Nrn1 (neuritin 1) - Rat Genome Database

Name: Nrn1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Nrn1 (neuritin 1) Rattus norvegicus

Analyze

Symbol:

Nrn1

Name:

neuritin 1

RGD ID:

621586

Description:

Predicted to enable identical protein binding activity. Involved in nervous system development. Predicted to be located in extracellular space; plasma membrane; and presynapse. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in glutamatergic synapse. Orthologous to human NRN1 (neuritin 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; fluoxetine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

MGC105351; neuritin; Nrn

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	NRN1 (neuritin 1)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Nrn1 (neuritin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Nrn1 (neuritin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	NRN1 (neuritin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	NRN1 (neuritin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Nrn1 (neuritin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	NRN1 (neuritin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	NRN1 (neuritin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Nrn1 (neuritin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	NRN1 (neuritin 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Nrn1 (neuritin 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	nrn1b (neuritin 1b)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	nrn1a (neuritin 1a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	17	28,129,969 - 28,138,898 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	28,129,977 - 28,138,896 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	27,988,531 - 27,997,495 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	17	29,592,060 - 29,601,025 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	17	27,958,988 - 27,967,948 (+)	NCBI	Rnor_WKY
Rnor_6.0	17	27,925,054 - 28,002,946 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	27,925,057 - 27,969,433 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	29,834,673 - 29,910,519 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	17	27,746,113 - 27,755,014 (+)	NCBI		Celera
Cytogenetic Map	17	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

combined oxidative phosphorylation deficiency 14 (ISO)

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-demecolcine (ISO)

(S)-nicotine (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

3-methylcholanthrene (ISO)

4,4'-sulfonyldiphenol (ISO)

5-azacytidine (ISO)

acrylamide (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

antirheumatic drug (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

Benzo[ghi]perylene (ISO)

bisphenol A (EXP,ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlordecone (ISO)

cocaine (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

dioxygen (ISO)

disodium selenite (ISO)

dorsomorphin (ISO)

entinostat (ISO)

ethanol (ISO)

ethyl methanesulfonate (ISO)

fluoxetine (EXP)

folic acid (ISO)

fonofos (ISO)

formaldehyde (ISO)

genistein (ISO)

gentamycin (EXP)

indometacin (ISO)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

mono(2-ethylhexyl) phthalate (ISO)

morphine (ISO)

N-methyl-4-phenylpyridinium (EXP)

N-nitrosodiethylamine (ISO)

nicotine (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

parathion (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

terbufos (ISO)

Testosterone propionate (EXP)

titanium dioxide (ISO)

trichloroethene (EXP)

trimellitic anhydride (ISO)

tris(2-butoxyethyl) phosphate (ISO)

undecane (EXP)

valproic acid (ISO)

vincristine (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

nervous system development (IDA,IEA)

neuron projection extension (IBA,ISO)

presynaptic modulation of chemical synaptic transmission (ISO)

Cellular Component

AMPA glutamate receptor complex (ISO)

extracellular space (ISO)

glutamatergic synapse (ISO)

plasma membrane (IEA,ISO)

Molecular Function

identical protein binding (ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Neuritin: a gene induced by neural activity and neurotrophins that promotes neuritogenesis.	Naeve GS, etal., Proc Natl Acad Sci U S A 1997 Mar 18;94(6):2648-53.
3.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
4.	GOA pipeline	RGD automated data pipeline
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:15489334	PMID:17909094	PMID:18265009	PMID:22177131	PMID:22632720	PMID:22733766	PMID:23066017	PMID:23212301	PMID:25036738	PMID:25101829	PMID:27966079
PMID:28475719	PMID:28852892	PMID:28871047	PMID:32607759	PMID:33323541

Genomics

Comparative Map Data

Nrn1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	17	28,129,969 - 28,138,898 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	28,129,977 - 28,138,896 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	27,988,531 - 27,997,495 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	17	29,592,060 - 29,601,025 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	17	27,958,988 - 27,967,948 (+)	NCBI	Rnor_WKY
Rnor_6.0	17	27,925,054 - 28,002,946 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	27,925,057 - 27,969,433 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	29,834,673 - 29,910,519 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	17	27,746,113 - 27,755,014 (+)	NCBI		Celera
Cytogenetic Map	17	p12	NCBI

NRN1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	5,997,999 - 6,007,518 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	6	5,997,999 - 6,007,605 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	5,998,232 - 6,007,751 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	5,943,231 - 5,952,632 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	5,943,233 - 5,952,632	NCBI
Celera	6	7,224,912 - 7,234,313 (-)	NCBI		Celera
Cytogenetic Map	6	p25.1	NCBI
HuRef	6	5,873,923 - 5,883,530 (-)	NCBI		HuRef
CHM1_1	6	6,001,212 - 6,010,814 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	5,866,869 - 5,876,393 (-)	NCBI		T2T-CHM13v2.0

