Casp9 (caspase 9) - Rat Genome Database

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Gene: Casp9 (caspase 9) Mus musculus
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Symbol: Casp9
Name: caspase 9
RGD ID: 62159
MGI Page MGI
Description: Enables cysteine-type endopeptidase activity. Involved in cellular response to dexamethasone stimulus. Acts upstream of or within several processes, including epithelial cell apoptotic process; fibroblast apoptotic process; and positive regulation of neuron apoptotic process. Located in cytosol and nucleus. Is expressed in several structures, including brain; early embryo; forelimb interdigital region; hemolymphoid system gland; and neural ectoderm. Human ortholog(s) of this gene implicated in several diseases, including Parkinson's disease; colorectal cancer; lung non-small cell carcinoma; pancreatic cancer; and type 2 diabetes mellitus. Orthologous to human CASP9 (caspase 9).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AI115399; APAF-3; apoptotic protease Mch-6; apoptotic protease-activating factor 3; AW493809; Casp; CASP-9; caspase-9; ICE-; ICE-LAP6; ICE-like apoptotic protease 6; Mch6
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394141,520,923 - 141,543,289 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4141,520,923 - 141,543,287 (+)EnsemblGRCm39 Ensembl
GRCm384141,793,612 - 141,815,978 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4141,793,612 - 141,815,976 (+)EnsemblGRCm38mm10GRCm38
MGSCv374141,349,527 - 141,371,890 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364141,065,688 - 141,088,051 (+)NCBIMGSCv36mm8
Celera4143,618,711 - 143,640,921 (+)NCBICelera
Cytogenetic Map4D3NCBI
cM Map474.75NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Liver Failure  (ISO)
alcohol use disorder  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
bacterial infectious disease  (IEP)
Brain Hypoxia-Ischemia  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
bronchopulmonary dysplasia  (ISO)
cataract  (ISO)
Cerebral Hemorrhage  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
chromosome 1p36 deletion syndrome  (ISO)
colorectal cancer  (ISO)
Diabetes Complications  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
dilated cardiomyopathy  (ISO)
Edema  (ISO)
endometritis  (ISO)
Endotoxemia  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Myocarditis  (IEP)
Experimental Diabetes Mellitus  (ISO)
Experimental Mammary Neoplasms  (IDA,ISO)
Experimental Radiation Injuries  (ISO)
focal segmental glomerulosclerosis  (ISO)
heart disease  (ISO)
hepatocellular carcinoma  (ISO)
Hereditary Pancreatitis  (ISO)
Huntington's disease  (IEP,ISO)
Hypercholesterolemia  (ISO)
hypertension  (ISO)
Intestinal Reperfusion Injury  (ISO)
kidney disease  (ISO)
liver cirrhosis  (IEP)
Liver Reperfusion Injury  (IEP,ISO)
lung non-small cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
middle cerebral artery infarction  (ISO)
Myocardial Reperfusion Injury  (IEP,ISO)
nervous system disease  (ISO)
NSAID-Enteropathy  (ISO)
osteoarthritis  (ISO)
pancreatic cancer  (ISO)
Parkinson's disease  (ISO)
Parkinsonism  (ISO)
peripheral nervous system disease  (ISO)
post-traumatic stress disorder  (ISO)
pre-malignant neoplasm  (ISO)
Prostatic Neoplasms  (ISO)
Reperfusion Injury  (ISO)
retinal detachment  (ISO)
scrapie  (IEP)
Sepsis  (ISO)
severe acute respiratory syndrome  (ISO)
Spinal Cord Injuries  (ISO)
stomach cancer  (ISO)
Subarachnoid Hemorrhage  (ISO)
Testis Reperfusion Injury  (ISO)
transient cerebral ischemia  (ISO)
traumatic brain injury  (ISO)
type 1 diabetes mellitus  (IDA,ISO)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (ISO)
urinary bladder cancer  (ISO)
varicocele  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-albicanol  (EXP)
(+)-alpha-viniferin  (ISO)
(+)-catechin  (ISO)
(+)-dexrazoxane  (EXP)
(+)-pilocarpine  (EXP)
(+)-taxifolin  (ISO)
(+)-Tetrandrine  (ISO)
(+)-trans-(S)-allethrin  (ISO)
(-)-anisomycin  (ISO)
(-)-Arctigenin  (ISO)
(-)-citrinin  (EXP,ISO)
(-)-ephedrine  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(-)-gambogic acid  (ISO)
(-)-matairesinol  (ISO)
(-)-noscapine  (ISO)
(20R)-protopanaxadiol  (ISO)
(20S)-ginsenoside Rg3  (EXP,ISO)
(20S)-ginsenoside Rh2  (ISO)
(aminomethyl)phosphonic acid  (ISO)
(R)-carnitine  (ISO)
(R)-lipoic acid  (ISO)
(R)-noradrenaline  (ISO)
(R,R,R)-alpha-tocopherol  (EXP,ISO)
(S)-colchicine  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP,ISO)
(S)-ropivacaine  (ISO)
(Z)-3-butylidenephthalide  (ISO)
(Z)-ligustilide  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
1,4-benzoquinone  (ISO)
1,4-dithiothreitol  (EXP)
1-(4-methoxybenzyl)-3-(5-nitro-1,3-thiazol-2-yl)urea  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
1-hydroxy-1-norresistomycin  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone  (ISO)
2'-Hydroxy-2,3,5'-trimethoxychalcone  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',4,5-tetrachlorobiphenyl  (EXP)
2,2,2-tetramine  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-D  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-(tert-butylimino)-5-phenyl-3-(propan-2-yl)-1,3,5-thiadiazinan-4-one  (ISO)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP,ISO)
2-deoxy-D-glucose  (ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
2-hydroxyethyl methacrylate  (ISO)
2-methoxy-17beta-estradiol  (EXP,ISO)
2-pyridylethylamine  (ISO)
25-hydroxycholesterol  (ISO)
28-deoxonimbolide  (ISO)
3',4',7-trihydroxyisoflavone  (ISO)
3',4'-dimethoxyflavone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5,5'-tetraiodothyroacetic acid  (ISO)
3,3'-Dichlorobenzidine  (ISO)
3,3'-diindolylmethane  (EXP)
3,4-dihydroxybenzoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-aminobenzamide  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-hydroxybutyric acid  (EXP,ISO)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (ISO)
3-methyladenine  (ISO)
3-methylcholanthrene  (ISO)
3-Nitrofluoranthene  (EXP)
3-nitropropanoic acid  (ISO)
3-phenoxybenzoic acid  (ISO)
3-phenylprop-2-enal  (EXP)
4'-epidoxorubicin  (ISO)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4,5,6,7-TETRABROMOBENZOTRIAZOLE  (ISO)
4-aminopyridine  (ISO)
4-hydroperoxycyclophosphamide  (EXP)
4-hydroxy-TEMPO  (ISO)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
4-Nerolidylcatechol  (ISO)
4-nitrophenol  (EXP)
4-nonylphenol  (EXP,ISO)
4-phenylbutyric acid  (EXP,ISO)
4-vinylcyclohexene dioxide  (EXP)
5-aminolevulinic acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (EXP)
5-fluorouracil  (EXP,ISO)
5-methoxypsoralen  (ISO)
6-(cyclohexylmethoxy)-5-nitrosopyrimidine-2,4-diamine  (ISO)
6-Methoxyflavone  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
7,8-diacetoxy-4-methylcoumarin  (ISO)
7-ketocholesterol  (ISO)
8-Br-cAMP  (ISO)
9'-cis-neoxanthin  (ISO)
9,10-anthraquinone  (ISO)
9,10-phenanthroquinone  (ISO)
9-hydroxycanthin-6-one  (ISO)
9-Methoxycamptothecin  (ISO)
[6]-Shogaol  (ISO)
AB-Fubinaca  (EXP)
abexinostat  (ISO)
ABT-737  (ISO)
acadesine  (EXP)
acetochlor  (ISO)
acetylsalicylic acid  (EXP,ISO)
aconitine  (ISO)
acrolein  (EXP,ISO)
acrylamide  (ISO)
actinomycin D  (EXP,ISO)
adenosine  (ISO)
aflatoxin B1  (EXP,ISO)
AICA ribonucleotide  (ISO)
