Nln (neurolysin) - Rat Genome Database

Name: Nln
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Nln (neurolysin) Rattus norvegicus

Analyze

Symbol:

Nln

Name:

neurolysin

RGD ID:

621518

Description:

Enables metalloendopeptidase activity and oligopeptidase activity. Involved in peptide catabolic process and protein catabolic process. Located in cytosol and mitochondrial intermembrane space. Orthologous to human NLN (neurolysin); PARTICIPATES IN renin-angiotensin cascade pathway; INTERACTS WITH 1,10-phenanthroline; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

MEP; microsomal endopeptidase; mitochondrial oligopeptidase M; neurolysin (metallopeptidase M3 family); neurolysin, mitochondrial; neurotensin endopeptidase

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	NLN (neurolysin)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Nln (neurolysin (metallopeptidase M3 family))	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Nln (neurolysin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	NLN (neurolysin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	NLN (neurolysin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Nln (neurolysin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	NLN (neurolysin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	NLN (neurolysin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Nln (neurolysin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	THOP1 (thimet oligopeptidase 1)	HGNC	OrthoDB
Alliance orthologs ³
Homo sapiens (human):	NLN (neurolysin)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Nln (neurolysin (metallopeptidase M3 family))	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	nln (neurolysin (metallopeptidase M3 family))	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	PRD1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	2	35,133,634 - 35,232,927 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	35,134,145 - 35,232,914 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	42,248,083 - 42,345,656 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	2	40,306,773 - 40,404,352 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	2	35,163,341 - 35,261,069 (-)	NCBI	Rnor_WKY
Rnor_6.0	2	34,086,970 - 34,185,835 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	34,087,880 - 34,185,812 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	53,215,233 - 53,314,136 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	34,915,111 - 35,031,566 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	34,835,479 - 34,951,935 (-)	NCBI
Celera	2	31,110,866 - 31,209,296 (-)	NCBI		Celera
Cytogenetic Map	2	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

COVID-19 (ISO)

Neurodevelopmental Disorders (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,10-phenanthroline (EXP)

17beta-estradiol (ISO)

17beta-hydroxy-17-methylestra-4,9,11-trien-3-one (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

3,3',4,4'-tetrachlorobiphenyl (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-chloropropane-1,2-diol (EXP)

4-hydroxyphenyl retinamide (ISO)

4-phenylbutyric acid (ISO)

6-propyl-2-thiouracil (EXP)

acrolein (ISO)

acrylamide (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

aristolochic acid A (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

buspirone (EXP)

carbon nanotube (ISO)

chromium(6+) (ISO)

cobalt dichloride (ISO)

cyclosporin A (ISO)

dextran sulfate (ISO)

dibutyl phthalate (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

EDTA(2-) (EXP)

entinostat (ISO)

ethanol (ISO)

ethyl methanesulfonate (ISO)

fipronil (EXP)

formaldehyde (ISO)

genistein (ISO)

ivermectin (ISO)

ketamine (EXP)

mercury dibromide (ISO)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

nickel atom (ISO)

oxaliplatin (EXP)

ozone (ISO)

paracetamol (EXP,ISO)

pentachlorophenol (ISO)

perfluorooctanoic acid (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

resveratrol (ISO)

rotenone (EXP)

SB 431542 (ISO)

sodium fluoride (ISO)

succimer (ISO)

sunitinib (ISO)

tetrachloromethane (ISO)

topotecan (EXP)

trichloroethene (EXP,ISO)

trichostatin A (ISO)

trimellitic anhydride (ISO)

triphenyl phosphate (EXP)

tunicamycin (ISO)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

peptide catabolic process (IDA)

peptide metabolic process (IBA)

protein catabolic process (IDA)

proteolysis (IBA,IEA)

regulation of gluconeogenesis (IEA,ISO)

regulation of skeletal muscle fiber differentiation (IEA,ISO)

Cellular Component

cytosol (IDA,ISO)

mitochondrial intermembrane space (IBA,IDA)

mitochondrion (ISO)

plasma membrane (IEA,ISO)

