Nln (neurolysin) - Rat Genome Database

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Gene: Nln (neurolysin) Rattus norvegicus
Analyze
Symbol: Nln
Name: neurolysin
RGD ID: 621518
Description: Enables metalloendopeptidase activity and oligopeptidase activity. Involved in peptide catabolic process and protein catabolic process. Located in cytosol and mitochondrial intermembrane space. Orthologous to human NLN (neurolysin); PARTICIPATES IN renin-angiotensin cascade pathway; INTERACTS WITH 1,10-phenanthroline; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MEP; microsomal endopeptidase; mitochondrial oligopeptidase M; neurolysin (metallopeptidase M3 family); neurolysin, mitochondrial; neurotensin endopeptidase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2235,133,634 - 35,232,927 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl235,134,145 - 35,232,914 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx242,248,083 - 42,345,656 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0240,306,773 - 40,404,352 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0235,163,341 - 35,261,069 (-)NCBIRnor_WKY
Rnor_6.0234,086,970 - 34,185,835 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl234,087,880 - 34,185,812 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0253,215,233 - 53,314,136 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4234,915,111 - 35,031,566 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1234,835,479 - 34,951,935 (-)NCBI
Celera231,110,866 - 31,209,296 (-)NCBICelera
Cytogenetic Map2q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,10-phenanthroline  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
aristolochic acid A  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
buspirone  (EXP)
carbon nanotube  (ISO)
chromium(6+)  (ISO)
cobalt dichloride  (ISO)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
EDTA(2-)  (EXP)
entinostat  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fipronil  (EXP)
formaldehyde  (ISO)
genistein  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
mercury dibromide  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
nickel atom  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
sodium fluoride  (ISO)
succimer  (ISO)
sunitinib  (ISO)
tetrachloromethane  (ISO)
topotecan  (EXP)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Molecular cloning and expression of rat brain endopeptidase 3.4.24.16. Dauch P, etal., J Biol Chem 1995 Nov 10;270(45):27266-71.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. Metalloendopeptidases EC 3.4.24.15/16 regulate bradykinin activity in the cerebral microvasculature. Norman MU, etal., Am J Physiol Heart Circ Physiol 2003 Jun;284(6):H1942-8. Epub 2003 Feb 13.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. Mapping sequence differences between thimet oligopeptidase and neurolysin implicates key residues in substrate recognition. Ray K, etal., Protein Sci 2002 Sep;11(9):2237-46.
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Novel natural peptide substrates for endopeptidase 24.15, neurolysin, and angiotensin-converting enzyme. Rioli V, etal., J Biol Chem. 2003 Mar 7;278(10):8547-55. doi: 10.1074/jbc.M212030200. Epub 2002 Dec 24.
11. Characterization of a mitochondrial metallopeptidase reveals neurolysin as a homologue of thimet oligopeptidase. Serizawa A, etal., J Biol Chem. 1995 Feb 3;270(5):2092-8.
12. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:9182559   PMID:11248043   PMID:12609826   PMID:16515556   PMID:17882707   PMID:18614015   PMID:22039052   PMID:23412923   PMID:24719317   PMID:24719333   PMID:25378390  


Genomics

Comparative Map Data
Nln
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2235,133,634 - 35,232,927 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl235,134,145 - 35,232,914 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx242,248,083 - 42,345,656 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0240,306,773 - 40,404,352 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0235,163,341 - 35,261,069 (-)NCBIRnor_WKY
Rnor_6.0234,086,970 - 34,185,835 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl234,087,880 - 34,185,812 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0253,215,233 - 53,314,136 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4234,915,111 - 35,031,566 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1234,835,479 - 34,951,935 (-)NCBI
Celera231,110,866 - 31,209,296 (-)NCBICelera
Cytogenetic Map2q12NCBI
NLN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38565,722,205 - 65,829,283 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl565,722,205 - 65,871,725 (+)EnsemblGRCh38hg38GRCh38
GRCh37565,018,032 - 65,125,111 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36565,053,841 - 65,155,149 (+)NCBINCBI36Build 36hg18NCBI36
Build 34565,053,840 - 65,155,143NCBI
Celera562,016,491 - 62,123,591 (+)NCBICelera
Cytogenetic Map5q12.3NCBI
HuRef561,976,109 - 62,083,226 (+)NCBIHuRef
CHM1_1565,017,717 - 65,124,844 (+)NCBICHM1_1
T2T-CHM13v2.0566,543,992 - 66,651,091 (+)NCBIT2T-CHM13v2.0
Nln
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913104,159,558 - 104,246,170 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13104,159,565 - 104,246,122 (-)EnsemblGRCm39 Ensembl
