Gabra4 (gamma-aminobutyric acid type A receptor subunit alpha 4) - Rat Genome Database

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Gene: Gabra4 (gamma-aminobutyric acid type A receptor subunit alpha 4) Rattus norvegicus
Analyze
Symbol: Gabra4
Name: gamma-aminobutyric acid type A receptor subunit alpha 4
RGD ID: 621670
Description: Enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in several processes, including GABAergic synaptic transmission; chloride transmembrane transport; and inhibitory synapse assembly. Predicted to act upstream of or within central nervous system development. Is active in GABA-ergic synapse and postsynaptic specialization membrane. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human GABRA4 (gamma-aminobutyric acid type A receptor subunit alpha4); INTERACTS WITH (+)-pilocarpine; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: GABA(A) receptor subunit alpha-4; GABA-A receptor alpha-4 subunit; GABAAR subunit alpha-4; gamma-aminobutyric acid (GABA) A receptor, alpha 4; gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 4; gamma-aminobutyric acid receptor subunit alpha-4; gamma-aminobutyric acid type A receptor alpha4 subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81436,944,747 - 37,021,652 (+)NCBIGRCr8
mRatBN7.21436,590,782 - 36,667,724 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1436,590,782 - 36,665,844 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1436,935,370 - 37,010,517 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01438,240,130 - 38,315,273 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01436,728,476 - 36,803,610 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01439,154,072 - 39,230,994 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1439,154,529 - 39,231,695 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01438,966,016 - 39,040,606 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41439,047,461 - 39,122,531 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11439,049,851 - 39,124,917 (+)NCBI
Celera1435,813,603 - 35,888,671 (+)NCBICelera
Cytogenetic Map14p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
3alpha-hydroxy-5beta-pregnan-20-one  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
amitriptyline  (EXP)
ammonium chloride  (EXP)
androgen antagonist  (EXP)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzamide  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP)
Butylparaben  (EXP)
chlorpyrifos  (ISO)
Cuprizon  (EXP)
DDE  (EXP)
delta-hexachlorocyclohexane  (ISO)
diazepam  (EXP)
dibutyl phthalate  (EXP)
diethylstilbestrol  (EXP)
dinitrogen oxide  (ISO)
doxorubicin  (ISO)
enzacamene  (EXP)
epoxiconazole  (EXP)
ethanol  (EXP,ISO)
felbamate  (ISO)
fipronil  (ISO)
flumazenil  (EXP)
folic acid  (ISO)
folpet  (ISO)
furosemide  (EXP)
gamma-aminobutyric acid  (EXP,ISO)
isoflurane  (ISO)
isotretinoin  (ISO)
ketoconazole  (EXP)
linuron  (EXP)
lipopolysaccharide  (ISO)
Lorazepam  (EXP)
methylmercury chloride  (ISO)
midazolam  (ISO)
morphine  (ISO)
niclosamide  (ISO)
paracetamol  (EXP)
paraquat  (EXP)
pentobarbital  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
picrotoxinin  (ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP)
prochloraz  (EXP)
procymidone  (EXP)
progesterone  (EXP)
propofol  (ISO)
razoxane  (EXP)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
streptozocin  (ISO)
tacrine  (EXP)
Testosterone propionate  (ISO)
tetrachloromethane  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
vinclozolin  (EXP)
XL147  (ISO)
zaleplon  (EXP)
zolpidem  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Atomic force microscopy reveals the stoichiometry and subunit arrangement of the alpha4beta3delta GABA(A) receptor. Barrera NP, etal., Mol Pharmacol. 2008 Mar;73(3):960-7. doi: 10.1124/mol.107.042481. Epub 2007 Dec 13.
2. Neonatal development of the rat visual cortex: synaptic function of GABAA receptor alpha subunits. Bosman LW, etal., J Physiol 2002 Nov 15;545(Pt 1):169-81.
3. GABAA Receptors and the Diversity in their Structure and Pharmacology. Chua HC and Chebib M, Adv Pharmacol. 2017;79:1-34. doi: 10.1016/bs.apha.2017.03.003. Epub 2017 May 2.
4. Investigation of autism and GABA receptor subunit genes in multiple ethnic groups. Collins AL, etal., Neurogenetics. 2006 Jul;7(3):167-74. Epub 2006 Jun 13.
5. mRNA and protein levels for GABAAalpha4, alpha5, beta1 and GABABR1 receptors are altered in brains from subjects with autism. Fatemi SH, etal., J Autism Dev Disord. 2010 Jun;40(6):743-50.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. GABAA receptors: structure, function, pharmacology, and related disorders. Ghit A, etal., J Genet Eng Biotechnol. 2021 Aug 21;19(1):123. doi: 10.1186/s43141-021-00224-0.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Sex differences in anxiety, sensorimotor gating and expression of the alpha4 subunit of the GABAA receptor in the amygdala after progesterone withdrawal. Gulinello M, etal., Eur J Neurosci 2003 Feb;17(3):641-8.
10. Chronic intermittent ethanol-induced switch of ethanol actions from extrasynaptic to synaptic hippocampal GABAA receptors. Liang J, etal., J Neurosci. 2006 Feb 8;26(6):1749-58. doi: 10.1523/JNEUROSCI.4702-05.2006.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Cloning, pharmacological characteristics and expression pattern of the rat GABAA receptor alpha 4 subunit. Wisden W, etal., FEBS Lett 1991 Sep 9;289(2):227-30.
Additional References at PubMed
PMID:1312131   PMID:1312132   PMID:1379501   PMID:1966765   PMID:15708482   PMID:15834956   PMID:16091474   PMID:17005728   PMID:17403139   PMID:18003843   PMID:18056985   PMID:18562204  
PMID:18922788   PMID:19144854   PMID:21155805   PMID:21439793   PMID:21924329   PMID:22213233   PMID:23079628   PMID:24011224   PMID:25223733   PMID:27382064   PMID:28218471  