alantolactone  (ISO)
alborixin  (ISO)
aldehydo-D-glucose  (ISO)
aldrithiol  (ISO)
alendronic acid  (ISO)
alginic acid  (EXP)
all-trans-acitretin  (ISO)
all-trans-neoxanthin  (ISO)
all-trans-retinoic acid  (EXP,ISO)
allethrin  (ISO)
alloxan  (ISO)
Aloe emodin  (ISO)
alogliptin  (ISO)
aloxistatin  (ISO)
alpha-D-galactose  (EXP,ISO)
alpha-mangostin  (ISO)
alpha-naphthoflavone  (EXP,ISO)
alpinumisoflavone  (ISO)
alternariol  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
alvocidib  (ISO)
amiloride  (ISO)
aminoguanidine  (EXP,ISO)
amiodarone  (EXP,ISO)
amlodipine  (ISO)
ammonium chloride  (ISO)
Ammothamnine  (ISO)
amosite asbestos  (ISO)
amphetamine  (ISO)
andrographolide  (ISO)
Anemoside B4  (EXP)
anethole  (ISO)
anthocyanin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
apigenin  (EXP,ISO)
arachidonic acid  (ISO)
arachidonyl-2'-chloroethylamide  (EXP)
arecoline  (EXP,ISO)
aristolochic acid A  (EXP,ISO)
arjunolic acid  (EXP)
Aroclor 1254  (ISO)
arsane  (EXP,ISO)
arsanilic acid  (ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
artesunate  (ISO)
asbestos  (ISO)
asiatic acid  (ISO)
aspartame  (EXP)
astilbin  (ISO)
atorvastatin calcium  (ISO)
atrazine  (ISO)
aucubin  (EXP)
Augmentin  (ISO)
auranofin  (ISO)
Auriculasin  (ISO)
azadirachtin A  (ISO)
azadiradione  (ISO)
azilsartan  (ISO)
bafilomycin A1  (ISO)
Bavachinin  (ISO)
beauvericin  (ISO)
beclomethasone  (ISO)
belinostat  (ISO)
benzene  (EXP,ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
berberine  (EXP,ISO)
Bergenin  (EXP)
beta-carboline  (ISO)
beta-ionone  (ISO)
Beta-Solamarine  (ISO)
betaxolol  (ISO)
betulin  (ISO)
betulinic acid  (ISO)
bifenthrin  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (EXP,ISO)
boric acid  (ISO)
bortezomib  (ISO)
brucine  (ISO)
Brusatol  (EXP,ISO)
budesonide  (ISO)
bufalin  (ISO)
Bufotalin  (ISO)
bupivacaine  (EXP,ISO)
buprofezin  (ISO)
bupropion  (ISO)
buserelin  (ISO)
busulfan  (ISO)
butachlor  (EXP)
butan-1-ol  (ISO)
butein  (ISO)
Butylbenzyl phthalate  (EXP)
butyric acid  (EXP)
C.I. Natural Red 20  (EXP)
cadmium acetate  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium telluride  (ISO)
caffeine  (EXP,ISO)
cajanol  (ISO)
Calcimycin  (EXP,ISO)
calciol  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium dichloride  (ISO)
calcium(0)  (ISO)
camphene  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
Cannabidivarin  (ISO)
cantharidic acid  (ISO)
cantharidin  (ISO)
capsaicin  (ISO)
capsazepine  (ISO)
CARBENOXOLONE  (ISO)
carbidopa  (EXP,ISO)
carbon atom  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (EXP,ISO)
carboplatin  (EXP,ISO)
carnosic acid  (EXP,ISO)
carvacrol  (ISO)
casticin  (EXP,ISO)
catechol  (ISO)
CCCP  (ISO)
celastrol  (ISO)
celecoxib  (EXP,ISO)
ceric oxide  (ISO)
ceritinib  (ISO)
cerivastatin  (ISO)
cerulenin  (EXP)
ceruletide  (ISO)
cetrorelix  (EXP,ISO)
CGP 52608  (ISO)
chalcone  (ISO)
chalcones  (ISO)
chelerythrine  (ISO)
chenodeoxycholic acid  (ISO)
chitosan  (ISO)
chloroacetic acid  (EXP)
chlorogenic acid  (ISO)
chloroquine  (ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (ISO)
choline  (ISO)
chromium atom  (ISO)
chromium(6+)  (EXP,ISO)
chromone  (ISO)
chrysazin  (ISO)
chrysin  (ISO)
ciglitazone  (ISO)
cilostazol  (ISO)
cimetidine  (ISO)
Cinobufotalin  (ISO)
ciprofloxacin  (ISO)
Cirsimarin  (ISO)
cisplatin  (EXP,ISO)
cladribine  (ISO)
clavulone II  (ISO)
Clivoline  (ISO)
clofarabine  (ISO)
clofibrate  (EXP)
clomipramine  (EXP)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
clorgyline  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP,ISO)
codeinone  (ISO)
coenzyme Q10  (ISO)
colistin  (EXP,ISO)
concanamycin A  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (EXP,ISO)
copper(II) sulfate  (ISO)
coptisine  (ISO)
cordycepin  (ISO)
corilagin  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (EXP,ISO)
crocin-1  (ISO)
crotonaldehyde  (ISO)
Cryptotanshinone  (ISO)
cucurbitacin E  (ISO)
cucurbitacin I  (ISO)
curcumin  (EXP,ISO)
cyclizine  (EXP)
cycloheximide  (EXP,ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyhalothrin  (ISO)
cylindrospermopsin  (ISO)
cypermethrin  (EXP,ISO)
cytochalasin B  (ISO)
D-glucitol  (ISO)
D-glucose  (ISO)
D-mannitol  (ISO)
D-penicillamine  (ISO)
dactolisib  (ISO)
dantrolene  (ISO)
DAPT  (ISO)
daunorubicin  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
delphinidin  (ISO)
demethoxycurcumin  (ISO)
demethoxyfumitremorgin C  (ISO)
Dendrobine  (ISO)
DENSPM  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (EXP,ISO)
Deoxyshikonin  (ISO)
desferrioxamine B  (ISO)
desipramine  (ISO)
Destruxin B  (ISO)
dexamethasone  (EXP,ISO)
dexmedetomidine  (ISO)
Di-n-octyl phthalate  (EXP)
Diacetoxyscirpenol  (EXP)
diallyl disulfide  (ISO)
Diallyl sulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (ISO)
dibenziodolium  (ISO)
dibenzoylmethane  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorvos  (ISO)
diclofenac  (ISO)
Didymin  (ISO)
dieckol  (EXP,ISO)
dieldrin  (ISO)
diepoxybutane  (ISO)
diethyl maleate  (ISO)
diethyl phthalate  (EXP)
diethyldithiocarbamic acid  (ISO)
digitoxin  (ISO)
dihydrolipoic acid  (EXP)
dihydrosanguinarine  (ISO)
Diisodecyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dimethylarsinic acid  (ISO)
dimethylarsinous acid  (ISO)
dioscin  (EXP,ISO)
diosgenin  (ISO)
diosmin  (ISO)
dioxygen  (ISO)
diquat  (EXP,ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
divanadium pentaoxide  (ISO)
dizocilpine maleate  (EXP)
donepezil hydrochloride  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
drimenol  (ISO)
ebselen  (ISO)
Echimidine  (ISO)
echinacoside  (EXP)
Echinocystic acid  (ISO)
edaravone  (ISO)
elemental carbon  (ISO)
elemental selenium  (EXP,ISO)
ellagic acid  (ISO)
ellipticine  (ISO)
embelin  (ISO)
emetine  (EXP)
emodin  (EXP,ISO)
enalapril  (ISO)
endosulfan  (ISO)
entinostat  (EXP)
epichlorohydrin  (ISO)
equol  (ISO)
eriocitrin  (ISO)
erythrosin B  (ISO)
esculetin  (ISO)
etacrynic acid  (ISO)
ethanol  (EXP,ISO)
ethylbenzene  (ISO)
ethylene glycol  (ISO)
etodolac  (ISO)
etoposide  (ISO)
eugenol  (EXP,ISO)
EUK-134  (ISO)
euscaphic acid  (ISO)
Evodiamine  (ISO)
farrerol  (ISO)
fenbendazole  (ISO)
fenhexamid  (ISO)
fenitrothion  (ISO)
fenpropathrin  (ISO)
fenpyroximate  (ISO)
fenvalerate  (ISO)
ferric oxide  (ISO)
ferrosoferric oxide  (ISO)
fipronil  (ISO)
fisetin  (ISO)
flavanone  (ISO)
flavones  (ISO)
flavonoids  (EXP,ISO)
flavonols  (ISO)
fluoxetine  (EXP)
flutamide  (EXP)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
formononetin  (ISO)
fraxetin  (ISO)
fructose  (EXP,ISO)
fulvestrant  (ISO)
fumonisin B1  (EXP,ISO)
furan  (ISO)
furosemide  (ISO)
Fusarenone X  (EXP)
galactose  (EXP,ISO)
gallic acid  (ISO)
gamma-aminobutyric acid  (ISO)
gamma-hexachlorocyclohexane  (ISO)
gamma-tocopherol  (ISO)
Ganoderic acid A  (EXP)
Ganoderic acid T  (ISO)
Garcinol  (ISO)
gardenin B  (ISO)
Gastrodin  (EXP)
gedunin  (ISO)
geldanamycin  (ISO)
gemcitabine  (EXP,ISO)
geneticin  (ISO)
genistein  (ISO)
gentamycin  (ISO)
Gentiopicrin  (EXP)
geraniol  (EXP,ISO)
gibberellin A3  (ISO)
gingerol  (EXP,ISO)
Ginkgoic acid  (ISO)
Ginkgolide C  (ISO)
ginsenoside Rg1  (EXP,ISO)
Ginsenoside Rg5  (EXP,ISO)
glabridin  (EXP,ISO)
glucaric acid  (EXP)
glucose  (ISO)