Molecular Function

metal ion binding (IEA)

metalloendopeptidase activity (IBA,IDA,IEA)

oligopeptidase activity (IDA)

peptidase activity (IDA,ISO)

peptide binding (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

renin-angiotensin cascade pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Molecular cloning and expression of rat brain endopeptidase 3.4.24.16.	Dauch P, etal., J Biol Chem 1995 Nov 10;270(45):27266-71.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
5.	Metalloendopeptidases EC 3.4.24.15/16 regulate bradykinin activity in the cerebral microvasculature.	Norman MU, etal., Am J Physiol Heart Circ Physiol 2003 Jun;284(6):H1942-8. Epub 2003 Feb 13.
6.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
7.	Mapping sequence differences between thimet oligopeptidase and neurolysin implicates key residues in substrate recognition.	Ray K, etal., Protein Sci 2002 Sep;11(9):2237-46.
8.	GOA pipeline	RGD automated data pipeline
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Novel natural peptide substrates for endopeptidase 24.15, neurolysin, and angiotensin-converting enzyme.	Rioli V, etal., J Biol Chem. 2003 Mar 7;278(10):8547-55. doi: 10.1074/jbc.M212030200. Epub 2002 Dec 24.
11.	Characterization of a mitochondrial metallopeptidase reveals neurolysin as a homologue of thimet oligopeptidase.	Serizawa A, etal., J Biol Chem. 1995 Feb 3;270(5):2092-8.
12.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:9182559	PMID:11248043	PMID:12609826	PMID:16515556	PMID:17882707	PMID:18614015	PMID:22039052	PMID:23412923	PMID:24719317	PMID:24719333	PMID:25378390

Genomics

Comparative Map Data

Nln
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	2	35,133,634 - 35,232,927 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	35,134,145 - 35,232,914 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	42,248,083 - 42,345,656 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	2	40,306,773 - 40,404,352 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	2	35,163,341 - 35,261,069 (-)	NCBI	Rnor_WKY
Rnor_6.0	2	34,086,970 - 34,185,835 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	34,087,880 - 34,185,812 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	53,215,233 - 53,314,136 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	34,915,111 - 35,031,566 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	34,835,479 - 34,951,935 (-)	NCBI
Celera	2	31,110,866 - 31,209,296 (-)	NCBI		Celera
Cytogenetic Map	2	q12	NCBI

NLN
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	65,722,205 - 65,829,283 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	5	65,722,205 - 65,871,725 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	65,018,032 - 65,125,111 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	65,053,841 - 65,155,149 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	65,053,840 - 65,155,143	NCBI
Celera	5	62,016,491 - 62,123,591 (+)	NCBI		Celera
Cytogenetic Map	5	q12.3	NCBI
HuRef	5	61,976,109 - 62,083,226 (+)	NCBI		HuRef
CHM1_1	5	65,017,717 - 65,124,844 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	66,543,992 - 66,651,091 (+)	NCBI		T2T-CHM13v2.0

Nln
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	104,159,558 - 104,246,170 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	104,159,565 - 104,246,122 (-)	Ensembl		GRCm39 Ensembl
GRCm38	13	104,023,050 - 104,109,673 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	104,023,057 - 104,109,614 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	104,813,519 - 104,899,694 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	105,143,604 - 105,229,957 (-)	NCBI		MGSCv36	mm8
Celera	13	108,414,173 - 108,500,684 (-)	NCBI		Celera
Cytogenetic Map	13	D1	NCBI

Nln
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955446	3,256,078 - 3,374,462 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955446	3,258,278 - 3,374,337 (-)	NCBI	ChiLan1.0	ChiLan1.0

NLN
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	5	49,834,121 - 49,938,192 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	49,840,482 - 49,938,192 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	5	48,180,768 - 48,283,281 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

NLN
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	51,445,941 - 51,551,425 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	51,444,566 - 51,538,028 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	48,400,415 - 48,494,439 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	51,935,923 - 52,030,529 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	51,935,938 - 52,041,328 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	48,995,440 - 49,095,747 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	49,784,767 - 49,878,766 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	50,676,985 - 50,771,434 (+)	NCBI		UU_Cfam_GSD_1.0

