Ramp2 (receptor (calcitonin) activity modifying protein 2) - Rat Genome Database

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Gene: Ramp2 (receptor (calcitonin) activity modifying protein 2) Mus musculus
Analyze
Symbol: Ramp2
Name: receptor (calcitonin) activity modifying protein 2
RGD ID: 62164
MGI Page MGI
Description: Enables coreceptor activity. Involved in several processes, including cell-cell junction assembly; circulatory system development; and negative regulation of endothelial cell apoptotic process. Acts upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in cytoplasm. Predicted to be part of adrenomedullin receptor complex. Predicted to be active in cell surface. Predicted to colocalize with plasma membrane. Is expressed in several structures, including central nervous system; forelimb bud; gut; heart; and prostate gland lobe. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human RAMP2 (receptor activity modifying protein 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: receptor activity-modifying protein 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911101,137,160 - 101,139,076 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11101,136,854 - 101,150,372 (+)EnsemblGRCm39 Ensembl
GRCm3811101,246,334 - 101,248,250 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11101,246,028 - 101,259,546 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711101,107,648 - 101,109,564 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611101,062,424 - 101,064,340 (+)NCBIMGSCv36mm8
Celera11112,542,561 - 112,544,477 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1164.47NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-Nitrobenzanthrone  (ISO)
4,4'-sulfonyldiphenol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
acrylamide  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
arsenous acid  (ISO)
Azoxymethane  (EXP)
benzo[a]pyrene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
cadmium dichloride  (ISO)
calciol  (EXP,ISO)
carbon nanotube  (EXP)
chlorpyrifos  (EXP)
choline  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (EXP)
D-glucose  (EXP)
desferrioxamine B  (ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
diethyl malate  (EXP)
dioxygen  (EXP,ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
ethanol  (EXP)
ethylparaben  (ISO)
fenofibrate  (EXP)
folic acid  (EXP)
gentamycin  (ISO)
glafenine  (ISO)
glucose  (EXP)
hydralazine  (ISO)
hydrochlorothiazide  (ISO)
indole-3-methanol  (ISO)
isoprenaline  (ISO)
L-methionine  (EXP)
lead(0)  (ISO)
methamphetamine  (EXP,ISO)
methotrexate  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nicotine  (ISO)
nitric oxide  (ISO)
nitroprusside  (ISO)
oxaliplatin  (ISO)
ozone  (EXP)
paracetamol  (ISO)
paraquat  (EXP)
phenobarbital  (EXP)
phenylephrine  (ISO)
pirinixic acid  (EXP)
resveratrol  (ISO)
rimonabant  (EXP)
silicon dioxide  (EXP)
sodium arsenite  (EXP,ISO)
Soman  (ISO)
sunitinib  (ISO)
tetrachloromethane  (EXP,ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
triptonide  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
urethane  (ISO)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
adrenomedullin receptor complex  (IEA,ISO)
cell surface  (IBA,ISO,ISS)
cytoplasm  (ISO,ISS)
plasma membrane  (ISO,ISS)
receptor complex  (IBA,ISO,ISS)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Deficiency of the adrenomedullin-RAMP3 system suppresses metastasis through the modification of cancer-associated fibroblasts. Dai K, etal., Oncogene. 2020 Feb;39(9):1914-1930. doi: 10.1038/s41388-019-1112-z. Epub 2019 Nov 21.
2. [Changes of intermedin/adrenomedullin 2 and its receptors in the right ventricle of rats with chronic hypoxic pulmonary hypertension.] Gong YS, etal., Sheng Li Xue Bao. 2007 Apr 25;59(2):210-4.
3. Adrenomedullin production is increased in colorectal adenocarcinomas; its relation to matrix metalloproteinase-9. Hikosaka T, etal., Peptides. 2011 Sep;32(9):1825-31. doi: 10.1016/j.peptides.2011.07.012. Epub 2011 Aug 3.