Genomics

Comparative Map Data
Gabra4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81436,944,747 - 37,021,652 (+)NCBIGRCr8
mRatBN7.21436,590,782 - 36,667,724 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1436,590,782 - 36,665,844 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1436,935,370 - 37,010,517 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01438,240,130 - 38,315,273 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01436,728,476 - 36,803,610 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01439,154,072 - 39,230,994 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1439,154,529 - 39,231,695 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01438,966,016 - 39,040,606 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41439,047,461 - 39,122,531 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11439,049,851 - 39,124,917 (+)NCBI
Celera1435,813,603 - 35,888,671 (+)NCBICelera
Cytogenetic Map14p11NCBI
GABRA4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38446,918,900 - 46,993,581 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl446,918,900 - 46,993,581 (-)EnsemblGRCh38hg38GRCh38
GRCh37446,920,917 - 46,995,598 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36446,615,674 - 46,690,337 (-)NCBINCBI36Build 36hg18NCBI36
Build 34446,761,846 - 46,836,508NCBI
Celera447,369,879 - 47,444,600 (-)NCBICelera
Cytogenetic Map4p12NCBI
HuRef446,239,865 - 46,315,415 (-)NCBIHuRef
CHM1_1446,920,103 - 46,995,631 (-)NCBICHM1_1
T2T-CHM13v2.0446,886,225 - 46,960,936 (-)NCBIT2T-CHM13v2.0
Gabra4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39571,727,077 - 71,815,651 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl571,727,092 - 71,815,651 (-)EnsemblGRCm39 Ensembl
GRCm38571,569,734 - 71,658,308 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl571,569,749 - 71,658,308 (-)EnsemblGRCm38mm10GRCm38
MGSCv37571,960,973 - 72,049,547 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36571,848,869 - 71,937,443 (-)NCBIMGSCv36mm8
Celera568,834,068 - 68,922,930 (-)NCBICelera
Cytogenetic Map5C3.2NCBI
cM Map538.08NCBI
Gabra4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554431,564,202 - 1,632,580 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554431,564,794 - 1,631,975 (+)NCBIChiLan1.0ChiLan1.0
GABRA4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2380,876,574 - 80,952,059 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1481,138,247 - 81,213,682 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0475,163,796 - 75,240,049 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1485,894,401 - 85,970,077 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl485,894,401 - 85,960,783 (+)Ensemblpanpan1.1panPan2
GABRA4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11342,889,100 - 42,958,604 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1342,897,655 - 42,959,206 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1342,690,028 - 42,908,686 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01343,345,979 - 43,564,367 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1343,500,264 - 43,565,899 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11343,023,386 - 43,242,431 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01343,085,285 - 43,303,834 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01343,439,087 - 43,657,538 (-)NCBIUU_Cfam_GSD_1.0
Gabra4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528533,123,748 - 33,190,987 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648213,109,803 - 13,174,492 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648213,109,803 - 13,174,492 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GABRA4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl836,874,331 - 36,942,773 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1836,875,649 - 36,943,016 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2838,744,693 - 38,811,740 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GABRA4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1273,253,789 - 3,323,102 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl273,254,735 - 3,321,128 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604749,315,895 - 49,393,069 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gabra4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476120,071,316 - 20,132,098 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476120,071,343 - 20,132,523 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gabra4
681 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:11
Count of miRNA genes:11
Interacting mature miRNAs:11
Transcripts:ENSRNOT00000003191
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14908897839057237Rat
10755459Coatc15Coat color QTL 150.01681coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)141983694464836944Rat
1300154Bp189Blood pressure QTL 1893.04arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)143088377768757901Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
2324617Coatc2Coat color QTL 20.001coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)143076702539153750Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)141759376142336881Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)141863134542337007Rat
7387267Uae42Urinary albumin excretion QTL 420.61urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)142216796767167967Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141854133263541332Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141762256142337007Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat

Markers in Region
D5Buc33  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21436,604,935 - 36,606,107 (+)MAPPERmRatBN7.2
Rnor_6.01439,168,211 - 39,169,382NCBIRnor6.0
Rnor_5.01438,979,686 - 38,980,857UniSTSRnor5.0
RGSC_v3.41439,061,615 - 39,062,786UniSTSRGSC3.4
Celera1435,827,757 - 35,828,928UniSTS
Cytogenetic Map14p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
5 8 49 108 48 48 23 17 23 6 162 82 93 45 59 25

Sequence


Ensembl Acc Id: ENSRNOT00000003191   ⟹   ENSRNOP00000003191
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1436,590,782 - 36,665,844 (+)Ensembl
Rnor_6.0 Ensembl1439,154,529 - 39,231,695 (+)Ensembl
RefSeq Acc Id: NM_080587   ⟹   NP_542154
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81436,944,747 - 37,019,815 (+)NCBI
mRatBN7.21436,590,782 - 36,665,854 (+)NCBI
Rnor_6.01439,154,541 - 39,229,131 (+)NCBI
Rnor_5.01438,966,016 - 39,040,606 (+)NCBI
RGSC_v3.41439,047,461 - 39,122,531 (+)RGD
Celera1435,813,603 - 35,888,671 (+)RGD
Sequence:
RefSeq Acc Id: XM_039091568   ⟹   XP_038947496
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81436,944,782 - 37,021,652 (+)NCBI
mRatBN7.21436,590,821 - 36,667,724 (+)NCBI
RefSeq Acc Id: XM_039091569   ⟹   XP_038947497
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81436,944,782 - 36,976,619 (+)NCBI
mRatBN7.21436,590,821 - 36,622,654 (+)NCBI
RefSeq Acc Id: XM_039091570   ⟹   XP_038947498
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81436,944,782 - 37,021,652 (+)NCBI
mRatBN7.21436,590,821 - 36,665,401 (+)NCBI
RefSeq Acc Id: XR_010057344
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81436,944,782 - 36,976,757 (+)NCBI
RefSeq Acc Id: NP_542154   ⟸   NM_080587
- Peptide Label: precursor
- UniProtKB: P28471 (UniProtKB/Swiss-Prot),   A6JD83 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000003191   ⟸   ENSRNOT00000003191
RefSeq Acc Id: XP_038947496   ⟸   XM_039091568
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038947498   ⟸   XM_039091570
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038947497   ⟸   XM_039091569
- Peptide Label: isoform X2
Protein Domains
Neurotransmitter-gated ion-channel ligand-binding   Neurotransmitter-gated ion-channel transmembrane

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P28471-F1-model_v2 AlphaFold P28471 1-552 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621670 AgrOrtholog
BioCyc Gene G2FUF-15837 BioCyc
Ensembl Genes ENSRNOG00000002336 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000003191.7 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.58.390 UniProtKB/Swiss-Prot
  2.70.170.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurotransmitter-gated ion-channel transmembrane domain UniProtKB/TrEMBL
InterPro GABAA/Glycine_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GABAAa_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GABBAa4_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gabra-1-6_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_chan_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_chan_lig-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neuro-gated_channel_TM_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neuro_actylchol_rec UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurotrans-gated_channel_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurotransmitter_ion_chnl_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:140675 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 140675 ENTREZGENE
PANTHER GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NEUROTRANSMITTER GATED ION CHANNEL UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
Pfam Neur_chan_LBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_chan_memb UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gabra4 PhenoGen
PRINTS GABAARALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GABAARALPHA4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GABAARECEPTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NRIONCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NEUROTR_ION_CHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002336 RatGTEx
Superfamily-SCOP Neurotransmitter-gated ion-channel transmembrane pore UniProtKB/TrEMBL
  Nicotinic receptor ligand binding domain-like UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  SSF90112 UniProtKB/Swiss-Prot
UniProt A6JD83 ENTREZGENE, UniProtKB/TrEMBL
  GBRA4_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-12-06 Gabra4  gamma-aminobutyric acid type A receptor subunit alpha 4  Gabra4  gamma-aminobutyric acid type A receptor alpha4 subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-11 Gabra4  gamma-aminobutyric acid type A receptor alpha4 subunit  Gabra4  gamma-aminobutyric acid (GABA) A receptor, alpha 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-04 Gabra4  gamma-aminobutyric acid (GABA) A receptor, alpha 4  Gabra4  gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Gabra4  gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 4      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Gabra4  gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 4      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation expression was up-regulated in females during progesterone withdrawal 1299322