine kinase 4  Flt4  FMS-like tyrosine kinase 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-25 Flt4  FMS-like tyrosine kinase 4  Flt4  fms-related tyrosine kinase 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-02-23 Flt4  fms-related tyrosine kinase 4  Flt4_predicted  FMS-like tyrosine kinase 4 (predicted)  Data merged from RGD:1306600 737654 APPROVED
2005-01-20 Flt4  fms-related tyrosine kinase 4      Symbol and Name status set to approved 1299863 APPROVED
2005-01-12 Flt4_predicted  FMS-like tyrosine kinase 4 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-08-07 Flt4  fms-related tyrosine kinase 4      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_product VEGF receptor-related tyrosine kinase 708324
gene_protein 65 amino acids; approximately 180 kDa; highly glycosylated, relatively stable, cell surface associated kinase 708324