4. The role of adrenomedullin and receptors in glomerular hyperfiltration in streptozotocin-induced diabetic rats. Hiragushi K, etal., Kidney Int. 2004 Feb;65(2):540-50.
5. The gene expression of adrenomedullin, calcitonin-receptor-like receptor and receptor activity modifying proteins (RAMPs) in CCl4-induced rat liver cirrhosis. Hwang IS, etal., Regul Pept. 2006 Jul 15;135(1-2):69-77. Epub 2006 May 19.
6. Intermedin1-53 protects the heart against isoproterenol-induced ischemic injury in rats. Jia YX, etal., Eur J Pharmacol. 2006 Nov 7;549(1-3):117-23. Epub 2006 Aug 17.
7. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
8. Alteration of the adrenomedullin receptor components gene expression associated with the blood pressure in pregnancy-induced hypertension. Makino Y, etal., J Clin Endocrinol Metab. 2001 Oct;86(10):5079-82.
9. Differential regulation of adrenomedullin gene expression in the fundic and pyloric regions of the rat stomach during acute and chronic starvation. Man SY, etal., Neuropeptides. 2007 Jun;41(3):177-87. Epub 2007 Mar 1.
10. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
11. MGDs mouse GO annotations MGD data from the GO Consortium
12. Rat receptor-activity-modifying proteins (RAMPs) for adrenomedullin/CGRP receptor: cloning and upregulation in obstructive nephropathy. Nagae T, etal., Biochem Biophys Res Commun 2000 Apr 2;270(1):89-93.
13. Ventricular adrenomedullin system in the transition from LVH to heart failure in rats. Nishikimi T, etal., Hypertension 2003 Mar;41(3):512-8.
14. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
15. Potentiated response to adrenomedullin in myocardia and aortas in spontaneously hypertensive rat. Pan ChS, etal., Basic Res Cardiol. 2006 May;101(3):193-203. Epub 2006 Feb 6.
16. Mouse MP Annotation Import Pipeline RGD automated import pipeline
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Association study of calcitonin-receptor-like receptor gene in essential hypertension. Sano M, etal., Am J Hypertens. 2005 Mar;18(3):403-8.
19. Upregulation of intracardiac adrenomedullin and its receptor system in rats with volume overload-induced cardiac hypertrophy. Yoshihara F, etal., Regul Pept. 2005 Apr 15;127(1-3):239-44.
20. [Alterations of intermedin and its receptor system in oleic acid-induced acute lung injury of rats] Yu XM, etal., Beijing Da Xue Xue Bao. 2006 Oct 18;38(5):496-500.
Additional References at PubMed
PMID:10349636   PMID:10777702   PMID:10828067   PMID:10854696   PMID:11042159   PMID:11060459   PMID:11076861   PMID:11854283   PMID:12477932   PMID:14610273   PMID:14659016   PMID:14681479  
PMID:15489334   PMID:15691893   PMID:16141072   PMID:16141073   PMID:16247769   PMID:16373602   PMID:17330803   PMID:17470425   PMID:18097473   PMID:18097475   PMID:18483404   PMID:19858409  
PMID:21566080   PMID:21677750   PMID:21782867   PMID:21862448   PMID:21873635   PMID:22563471   PMID:23297372   PMID:23355623   PMID:23562442   PMID:24505304   PMID:24813793   PMID:25252154  
PMID:25264174   PMID:26238476   PMID:27307317   PMID:27402918   PMID:27940069   PMID:28324104   PMID:28727763   PMID:30115739   PMID:30658846   PMID:32457985   PMID:33385343   PMID:33545715  
PMID:33955458   PMID:34321999   PMID:35364055   PMID:38012983  


Genomics

Comparative Map Data
Ramp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911101,137,160 - 101,139,076 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11101,136,854 - 101,150,372 (+)EnsemblGRCm39 Ensembl
GRCm3811101,246,334 - 101,248,250 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11101,246,028 - 101,259,546 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711101,107,648 - 101,109,564 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611101,062,424 - 101,064,340 (+)NCBIMGSCv36mm8
Celera11112,542,561 - 112,544,477 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1164.47NCBI
RAMP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381742,761,227 - 42,763,041 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1742,758,447 - 42,763,041 (+)EnsemblGRCh38hg38GRCh38
GRCh371740,913,245 - 40,915,059 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361738,166,738 - 38,168,585 (+)NCBINCBI36Build 36hg18NCBI36
