Trib1 (tribbles pseudokinase 1) - Rat Genome Database

Name: Trib1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Trib1 (tribbles pseudokinase 1) Rattus norvegicus

Analyze

Symbol:

Trib1

Name:

tribbles pseudokinase 1

RGD ID:

621596

Description:

Predicted to enable several functions, including enzyme binding activity; protein kinase inhibitor activity; and ubiquitin-protein transferase regulator activity. Predicted to be involved in several processes, including negative regulation of lipopolysaccharide-mediated signaling pathway; regulation of myeloid leukocyte differentiation; and regulation of protein metabolic process. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human TRIB1 (tribbles pseudokinase 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2-amino-4,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

G-protein-coupled receptor induced protein GIG2; Gig2; tribbles homolog 1; tribbles homolog 1 (Drosophila)

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TRIB1 (tribbles pseudokinase 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Trib1 (tribbles pseudokinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Trib1 (tribbles pseudokinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TRIB1 (tribbles pseudokinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TRIB1 (tribbles pseudokinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Trib1 (tribbles pseudokinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TRIB1 (tribbles pseudokinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TRIB1 (tribbles pseudokinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Trib1 (tribbles pseudokinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	IFIT1 (interferon induced protein with tetratricopeptide repeats 1)	HGNC	OMA
Homo sapiens (human):	IFIT1B (interferon induced protein with tetratricopeptide repeats 1B)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Trib1 (tribbles pseudokinase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	TRIB1 (tribbles pseudokinase 1)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	trib1 (tribbles pseudokinase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	nipi-3	Alliance	DIOPT (OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	trbl	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	trib1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	7	91,206,579 - 91,213,126 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	91,206,579 - 91,214,731 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	93,092,395 - 93,098,946 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	7	95,293,606 - 95,300,157 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	7	95,125,539 - 95,132,086 (+)	NCBI	Rnor_WKY
Rnor_6.0	7	99,954,492 - 99,961,026 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	99,954,492 - 99,961,026 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	100,534,391 - 100,540,925 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	96,442,239 - 96,448,785 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	96,477,093 - 96,482,772 (+)	NCBI
Celera	7	87,967,385 - 87,973,931 (+)	NCBI		Celera
Cytogenetic Map	7	q33	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

coronary artery disease (ISO)

genetic disease (ISO)

non-alcoholic fatty liver disease (ISO)

trichorhinophalangeal syndrome type I (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

1-fluoro-2,4-dinitrobenzene (ISO)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2-amino-4,6-dinitrotoluene (EXP)

2-hydroxypropanoic acid (ISO)

3,7-dihydropurine-6-thione (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-diaminodiphenylmethane (ISO)

4-(ethoxymethylene)-2-phenyloxazol-5-one (ISO)

4-hydroxyphenyl retinamide (ISO)

5-azacytidine (ISO)

acetamide (EXP)

acrolein (ISO)

acrylamide (EXP,ISO)

afimoxifene (ISO)

aflatoxin B1 (EXP,ISO)

Aflatoxin B2 alpha (ISO)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

ammonium chloride (EXP)

antimycin A (ISO)

antirheumatic drug (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

atrazine (ISO)

azathioprine (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

butan-1-ol (ISO)

C60 fullerene (EXP)

cadmium atom (ISO)

calcitriol (ISO)

cannabidiol (ISO)

carbon nanotube (ISO)

chloropicrin (ISO)

choline (ISO)

cisplatin (ISO)

cobalt dichloride (ISO)

cocaine (EXP)

copper atom (EXP)

copper(0) (EXP)

copper(II) sulfate (ISO)

coumestrol (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

deguelin (ISO)

dexamethasone (ISO)

dibenz[a,h]anthracene (ISO)

dibutyl phthalate (EXP,ISO)

diethyl maleate (ISO)

dioxygen (EXP,ISO)

dorsomorphin (ISO)

doxorubicin (EXP,ISO)

Enterolactone (ISO)

epoxiconazole (ISO)

ethanol (ISO)

ethyl methanesulfonate (ISO)

fluoranthene (ISO)

folic acid (ISO)

folpet (ISO)

formaldehyde (ISO)

gentamycin (EXP)

glycidol (EXP)

hydrogen peroxide (ISO)

hydroquinone (ISO)

indole-3-methanol (EXP)

indometacin (ISO)

inulin (ISO)

irinotecan (ISO)

L-methionine (ISO)

lead diacetate (EXP)

leflunomide (ISO)

melphalan (ISO)

mercaptopurine (EXP)

mercury dichloride (EXP)

methotrexate (ISO)

methyl methanesulfonate (ISO)

methylisothiazolinone (ISO)

methylseleninic acid (ISO)

mitoxantrone (ISO)

monosodium L-glutamate (ISO)

N-acetyl-L-cysteine (EXP)

N-methyl-4-phenylpyridinium (EXP)

N-nitrosodiethylamine (EXP,ISO)

N-nitrosodimethylamine (ISO)

N-Nitrosopyrrolidine (ISO)

nickel dichloride (ISO)

oxaliplatin (EXP)

ozone (ISO)

paracetamol (EXP,ISO)

paraquat (EXP)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

phenobarbital (ISO)

phenol (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

purine-6-thiol (EXP)

rac-lactic acid (ISO)

raloxifene (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (ISO)

sotorasib (ISO)

sunitinib (ISO)

tamibarotene (ISO)

tamoxifen (ISO)

temozolomide (ISO)

tert-butyl hydroperoxide (ISO)

tetrachloromethane (EXP,ISO)

thapsigargin (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

topotecan (EXP)

torcetrapib (ISO)

trametinib (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

triclosan (ISO)

Triptolide (EXP)

triptonide (ISO)

urethane (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vincristine (ISO)

vorinostat (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

JNK cascade (ISO)

negative regulation of DNA-binding transcription factor activity (ISO)

negative regulation of lipopolysaccharide-mediated signaling pathway (ISO)

negative regulation of neutrophil differentiation (ISO)

negative regulation of protein kinase activity (ISO)

negative regulation of smooth muscle cell migration (ISO)

negative regulation of smooth muscle cell proliferation (ISO)

positive regulation of eosinophil differentiation (ISO)

positive regulation of macrophage differentiation (ISO)

positive regulation of proteasomal ubiquitin-dependent protein catabolic process (IBA,ISO)

protein phosphorylation (IEA)

regulation of MAP kinase activity (IBA,ISO)

response to lipopolysaccharide (ISO)

Cellular Component

cytoplasm (ISO)

nucleus (IBA,ISO)

Molecular Function

ATP binding (IEA)

mitogen-activated protein kinase kinase binding (IBA,ISO)

protein binding (ISO)

protein kinase activity (IEA)

protein kinase inhibitor activity (ISO)

RNA polymerase II-specific DNA-binding transcription factor binding (ISO)

ubiquitin protein ligase binding (ISO)

ubiquitin-protein transferase regulator activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
5.	GOA pipeline	RGD automated data pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Information Derived from GenBank Report	RGD, Sept. 2003

Additional References at PubMed

PMID:8889548	PMID:15299019	PMID:17452330	PMID:17724128	PMID:20410507	PMID:23515163

Genomics

Comparative Map Data

Trib1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	7	91,206,579 - 91,213,126 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	91,206,579 - 91,214,731 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	93,092,395 - 93,098,946 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	7	95,293,606 - 95,300,157 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	7	95,125,539 - 95,132,086 (+)	NCBI	Rnor_WKY
Rnor_6.0	7	99,954,492 - 99,961,026 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	99,954,492 - 99,961,026 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	100,534,391 - 100,540,925 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	96,442,239 - 96,448,785 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	96,477,093 - 96,482,772 (+)	NCBI
Celera	7	87,967,385 - 87,973,931 (+)	NCBI		Celera
Cytogenetic Map	7	q33	NCBI

TRIB1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	125,430,358 - 125,438,403 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	8	125,430,358 - 125,438,403 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	126,442,600 - 126,450,645 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	126,511,745 - 126,519,827 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	8	126,511,744 - 126,519,824	NCBI
Celera	8	122,631,533 - 122,639,615 (+)	NCBI		Celera
Cytogenetic Map	8	q24.13	NCBI
HuRef	8	121,766,406 - 121,774,484 (+)	NCBI		HuRef
CHM1_1	8	126,482,807 - 126,490,884 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	8	126,563,804 - 126,571,849 (+)	NCBI		T2T-CHM13v2.0

Trib1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	59,520,503 - 59,528,948 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	59,520,199 - 59,528,948 (+)	Ensembl		GRCm39 Ensembl
GRCm38	15	59,648,654 - 59,657,099 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	59,648,350 - 59,657,099 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	59,480,209 - 59,488,654 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	59,478,335 - 59,486,780 (+)	NCBI		MGSCv36	mm8
Celera	15	61,178,271 - 61,186,716 (+)	NCBI		Celera
Cytogenetic Map	15	D1	NCBI

Trib1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955461	494,003 - 501,990 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955461	494,003 - 501,928 (+)	NCBI	ChiLan1.0	ChiLan1.0

TRIB1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	8	118,364,202 - 118,371,720 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	122,115,194 - 122,123,319 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	124,867,334 - 124,874,863 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	124,867,359 - 124,872,924 (+)	Ensembl	panpan1.1		panPan2

TRIB1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	13	23,337,788 - 23,346,304 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	13	23,337,788 - 23,346,304 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	13	23,310,655 - 23,319,064 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	13	23,683,492 - 23,691,935 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	13	23,682,916 - 23,691,935 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	13	23,404,842 - 23,413,262 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	13	23,511,711 - 23,520,081 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	13	23,755,679 - 23,764,091 (+)	NCBI		UU_Cfam_GSD_1.0

Trib1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	14,975,282 - 14,983,509 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936470	22,401,379 - 22,409,490 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936470	22,401,713 - 22,408,808 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TRIB1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	14,289,751 - 14,297,663 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	14,289,739 - 14,298,119 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

TRIB1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	120,013,757 - 120,021,823 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	120,014,339 - 120,019,887 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666039	20,151,213 - 20,159,305 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Trib1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624735	29,879,310 - 29,888,305 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624735	29,880,732 - 29,888,117 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Trib1
28 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	64
Count of miRNA genes:	49
Interacting mature miRNAs:	59
Transcripts:	ENSRNOT00000005885
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	924703	115097879	Rat
1643004	Pain2	Pain QTL 2	1		mechanical nociception trait (VT:0002734)	self mutilation severity score (CMO:0002145)	7	9462246	98011544	Rat
61357	Bp38	Blood pressure QTL 38	1.6	0.052	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	41333674	119109060	Rat
1358361	Sradr5	Stress Responsive Adrenal Weight QTL 5	5.55		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	7	43747012	108555253	Rat
1300179	Kidm5	Kidney mass QTL 5	3.51		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	43747012	135012528	Rat
1300149	Cm6	Cardiac mass QTL 6	4.09		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	7	43747099	102228765	Rat
631504	Cm27	Cardiac mass QTL 27	3.45		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	7	44421311	118198041	Rat
738030	Anxrr8	Anxiety related response QTL 8	4.1		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	46590070	91590070	Rat
2293696	Bmd32	Bone mineral density QTL 32	5.1	0.0001	femur strength trait (VT:0010010)	femoral neck polar moment of inertia (CMO:0001670)	7	47651439	92651439	Rat
2293707	Bss32	Bone structure and strength QTL 32	7.64	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	7	47651439	92651439	Rat
2300178	Bmd54	Bone mineral density QTL 54	5.3	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	7	47651439	92651439	Rat
2293644	Bmd29	Bone mineral density QTL 29	5.4	0.0001	femur size trait (VT:1000369)	femoral neck cross-sectional area (CMO:0001697)	7	47651439	92651439	Rat
2293667	Bss42	Bone structure and strength QTL 42	7.25	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra cross-sectional area (CMO:0001689)	7	47651439	92651439	Rat
2293678	Bss24	Bone structure and strength QTL 24	6.71	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	7	47651439	92651439	Rat
2293685	Bmd21	Bone mineral density QTL 21	4.2	0.0003	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	7	47651439	92651439	Rat
1300151	Bp181	Blood pressure QTL 181	3.36		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	7	53612714	103945643	Rat
2317035	Aia16	Adjuvant induced arthritis QTL 16	2.71		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	7	59238038	104238038	Rat
1298528	Bp169	Blood pressure QTL 169		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	61074194	106074194	Rat
1559283	Emca4	Estrogen-induced mammary cancer QTL 4	3.7		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	7	62004452	101773158	Rat
1576303	Ept7	Estrogen-induced pituitary tumorigenesis QTL 7	3.7		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	7	62004452	101773158	Rat
70173	Niddm19	Non-insulin dependent diabetes mellitus QTL 19	4.33	0.00005	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	7	64002457	135012528	Rat
2316947	Rf58	Renal function QTL 58	7.8		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	7	68938720	113886318	Rat
2316952	Pur22	Proteinuria QTL 22	5.2		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	7	68938720	113886318	Rat
2316955	Stl24	Serum triglyceride level QTL 24	7.1		blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	7	68938720	113886318	Rat
631540	Bw9	Body weight QTL 9	4.5		body mass (VT:0001259)	body weight (CMO:0000012)	7	69736226	117455174	Rat
1357338	Stl17	Serum triglyceride level QTL 17	3.23		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	7	69736356	112729554	Rat
634331	Pia17	Pristane induced arthritis QTL 17	4.7		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	7	73829340	130221005	Rat
7411654	Foco25	Food consumption QTL 25	9.3	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	75918751	120918751	Rat
7411607	Foco15	Food consumption QTL 15		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	75918751	120918751	Rat
724537	Niddm52	Non-insulin dependent diabetes mellitus QTL 52		0.02	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	7	80221299	93595843	Rat
1641908	Teswt1	Testicular weight QTL 1	3.28		testis mass (VT:1000644)	both testes wet weight (CMO:0000175)	7	80221299	94811326	Rat
631529	Tls2	T-lymphoma susceptibility QTL 2	0	0.001	thymus integrity trait (VT:0010555)	percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)	7	80221299	109401111	Rat
1331746	Kidm9	Kidney mass QTL 9	3.934		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	7	80221299	112308525	Rat
1331728	Bp214	Blood pressure QTL 214	2.825		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	80221299	124373579	Rat
1331768	Kidm10	Kidney mass QTL 10	4.62096		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	80221299	125221299	Rat
2317052	Aia17	Adjuvant induced arthritis QTL 17	2.13		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	7	81737938	126737938	Rat
634322	Bw12	Body weight QTL 12	0		body mass (VT:0001259)	body weight (CMO:0000012)	7	83153392	128153392	Rat
1358891	Bp265	Blood pressure QTL 265	2.21		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	83591953	134666232	Rat
1358914	Bp266	Blood pressure QTL 266			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	83591953	134666232	Rat
71114	Niddm14	Non-insulin dependent diabetes mellitus QTL 14	4.5		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	7	84257275	129257275	Rat
2298475	Eau6	Experimental allergic uveoretinitis QTL 6		0.0029	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	7	84257275	129257275	Rat
1558655	Swd4	Spike wave discharge measurement QTL 4	3.68	0.0002	brain electrophysiology trait (VT:0010557)	brain spike-and-wave discharge severity grade (CMO:0001988)	7	86983365	131983365	Rat
10450828	Scl79	Serum cholesterol level QTL 79	3.5	0.001	blood HDL cholesterol amount (VT:0000184)	blood low density lipoprotein cholesterol level (CMO:0000053)	7	89867376	101773158	Rat
1549899	Stresp8	Stress response QTL 8	4.37	0.0008	stress-related behavior trait (VT:0010451)	defensive burying duration (CMO:0001961)	7	90482196	135012528	Rat

