Fdxr (ferredoxin reductase) - Rat Genome Database

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Gene: Fdxr (ferredoxin reductase) Rattus norvegicus
Analyze
Symbol: Fdxr
Name: ferredoxin reductase
RGD ID: 621648
Description: Enables ferredoxin-NADP+ reductase activity. Predicted to be involved in steroid biosynthetic process. Predicted to act upstream of with a positive effect on ubiquinone biosynthetic process. Located in mitochondrion. Orthologous to human FDXR (ferredoxin reductase); PARTICIPATES IN aldosterone biosynthetic pathway; cortisol biosynthetic pathway; estradiol biosynthetic pathway; INTERACTS WITH (+)-schisandrin B; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: adrenodoxin reductase; AR; ferredoxin--NADP(+) reductase; NADPH:adrenodoxin oxidoreductase, mitochondrial
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810101,006,845 - 101,015,582 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl10101,006,849 - 101,015,542 (-)EnsemblGRCr8
mRatBN7.210100,507,863 - 100,516,649 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10100,507,865 - 100,516,658 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx10105,568,049 - 105,576,738 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010105,031,109 - 105,039,798 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010100,428,857 - 100,437,546 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.010103,817,724 - 103,826,413 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10103,817,704 - 103,826,448 (-)Ensemblrn6Rnor6.0
Rnor_5.010104,468,590 - 104,477,279 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.410105,342,684 - 105,351,374 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1099,084,255 - 99,092,947 (-)NCBICelera
RGSC_v3.110105,357,187 - 105,365,878 (-)NCBI
Cytogenetic Map10q32.1NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-colchicine  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
5-fluorouracil  (ISO)
8-Br-cAMP  (ISO)
acetamide  (EXP)
actinomycin D  (ISO)
adenine  (ISO)
aflatoxin B1  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
cadmium dichloride  (ISO)
camptothecin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlorohydrocarbon  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
cyclosporin A  (ISO)
daunorubicin  (ISO)
DDE  (ISO)
dextran sulfate  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
furfural  (ISO)
glafenine  (EXP)
hydrogen peroxide  (ISO)
indometacin  (EXP)
ivermectin  (ISO)
L-ascorbic acid  (EXP)
lamivudine  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
menadione  (ISO)
methyl methanesulfonate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
Nutlin-3  (ISO)
ozone  (EXP)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
pifithrin-alpha hydrobromide  (ISO)
piroxicam  (ISO)
potassium dichromate  (ISO)
propanal  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium fluoride  (ISO)
sotorasib  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
theophylline  (ISO)
trametinib  (ISO)
trichloroethene  (EXP)
triptonide  (ISO)
trovafloxacin  (ISO)
Tungsten carbide  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)
mitochondrial inner membrane  (IEA)
mitochondrion  (IBA,IDA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Assessment of gene expression profiles in peripheral occlusive arterial disease. Bubenek S, etal., Can J Cardiol. 2012 Nov-Dec;28(6):712-20. doi: 10.1016/j.cjca.2012.03.013. Epub 2012 Jun 19.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Induction and mitochondrial localization of cytochrome P450scc system enzymes in normal and transformed ovarian granulosa cells. Hanukoglu I, etal., J Cell Biol. 1990 Oct;111(4):1373-81.
5. Iron-sulfur cluster biogenesis in mammalian cells: New insights into the molecular mechanisms of cluster delivery. Maio N and Rouault TA, Biochim Biophys Acta. 2015 Jun;1853(6):1493-512. doi: 10.1016/j.bbamcr.2014.09.009. Epub 2014 Sep 19.
6. Differential capacity for cholesterol transport and processing in large and small rat luteal cells. McLean MP, etal., Endocrinology. 1992 Nov;131(5):2203-12.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Androgen synthesis in adrenarche. Miller WL Rev Endocr Metab Disord. 2009 Mar;10(1):3-17.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. cDNA cloning, overproduction and characterization of rat adrenodoxin reductase. Sagara Y, etal., Biochim Biophys Acta 1999 Oct 12;1434(2):284-95.