Nrn1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	36,909,596 - 36,918,451 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	36,909,335 - 36,919,105 (-)	Ensembl		GRCm39 Ensembl
GRCm38	13	36,725,622 - 36,734,477 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	36,725,361 - 36,735,131 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	36,817,494 - 36,826,323 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	36,733,091 - 36,741,922 (-)	NCBI		MGSCv36	mm8
Celera	13	37,844,580 - 37,853,452 (-)	NCBI		Celera
Cytogenetic Map	13	A3.3	NCBI

Nrn1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955465	7,702,605 - 7,711,986 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955465	7,703,301 - 7,711,927 (+)	NCBI	ChiLan1.0	ChiLan1.0

NRN1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	6	6,014,000 - 6,022,869 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	6,014,000 - 6,022,870 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	6	5,832,603 - 5,841,975 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

NRN1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	35	6,070,456 - 6,079,214 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	35	6,070,379 - 6,078,965 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	35	6,075,854 - 6,084,239 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	35	6,145,299 - 6,153,696 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	35	6,144,597 - 6,153,662 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	35	6,006,507 - 6,014,905 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	35	6,032,496 - 6,040,856 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	35	7,365,880 - 7,374,292 (-)	NCBI		UU_Cfam_GSD_1.0

Nrn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	18,190,327 - 18,195,267 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936534	6,459,431 - 6,464,253 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NRN1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	3,682,571 - 3,691,349 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	3,682,568 - 3,691,328 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	3,884,762 - 3,893,524 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NRN1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	66,187,338 - 66,196,928 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	66,187,723 - 66,196,934 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666044	5,933,827 - 5,943,198 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Nrn1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624756	19,365,444 - 19,375,494 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624756	19,365,665 - 19,374,008 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Nrn1
80 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	93
Count of miRNA genes:	81
Interacting mature miRNAs:	86
Transcripts:	ENSRNOT00000073967
Prediction methods:	Miranda, Pita, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10401807	Kidm52	Kidney mass QTL 52			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	17	1	31701463	Rat
70184	BpQTLcluster14	Blood pressure QTL cluster 14	3.38		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	1	31990913	Rat
631207	Niddm41	Non-insulin dependent diabetes mellitus QTL 41			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	17	1	37830672	Rat
1354658	Spl8	Serum phospholipid level QTL 8	3.8		blood VLDL phospholipid amount (VT:0010507)	blood very low density lipoprotein phospholipid level (CMO:0001571)	17	1	60781592	Rat
1354581	Bp247	Blood pressure QTL 247	4.5		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	17	1	69599340	Rat
1354662	Rf49	Renal function QTL 49	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	17	1	69599340	Rat
1300123	Bp194	Blood pressure QTL 194	2.82		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	2115149	34551001	Rat
1354613	Kidm14	Kidney mass QTL 14	6.2		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	17	4299130	35837242	Rat
1354596	Bw32	Body weight QTL 32	4.5		body mass (VT:0001259)	body weight (CMO:0000012)	17	4299130	60781592	Rat
1354630	Cm34	Cardiac mass QTL 34	8.7		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	17	4299130	69599340	Rat
1354638	Insul1	Insulin level QTL 1	4.8		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	17	4299130	69599340	Rat
1354651	Lmblg2	Limb length QTL 2	6		tibia length (VT:0004357)	tibia length (CMO:0000450)	17	4299130	69599340	Rat
2303627	Vencon8	Ventilatory control QTL 8		0.001	respiration trait (VT:0001943)	tidal volume (CMO:0000222)	17	4528038	49528038	Rat
10054088	Scort28	Serum corticosterone level QTL 28	2.04	0.0102	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	17	4528038	49528038	Rat
2303561	Bw91	Body weight QTL 91	2		body mass (VT:0001259)	body weight (CMO:0000012)	17	8868462	53868462	Rat
2300002	Iddm36	Insulin dependent diabetes mellitus QTL 36	1.98		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	17	9991286	40540197	Rat
1331765	Hrtrt15	Heart rate QTL 15	4.094		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	17	15330613	55836425	Rat
1354640	Scl32	Serum cholesterol level QTL 32	5.4		blood HDL cholesterol amount (VT:0000184)	blood high density lipoprotein cholesterol level (CMO:0000052)	17	15781592	60781592	Rat
1354659	Scl68	Serum cholesterol level QTL 68	3.9		blood VLDL cholesterol amount (VT:0005144)	blood very low density lipoprotein cholesterol level (CMO:0000648)	17	15781592	60781592	Rat
7394837	Memor18	Memory QTL 18			exploratory behavior trait (VT:0010471)	measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)	17	18640182	63640182	Rat
1354628	Stl13	Serum triglyceride level QTL 13	3.8		blood triglyceride amount (VT:0002644)	blood triglyceride level (CMO:0000118)	17	21293039	60781592	Rat
70157	Niddm32	Non-insulin dependent diabetes mellitus QTL 32	4.34		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	17	22454924	50909196	Rat
61394	Bp8	Blood pressure QTL 8	2.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	23080567	59555013	Rat
7488966	Bp370	Blood pressure QTL 370		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	23653184	57246843	Rat
12903978	Cm118	Cardiac mass QTL 118		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	17	23653184	68653184	Rat
12903979	Cm119	Cardiac mass QTL 119		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	17	23653184	68653184	Rat
12903980	Cm120	Cardiac mass QTL 120		0.002	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	17	23653184	68653184	Rat
12903981	Am17	Aortic mass QTL 17		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	17	23653184	68653184	Rat
1559055	Bp278	Blood pressure QTL 278		0.04	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	23653184	68653184	Rat
12903982	Kidm70	Kidney mass QTL 70		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	17	23653184	70974005	Rat
1354619	Bp242	Blood pressure QTL 242	6.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	24599340	69599340	Rat
4889891	Eae32	Experimental allergic encephalomyelitis QTL 32	4.8	0.0002	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	17	27027949	36146731	Rat
1581512	Cm55	Cardiac mass QTL 55	2.8	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	17	27027949	56836890	Rat
4889955	Bss93	Bone structure and strength QTL 93	4.4		tibia size trait (VT:0100001)	tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)	17	27027949	60463643	Rat
2302377	Scl61	Serum cholesterol level QTL 61	4.36		blood HDL cholesterol amount (VT:0000184)	serum high density lipoprotein cholesterol level (CMO:0000361)	17	27389946	53481766	Rat