glutathione  (EXP,ISO)
glyburide  (ISO)
glycochenodeoxycholic acid  (ISO)
glycyrrhizinic acid  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
gossypin  (ISO)
gossypol  (EXP,ISO)
graphite  (ISO)
Grifolin  (ISO)
griseofulvin  (ISO)
GSK2656157  (ISO)
guggulsterone  (ISO)
harman  (ISO)
Heliotrine  (ISO)
hesperidin  (ISO)
hexachlorobenzene  (ISO)
hexadecanoic acid  (ISO)
hispidin  (ISO)
homocysteine  (ISO)
homoeriodictyol  (ISO)
Honokiol  (ISO)
hydrogen chloride  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (EXP,ISO)
hydroxamic acid  (ISO)
hydroxyurea  (EXP)
icariin  (ISO)
icariside II  (ISO)
idarubicin  (EXP)
ifosfamide  (ISO)
indocyanine green  (ISO)
indole-3-methanol  (EXP,ISO)
indometacin  (ISO)
insulin  (ISO)
inulin  (EXP)
iohexol  (ISO)
iopamidol  (ISO)
irinotecan  (ISO)
iron(III) nitrilotriacetate  (ISO)
isatin  (ISO)
Isoangustone A  (ISO)
isoflavones  (ISO)
isoflurane  (EXP,ISO)
Isoliensinine  (ISO)
isoliquiritigenin  (EXP,ISO)
isoniazide  (ISO)
isoprenaline  (ISO)
isorhamnetin  (ISO)
isotretinoin  (EXP)
kaempferol  (ISO)
kahweol  (ISO)
ketamine  (ISO)
ketoconazole  (EXP)
Kukoamine B  (ISO)
L-1,4-dithiothreitol  (EXP)
L-ascorbic acid  (ISO)
L-cystathionine  (ISO)
L-gamma-glutamyl-L-cysteine  (ISO)
L-glutamic acid  (ISO)
L-methionine  (ISO)
L-mimosine  (ISO)
lanthanum trichloride  (ISO)
lapatinib  (ISO)
lead diacetate  (EXP,ISO)
lead nitrate  (EXP,ISO)
lead(0)  (EXP,ISO)
lead(II) chloride  (ISO)
leflunomide  (ISO)
Leonurine  (EXP,ISO)
leuprolide  (ISO)
Licochalcone A  (ISO)
licoricidin  (ISO)
lidocaine  (ISO)
Liensinine  (EXP)
limonin  (ISO)
linalool  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium carbonate  (EXP)
lithium chloride  (ISO)
lithocholic acid  (ISO)
Lobetyolin  (ISO)
loganin  (EXP)
lonafarnib  (ISO)
Longikaurin A  (ISO)
lonidamine  (ISO)
loratadine  (ISO)
losartan  (ISO)
lovastatin  (EXP,ISO)
lupeol  (ISO)
Lupiwighteone  (ISO)
luteolin  (ISO)
luteolin 7-O-beta-D-glucoside  (ISO)
LY294002  (EXP,ISO)
lycopene  (EXP,ISO)
magnesium oxide  (ISO)
Magnolol  (ISO)
malathion  (EXP,ISO)
malonic acid  (ISO)
mancozeb  (EXP,ISO)
maneb  (EXP,ISO)
manganese (III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP,ISO)
mangiferin  (EXP,ISO)
masoprocol  (ISO)
mechlorethamine  (ISO)
melamine  (ISO)
melatonin  (EXP,ISO)
melittin  (EXP,ISO)
meloxicam  (ISO)
melphalan  (ISO)
memantine  (ISO)
menadione  (ISO)
mercury atom  (ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (ISO)
methimazole  (ISO)
methotrexate  (ISO)
methoxsalen  (ISO)
methoxyacetic acid  (ISO)
methoxychlor  (EXP,ISO)
methyl methanesulfonate  (EXP)
methylglyoxal  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
Methylone  (ISO)
methylphenidate  (EXP)
methylseleninic acid  (ISO)
methyltestosterone  (ISO)
metoprolol  (ISO)
mevalonic acid  (ISO)
microcystin-LR  (EXP,ISO)
mifepristone  (ISO)
minocycline  (EXP,ISO)
mitomycin C  (ISO)
MitoTEMPO  (ISO)
mitoxantrone  (ISO)
MK-2206  (ISO)
ML-7  (ISO)
molybdenum atom  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotophos  (ISO)
monosodium L-glutamate  (EXP)
morin  (ISO)
morphine  (ISO)
Morroniside  (EXP)
morusin  (ISO)
Muconic dialdehyde  (ISO)
myo-inositol hexakisphosphate  (ISO)
myricetin  (ISO)
myristicin  (ISO)
Myrtucommulone A  (EXP)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,N-dimethylformamide  (ISO)
N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide  (ISO)
N-(p-amylcinnamoyl)anthranilic acid  (EXP,ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetyl-L-tryptophan  (EXP)
N-acylsphinganine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP,ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-phenylthiourea  (ISO)
N-phosphocreatine  (ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
naphthalene  (ISO)
naringin  (ISO)
navitoclax  (ISO)
NCX-4040  (ISO)
nefazodone  (ISO)
Neferine  (ISO)
nelfinavir  (EXP)
neoastilbin  (ISO)
neomycin  (EXP)
nevadensin  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nickel ferrite  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotinamide  (EXP,ISO)
nicotine  (EXP,ISO)
Niflumic acid  (ISO)
nifuroxazide  (ISO)
nilotinib  (ISO)
nimesulide  (ISO)
nimodipine  (ISO)
nimustine  (ISO)
nitric oxide  (EXP,ISO)
nitroprusside  (EXP,ISO)
NMS-873  (ISO)
nobiletin  (ISO)
nocodazole  (ISO)
Nodularin  (ISO)
NORCANTHARIDIN  (ISO)
notoginsenoside R1  (EXP,ISO)
NS-398  (ISO)
Nutlin-3  (ISO)
O-acetyl-L-carnitine  (ISO)
Obacunone  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (ISO)
olaparib  (ISO)
oleamide  (ISO)
oleanolic acid  (EXP,ISO)
oleic acid  (ISO)
oligopeptide  (ISO)
omacetaxine mepesuccinate  (ISO)
orlistat  (EXP,ISO)
oroxylin A  (ISO)
osthole  (ISO)
ouabain  (ISO)
oxidopamine  (ISO)
oxybenzone  (ISO)
oxybuprocaine  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
Pachymic acid  (ISO)
paclitaxel  (EXP,ISO)
paeoniflorin  (EXP)
pamidronate  (ISO)
Panduratin A  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraoxon  (EXP)
paraquat  (EXP,ISO)
parathion-methyl  (ISO)
paroxetine  (EXP)
Parthenin  (ISO)
patulin  (ISO)
Pendulone  (ISO)
pentachlorophenol  (ISO)
pentetic acid  (ISO)
Pentoxifylline  (ISO)
pepstatin A  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
peroxynitrous acid  (ISO)
phenanthridone  (ISO)
phenethyl caffeate  (EXP)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
phenol  (ISO)
phenylephrine  (ISO)
phloretin  (ISO)
phloroglucinol  (ISO)
phorate  (ISO)
phorbol 12,13-dibutanoate  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosphatidylcholine  (ISO)
phytol  (EXP)
phytosphingosine  (ISO)
pifithrin-alpha hydrobromide  (EXP,ISO)
Pinacidil  (ISO)
pinostrobin  (ISO)
piperine  (ISO)
pirinixic acid  (EXP)
pitavastatin  (ISO)
pitavastatin(1-)  (ISO)
platinum  (ISO)
platinum(0)  (ISO)
platycodin D  (ISO)
plumbagin  (EXP,ISO)
podophyllotoxin  (ISO)
poly(I:C)  (ISO)
poly(methyl methacrylate) macromolecule  (ISO)
Polygodial  (ISO)
ponatinib  (EXP)
potassium chromate  (EXP)
potassium dichromate  (EXP,ISO)
potassium iodide  (ISO)
Pramanicin  (ISO)
Pranoprofen  (ISO)
pravastatin  (ISO)
prazosin  (ISO)
prednisone  (EXP)
probenecid  (EXP)
procyanidin B2  (ISO)
procymidone  (EXP)
prodigiosin  (ISO)
progesterone  (ISO)
propiconazole  (EXP)
propofol  (EXP,ISO)
propranolol  (ISO)
propylparaben  (ISO)
prostaglandin E2  (ISO)
pterostilbene  (EXP,ISO)
Pulsatilla saponin D  (EXP,ISO)
punicalagin  (ISO)
puromycin  (EXP)
putrescine  (ISO)
pyrethrins  (ISO)
pyrimethamine  (ISO)
pyrogallol  (EXP)
pyrroles  (ISO)
pyrrolidine dithiocarbamate  (ISO)
pyrroloquinoline quinone  (ISO)
pyruvic acid  (ISO)
quercetin  (EXP,ISO)
quercetin 4'-O-beta-D-glucopyranoside  (ISO)
quinacrine  (ISO)
ranitidine  (ISO)
reactive oxygen species  (ISO)
Rebamipide  (ISO)
resveratrol  (EXP,ISO)
Rhein  (ISO)
riboflavin  (EXP)
ricolinostat  (ISO)
Riluzole  (ISO)
Risedronate sodium  (ISO)
Ro 31-8220  (ISO)
romidepsin  (ISO)
ropinirole  (ISO)
rosmarinic acid  (EXP)
rotenone  (EXP,ISO)
rottlerin  (EXP,ISO)
royal jelly  (ISO)
rubimaillin  (ISO)
rubitecan  (ISO)
ruthenium atom  (ISO)
rutin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
safrole  (ISO)
Salinomycin  (ISO)
salubrinal  (EXP)
Sanggenon C  (ISO)
sanguinarine  (ISO)
sappanchalcone  (ISO)
saquinavir  (ISO)
sarpogrelate  (EXP,ISO)
SB 203580  (ISO)
SB 431542  (ISO)
Schizandrin  (ISO)
sclareol  (ISO)
scopoletin  (ISO)
scutellarin  (EXP)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
selenium atom  (EXP,ISO)
selenocystine  (ISO)
semilicoisoflavone B  (ISO)
senecionine  (ISO)
Senkirkine  (ISO)
sepantronium  (ISO)
serpentine asbestos  (ISO)
sertraline  (ISO)
Sesamol  (EXP,ISO)
sesquiterpene  (ISO)
sevoflurane  (ISO)
Shikonin  (EXP)
sildenafil citrate  (ISO)
silibinin  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sinapic acid  (ISO)
sirolimus  (EXP,ISO)
sirtinol  (ISO)
SM-164  (ISO)
SNX-2112  (ISO)
sodium arsenite  (EXP,ISO)
sodium benzoate  (ISO)
sodium cyanate  (EXP,ISO)
sodium dichromate  (EXP,ISO)
sodium disulfite  (ISO)
sodium fluoride  (EXP,ISO)
sodium thiosulfate pentahydrate  (ISO)
solasodine  (ISO)
sorafenib  (ISO)
spermine  (EXP,ISO)
spironolactone  (ISO)
staurosporine  (ISO)
stilbenoid  (ISO)
streptozocin  (EXP,ISO)
styrene  (ISO)
Suillin  (ISO)
sulfasalazine  (ISO)
sulforaphane  (ISO)
sulfur dioxide  (ISO)
sulindac  (ISO)
sulindac sulfide  (ISO)
surfactin  (ISO)
surfactin C  (ISO)
swainsonine  (ISO)
syringic acid  (EXP,ISO)
T-2 toxin  (EXP,ISO)
tacrolimus hydrate  (EXP,ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
tanespimycin  (ISO)
tangeretin  (ISO)
tannic acid  (ISO)
tapentadol  (ISO)
tartrazine  (ISO)
taurine  (ISO)
taurocholic acid  (ISO)
taurodeoxycholic acid  (ISO)
tauroursodeoxycholic acid  (ISO)
temozolomide  (ISO)
TEMPO  (ISO)
tenofovir disoproxil fumarate  (ISO)
Terfenadine  (ISO)
tert-butyl hydroperoxide  (EXP,ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetramethylpyrazine  (ISO)
thalidomide  (ISO)
thapsigargin  (EXP,ISO)
Theaflavin 3,3'-digallate  (ISO)
thiabendazole  (ISO)
thimerosal  (EXP,ISO)
thioacetamide  (EXP,ISO)
thymidine  (ISO)
thymol  (ISO)
thymol sulfate(1-)  (ISO)
thymoquinone  (EXP,ISO)
Tiron  (ISO)
titanium dioxide  (EXP,ISO)
toluene  (ISO)
Tomentosin  (ISO)
toosendanin  (ISO)
topotecan  (EXP)
Tormentic acid  (ISO)
Torularhodin  (EXP)
torulene  (EXP)
trametinib  (ISO)
tranexamic acid  (ISO)
trans-anethole  (ISO)
trans-chalcone  (ISO)
triadimefon  (EXP)
triamcinolone  (ISO)
triazoles  (ISO)
tributylstannane  (ISO)
trichostatin A  (ISO)
triclosan  (EXP,ISO)
trifluridine  (ISO)
trimethylenediamine  (ISO)
triphenyl phosphate  (EXP,ISO)
Triptolide  (EXP,ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tunicamycin  (EXP,ISO)
tyrphostin B42  (ISO)
urethane  (EXP,ISO)
uridine  (ISO)
ursodeoxycholic acid  (ISO)
ursolic acid  (ISO)
usnic acid  (ISO)
valproic acid  (EXP,ISO)
vanadyl sulfate  (ISO)
vancomycin  (ISO)
vandetanib  (ISO)
vanillic acid  (ISO)
venetoclax  (ISO)
venom  (ISO)
verapamil  (ISO)
verteporfin  (ISO)
violacein  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)
WIN 55212-2  (ISO)
withaferin A  (ISO)
wortmannin  (EXP,ISO)
xanthohumol  (ISO)
Xanthorrhizol  (ISO)
XAV939  (ISO)
Y-27632  (ISO)
ytterbium  (ISO)
zearalenone  (EXP,ISO)
zebularine  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc oxide  (EXP,ISO)
zinc protoporphyrin  (EXP,ISO)
zinc pyrithione  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)
zingerone  (ISO)
ziram  (ISO)
zoledronic acid  (EXP,ISO)
zolmitriptan  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
apoptosome  (IEA,ISO)
caspase complex  (IEA,ISO)
cytoplasm  (IBA,IEA,ISO)
cytosol  (IBA,IDA,IEA,ISO,TAS)
mitochondrion  (IEA,ISO)
nucleus  (IDA)
protein-containing complex  (IEA,ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal apoptosis  (IAGP)
abnormal brain commissure morphology  (IAGP)
abnormal brain development  (IAGP)
abnormal brain morphology  (IAGP)
abnormal brain ventricle morphology  (IAGP)
abnormal cell physiology  (IAGP)
abnormal cerebral cortex morphology  (IAGP)
abnormal cerebral hemisphere morphology  (IAGP)
abnormal embryonic neuroepithelial layer differentiation  (IAGP)
abnormal forebrain development  (IAGP)
abnormal lamina terminalis morphology  (IAGP)
abnormal lateral ventricle morphology  (IAGP)
abnormal midbrain-hindbrain boundary morphology  (IAGP)
abnormal neural tube closure  (IAGP)
abnormal olfactory epithelium morphology  (IAGP)
abnormal respiratory electron transport chain  (IAGP)
abnormal splenocyte apoptosis  (IAGP)
abnormal T cell physiology  (IAGP)
abnormal telencephalon development  (IAGP)
abnormal telencephalon morphology  (IAGP)
abnormal third ventricle morphology  (IAGP)
abnormal thymocyte apoptosis  (IAGP)
absent corpus callosum  (IAGP)
brain ventricle stenosis  (IAGP)
decreased apoptosis  (IAGP)
decreased birth body size  (IAGP)
decreased body size  (IAGP)
decreased cellular sensitivity to gamma-irradiation  (IAGP)
decreased neuron apoptosis  (IAGP)
decreased sensitivity to induced cell death  (IAGP)
decreased T cell apoptosis  (IAGP)
exencephaly  (IAGP)
hydrocephaly  (IAGP)
increased apoptosis  (IAGP)
increased midbrain size  (IAGP)
increased neuron apoptosis  (IAGP)
intracerebral hemorrhage  (IAGP)
perinatal lethality  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Diabetes enhances mRNA levels of proapoptotic genes and caspase activity, which contribute to impaired healing. Al-Mashat HA, etal., Diabetes. 2006 Feb;55(2):487-95.
2. Bladder cancer SNP panel predicts susceptibility and survival. Andrew AS, etal., Hum Genet. 2009 Jun;125(5-6):527-39. Epub 2009 Mar 1.
3. Activation of caspase 8 in the pituitaries of streptozotocin-induced diabetic rats: implication in increased apoptosis of lactotrophs. Arroba AI, etal., Endocrinology. 2005 Oct;146(10):4417-24. Epub 2005 Jun 23.
4. Induction of the unfolded protein response in familial amyotrophic lateral sclerosis and association of protein-disulfide isomerase with superoxide dismutase 1. Atkin JD, etal., J Biol Chem. 2006 Oct 6;281(40):30152-65. Epub 2006 Jul 17.
5. Bax and Bid act in synergy to bring about T11TS-mediated glioma apoptosis via the release of mitochondrial cytochrome c and subsequent caspase activation. Bhattacharjee M, etal., Int Immunol. 2008 Dec;20(12):1489-505. Epub 2008 Oct 17.
6. Pomegranate exerts chemoprevention of experimentally induced mammary tumorigenesis by suppression of cell proliferation and induction of apoptosis. Bishayee A, etal., Nutr Cancer. 2016;68(1):120-30. doi: 10.1080/01635581.2016.1115094. Epub 2015 Dec 23.
7. Peripheral proteasome and caspase activity in Parkinson disease and Alzheimer disease. Blandini F, etal., Neurology. 2006 Feb 28;66(4):529-34. doi: 10.1212/01.wnl.0000198511.09968.b3.
8. Hypothyroidism minimizes the effects of acute hepatic failure caused by endoplasmic reticulum stress and redox environment alterations in rats. Blas-Valdivia V, etal., Acta Histochem. 2015 Oct;117(8):811-9. doi: 10.1016/j.acthis.2015.07.003. Epub 2015 Jul 31.
9. Role of p97/Valosin-containing protein (VCP) and Jab1/CSN5 in testicular ischaemia-reperfusion injury. Cayli S, etal., J Mol Histol. 2016 Feb;47(1):91-100. doi: 10.1007/s10735-016-9652-9. Epub 2016 Jan 11.
10. 4'-O-ß-D-Glucosyl-5-O-Methylvisamminol, A Natural Histone H3 Phosphorylation Epigenetic Suppressor, Exerts a Neuroprotective Effect Through PI3K/Akt Signaling Pathway on Focal Cerebral Ischemia in Rats. Chang CZ and Wu SC, World Neurosurg. 2016 May;89:474-88. doi: 10.1016/j.wneu.2016.01.061. Epub 2016 Feb 8.
11. A purine antimetabolite attenuates toll-like receptor-2, -4, and subarachnoid hemorrhage-induced brain apoptosis. Chang CZ, etal., J Surg Res. 2015 Dec;199(2):676-87. doi: 10.1016/j.jss.2015.06.011. Epub 2015 Jun 12.
12. Dihydroartemisinin inhibits growth of pancreatic cancer cells in vitro and in vivo. Chen H, etal., Anticancer Drugs. 2009 Feb;20(2):131-40. doi: 10.1097/CAD.0b013e3283212ade.
13. Insulin-like growth factor (IGF)-I/IGF-binding protein-3 complex: therapeutic efficacy and mechanism of protection against type 1 diabetes. Chen W, etal., Endocrinology. 2004 Feb;145(2):627-38. Epub 2003 Nov 14.
14. Time-dependent increases in protease activities for neuronal apoptosis in spinal cords of Lewis rats during development of acute experimental autoimmune encephalomyelitis. Das A, etal., J Neurosci Res. 2008 Oct;86(13):2992-3001.
15. Defective function of the Fas apoptotic pathway in type 1 diabetes mellitus correlates with age at onset. De Franco S, etal., Int J Immunopathol Pharmacol. 2007 Jul-Sep;20(3):567-76.
16. Activation of cell death pathway after a brief period of global ischemia in diabetic and non-diabetic animals. Ding C, etal., Exp Neurol. 2004 Aug;188(2):421-9.
17. [Study of L-NAME treatment on experimental autoimmune myocarditis]. Ding GL, etal., Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2013 Mar;29(2):119-23.
18. Histone deacetylase inhibitors and paclitaxel cause synergistic effects on apoptosis and microtubule stabilization in papillary serous endometrial cancer cells. Dowdy SC, etal., Mol Cancer Ther. 2006 Nov;5(11):2767-76.
19. Effect of maternal diabetes and hypercholesterolemia on fetal liver of albino Wistar rats. El-Sayyad HI, etal., Nutrition. 2014 Mar;30(3):326-36. doi: 10.1016/j.nut.2013.08.016.
20. Renoprotective effect of nifuroxazide in diabetes-induced nephropathy: impact on NF¿B, oxidative stress, and apoptosis. Elsherbiny NM, etal., Toxicol Mech Methods. 2018 Jul;28(6):467-473. doi: 10.1080/15376516.2018.1459995. Epub 2018 Apr 16.
21. Evaluation of the effects of a high dose of erythropoietin-beta on early endotoxemia using a rat model. Eren Z, etal., Adv Clin Exp Med. 2012 May-Jun;21(3):321-9.
22. The role of heme oxygenase-1 (HO-1) in the regulation of inflammatory reaction, neuronal cell proliferation and apoptosis in rats after intracerebral hemorrhage (ICH). Fan X and Mu L, Neuropsychiatr Dis Treat. 2016 Dec 28;13:77-85. doi: 10.2147/NDT.S120496. eCollection 2017.
23. Temporal and spatial profile of Bid cleavage after experimental traumatic brain injury. Franz G, etal., J Cereb Blood Flow Metab 2002 Aug;22(8):951-8.
24. Caspase 9 and caspase 8 gene polymorphisms and susceptibility to bladder cancer in north Indian population. Gangwar R, etal., Ann Surg Oncol. 2009 Jul;16(7):2028-34. Epub 2009 May 2.
25. Cardiomyocyte apoptosis induced by short-term diabetes requires mitochondrial GSH depletion. Ghosh S, etal., Am J Physiol Heart Circ Physiol. 2005 Aug;289(2):H768-76. Epub 2005 Apr 1.
26. hnRNP L regulates the tumorigenic capacity of lung cancer xenografts in mice via caspase-9 pre-mRNA processing. Goehe RW, etal., J Clin Invest. 2010 Nov;120(11):3923-39. doi: 10.1172/JCI43552. Epub 2010 Oct 25.
27. Implication of caspases and subcellular compartments in tert-butylhydroperoxide induced apoptosis. Haidara K, etal., Toxicol Appl Pharmacol. 2008 May 15;229(1):65-76. Epub 2008 Jan 29.
28. Chloroquine upregulates TRAIL/TRAILR2 expression and potentiates doxorubicin anti-tumor activity in thioacetamide-induced hepatocellular carcinoma model. Helmy SA, etal., Chem Biol Interact. 2018 Jan 5;279:84-94. doi: 10.1016/j.cbi.2017.11.009. Epub 2017 Nov 10.
29. MicroRNA-29a mitigation of endoplasmic reticulum and autophagy aberrance counteracts in obstructive jaundice-induced fibrosis in mice. Huang YH, etal., Exp Biol Med (Maywood). 2018 Jan;243(1):13-21. doi: 10.1177/1535370217741500. Epub 2017 Nov 6.
30. Fish oil improves learning impairments of diabetic rats by blocking PI3K/AKT/nuclear factor-¿B-mediated inflammatory pathways. Jia D, etal., Neuroscience. 2014 Jan 31;258:228-37. doi: 10.1016/j.neuroscience.2013.11.016. Epub 2013 Nov 16.
31. CART peptide activates the Nrf2/HO-1 antioxidant pathway and protects hippocampal neurons in a rat model of Alzheimer's disease. Jiao W, etal., Biochem Biophys Res Commun. 2018 Jul 2;501(4):1016-1022. doi: 10.1016/j.bbrc.2018.05.101. Epub 2018 May 18.
32. Cytochrome C and caspase-9 expression in Huntington's disease. Kiechle T, etal., Neuromolecular Med. 2002;1(3):183-95.
33. The apoptotic effects of oxidative stress and antiapoptotic effects of caspase inhibitors on rat notochordal cells. Kim KW, etal., Spine (Phila Pa 1976). 2007 Oct 15;32(22):2443-8.
34. Elucidating the molecular physiopathology of acute respiratory distress syndrome in severe acute respiratory syndrome patients. Kong SL, etal., Virus Res. 2009 Nov;145(2):260-9. Epub 2009 Jul 25.
35. p53- and Bax-mediated apoptosis in injured rat spinal cord. Kotipatruni RR, etal., Neurochem Res. 2011 Nov;36(11):2063-74. doi: 10.1007/s11064-011-0530-2. Epub 2011 Jul 7.
36. Expression of apoptosome pathway-related transcripts in non-small cell lung cancer. Krepela E, etal., J Cancer Res Clin Oncol. 2006 Jan;132(1):57-68. Epub 2005 Oct 18.
37. Caspase function in programmed cell death. Kumar S Cell Death Differ. 2007 Jan;14(1):32-43. Epub 2006 Nov 3.
38. Role of epigenetic regulatory mechanisms in neonatal hypoxic-ischemic brain injury. Kumral A, etal., Early Hum Dev. 2013 Mar;89(3):165-73. doi: 10.1016/j.earlhumdev.2012.09.016. Epub 2012 Oct 6.
39. Involved intrinsic apoptotic pathway of testicular tissues in varicocele-induced rats. Lee JD, etal., World J Urol. 2009 Jan 15.
40. Polymorphisms in the caspase genes and the risk of lung cancer. Lee SY, etal., J Thorac Oncol. 2010 Aug;5(8):1152-8. doi: 10.1097/JTO.0b013e3181e04543.
41. Radioprotective effect of a pan-caspase inhibitor in a novel model of radiation injury to the nucleus of the abducens nerve. Li J, etal., Mol Med Rep. 2014 Sep;10(3):1433-7. doi: 10.3892/mmr.2014.2334. Epub 2014 Jun 16.
42. Glutamine reduces myocardial cell apoptosis in a rat model of sepsis by promoting expression of heat shock protein 90. Li W, etal., J Surg Res. 2017 Dec;220:247-254. doi: 10.1016/j.jss.2017.06.090. Epub 2017 Aug 5.
43. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae Li Y, etal., Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2005 Jun;27(3):274-9.
44. Ginkgolic acid (GA) suppresses gastric cancer growth by inducing apoptosis and suppressing STAT3/JAK2 signaling regulated by ROS. Liang JR and Yang H, Biomed Pharmacother. 2020 May;125:109585. doi: 10.1016/j.biopha.2019.109585. Epub 2020 Feb 25.
45. Isolated mitochondria infusion mitigates ischemia-reperfusion injury of the liver in rats. Lin HC, etal., Shock. 2013 Mar;39(3):304-10. doi: 10.1097/SHK.0b013e318283035f.
46. The Coexistence of Hypertension and Ovariectomy Additively Increases Cardiac Apoptosis. Lin YY, etal., Int J Mol Sci. 2016 Dec 6;17(12). pii: ijms17122036. doi: 10.3390/ijms17122036.
47. Cellular communication network factor 1 (CCN1) knockdown exerts a protective effect for hepatic ischemia/reperfusion injury by deactivating the MEK/ERK pathway. Liu H, etal., Clin Res Hepatol Gastroenterol. 2021 Sep;45(5):101737. doi: 10.1016/j.clinre.2021.101737. Epub 2021 Jun 16.
48. Association of CASP9, CASP10 gene polymorphisms and tea drinking with colorectal cancer risk in the Han Chinese population. Liu H, etal., J Zhejiang Univ Sci B. 2013 Jan;14(1):47-57. doi: 10.1631/jzus.B1200218.
49. Selenium Plays a Protective Role in Staphylococcus aureus-Induced Endometritis in the Uterine Tissue of Rats. Liu Y, etal., Biol Trace Elem Res. 2016 Oct;173(2):345-53. doi: 10.1007/s12011-016-0659-6. Epub 2016 Feb 26.
50. Hypochlorite modified albumins promote cell death in the tubule interstitium in rats via mitochondrial damage in obstructive nephropathy and the protective effects of antioxidant peptides. Liu ZR, etal., Free Radic Res. 2018 May;52(5):616-628. doi: 10.1080/10715762.2018.1457789.
51. [A study on the expression of CASP9 gene and its polymorphism distribution in non-small cell lung cancer]. Lou Y, etal., Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2007 Feb;24(1):59-62.
52. Trichosanthes kirilowii lectin alleviates diabetic nephropathy by inhibiting the LOX1/NF-¿B/caspase-9 signaling pathway. Lu J, etal., Biosci Rep. 2018 Jul 23. pii: BSR20180071. doi: 10.1042/BSR20180071.
53. Pre-administration of BAX-inhibiting peptides decrease the loss of the nigral dopaminergic neurons in rats. Ma C, etal., Life Sci. 2016 Jan 1;144:113-20. doi: 10.1016/j.lfs.2015.11.019. Epub 2015 Dec 2.
54. Suppression of mammary gland carcinogenesis by post-initiation treatment of rats with tamoxifen or indole-3-carbinol or their combination. Malejka-Giganti D, etal., Eur J Cancer Prev. 2007 Apr;16(2):130-41.
55. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
56. MGDs mouse GO annotations MGD data from the GO Consortium
57. MGD IEA MGD IEA
58. Chaperone peptides of a-crystallin inhibit epithelial cell apoptosis, protein insolubilization, and opacification in experimental cataracts. Nahomi RB, etal., J Biol Chem. 2013 May 3;288(18):13022-35. doi: 10.1074/jbc.M112.440214. Epub 2013 Mar 18.
59. Precision cut intestinal slices are an appropriate ex vivo model to study NSAID-induced intestinal toxicity in rats. Niu X, etal., Toxicol In Vitro. 2014 Oct;28(7):1296-305. doi: 10.1016/j.tiv.2014.06.010. Epub 2014 Jul 8.
60. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
61. Mitochondria- and caspase-dependent cell death pathway involved in neuronal degeneration in diabetic retinopathy. Oshitari T, etal., Br J Ophthalmol. 2008 Apr;92(4):552-6.
62. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
63. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
64. Caspase gene expression in the brain as a function of the clinical progression of Alzheimer disease. Pompl PN, etal., Arch Neurol. 2003 Mar;60(3):369-76.
65. Neuroprotective effects of microRNA-210 on hypoxic-ischemic encephalopathy. Qiu J, etal., Biomed Res Int. 2013;2013:350419. doi: 10.1155/2013/350419. Epub 2013 Sep 9.
66. Long-term hormonal promotion overcomes genetic resistance to mammary cancer. Rajkumar L, etal., Steroids. 2011 Jan;76(1-2):31-7. doi: 10.1016/j.steroids.2010.08.004. Epub 2010 Aug 21.
67. Comparative analysis of apoptosis and inflammation genes of mice and humans. Reed JC, etal., Genome Res 2003 Jun;13(6B):1376-88.
68. Effect of saffron (stigma of Crocus sativus L.) aqueous extract on ethanol toxicity in rats: A biochemical, histopathological and molecular study. Rezaee-Khorasany A, etal., J Ethnopharmacol. 2019 Jun 12;237:286-299. doi: 10.1016/j.jep.2019.03.048. Epub 2019 Mar 26.
69. Mouse MP Annotation Import Pipeline RGD automated import pipeline
70. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
71. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
72. Effects of injury severity on regional and temporal mRNA expression levels of calpains and caspases after traumatic brain injury in rats. Ringger NC, etal., J Neurotrauma. 2004 Jul;21(7):829-41.
73. Different signaling pathways induce apoptosis in endothelial cells and cardiac myocytes during ischemia/reperfusion injury. Scarabelli TM, etal., Circ Res. 2002 Apr 5;90(6):745-8.
74. Involvement of caspases and their upstream regulators in myocardial apoptosis in a rat model of selenium deficiency-induced dilated cardiomyopathy. Shan H, etal., J Trace Elem Med Biol. 2015;31:85-91. doi: 10.1016/j.jtemb.2015.03.005. Epub 2015 Apr 16.
75. Inhibition of mammary tumor growth by estrogens: is there a specific role for estrogen receptors alpha and beta? Soldati R, etal., Breast Cancer Res Treat. 2009 Dec 11.
76. Stromal Cell-Derived Factor-1a Alleviates Calcium-Sensing Receptor Activation-Mediated Ischemia/Reperfusion Injury by Inhibiting Caspase-3/Caspase-9-Induced Cell Apoptosis in Rat Free Flaps. Song L, etal., Biomed Res Int. 2018 Jan 11;2018:8945850. doi: 10.1155/2018/8945850. eCollection 2018.
77. p,p'-DDE induces mitochondria-mediated apoptosis of cultured rat Sertoli cells. Song Y, etal., Toxicology. 2008 Nov 20;253(1-3):53-61. Epub 2008 Sep 4.
78. Apigetrin inhibits gastric cancer progression through inducing apoptosis and regulating ROS-modulated STAT3/JAK2 pathway. Sun Q, etal., Biochem Biophys Res Commun. 2018 Mar 25;498(1):164-170. doi: 10.1016/j.bbrc.2018.02.009. Epub 2018 Mar 5.
79. Role of inhibitor of apoptosis protein in gentamicin-induced cochlear hair cell damage. Tabuchi K, etal., Neuroscience. 2007 Oct 12;149(1):213-22. Epub 2007 Aug 2.
80. Polymorphisms of caspase 8 and caspase 9 gene and colorectal cancer susceptibility and prognosis. Theodoropoulos GE, etal., Int J Colorectal Dis. 2011 Sep;26(9):1113-8. doi: 10.1007/s00384-011-1217-5. Epub 2011 May 3.
81. Effects of caspase-9 and survivin gene polymorphisms in pancreatic cancer risk and tumor characteristics. Theodoropoulos GE, etal., Pancreas. 2010 Oct;39(7):976-80. doi: 10.1097/MPA.0b013e3181d705d4.
82. Genetic expression profiles and chromosomal alterations in sporadic breast cancer in Mexican women. Valladares A, etal., Cancer Genet Cytogenet. 2006 Oct 15;170(2):147-51.
83. Critical role of regulator of calcineurin 1 in spinal cord injury. Wang G, etal., J Physiol Biochem. 2016 Dec;72(4):605-613. doi: 10.1007/s13105-016-0499-z. Epub 2016 Jun 23.
84. Role of Protease-Activated Receptor 2 in Regulating Focal Segmental Glomerulosclerosis. Wang Y, etal., Cell Physiol Biochem. 2017;41(3):1147-1155. doi: 10.1159/000464121. Epub 2017 Feb 28.
85. Resveratrol ameliorates inflammatory damage and protects against osteoarthritis in a rat model of osteoarthritis. Wei Y, etal., Mol Med Rep. 2018 Jan;17(1):1493-1498. doi: 10.3892/mmr.2017.8036. Epub 2017 Nov 13.
86. XZ-1 regulates cell apoptosis of gastric epithelial dysplasia via NF-¿B/p53/Ki67 signaling pathway. Xu B, etal., Biosci Rep. 2018 Jun 12;38(3). pii: BSR20171529. doi: 10.1042/BSR20171529. Print 2018 Jun 29.
87. Activation of caspase-12 at early stage contributes to cardiomyocyte apoptosis in trauma-induced secondary cardiac injury. Yan Z, etal., Sheng Li Xue Bao. 2017 Aug 25;69(4):367-377.
88. Tumor necrosis factor-a mediates JNK activation response to intestinal ischemia-reperfusion injury. Yang Q, etal., World J Gastroenterol. 2013 Aug 14;19(30):4925-34. doi: 10.3748/wjg.v19.i30.4925.
89. MicroRNA-140 attenuates myocardial ischemia-reperfusion injury through suppressing mitochondria-mediated apoptosis by targeting YES1. Yang S, etal., J Cell Biochem. 2019 Mar;120(3):3813-3821. doi: 10.1002/jcb.27663. Epub 2018 Sep 27.
90. Aberrant Alterations of Mitochondrial Factors Drp1 and Opa1 in the Brains of Scrapie Experiment Rodents. Yang X-, etal., J Mol Neurosci. 2017 Mar;61(3):368-378. doi: 10.1007/s12031-016-0866-9. Epub 2016 Dec 6.
91. Neonatal bronchopulmonary dysplasia increases neuronal apoptosis in the hippocampus through the HIF-1alpha and p53 pathways. Yin R, etal., Respir Physiol Neurobiol. 2016 Jan;220:81-7. doi: 10.1016/j.resp.2015.09.011. Epub 2015 Sep 30.
92. The effect of low-energy laser irradiation on apoptotic factors following experimentally induced transient cerebral ischemia. Yip KK, etal., Neuroscience. 2011 Sep 8;190:301-6. doi: 10.1016/j.neuroscience.2011.06.022. Epub 2011 Jun 17.
93. Single Prolonged Stress induces ATF6 alpha-dependent Endoplasmic reticulum stress and the apoptotic process in medial Frontal Cortex neurons. Yu B, etal., BMC Neurosci. 2014 Oct 21;15:115. doi: 10.1186/s12868-014-0115-5.
94. Apoptosis and cell proliferation in short-term and long-term effects of radioiodine-131-induced kidney damage: an experimental and immunohistochemical study. Yumusak N, etal., Nucl Med Commun. 2018 Feb;39(2):131-139. doi: 10.1097/MNM.0000000000000788.
95. Cardioprotection of tilianin ameliorates myocardial ischemia-reperfusion injury: Role of the apoptotic signaling pathway. Zeng C, etal., PLoS One. 2018 Mar 14;13(3):e0193845. doi: 10.1371/journal.pone.0193845. eCollection 2018.
96. H3 Relaxin Protects Against Myocardial Injury in Experimental Diabetic Cardiomyopathy by Inhibiting Myocardial Apoptosis, Fibrosis and Inflammation. Zhang X, etal., Cell Physiol Biochem. 2017;43(4):1311-1324. doi: 10.1159/000481843. Epub 2017 Oct 9.
Additional References at PubMed
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PMID:10671365   PMID:10687948   PMID:10739648   PMID:10739653   PMID:10922068   PMID:10960682   PMID:11042159   PMID:11062535   PMID:11076861   PMID:11092819   PMID:11150333   PMID:11217851  
PMID:11279485   PMID:11425902   PMID:11514563   PMID:11526440   PMID:11549720   PMID:11550085   PMID:11739563   PMID:11937545   PMID:12097332   PMID:12107826   PMID:12142566   PMID:12218135  
PMID:12374983   PMID:12477932   PMID:12581736   PMID:12616497   PMID:12646305   PMID:12660414   PMID:12667446   PMID:12717433   PMID:12801416   PMID:12815069   PMID:12847083   PMID:12851714  
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PMID:36693838   PMID:37048108   PMID:37553330   PMID:37813816   PMID:38056894   PMID:38157331  


Genomics

Comparative Map Data
Casp9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394141,520,923 - 141,543,289 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4141,520,923 - 141,543,287 (+)EnsemblGRCm39 Ensembl
GRCm384141,793,612 - 141,815,978 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4141,793,612 - 141,815,976 (+)EnsemblGRCm38mm10GRCm38
MGSCv374141,349,527 - 141,371,890 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364141,065,688 - 141,088,051 (+)NCBIMGSCv36mm8
Celera4143,618,711 - 143,640,921 (+)NCBICelera
Cytogenetic Map4D3NCBI
cM Map474.75NCBI
CASP9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38115,491,401 - 15,524,912 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl115,490,832 - 15,526,534 (-)EnsemblGRCh38hg38GRCh38
GRCh37115,817,896 - 15,851,285 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36115,691,378 - 15,723,377 (-)NCBINCBI36Build 36hg18NCBI36
Build 34115,564,102 - 15,596,096NCBI
Celera114,301,661 - 14,333,662 (-)NCBICelera
Cytogenetic Map1p36.21NCBI
HuRef114,337,387 - 14,370,798 (-)NCBIHuRef
CHM1_1115,616,531 - 15,649,948 (-)NCBICHM1_1
T2T-CHM13v2.0114,936,101 - 14,969,610 (-)NCBIT2T-CHM13v2.0
Casp9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8 Ensembl5159,391,188 - 159,409,648 (+)EnsemblGRCr8 Ensembl
mRatBN7.25154,108,872 - 154,126,628 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5154,109,046 - 154,126,626 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5156,793,940 - 156,811,532 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05158,567,234 - 158,584,828 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05158,556,396 - 158,573,978 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05160,356,211 - 160,373,774 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5160,355,833 - 160,373,778 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05164,067,734 - 164,085,297 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45160,704,234 - 160,721,796 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5152,461,154 - 152,478,717 (+)NCBICelera
RGSC_v3.15160,714,421 - 160,731,984 (+)NCBI
Cytogenetic Map5q36NCBI
Casp9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555272,613,683 - 2,629,738 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555272,613,691 - 2,630,217 (+)NCBIChiLan1.0ChiLan1.0
CASP9
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21211,395,731 - 211,430,328 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11210,644,170 - 210,678,765 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0114,630,659 - 14,662,865 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1115,624,666 - 15,656,266 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl115,624,666 - 15,656,266 (-)Ensemblpanpan1.1panPan2
CASP9
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1282,033,759 - 82,076,710 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl282,031,563 - 82,090,484 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha278,571,149 - 78,590,692 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0282,683,018 - 82,723,170 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl282,682,995 - 82,725,574 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1279,435,738 - 79,455,337 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0280,453,740 - 80,473,245 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0281,519,391 - 81,539,023 (+)NCBIUU_Cfam_GSD_1.0
Casp9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505837,353,117 - 37,371,367 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049364743,178,097 - 3,196,130 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CASP9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl674,706,516 - 74,730,007 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1674,707,597 - 74,730,033 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2669,087,179 - 69,111,408 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CASP9
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120116,772,819 - 116,798,402 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20116,772,155 - 116,798,930 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605420,315,214 - 20,346,777 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Casp9
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247641,773,455 - 1,789,423 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247641,769,270 - 1,789,399 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Casp9
1754 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1571
Count of miRNA genes:714
Interacting mature miRNAs:917
Transcripts:ENSMUST00000030747, ENSMUST00000097805, ENSMUST00000124161, ENSMUST00000128660, ENSMUST00000138359, ENSMUST00000153094
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301267Bcmd2_mB cell maturation defect 2 (mouse)Not determined4133154678150789451Mouse
4142139Adip12_madiposity 12 (mouse)Not determined4124621281156860686Mouse
10047132Albq19_malbuminuria QTL 19 (mouse)Not determined4112824389146824389Mouse
1301525Lmb1_mlupus in MRL and B6 F2 cross (mouse)Not determined4124264957150676858Mouse
14746982Manh56_mmandible shape 56 (mouse)4117815917151815917Mouse
25314312Syncl2_msynaptonemal complex length 2 (mouse)465718237146584457Mouse
1300743Skull6_mskull morphology 6 (mouse)Not determined4111009051145009280Mouse
1301382Arvm2_mautoimmune renal vasculitis 2 (mouse)Not determined4107791564141791756Mouse
1302149Tlsr2_mthymic lymphoma suppressor region 2 (mouse)Not determined4124264957142230960Mouse
1300874Gasa2_mgastritis type A susceptibility locus 2 (mouse)Not determined4133010494156860686Mouse
27226757Femd1_mfemur midshaft diameter 1, 5 week (mouse)4123993793144326570Mouse
1300621Tpnr1_mthermal pain response 1 (mouse)Not determined4125230872156860686Mouse
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
4142493Femwf13_mfemur work to failure 13 (mouse)Not determined116154678150154782Mouse
1301815Sles2_msystemic lupus erythmatosus suppressor 2 (mouse)Not determined494957579150676858Mouse
1300917Gasa1_mgastritis type A susceptibility locus 1 (mouse)Not determined4124055093142438020Mouse
1300537Ap3q_malcohol preference 3 QTL (mouse)Not determined4134654451156860686Mouse
1301823Bmd7_mbone mineral density 7 (mouse)Not determined488982069151654550Mouse
10412210Cypr6_mcytokine production 6 (mouse)Not determined4120617848154617995Mouse
1302078Sluc21_msusceptibility to lung cancer 21 (mouse)Not determined4117401141151401275Mouse
10045620Heal22_mwound healing/regeneration 22 (mouse)Not determined4125230872156860686Mouse
4142481Gct1_mgranulosa cell tumorigenesis 1 (mouse)Not determined4127784226156860686Mouse
4141065Shali2_msurvival time to hyperoxic acute lung injury 2 (mouse)Not determined124055093141572792Mouse
13503348Bntq18_mbone traits QTL 18 (mouse)4120617848154617995Mouse
13208562Wght7_mweight 7 (mouse)490888237148084457Mouse
4141184Tb2r1_mTGF-beta2 responsiveness 1 (mouse)Not determined137674005150676858Mouse
1300780Cocrb16_mcocaine related behavior 16 (mouse)Not determined4138943725156860686Mouse
4142077Ignpq2_mIgA nephropathy QTL 2 (mouse)Not determined4133676733156860686Mouse
4141180Ssic1_msusceptibility to small intestinal cancer 1 (mouse)Not determined120674005154674151Mouse
1301584Lrdg2_mlight induced retinal degeneration 2 (mouse)Not determined4129465811151654550Mouse
1302102Bis1_mbeta-carboline-induced seizures 1 (mouse)Not determined4119864433153864536Mouse
10043996Gct5_mgranulosa cell tumorigenesis 5 (mouse)Not determined4127784226156860686Mouse
26884445Sklq7_mskull length QTL 7, 10 week (mouse)468018237150884457Mouse
10043985Stheal12_msoft tissue heal 12 (mouse)Not determined4121342649155342753Mouse
1357534Cinda3_mcytokine induced activation 3 (mouse)Not determined4137617848142289472Mouse
1301982Pltiq1_mphospholipid transfer protein inducibility QTL 1 (mouse)Not determined4124621281156860686Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155684457Mouse
1300803Sluc6_msusceptibility to lung cancer 6 (mouse)Not determined4120674005154674151Mouse
4142061Chlq16_mcirculating hormone level QTL 16 (mouse)Not determined4121342649155342753Mouse
1300933Cdcs9_mcytokine deficiency colitis susceptibility 9 (mouse)Not determined4125230872156860686Mouse
1300553Athsq1_matherosclerosis susceptibility QTL 1 (mouse)Not determined4137617848151654550Mouse
1301964Bw8q2_mbody weight at 8 weeks QTL 2 (mouse)Not determined4119864433153864536Mouse
1301452Elsgp1_melevated serum gp70 1 (mouse)Not determined4121342649155342753Mouse
10755520Rbc1_mred blood cell count 1 (mouse)4108477692142477692Mouse
10755521Hct1_mhematocrit 1 (mouse)4108477692142477692Mouse
10755522Hgb1_mhemoglobin 1 (mouse)4108477692142477692Mouse
1301108Scon2_msucrose consumption 2 (mouse)Not determined4134654451156860686Mouse
1300858Tafat_mtally ho associated mesenteric fat pad weight (mouse)Not determined4124621281156860686Mouse
10755531Lymph3_mlymphocyte differential 3 (mouse)4124553483156860686Mouse
11533916Mts1_mmammary tumor susceptibility 1 (mouse)4125289325156860686Mouse
1300839Dyscalc2_mdystrophic cardiac calcinosis 2 (mouse)Not determined4111009051145009280Mouse
4141001Tgq17_mtriglyceride QTL 17 (mouse)Not determined112523489146523489Mouse
15039385Mvlq3_mmacrovesicular liver lesion QTL 3 (mouse)4112182386146182386Mouse

Markers in Region
RH135858  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384141,815,499 - 141,815,628UniSTSGRCm38
MGSCv374141,371,414 - 141,371,543UniSTSGRCm37
Celera4143,640,445 - 143,640,574UniSTS
Cytogenetic Map4E1UniSTS
AW493809  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384141,814,562 - 141,814,661UniSTSGRCm38
MGSCv374141,370,477 - 141,370,576UniSTSGRCm37
Celera4143,639,508 - 143,639,607UniSTS
Cytogenetic Map4E1UniSTS
Whitehead/MRC_RH41857.39UniSTS
Casp9  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4E1UniSTS
cM Map4 UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001277932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001355176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429870 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_015733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB019600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB019601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK085095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK085152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK085561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154495 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK156500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK162863 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK203861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL928577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB610740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC056372 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC056447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY549141 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT010400 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000030747   ⟹   ENSMUSP00000030747
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4141,520,923 - 141,543,287 (+)Ensembl
GRCm38.p6 Ensembl4141,793,612 - 141,815,976 (+)Ensembl
Ensembl Acc Id: ENSMUST00000097805   ⟹   ENSMUSP00000095414
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4141,520,923 - 141,540,998 (+)Ensembl
GRCm38.p6 Ensembl4141,793,612 - 141,813,687 (+)Ensembl
Ensembl Acc Id: ENSMUST00000124161
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4141,542,069 - 141,543,287 (+)Ensembl
GRCm38.p6 Ensembl4141,814,758 - 141,815,976 (+)Ensembl
Ensembl Acc Id: ENSMUST00000128660
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4141,520,923 - 141,525,397 (+)Ensembl
GRCm38.p6 Ensembl4141,793,612 - 141,798,086 (+)Ensembl
Ensembl Acc Id: ENSMUST00000138359
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4141,521,155 - 141,523,885 (+)Ensembl
GRCm38.p6 Ensembl4141,793,844 - 141,796,574 (+)Ensembl
Ensembl Acc Id: ENSMUST00000153094   ⟹   ENSMUSP00000121331
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4141,521,021 - 141,532,753 (+)Ensembl
GRCm38.p6 Ensembl4141,793,710 - 141,805,442 (+)Ensembl
RefSeq Acc Id: NM_001277932   ⟹   NP_001264861
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394141,520,923 - 141,543,289 (+)NCBI
GRCm384141,793,612 - 141,815,978 (+)NCBI
Celera4143,618,711 - 143,640,924 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001355176   ⟹   NP_001342105
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394141,520,923 - 141,543,289 (+)NCBI
GRCm384141,793,612 - 141,815,978 (+)NCBI
Sequence:
RefSeq Acc Id: NM_015733   ⟹   NP_056548
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394141,520,923 - 141,543,289 (+)NCBI
GRCm384141,793,612 - 141,815,978 (+)NCBI
MGSCv374141,349,527 - 141,371,890 (+)RGD
Celera4143,618,711 - 143,640,924 (+)NCBI
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_056548   ⟸   NM_015733
- Peptide Label: isoform 1 precursor
- UniProtKB: Q8C3Q9 (UniProtKB/Swiss-Prot),   Q4FJK5 (UniProtKB/TrEMBL),   Q8C3Q0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001264861   ⟸   NM_001277932
- Peptide Label: isoform 2
- UniProtKB: A2AS93 (UniProtKB/TrEMBL),   Q9R0S9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001342105   ⟸   NM_001355176
- Peptide Label: isoform 3 precursor
- UniProtKB: Q4FJK5 (UniProtKB/TrEMBL),   Q8C3Q0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000121331   ⟸   ENSMUST00000153094
Ensembl Acc Id: ENSMUSP00000030747   ⟸   ENSMUST00000030747
Ensembl Acc Id: ENSMUSP00000095414   ⟸   ENSMUST00000097805
Protein Domains
CARD   Caspase family p10   Caspase family p20

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8C3Q9-F1-model_v2 AlphaFold Q8C3Q9 1-454 view protein structure

Promoters
RGD ID:6835003
Promoter ID:MM_KWN:40514
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000023070,   OTTMUST00000023071,   OTTMUST00000023072,   OTTMUST00000023219,   OTTMUST00000023220,   UC008VPH.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364141,349,171 - 141,349,922 (+)MPROMDB
RGD ID:6835002
Promoter ID:MM_KWN:40515
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:OTTMUST00000023224
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364141,369,621 - 141,370,121 (+)MPROMDB
RGD ID:6885344
Promoter ID:EPDNEW_M6122
Type:initiation region
Name:Casp9_2
Description:Mus musculus caspase 9 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M6123  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384141,793,587 - 141,793,647EPDNEW
RGD ID:6885346
Promoter ID:EPDNEW_M6123
Type:initiation region
Name:Casp9_1
Description:Mus musculus caspase 9 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M6122  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384141,793,826 - 141,793,886EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1277950 AgrOrtholog
Ensembl Genes ENSMUSG00000028914 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000030747 ENTREZGENE
  ENSMUST00000030747.11 UniProtKB/Swiss-Prot
  ENSMUST00000097805 ENTREZGENE
Gene3D-CATH 1.10.533.10 UniProtKB/Swiss-Prot
  3.40.50.1460 UniProtKB/Swiss-Prot
InterPro CARD UniProtKB/Swiss-Prot
  CARD_CASP9 UniProtKB/Swiss-Prot
  Caspase-like_dom_sf UniProtKB/Swiss-Prot
  Caspase_cys_AS UniProtKB/Swiss-Prot
  Caspase_his_AS UniProtKB/Swiss-Prot
  DEATH-like_dom_sf UniProtKB/Swiss-Prot
  Pept_C14 UniProtKB/Swiss-Prot
  Pept_C14_caspase UniProtKB/Swiss-Prot
  Pept_C14_p10 UniProtKB/Swiss-Prot
  Pept_C14_p20 UniProtKB/Swiss-Prot
  Pept_C14A UniProtKB/Swiss-Prot
KEGG Report mmu:12371 UniProtKB/Swiss-Prot
MGD MGI:1277950 ENTREZGENE
NCBI Gene 12371 ENTREZGENE
PANTHER CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18 UniProtKB/Swiss-Prot
  CASPASE-3 UniProtKB/Swiss-Prot
Pfam CARD UniProtKB/Swiss-Prot
  Peptidase_C14 UniProtKB/Swiss-Prot
PharmGKB CASP9 RGD
PhenoGen Casp9 PhenoGen
PIRSF Caspase_ICE UniProtKB/Swiss-Prot
PRINTS IL1BCENZYME UniProtKB/Swiss-Prot
PROSITE CARD UniProtKB/Swiss-Prot
  CASPASE_CYS UniProtKB/Swiss-Prot
  CASPASE_HIS UniProtKB/Swiss-Prot
  CASPASE_P10 UniProtKB/Swiss-Prot
  CASPASE_P20 UniProtKB/Swiss-Prot
SMART CARD UniProtKB/Swiss-Prot
  CASc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47986 UniProtKB/Swiss-Prot
  SSF52129 UniProtKB/Swiss-Prot
UniProt A2AS92_MOUSE UniProtKB/TrEMBL
  A2AS93 ENTREZGENE, UniProtKB/TrEMBL
  CASP9_MOUSE UniProtKB/Swiss-Prot
  Q3TRE1_MOUSE UniProtKB/TrEMBL
  Q4FJK5 ENTREZGENE, UniProtKB/TrEMBL
  Q8C3Q0 ENTREZGENE, UniProtKB/TrEMBL
  Q8C3Q9 ENTREZGENE
  Q9R0S9 ENTREZGENE, UniProtKB/TrEMBL
  Q9R0T0_MOUSE UniProtKB/TrEMBL