Additional References at PubMed
PMID:12477932   PMID:12865426   PMID:14651853   PMID:15489334   PMID:18614015  


Genomics

Comparative Map Data
Fdxr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810101,006,845 - 101,015,582 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl10101,006,849 - 101,015,542 (-)EnsemblGRCr8
mRatBN7.210100,507,863 - 100,516,649 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10100,507,865 - 100,516,658 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx10105,568,049 - 105,576,738 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010105,031,109 - 105,039,798 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010100,428,857 - 100,437,546 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.010103,817,724 - 103,826,413 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10103,817,704 - 103,826,448 (-)Ensemblrn6Rnor6.0
Rnor_5.010104,468,590 - 104,477,279 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.410105,342,684 - 105,351,374 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1099,084,255 - 99,092,947 (-)NCBICelera
RGSC_v3.110105,357,187 - 105,365,878 (-)NCBI
Cytogenetic Map10q32.1NCBI
FDXR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381774,862,497 - 74,872,994 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1774,862,497 - 74,873,031 (-)Ensemblhg38GRCh38
GRCh371772,858,619 - 72,869,119 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361770,370,214 - 70,380,751 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341770,370,220 - 70,380,692NCBI
Celera1769,451,871 - 69,462,405 (-)NCBICelera
Cytogenetic Map17q25.1NCBI
HuRef1768,269,147 - 68,279,670 (-)NCBIHuRef
CHM1_11772,923,450 - 72,933,984 (-)NCBICHM1_1
T2T-CHM13v2.01775,754,283 - 75,764,782 (-)NCBIT2T-CHM13v2.0
Fdxr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911115,158,850 - 115,167,925 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11115,158,850 - 115,167,876 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3811115,268,024 - 115,277,101 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11115,268,024 - 115,277,050 (-)Ensemblmm10GRCm38
MGSCv3711115,129,339 - 115,138,283 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3611115,084,115 - 115,093,059 (-)NCBIMGSCv36mm8
Celera11127,033,656 - 127,042,608 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1180.84NCBI
Fdxr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555531,746,670 - 1,755,315 (-)Ensembl
ChiLan1.0NW_0049555531,746,759 - 1,755,316 (-)NCBIChiLan1.0ChiLan1.0
FDXR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21990,899,791 - 90,910,451 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11795,722,695 - 95,733,347 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01768,808,123 - 68,818,642 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11774,364,343 - 74,374,852 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1774,364,343 - 74,374,852 (-)EnsemblpanPan2panpan1.1
FDXR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.195,567,411 - 5,577,427 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl95,567,328 - 5,577,277 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha96,246,975 - 6,256,975 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.096,239,485 - 6,249,477 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl96,239,458 - 6,249,473 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.196,276,453 - 6,286,449 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.096,387,040 - 6,397,024 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.096,447,362 - 6,457,354 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fdxr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056026,188,212 - 6,196,794 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936594215,155 - 223,771 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936594215,165 - 223,715 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FDXR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl126,372,009 - 6,382,769 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1126,372,224 - 6,382,769 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2126,362,701 - 6,373,244 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap12pNCBI
FDXR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11646,785,669 - 46,796,154 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1646,785,591 - 46,796,187 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607717,571,055 - 17,581,546 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fdxr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248014,713,519 - 4,722,612 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248014,714,341 - 4,722,588 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Fdxr
25 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:138
Count of miRNA genes:106
Interacting mature miRNAs:112
Transcripts:ENSRNOT00000004592
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093723381107556066Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)1079272424102982300Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