Markers in Region

RH134126

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	91,205,354 - 91,205,535 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	99,953,268 - 99,953,448	NCBI	Rnor6.0
Rnor_5.0	7	100,533,167 - 100,533,347	UniSTS	Rnor5.0
RGSC_v3.4	7	96,441,015 - 96,441,195	UniSTS	RGSC3.4
Celera	7	87,966,161 - 87,966,341	UniSTS
RH 3.4 Map	7	651.28	UniSTS
Cytogenetic Map	7	q33	UniSTS

RH143669

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	91,206,640 - 91,206,831 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	99,954,554 - 99,954,744	NCBI	Rnor6.0
Rnor_5.0	7	100,534,453 - 100,534,643	UniSTS	Rnor5.0
RGSC_v3.4	7	96,442,301 - 96,442,491	UniSTS	RGSC3.4
Celera	7	87,967,447 - 87,967,637	UniSTS
RH 3.4 Map	7	651.9	UniSTS
Cytogenetic Map	7	q33	UniSTS

BE100119

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	91,213,351 - 91,213,532 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	99,961,252 - 99,961,432	NCBI	Rnor6.0
Rnor_5.0	7	100,541,151 - 100,541,331	UniSTS	Rnor5.0
RGSC_v3.4	7	96,449,011 - 96,449,191	UniSTS	RGSC3.4
Celera	7	87,974,157 - 87,974,337	UniSTS
Cytogenetic Map	7	q33	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	2	1	16	12	7	12	4	7	17	35	15	11	4
Low	1	42	41	29	12	29	4	4	57		25		4
Below cutoff											1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_023985	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AA964141	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF205438	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AI601976	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AW530250	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BE096693	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473950	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000185	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000005885 ⟹ ENSRNOP00000005885

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	91,206,579 - 91,213,126 (+)	Ensembl
Rnor_6.0 Ensembl	7	99,954,492 - 99,961,026 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000105083 ⟹ ENSRNOP00000088193

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	91,210,314 - 91,214,731 (+)	Ensembl

RefSeq Acc Id:

NM_023985 ⟹ NP_076475

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	7	91,206,579 - 91,213,126 (+)	NCBI
Rnor_6.0	7	99,954,492 - 99,961,026 (+)	NCBI
Rnor_5.0	7	100,534,391 - 100,540,925 (+)	NCBI
RGSC_v3.4	7	96,442,239 - 96,448,785 (+)	RGD
Celera	7	87,967,385 - 87,973,931 (+)	RGD

Sequence:

show sequence

ACACAGCCCGGGCTGTGAGTGTGTGTGTGTGTATACAGCGTGAGTCACCGGGAGGCGGAGGAGG
TGGAGGAAAAGGAGAAGGAGTGCACTGGCCGGGATCAGTGCGGCACACACTCATATTCAGTCAC
TCTCTCTAAGCGCGTCTCGCTCGCTCACACGCCTGGAGCCCAGGAGCGCGCAGGATCCCGAGCG
GCGCGGAAAAGTTGCACCGGCTTTTACTCAAGACTAATTGCTTTGGGAAGTGCGTTTGCTCGGT
GAAGCCAACGAGCCTGCGGAATCTGTCCTCCAGGCTCAGCACCCGGGAACTCGGGCGGCCTCCA
CGTCCCGGGCTATCCACGGTCTCGGCAACAATAGCGGCCGCCACCGCCAGCGAGGCGTCCAGAC
CTGGTGCCTGCCGGGGTCTGGGGACCTTAGCCGGCCTCCCACCCTTGGACGCGTGGCCAGTGTG
GTTCTCGTGTACAACATCAGCGTCCTGGAACTGCTCTCGTTTTGCTCCTTTTGGGGACCGATCC
AAGCTCTATCTGCAGACTCCATCCCGCGGACTGGAAGTCGTAGCGCGGATCCAGGGATTTACAA
AGCCGGGGCCGCTCCGGCCAGGGCCGCGATGCGGGTCGGTCCCGTGCGTTTTGCCCTGAGCGGC
GCCTCGCAGCCCCGCGGACCGGCTCTACTGTTCCCGGCTGCCCGGGGCACCCCGGCCAAACGCC
TGCTGGACACGGACGACGCGGCGGCCGTGGCGGCCAAGTGTCCGCGCCTCTCTGAGTGCTCGAA
TCCCCCTGACTACCTCAGTCCCCCCGGCTCGCCCTGCAGTCCTCAGCCTCCACCCTCGGCGCAG
GGGACCGGCGGCAGCTGTGTGAGCGCACCCGGGCCCAGCCGAATCGCCGACTACCTGCTGCTAC
CCCTAGCTGAGCGCGAGCATGTGTCCCGGGCACTGTGCATCCACACCGGCCGCGAGCTGCGCTG
CAAGGTGTTTCCCATTAAACACTACCAAGACAAAATCAGGCCTTACACCCAGCTGCCGTCCCAT
AGAAACATTACTGGCATCGTGGAAGTGATCCTCGGGGAGAGCAAGGCCTACGTTTTCTTTGAGA
AGGACTTTGGAGACATGCACTCCTATGTACGAAGCCGGAAAAGGCTTCGGGAAGAGGAGGCCGC
TCGGCTCTTCAAGCAAATTGTTTCCGCCGTTGCCCACTGCCACCAGTCAGCCATTGTGCTGGGG
GACCTGAAGCTTAGGAAATTCGTCTTCTCCACAGAGGAGAGGACCCAGCTTAGACTGGAAAGCC
TAGAAGATACGCACATGATAAAGGGTGAAGATGACGCATTGTCAGATAAACATGGCTGCCCGGC
CTATGTGAGCCCTGAGATCCTCAACACTACTGGGACCTACTCCGGAAAGGCAGCGGATGTTTGG
AGCCTTGGGGTGATGCTCTACACCCTTTTGGTCGGACGATACCCCTTTCATGACTCAGACCCGA
GCGCCCTTTTCTCCAAAATCCGTCGGGGACAGTTTTGCATTCCCGAGCATGTTTCCCCCAAAGC
CAGGTGCCTCATCCGCAGCCTCCTGAGACGAGAACCTTCTGAGAGACTCACAGCTCCTGAGATC
TTACTCCATCCCTGGTTTGAATACGTCTTGGAACCGGGGTATGTTGACTCAGAAGTAGGAACTT
CTGACCAGATTGTTCCCGAGTACCAGGACGACAATGACGTTAGTTCCTTTTTCTGCTAATCCCC
CCCCCCCAAAAAAAAACCTCAGAAACCTCATAATTCTCACACATGGCATTTCTAATGATGGGCA
GGCCCTCTTACACGGTGCCAGCCAGCTATGGGGACGGAGCACCATTGTCCCTGTGGGGCTCAGT
GTGGTGCCACCTCTCGGGCCGAGTGACTTGATTTGACCAGCATGCACTCAGATTAGCTGCTTGA
CAAAGGTGTCCCCTTTTCGATGACCATCGTGACTGTCCCGGTGTCGGAGGCA