GRCm3813104,023,050 - 104,109,673 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13104,023,057 - 104,109,614 (-)EnsemblGRCm38mm10GRCm38
MGSCv3713104,813,519 - 104,899,694 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613105,143,604 - 105,229,957 (-)NCBIMGSCv36mm8
Celera13108,414,173 - 108,500,684 (-)NCBICelera
Cytogenetic Map13D1NCBI
Nln
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554463,256,078 - 3,374,462 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554463,258,278 - 3,374,337 (-)NCBIChiLan1.0ChiLan1.0
NLN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1549,834,121 - 49,938,192 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl549,840,482 - 49,938,192 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0548,180,768 - 48,283,281 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
NLN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1251,445,941 - 51,551,425 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl251,444,566 - 51,538,028 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha248,400,415 - 48,494,439 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0251,935,923 - 52,030,529 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl251,935,938 - 52,041,328 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1248,995,440 - 49,095,747 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0249,784,767 - 49,878,766 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0250,676,985 - 50,771,434 (+)NCBIUU_Cfam_GSD_1.0
Nln
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213194,447,083 - 194,544,535 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364803,383,540 - 3,481,009 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049364803,383,514 - 3,480,991 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NLN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1644,225,677 - 44,334,610 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11644,225,706 - 44,333,623 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21647,574,962 - 47,681,332 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NLN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1461,918,079 - 62,022,517 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl461,918,137 - 62,016,144 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604910,561,550 - 10,666,098 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nln
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248154,017,514 - 4,162,237 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248154,020,212 - 4,162,233 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nln
309 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:86
Count of miRNA genes:65
Interacting mature miRNAs:78
Transcripts:ENSRNOT00000066925
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631682Bp115Blood pressure QTL 1154.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2137410502Rat
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2141244106Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2788777242804738Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2902351954023519Rat
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)21185206249003364Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22490385374786777Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22691781781754745Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
1331764Bp205Blood pressure QTL 2053.476arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22699957143154682Rat
1643006Pain1Pain QTL 13.630.005mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)22699957148268661Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22715716072157160Rat
1300160Hrtrt3Heart rate QTL 33.62heart pumping trait (VT:2000009)absolute change in heart rate (CMO:0000534)22997159351729300Rat
10755434Coatc7Coat color QTL 70.04794coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23064806575648065Rat
731179Mamtr3Mammary tumor resistance QTL 30.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)23237377043665178Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23502311780023117Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23513484188029593Rat

Markers in Region
D2Mgh1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2235,134,841 - 35,134,970 (+)MAPPERmRatBN7.2
Rnor_6.0234,088,175 - 34,088,303NCBIRnor6.0
Rnor_5.0253,216,438 - 53,216,566UniSTSRnor5.0
RGSC_v3.4234,914,943 - 34,915,072RGDRGSC3.4
RGSC_v3.4234,914,944 - 34,915,072UniSTSRGSC3.4
RGSC_v3.1234,835,312 - 34,835,441RGD
Celera231,110,695 - 31,110,827UniSTS
RH 3.4 Map2126.7UniSTS
RH 3.4 Map2126.7RGD
RH 2.0 Map2189.6RGD
SHRSP x BN Map215.0498RGD
FHH x ACI Map223.0699RGD
Cytogenetic Map2q13UniSTS
RH132947  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2235,231,684 - 35,232,738 (+)MAPPERmRatBN7.2
Rnor_6.0234,184,591 - 34,185,644NCBIRnor6.0
Rnor_5.0253,312,891 - 53,313,944UniSTSRnor5.0
RGSC_v3.4235,030,475 - 35,031,528UniSTSRGSC3.4
Celera231,208,205 - 31,209,258UniSTS
RH 3.4 Map2139.8UniSTS
Cytogenetic Map2q13UniSTS
BM382907  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2235,135,013 - 35,135,165 (+)MAPPERmRatBN7.2
Rnor_6.0234,088,347 - 34,088,498NCBIRnor6.0
Rnor_5.0253,216,610 - 53,216,761UniSTSRnor5.0
RGSC_v3.4234,915,116 - 34,915,267UniSTSRGSC3.4
Celera231,110,871 - 31,111,022UniSTS
RH 3.4 Map2123.4UniSTS
Cytogenetic Map2q13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 20 57 41 19 41 8 10 74 35 35 11 8
Low 23 1 6
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231881 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017590591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005500227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005500228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC129167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC072687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230641 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X87157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000066925   ⟹   ENSRNOP00000059652
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl235,135,300 - 35,232,914 (-)Ensembl
Rnor_6.0 Ensembl234,088,342 - 34,185,682 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000082755   ⟹   ENSRNOP00000069520
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl235,134,145 - 35,197,739 (-)Ensembl
Rnor_6.0 Ensembl234,087,880 - 34,185,812 (-)Ensembl
RefSeq Acc Id: NM_053970   ⟹   NP_446422
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2235,135,009 - 35,232,776 (-)NCBI
Rnor_6.0234,088,342 - 34,185,682 (-)NCBI
Rnor_5.0253,215,233 - 53,314,136 (-)NCBI
RGSC_v3.4234,915,111 - 35,031,566 (-)RGD
Celera231,110,866 - 31,209,296 (-)RGD
Sequence:
RefSeq Acc Id: XM_006231880   ⟹   XP_006231942
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2235,135,539 - 35,232,925 (-)NCBI
Rnor_6.0234,097,165 - 34,185,835 (-)NCBI
Rnor_5.0253,215,233 - 53,314,136 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039101583   ⟹   XP_038957511
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2235,133,634 - 35,232,925 (-)NCBI
RefSeq Acc Id: XM_039101584   ⟹   XP_038957512
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2235,133,637 - 35,232,926 (-)NCBI
RefSeq Acc Id: XM_039101585   ⟹   XP_038957513
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2235,153,414 - 35,232,927 (-)NCBI
RefSeq Acc Id: XR_005500227
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2235,135,536 - 35,232,925 (-)NCBI
RefSeq Acc Id: XR_005500228
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2235,133,637 - 35,232,926 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_446422   ⟸   NM_053970
- Peptide Label: precursor
- UniProtKB: P42676 (UniProtKB/Swiss-Prot),   A0A0G2JSY3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231942   ⟸   XM_006231880
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSRNOP00000069520   ⟸   ENSRNOT00000082755
RefSeq Acc Id: ENSRNOP00000059652   ⟸   ENSRNOT00000066925
RefSeq Acc Id: XP_038957511   ⟸   XM_039101583
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038957512   ⟸   XM_039101584
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038957513   ⟸   XM_039101585
- Peptide Label: isoform X4
Protein Domains
Peptidase_M3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P42676-F1-model_v2 AlphaFold P42676 1-704 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691119
Promoter ID:EPDNEW_R1644
Type:initiation region
Name:Nln_1
Description:neurolysin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0234,185,744 - 34,185,804EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621518 AgrOrtholog
BioCyc Gene G2FUF-54558 BioCyc
Ensembl Genes ENSRNOG00000011561 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000059652 ENTREZGENE
  ENSRNOP00000059652.1 UniProtKB/TrEMBL
  ENSRNOP00000069520.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000066925 ENTREZGENE
  ENSRNOT00000066925.2 UniProtKB/TrEMBL
  ENSRNOT00000082755.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1370.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.1050.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7099208 IMAGE-MGC_LOAD
InterPro MetalloPept_cat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurolysin/TOP_dom2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurolysin/TOP_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M3A_M3B UniProtKB/Swiss-Prot
  Pept_M3A_M3B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M3A_M3B UniProtKB/TrEMBL
KEGG Report rno:117041 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:91547 IMAGE-MGC_LOAD
NCBI Gene 117041 ENTREZGENE
PANTHER PTHR11804 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Peptidase_M3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nln PhenoGen
PROSITE ZINC_PROTEASE UniProtKB/Swiss-Prot
UniProt A0A0G2JSY3 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2JVK4_RAT UniProtKB/TrEMBL
  NEUL_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q6GQQ4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-03 Nln  neurolysin  Nln  neurolysin (metallopeptidase M3 family)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Nln  neurolysin (metallopeptidase M3 family)      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Nln  neurolysin (metallopeptidase M3 family)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in brain, ileum, kidney, and testis 729279
gene_protein 704-amino acid protein 729279