Build 341738,166,737 - 38,168,580NCBI
Celera1737,569,491 - 37,571,338 (+)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1736,678,311 - 36,680,158 (+)NCBIHuRef
CHM1_11741,148,776 - 41,150,623 (+)NCBICHM1_1
T2T-CHM13v2.01743,618,368 - 43,620,182 (+)NCBIT2T-CHM13v2.0
Ramp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,689,148 - 86,690,956 (+)NCBIGRCr8
mRatBN7.21086,187,366 - 86,190,692 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1086,188,812 - 86,231,829 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1091,226,790 - 91,228,598 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,701,301 - 90,703,109 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01086,094,462 - 86,096,270 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01089,166,170 - 89,168,962 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1089,166,890 - 89,168,965 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01088,965,679 - 88,967,458 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41090,275,463 - 90,277,242NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11090,289,832 - 90,291,611NCBI
Cytogenetic Map10q31NCBI
Ramp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545116,584,742 - 16,586,093 (+)NCBIChiLan1.0ChiLan1.0
RAMP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21922,222,750 - 22,225,040 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11724,112,840 - 24,115,133 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01714,554,888 - 14,557,175 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11714,779,666 - 14,781,481 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1714,779,666 - 14,781,481 (-)Ensemblpanpan1.1panPan2
RAMP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1920,250,711 - 20,252,485 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha919,712,023 - 19,713,795 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0920,969,093 - 20,970,865 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl920,969,095 - 20,971,385 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1919,753,999 - 19,755,771 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0920,020,208 - 20,021,980 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0920,122,921 - 20,124,693 (-)NCBIUU_Cfam_GSD_1.0
Ramp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560219,593,351 - 19,595,280 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649017,479,650 - 17,482,716 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649017,479,899 - 17,481,788 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAMP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1220,092,196 - 20,094,469 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11220,092,204 - 20,094,426 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21220,346,948 - 20,349,170 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RAMP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11663,526,915 - 63,529,697 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1663,526,305 - 63,528,767 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607734,320,238 - 34,322,154 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ramp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247951,435,121 - 1,436,421 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ramp2
55 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1870
Count of miRNA genes:615
Interacting mature miRNAs:742
Transcripts:ENSMUST00000107282, ENSMUST00000122006, ENSMUST00000128260, ENSMUST00000129680, ENSMUST00000138229, ENSMUST00000149006, ENSMUST00000149585, ENSMUST00000151830
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191604608121973369Mouse
1301012Vispl_mvisual placing (mouse)Not determined11101022590121973369Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170691198104691366Mouse
1301535Pas5b_mpulmonary adenoma susceptibility 5b (mouse)Not determined1196176465108806384Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181574481115574636Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172019649106019734Mouse
12910539Sstapa3_msuseptibility to Staphylococcus aureus infection 3 (mouse)1196897693110603991Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
27226758Femd3_mfemur midshaft diameter 3, 5 week (mouse)1180890826101890826Mouse
14747003Mancz9_mmandible centroid size 9 (mouse)1185844911119844911Mouse
1301640Lore4_mloss of righting induced by ethanol 4 (mouse)Not determined1179156009107616472Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181810267115810267Mouse
11251723Ewc5_methanol withdrawal and consumption 5 (mouse)1189869251121973369Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170691198104691366Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170691198104691366Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177770978111771099Mouse
4141465Dbm2_mdiabetes modifier 2 (mouse)Not determined94437183118022724Mouse
10045617Heal26_mwound healing/regeneration 26 (mouse)Not determined1192939373112544554Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177437183111437322Mouse
1357631Motr1_mmodifier of tubby retinal degeneration 1 (mouse)Not determined1187691198103274115Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172726125106726289Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172818615106818733Mouse
11341721Rvfs2_mRift Valley fever susceptibility 2 (mouse)11100254186120887165Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177437183111437322Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170691198104691366Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181574481115574636Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187490826121873369Mouse
14746970Manh71_mmandible shape 71 (mouse)1179416257113416257Mouse
10043865T2dm5sa_mtype 2 diabetes mellitus 5 in SMXA RI mice (mouse)Not determined1179813759104502698Mouse
1300944Alcp20_malcohol preference locus 20 (mouse)Not determined1195403965121973369Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182377698116377820Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172818615106818733Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
1301983Berr2_mberghei resistance locus 2 (mouse)Not determined1198352609121973369Mouse
4141939Pregq2_mpregnancy QTL 2 (mouse)Not determined1194063779118022724Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177063779111063918Mouse
10043976Obq33_mobesity QTL 33 (mouse)Not determined1198500469121973369Mouse
1301057Nidd4_mnon-insulin-dependent diabetes mellitus 4 (mouse)Not determined1196810136121973369Mouse
1301958Alcp18_malcohol preference locus 18 (mouse)Not determined1195403965121973369Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186608320120608320Mouse
15039374Adip29_madiposity 29 (mouse)1186608320120608320Mouse
1300962Cd8mts4_mCD8 memory T cell subset 4 (mouse)Not determined1196137674121973369Mouse
1301095El6_mepilepsy 6 (mouse)Not determined1193229183121973369Mouse
27226731Tibmd4_mtibia midshaft diameter 4, 10 week (mouse)1194190826118890826Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186608320120608320Mouse
1558753Ath19_matherosclerosis 19 (mouse)Not determined1191604608121973369Mouse
10044001Alcw8_malcohol withdrawal 8 (mouse)Not determined1199254187121973369Mouse
11553867Stmm5_mskin tumor modifier of MSM 5 (mouse)11100058103121973369Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187502600121502698Mouse

Markers in Region
Ramp2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811101,248,150 - 101,248,210UniSTSGRCm38
MGSCv3711101,109,464 - 101,109,524UniSTSGRCm37
Celera11112,544,377 - 112,544,437UniSTS
Cytogenetic Map11DUniSTS
cM Map1161.5UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000107282   ⟹   ENSMUSP00000102903
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11101,137,919 - 101,138,890 (+)Ensembl
GRCm38.p6 Ensembl11101,247,093 - 101,248,064 (+)Ensembl
Ensembl Acc Id: ENSMUST00000122006   ⟹   ENSMUSP00000114061
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11101,137,255 - 101,139,076 (+)Ensembl
GRCm38.p6 Ensembl11101,246,429 - 101,248,250 (+)Ensembl
Ensembl Acc Id: ENSMUST00000128260   ⟹   ENSMUSP00000127718
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11101,137,217 - 101,150,372 (+)Ensembl
GRCm38.p6 Ensembl11101,246,391 - 101,259,546 (+)Ensembl
Ensembl Acc Id: ENSMUST00000129680   ⟹   ENSMUSP00000122072
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11101,136,854 - 101,139,076 (+)Ensembl
GRCm38.p6 Ensembl11101,246,028 - 101,248,250 (+)Ensembl
Ensembl Acc Id: ENSMUST00000138229
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11101,137,759 - 101,139,076 (+)Ensembl
GRCm38.p6 Ensembl11101,246,933 - 101,248,250 (+)Ensembl
Ensembl Acc Id: ENSMUST00000149006
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11101,137,138 - 101,138,510 (+)Ensembl
GRCm38.p6 Ensembl11101,246,312 - 101,247,684 (+)Ensembl
Ensembl Acc Id: ENSMUST00000149585   ⟹   ENSMUSP00000116331
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11101,137,258 - 101,139,076 (+)Ensembl
GRCm38.p6 Ensembl11101,246,432 - 101,248,250 (+)Ensembl
Ensembl Acc Id: ENSMUST00000151830   ⟹   ENSMUSP00000123150
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11101,137,393 - 101,138,462 (+)Ensembl
GRCm38.p6 Ensembl11101,246,567 - 101,247,636 (+)Ensembl
RefSeq Acc Id: NM_019444   ⟹   NP_062317
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911101,137,160 - 101,139,076 (+)NCBI
GRCm3811101,246,334 - 101,248,250 (+)ENTREZGENE
MGSCv3711101,107,648 - 101,109,564 (+)RGD
Celera11112,542,561 - 112,544,477 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_062317   ⟸   NM_019444
- Peptide Label: precursor
- UniProtKB: Q9WUP0 (UniProtKB/Swiss-Prot),   Q6IS25 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000123150   ⟸   ENSMUST00000151830
Ensembl Acc Id: ENSMUSP00000102903   ⟸   ENSMUST00000107282
Ensembl Acc Id: ENSMUSP00000116331   ⟸   ENSMUST00000149585
Ensembl Acc Id: ENSMUSP00000122072   ⟸   ENSMUST00000129680
Ensembl Acc Id: ENSMUSP00000127718   ⟸   ENSMUST00000128260
Ensembl Acc Id: ENSMUSP00000114061   ⟸   ENSMUST00000122006

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WUP0-F1-model_v2 AlphaFold Q9WUP0 1-189 view protein structure

Promoters
RGD ID:6822443
Promoter ID:MM_KWN:9869
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney,   Lung
Transcripts:ENSMUST00000107282,   OTTMUST00000005496,   OTTMUST00000005498,   OTTMUST00000005499,   OTTMUST00000005500,   OTTMUST00000005501,   OTTMUST00000005509,   OTTMUST00000072892,   UC007LNZ.1,   UC007LOA.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3611101,107,421 - 101,107,921 (+)MPROMDB
RGD ID:8676778
Promoter ID:EPDNEW_M16419
Type:multiple initiation site
Name:Ramp2_1
Description:Mus musculus receptor activity modifying protein 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3811101,246,414 - 101,246,474EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1859650 AgrOrtholog
Ensembl Genes ENSMUSG00000001240 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000107282.4 UniProtKB/TrEMBL
  ENSMUST00000122006.8 UniProtKB/TrEMBL
  ENSMUST00000128260.9 UniProtKB/TrEMBL
  ENSMUST00000129680 ENTREZGENE
  ENSMUST00000129680.8 UniProtKB/Swiss-Prot
  ENSMUST00000149585.8 UniProtKB/TrEMBL
  ENSMUST00000151830.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.150.510 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro RAMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAMP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:54409 UniProtKB/Swiss-Prot
MGD MGI:1859650 ENTREZGENE
NCBI Gene Ramp2 ENTREZGENE
PANTHER PTHR14076 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RECEPTOR ACTIVITY-MODIFYING PROTEIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RAMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ramp2 PhenoGen
UniProt A2A4K2_MOUSE UniProtKB/TrEMBL
  A8XY18_MOUSE UniProtKB/TrEMBL
  D6RHQ4_MOUSE UniProtKB/TrEMBL
  E9Q0S5_MOUSE UniProtKB/TrEMBL
  F6YPZ1_MOUSE UniProtKB/TrEMBL
  Q6IS25 ENTREZGENE
  Q9WUP0 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q6IS25 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-08-26 Ramp2  receptor (calcitonin) activity modifying protein 2  Ramp2-pending  receptor-activity modifying protein 2  Symbol and/or name updated 27372883 PROVISIONAL
2024-08-21 Ramp2-pending  receptor-activity modifying protein 2  Ramp2  receptor (calcitonin) activity modifying protein 2  Symbol and/or name change 5135510 APPROVED