Markers in Region

BE111902

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Celera	17	27,752,355 - 27,752,545	UniSTS
RH 3.4 Map	17	331.1	UniSTS

RH138969

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Celera	17	27,751,872 - 27,752,121	UniSTS
RH 3.4 Map	17	339.5	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium		2							72		2	1
Low	3	41	57	41	19	41	7	7	2	34	26	10	7
Below cutoff							1	4		1	11		1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053346	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039096113	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC087582	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473977	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ213150	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000288	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U88958	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000073967 ⟹ ENSRNOP00000066878

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	28,129,977 - 28,138,893 (+)	Ensembl
Rnor_6.0 Ensembl	17	27,925,057 - 27,969,433 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000116839 ⟹ ENSRNOP00000082569

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	28,130,068 - 28,138,896 (+)	Ensembl

RefSeq Acc Id:

NM_053346 ⟹ NP_445798

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	17	28,129,969 - 28,138,898 (+)	NCBI
Rnor_6.0	17	27,925,054 - 28,002,946 (-)	NCBI
Rnor_5.0	17	29,834,673 - 29,910,519 (-)	NCBI
Celera	17	27,746,113 - 27,755,014 (+)	RGD

Sequence:

show sequence

TACTCTCTCGCTCTCTTTCTGTCTCTTCCTCGCTCCCTCTCTTTCTCTCCTCCCTCTGCCTTCC
CAGTGCATAAAGTCTCTGTCGCTCCCGGAACTTGTTGGCAATGCCTATTTTTCAGCTTTCCCCC
GCGTTCTCTAAACTAACTATTTAAAGGTCTGCGGTCGCAAATGGTTTGACTAAACGTAGGATGG
GACTTAAGTTGAACGGCAGATATATTTCACTGATCCTCGCGGTGCAAATAGCTTACCTGGTGCA
GGCCGTGAGAGCAGCAGGCAAGTGCGATGCAGTCTTTAAGGGCTTTTCAGACTGTTTGCTCAAG
CTGGGTGACAGCATGGCCAACTACCCGCAGGGCCTGGACGACAAGACGAACATCAAGACCGTGT
GCACATACTGGGAGGATTTCCACAGCTGCACGGTCACAGCTCTTACGGATTGCCAGGAAGGGGC
GAAAGATATGTGGGATAAACTGAGAAAAGAATCGAAAAACCTCAATATCCAAGGCAGCTTATTC
GAACTCTGCGGCAGCGGCAACGGGGCGGCGGGGTCCCTGCTCCCGGCGCTTTCCGTGCTCCTGG
TGTCTCTCTCGGCAGCTTTAGCGACCTGGCTTTCCTTCTGAGCACGGGGCCGGGTCCCCCCTCC
GCTCACCCACCCACACTCACTCCATGCTCCCGGAAATCGAGAGGAAGAGCCATTCGTTCTCTAA
GGACGTTGTGATTCTCTGTGATATTGAAAACACTCATATGGGATTGTGGGAAATCCTGTTTCTC
TCTTTTTTTTTTTTTAATTTTTTTTTATTTTGGTTGAGTCCTTGTGTTTTAGTTGCCAAATGTT
ACCGATCAGTGAGCAAAGCAAGCACAGCCAAAATCGGACCTCACCTTAAGTCCGTCTTCACACA
AAAATAAGAAAACGGCAAACTCACCCCCATTTTTAATTTTGTTTTTAATTTTACTTACTTATTT
ATTTATTTATTTTTTGGCAAAAGAATCTCAGGAATGGCCCTGGGCCACCTACTATATTAATCAT
GTTGATAACATGAAAAATGATGGGCTCCTCCTAATGAGAAAGCGAGGAGAGGAGAAGGCCAGGG
GAATGAGCTCAAGAGTGATGCCCACGTGGGGAGCATCTGGTGAATAATCGCTCACGTCTTTCTT
CCACAGTACCTTGTTTTGATCATTTCCACAGCACATTTCTCCTCCAGAAACGCGAAAAACACAA
GCGTGTGGGTTCTGCATTTTTAAGGATAAGAGAGAGAAAGAGGTTGGGTATAGTAGGACAGGTT