hide sequence

Protein Sequences


Protein RefSeqs	NP_076475	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAG35664	(Get FASTA)	NCBI Sequence Viewer
	EDM16196	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_076475 ⟸ NM_023985

- UniProtKB:

G3V6J8 (UniProtKB/TrEMBL), Q9EQL6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MRVGPVRFALSGASQPRGPALLFPAARGTPAKRLLDTDDAAAVAAKCPRLSECSNPPDYLSPPG
SPCSPQPPPSAQGTGGSCVSAPGPSRIADYLLLPLAEREHVSRALCIHTGRELRCKVFPIKHYQ
DKIRPYTQLPSHRNITGIVEVILGESKAYVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSA
VAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHMIKGEDDALSDKHGCPAYVSPEILNT
TGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHVSPKARCLIRSLLR
REPSERLTAPEILLHPWFEYVLEPGYVDSEVGTSDQIVPEYQDDNDVSSFFC

hide sequence

RefSeq Acc Id:

ENSRNOP00000005885 ⟸ ENSRNOT00000005885

RefSeq Acc Id:

ENSRNOP00000088193 ⟸ ENSRNOT00000105083

Protein Domains

Protein kinase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-G3V6J8-F1-model_v2	AlphaFold	G3V6J8	1-372	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695360

Promoter ID:

EPDNEW_R5884

Type:

initiation region

Name:

Trib1_1

Description:

tribbles pseudokinase 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	99,954,592 - 99,954,652	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621596	AgrOrtholog
BioCyc Gene	G2FUF-33279	BioCyc
Ensembl Genes	ENSRNOG00000004100	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000005885	ENTREZGENE
	ENSRNOP00000005885.4	UniProtKB/TrEMBL
	ENSRNOP00000088193.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000005885	ENTREZGENE
	ENSRNOT00000005885.6	UniProtKB/TrEMBL
	ENSRNOT00000105083.1	UniProtKB/TrEMBL
Gene3D-CATH	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
InterPro	Kinase-like_dom	UniProtKB/TrEMBL
	Prot_kinase_cat_dom	UniProtKB/TrEMBL
	TRB1	UniProtKB/TrEMBL
	Tribbles/Ser_Thr_kinase_40	UniProtKB/TrEMBL
KEGG Report	rno:78969	UniProtKB/TrEMBL
NCBI Gene	78969	ENTREZGENE
PANTHER	PTHR22961	UniProtKB/TrEMBL
	PTHR22961:SF17	UniProtKB/TrEMBL
Pfam	Pkinase	UniProtKB/TrEMBL
PhenoGen	Trib1	PhenoGen
PROSITE	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
SMART	S_TKc	UniProtKB/TrEMBL
Superfamily-SCOP	Kinase_like	UniProtKB/TrEMBL
UniProt	A0A8I6A5Q0_RAT	UniProtKB/TrEMBL
	G3V6J8	ENTREZGENE, UniProtKB/TrEMBL
	Q9EQL6	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-11-11	Trib1	tribbles pseudokinase 1	Trib1	tribbles homolog 1 (Drosophila)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Trib1	tribbles homolog 1 (Drosophila)	Gig2	G-protein-coupled receptor induced protein GIG2	Symbol and Name updated	1299863	APPROVED
2002-08-07	Gig2	G-protein-coupled receptor induced protein GIG2			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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