1578672Bmd16Bone mineral density QTL 166.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)1097202388107556066Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087807758107713808Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1091127270107556066Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
1578663Bss18Bone structure and strength QTL 183.6femur width (VT:1000666)femoral neck width (CMO:0001695)1097202388107556066Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1081012077101828297Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1089039175107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
1576313Pia25Pristane induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096620293107713808Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1576307Cia28Collagen induced arthritis QTL 28joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096620293107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091727883107713808Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 356 192 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000085636   ⟹   ENSRNOP00000075248
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl10101,006,849 - 101,015,542 (-)Ensembl
mRatBN7.2 Ensembl10100,507,865 - 100,516,658 (-)Ensembl
Rnor_6.0 Ensembl10103,817,704 - 103,826,448 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103108   ⟹   ENSRNOP00000079013
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl10101,006,849 - 101,015,542 (-)Ensembl
mRatBN7.2 Ensembl10100,507,865 - 100,516,658 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000144675   ⟹   ENSRNOP00000099119
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl10101,006,849 - 101,015,542 (-)Ensembl
RefSeq Acc Id: NM_024153   ⟹   NP_077067
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810101,006,846 - 101,015,535 (-)NCBI
mRatBN7.210100,507,865 - 100,516,556 (-)NCBI
Rnor_6.010103,817,724 - 103,826,413 (-)NCBI
Rnor_5.010104,468,590 - 104,477,279 (+)NCBI
RGSC_v3.410105,342,684 - 105,351,374 (-)RGD
Celera1099,084,255 - 99,092,947 (-)RGD
Sequence:
RefSeq Acc Id: XM_039086911   ⟹   XP_038942839
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810101,006,845 - 101,015,582 (-)NCBI
mRatBN7.210100,507,863 - 100,516,449 (-)NCBI
Protein Sequences
Protein RefSeqs NP_077067 (Get FASTA)   NCBI Sequence Viewer  
  XP_038942839 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH88844 (Get FASTA)   NCBI Sequence Viewer  
  BAA23759 (Get FASTA)   NCBI Sequence Viewer  
  EDM06569 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000075248
  ENSRNOP00000075248.1
GenBank Protein P56522 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_077067   ⟸   NM_024153
- Peptide Label: precursor
- UniProtKB: P56522 (UniProtKB/Swiss-Prot),   A6HKL4 (UniProtKB/TrEMBL),   A0A8I6G2P7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075248   ⟸   ENSRNOT00000085636
RefSeq Acc Id: XP_038942839   ⟸   XM_039086911
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000079013   ⟸   ENSRNOT00000103108
Ensembl Acc Id: ENSRNOP00000099119   ⟸   ENSRNOT00000144675
Protein Domains
FAD/NAD(P)-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P56522-F1-model_v2 AlphaFold P56522 1-494 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697881
Promoter ID:EPDNEW_R8406
Type:initiation region
Name:Fdxr_1
Description:ferredoxin reductase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.010103,826,465 - 103,826,525EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621648 AgrOrtholog
BioCyc Gene G2FUF-22693 BioCyc
Ensembl Genes ENSRNOG00000058497 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000085636 ENTREZGENE
  ENSRNOT00000085636.2 UniProtKB/Swiss-Prot
Gene3D-CATH 3.50.50.60 UniProtKB/Swiss-Prot
  NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7308634 IMAGE-MGC_LOAD
InterPro FAD/NAD-bd_sf UniProtKB/Swiss-Prot
  FAD/NAD-binding_dom UniProtKB/Swiss-Prot
  Ferredox_Rdtase UniProtKB/Swiss-Prot
  Ferredox_Rdtase_adrenod UniProtKB/Swiss-Prot
KEGG Report rno:79122 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105420 IMAGE-MGC_LOAD
NCBI Gene 79122 ENTREZGENE
PANTHER GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE UniProtKB/Swiss-Prot
  GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE UniProtKB/Swiss-Prot
Pfam Pyr_redox_2 UniProtKB/Swiss-Prot
PhenoGen Fdxr PhenoGen
PIRSF FNR UniProtKB/Swiss-Prot
PRINTS ADXRDTASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000058497 RatGTEx
Superfamily-SCOP Nucleotide-binding domain UniProtKB/Swiss-Prot
  SSF51905 UniProtKB/Swiss-Prot
UniProt A0A8I6G2P7 ENTREZGENE, UniProtKB/TrEMBL
  A6HKL4 ENTREZGENE, UniProtKB/TrEMBL
  ADRO_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Fdxr  ferredoxin reductase    adrenodoxin reductase  Name updated 1299863 APPROVED
2002-08-07 Fdxr  adrenodoxin reductase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction binds to adrenodoxin (Ad) by ionic interaction 727285