GTCAGAAGAGATGCTGCTATGGTCACGAGGGGCCGGTTTCACCTGCTATTGTCGTCGCCTCCTT
CAGTTCCACTGCCTTTATGTCCCCTCCTCTCTCTTGTTTTAGCTGTTACACATACAGTAATACC
TGAATATCCAACGGTATAGTTCACAAGGGGGTAATCAATGTTAAATCTAAAATAGAATTTAAAA
AAAAAAGATTTTGACATAAAAGAGCCTTGATTTTAAAAAAAAAGAGAGAGATGTAATTTAAAAA
GTTTATTATAAATTAAATTCAGCAAAAATTTGCTACAAAGTATAGAGAAGTATAAAATAAAAGT
TATTGTTTGAAAAA

hide sequence

RefSeq Acc Id:

XM_039096113 ⟹ XP_038952041

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	17	28,134,065 - 28,138,898 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_445798	(Get FASTA)	NCBI Sequence Viewer
	XP_038952041	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB53415	(Get FASTA)	NCBI Sequence Viewer
	AAH87582	(Get FASTA)	NCBI Sequence Viewer
	EDL98281	(Get FASTA)	NCBI Sequence Viewer
	O08957	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_445798 ⟸ NM_053346
- Peptide Label:	precursor
- UniProtKB:	O08957 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MGLKLNGRYISLILAVQIAYLVQAVRAAGKCDAVFKGFSDCLLKLGDSMANYPQGLDDKTNIKT VCTYWEDFHSCTVTALTDCQEGAKDMWDKLRKESKNLNIQGSLFELCGSGNGAAGSLLPALSVL LVSLSAALATWLSF hide sequence

RefSeq Acc Id:

ENSRNOP00000066878 ⟸ ENSRNOT00000073967

RefSeq Acc Id:	XP_038952041 ⟸ XM_039096113
- Peptide Label:	isoform X1

RefSeq Acc Id:

ENSRNOP00000082569 ⟸ ENSRNOT00000116839

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O08957-F1-model_v2	AlphaFold	O08957	1-142	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621586	AgrOrtholog
BioCyc Gene	G2FUF-9641	BioCyc
Ensembl Genes	ENSRNOG00000050767	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000066878.2	UniProtKB/TrEMBL
	ENSRNOP00000082569	ENTREZGENE
	ENSRNOP00000082569.1	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000073967.2	UniProtKB/TrEMBL
	ENSRNOT00000116839	ENTREZGENE
	ENSRNOT00000116839.1	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7315687	IMAGE-MGC_LOAD
InterPro	Neuritin_fam	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:83834	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:105351	IMAGE-MGC_LOAD
NCBI Gene	83834	ENTREZGENE
PANTHER	NEURITIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR15902	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	NRN1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Nrn1	PhenoGen
UniProt	M0RBE5_RAT	UniProtKB/TrEMBL
	NRN1_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-02-25	Nrn1	neuritin 1	Nrn1	neuritin	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Nrn1	neuritin	Nrn		Symbol and Name updated	1299863	APPROVED
2002-08-07	Nrn	neuritin			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expression is induced by neuronal activity and by neurotrophins BDNF and NT-3	633434
gene_protein	has a glycosylphosphatidylinositol anchor	633434

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar