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Gene: Acta2 (actin alpha 2, smooth muscle) Rattus norvegicus
Symbol: Acta2
Name: actin alpha 2, smooth muscle
RGD ID: 621676
Description: Predicted to have protein kinase binding activity. Involved in several processes, including positive regulation of ERK1 and ERK2 cascade; positive regulation of cellular component movement; and positive regulation of hepatic stellate cell activation. Localizes to cytoplasm and stress fiber. Human ortholog(s) of this gene implicated in Moyamoya disease and thoracic aortic aneurysm. Orthologous to human ACTA2 (actin alpha 2, smooth muscle); PARTICIPATES IN platelet-derived growth factor signaling pathway; INTERACTS WITH (+)-schisandrin B; (+)-Tetrandrine; (-)-epigallocatechin 3-gallate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: actin, alpha 2, smooth muscle, aorta; actin, aortic smooth muscle; alpha-actin-2; smooth muscle alpha-actin
Homo sapiens (human) : ACTA2 (actin alpha 2, smooth muscle)  HGNC  Alliance
Mus musculus (house mouse) : Acta2 (actin, alpha 2, smooth muscle, aorta)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Acta2 (actin alpha 2, smooth muscle)
Pan paniscus (bonobo/pygmy chimpanzee) : ACTA2 (actin alpha 2, smooth muscle)
Canis lupus familiaris (dog) : ACTA2 (actin alpha 2, smooth muscle)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Acta2 (actin alpha 2, smooth muscle)
Sus scrofa (pig) : ACTA2 (actin alpha 2, smooth muscle)
Chlorocebus sabaeus (African green monkey) : ACTA2 (actin alpha 2, smooth muscle)
Heterocephalus glaber (naked mole-rat) : Acta2 (actin alpha 2, smooth muscle)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01252,537,614 - 252,550,394 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1252,537,615 - 252,550,394 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01259,760,521 - 259,773,301 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1228,860,239 - 228,873,019 (-)NCBICelera
Cytogenetic Map1q52NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Acta2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621676
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.