Nln
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	194,447,083 - 194,544,535 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936480	3,383,540 - 3,481,009 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936480	3,383,514 - 3,480,991 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NLN
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	16	44,225,677 - 44,334,610 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	16	44,225,706 - 44,333,623 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	16	47,574,962 - 47,681,332 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NLN
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	4	61,918,079 - 62,022,517 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	4	61,918,137 - 62,016,144 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666049	10,561,550 - 10,666,098 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Nln
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624815	4,017,514 - 4,162,237 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624815	4,020,212 - 4,162,233 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Nln
309 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	86
Count of miRNA genes:	65
Interacting mature miRNAs:	78
Transcripts:	ENSRNOT00000066925
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631682	Bp115	Blood pressure QTL 115	4.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	1	37410502	Rat
738010	Lnnr3	Liver neoplastic nodule remodeling QTL 3	2.94		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	2	1	41244106	Rat
61355	Bp36	Blood pressure QTL 36	2.9		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	2	5873687	102844969	Rat
1600379	Mcs18	Mammary carcinoma susceptibility QTL 18	2.6		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	2	7887772	42804738	Rat
738012	Anxrr3	Anxiety related response QTL 3	3.8		exploratory behavior trait (VT:0010471)	percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)	2	9023519	54023519	Rat
10755430	Coatc6	Coat color QTL 6		0.02576	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	2	11591100	56591100	Rat
1578664	Bmd9	Bone mineral QTL density 9	5		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	2	11852062	49003364	Rat
731184	Mamtr4	Mammary tumor resistance QTL 4		0.0003	mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	2	16491740	61491740	Rat
1357990	Ael1	Aortic elastin QTL 1	3.1	0.00091	aorta elastin amount (VT:0003905)	aortic elastin	2	19076825	64076825	Rat
731167	Glom4	Glomerulus QTL 4	2.4	0.0082	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	2	20304672	65304672	Rat
2300168	Bmd47	Bone mineral density QTL 47	6.6	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	2	20662448	65662448	Rat
10402051	Gdil2	Gastrointestinal dilation QTL 2			enteric ganglion morphology trait (VT:0001045)	length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)	2	24903853	74786777	Rat
1302794	Stl27	Serum triglyceride level QTL 27	4.4	0.0001	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	2	25413423	143657569	Rat
1358894	Kidm24	Kidney mass QTL 24	4.03		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
1358899	Kidm23	Kidney mass QTL 23	3.88		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
1358901	Cm38	Cardiac mass QTL 38	2		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	157142209	Rat
1358904	Cm39	Cardiac mass QTL 39	2.26		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	157142209	Rat
1358910	Kidm27	Kidney mass QTL 27	5.77		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
1358911	Kidm28	Kidney mass QTL 28	5.42		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	203928301	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	203928301	Rat
1358887	Bw50	Body weight QTL 50	2.39		body mass (VT:0001259)	body weight (CMO:0000012)	2	25413652	157142078	Rat
1358908	Bw49	Body weight QTL 49	3.36		body mass (VT:0001259)	body weight (CMO:0000012)	2	25413652	157142078	Rat
1354617	Bp240	Blood pressure QTL 240	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	26917817	81754745	Rat
1354617	Bp240	Blood pressure QTL 240	4		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	26917817	81754745	Rat
1354617	Bp240	Blood pressure QTL 240	4		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	26917817	81754745	Rat
1354603	Bp243	Blood pressure QTL 243	3.9		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	26917817	127469484	Rat
2290453	Scl55	Serum cholesterol level QTL 55	2.83		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	2	26917817	136917119	Rat
1331764	Bp205	Blood pressure QTL 205	3.476		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	26999571	43154682	Rat
1643006	Pain1	Pain QTL 1	3.63	0.005	mechanical nociception trait (VT:0002734)	self mutilation severity score (CMO:0002145)	2	26999571	48268661	Rat
9590095	Sffal3	Serum free fatty acids level QTL 3	6.78	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	2	27157160	72157160	Rat
1300160	Hrtrt3	Heart rate QTL 3	3.62		heart pumping trait (VT:2000009)	absolute change in heart rate (CMO:0000534)	2	29971593	51729300	Rat
10755434	Coatc7	Coat color QTL 7		0.04794	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	2	30648065	75648065	Rat
731179	Mamtr3	Mammary tumor resistance QTL 3		0.0001	mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	2	32373770	43665178	Rat
10755436	Coatc8	Coat color QTL 8		0.02431	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	2	35023117	80023117	Rat
61371	Edpm1	Estrogen-dependent pituitary mass QTL 1	4	0.05	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	2	35134841	88029593	Rat

Markers in Region

D2Mgh1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	35,134,841 - 35,134,970 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	34,088,175 - 34,088,303	NCBI	Rnor6.0
Rnor_5.0	2	53,216,438 - 53,216,566	UniSTS	Rnor5.0
RGSC_v3.4	2	34,914,943 - 34,915,072	RGD	RGSC3.4
RGSC_v3.4	2	34,914,944 - 34,915,072	UniSTS	RGSC3.4
RGSC_v3.1	2	34,835,312 - 34,835,441	RGD
Celera	2	31,110,695 - 31,110,827	UniSTS
RH 3.4 Map	2	126.7	UniSTS
RH 3.4 Map	2	126.7	RGD
RH 2.0 Map	2	189.6	RGD
SHRSP x BN Map	2	15.0498	RGD
FHH x ACI Map	2	23.0699	RGD
Cytogenetic Map	2	q13	UniSTS

RH132947

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	35,231,684 - 35,232,738 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	34,184,591 - 34,185,644	NCBI	Rnor6.0
Rnor_5.0	2	53,312,891 - 53,313,944	UniSTS	Rnor5.0
RGSC_v3.4	2	35,030,475 - 35,031,528	UniSTS	RGSC3.4
Celera	2	31,208,205 - 31,209,258	UniSTS
RH 3.4 Map	2	139.8	UniSTS
Cytogenetic Map	2	q13	UniSTS

BM382907

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	35,135,013 - 35,135,165 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	34,088,347 - 34,088,498	NCBI	Rnor6.0
Rnor_5.0	2	53,216,610 - 53,216,761	UniSTS	Rnor5.0
RGSC_v3.4	2	34,915,116 - 34,915,267	UniSTS	RGSC3.4
Celera	2	31,110,871 - 31,111,022	UniSTS
RH 3.4 Map	2	123.4	UniSTS
Cytogenetic Map	2	q13	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	20	57	41	19	41	8	10	74	35	35	11	8
Low		23						1			6
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053970	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006231880	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006231881	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017590591	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039101583	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039101584	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039101585	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005500227	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005500228	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC129167	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC072687	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473955	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ228111	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ230641	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000065	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X87157	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000066925 ⟹ ENSRNOP00000059652

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	35,135,300 - 35,232,914 (-)	Ensembl
Rnor_6.0 Ensembl	2	34,088,342 - 34,185,682 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000082755 ⟹ ENSRNOP00000069520

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	35,134,145 - 35,197,739 (-)	Ensembl
Rnor_6.0 Ensembl	2	34,087,880 - 34,185,812 (-)	Ensembl

RefSeq Acc Id:

NM_053970 ⟹ NP_446422

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	35,135,009 - 35,232,776 (-)	NCBI
Rnor_6.0	2	34,088,342 - 34,185,682 (-)	NCBI
Rnor_5.0	2	53,215,233 - 53,314,136 (-)	NCBI
RGSC_v3.4	2	34,915,111 - 35,031,566 (-)	RGD
Celera	2	31,110,866 - 31,209,296 (-)	RGD

Sequence:

show sequence

GACGCGCCAGCTGCTGCCGGCCTCCCGGCGTGCCCATGATCACCCTGTGCCTTTCGACTCTGCG
AGGCCTCCACAGAGCTGGTGGCTCCAGGCTTCAGCTGACAATGACACTGGGAAAGGAGCTGGCT
TCTCCTCTTCAAGCTATGTCTTCCTACACTGCGGCTGGCAGGAATGTTCTCAGATGGGACCTTT
CTCCAGAGCAGATCAAGACGAGGACAGAGCAGCTCATAGCACAGACCAAGCAGGTGTACGACAC
CGTGGGGACAATCGCCCTGAAAGAAGTAACTTATGAGAACTGTCTGCAGGTGCTGGCTGACATA
GAAGTGACGTACATAGTGGAAAGGACCATGCTGGACTTCCCTCAGCACGTGTCATCTGACAGAG
AAGTGCGGGCTGCAAGCACAGAAGCAGACAAAAGGCTTTCTCGTTTTGATATTGAGATGAGCAT
GAGAGAAGATGTGTTTCAGAGAATTGTTCATTTACAAGAAACATGCGATTTGGAGAAGATAAAG
CCTGAAGCCAGGCGATACTTGGAAAAGTCAATTAAAATGGGAAAAAGGAATGGACTCCATCTTT
CAGAACACATAAGAAATGAAATCAAATCAATGAAGAAGAGAATGAGTGAGCTATGCATTGACTT
CAACAAGAACCTCAATGAGGACGACACTTCCCTTGTATTCTCCAAGGCTGAACTTGGTGCTCTT
CCTGATGACTTCATTGACAGTTTAGAAAAAACAGATGAAGACAAGTACAAAGTTACCTTAAAGT
ATCCTCACTACTTCCCTGTCATGAAGAAATGCTGTGTCCCTGAAACTCGAAGGAAGATGGAAAT
GGCTTTTCATACCAGGTGCAAACAGGAAAACACCGCAATTCTGCAACAGCTCCTCCCGCTGCGA
GCTCAAGTGGCCAAGCTGCTGGGCTATAACACCCATGCTGACTTTGTCCTTGAACTGAACACTG
CGAAGAGCACCAGCCGCGTGGCCGCCTTTCTAGATGATTTAAGCCAGAAATTGAAACCCTTGGG
TGAGGCAGAACGGGAGTTTATTTTGAGCCTGAAGAAGAAGGAATGTGAAGAGCGAGGTTTTGAA
TACGACGGGAAGATCAATGCATGGGACCTCCATTACTACATGACACAGACAGAGGAGCTCAAGT
ACTCGGTGGACCAGGAGTCCCTTAAGGAGTACTTCCCCATTGAGGTGGTCACGGAAGGCTTGCT
AAGCATCTACCAGGAGCTGCTGGGACTTTCATTTGAACAAGTGCCCGATGCTCATGTTTGGAAT
AAGAGCGTTTCACTTTACACTGTGAAGGATAAAGCTACAGGAGAGGTCCTGGGGCAGTTCTACC
TGGACCTCTATCCAAGGGAAGGAAAATACAACCATGCAGCCTGCTTCGGTCTCCAGCCAGGCTG
CCTTCTCCCTGATGGCAGTCGGATGATGTCTGTGGCCGCCCTGGTGGTCAACTTCTCTCAGCCT
GTAGCAGGTCGGCCCTCTCTCCTGAGACATGATGAAGTGCGGACTTACTTCCACGAGTTCGGTC
ACGTCATGCATCAGATCTGTGCGCAGACTGACTTTGCACGATTCAGTGGAACAAACGTGGAAAC
TGACTTTGTAGAGGTGCCATCACAAATGCTTGAAAACTGGGTGTGGGACGTTGATTCCCTGCGA
AAACTGTCAAAGCATTATAAAGATGGACACCCTATCACAGACGAGCTGCTCGAGAAGCTTGTTG
CTTCTAGGCTGGTCAACACAGGTCTTCTGACGCTGCGCCAAATTGTTTTGAGCAAAGTTGACCA
ATCTCTCCATACCAATGCGACTCTGGATGCCGCGAGCGAATACGCTAAATACTGCACAGAAATT
CTGGGAGTTGCAGCTACGCCAGGCACAAATATGCCAGCTACTTTTGGACACTTGGCAGGAGGGT
ATGATGGCCAATATTATGGATATCTTTGGAGTGAAGTGTTTTCCATGGACATGTTTCACAGCTG
TTTTAAAAAAGAGGGGATCATGAATCCAGAGGTTGGAATGAAATACAGAAACTTAATCCTGAAG
CCTGGGGGGTCCCTGGACGGCATGGACATGCTCCAGAATTTCTTGCAACGTGAGCCAAACCAAA
AAGCATTCCTAATGAGTCGAGGCCTGAATGGTTCGTAAGCCAGGGATCCTGGGAGTTGTCCATG
TCTGGAGGACAAGTCAACACTGTCATGTGGTGCCGGCCTGGAGACTGAAGAGAGTTTTACAAAA
GAAAACTTAGATTTCTATTGATTTGCTTTTGTTTTTTAATTTTAAAAATTATACAGATGTAAAT
GGAATTATAAATACTGTGACCTAAGGAAAGACCAACTAAAAATAATTGTACTATAAAGTTTCAT
AAAAATGGATTTGATTTCTTTTGATAAAAGTTTCATATGAATGTAATTTGATTTTTTTTACAGT
TATAATCCAGATAATATAATGTAAGAGGGCTAAGACATTTTAAATTGAATCACATACATGATAT
AATTTGATCCTTCTTATATCTTGAAGTTTTATACTTGCGATCTCTGGACTGATAAATGAATCAC
CACATTCTCTCTGGTAAATATTTCCTCCGAGCCCTGTGTCAACCTTGACCCTCTGCCTCAGAGC
TAGGCGACAGTCTGCCTGCGTGTGTCAAGGCCAGCACAACATGTTTCAGTAGTGTTAAAAAAAA
AAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006231880 ⟹ XP_006231942

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	35,135,539 - 35,232,925 (-)	NCBI
Rnor_6.0	2	34,097,165 - 34,185,835 (-)	NCBI
Rnor_5.0	2	53,215,233 - 53,314,136 (-)	NCBI

Sequence:

show sequence

CCACGGCGTAGGCGTGGGCCTGAAGCACGTGGGAGGGCGCTGGCAGGACTGACGGCCTCCGTCT
CGAGATCTGGTCTCCTCGGCTTGGCCCACTCCTGGCTTCCGGGCCCGCAGACACCACCGCCTGC
CTCCTGCACCTACAAGCGGGAGGACGACGCGCCAGCTGCTGCCGGCCTCCCGGCGTGCCCATGA
TCACCCTGTGCCTTTCGACTCTGCGAGGCCTCCACAGAGCTGGTGGCTCCAGGCTTCAGCTGAC
AATGACACTGGGAAAGGAGCTGGCTTCTCCTCTTCAAGCTATGTCTTCCTACACTGCGGCTGGC
AGGAATGTTCTCAGATGGGACCTTTCTCCAGAGCAGATCAAGACGAGGACAGAGCAGCTCATAG
CACAGACCAAGCAGGTGTACGACACCGTGGGGACAATCGCCCTGAAAGAAGTAACTTATGAGAA
CTGTCTGCAGGTGCTGGCTGACATAGAAGTGACGTACATAGTGGAAAGGACCATGCTGGACTTC
CCTCAGCACGTGTCATCTGACAGAGAAGTGCGGGCTGCAAGCACAGAAGCAGACAAAAGGCTTT
CTCGTTTTGATATTGAGATGAGCATGAGAGAAGATGTGTTTCAGAGAATTGTTCATTTACAAGA
AACATGCGATTTGGAGAAGATAAAGCCTGAAGCCAGGCGATACTTGGAAAAGTCAATTAAAATG
GGAAAAAGGAATGGACTCCATCTTTCAGAACACATAAGAAATGAAATCAAATCAATGAAGAAGA
GAATGAGTGAGCTATGCATTGACTTCAACAAGAACCTCAATGAGGACGACACTTCCCTTGTATT
CTCCAAGGCTGAACTTGGTGCTCTTCCTGATGACTTCATTGACAGTTTAGAAAAAACAGATGAA
GACAAGTACAAAGTTACCTTAAAGTATCCTCACTACTTCCCTGTCATGAAGAAATGCTGTGTCC
CTGAAACTCGAAGGAAGATGGAAATGGCTTTTCATACCAGGTGCAAACAGGAAAACACCGCAAT
TCTGCAACAGCTCCTCCCGCTGCGAGCTCAAGTGGCCAAGCTGCTGGGCTATAACACCCATGCT
GACTTTGTCCTTGAACTGAACACTGCGAAGAGCACCAGCCGCGTGGCCGCCTTTCTAGATGATT
TAAGCCAGAAATTGAAACCCTTGGGTGAGGCAGAACGGGAGTTTATTTTGAGCCTGAAGAAGAA
GGAATGTGAAGAGCGAGGTTTTGAATACGACGGGAAGATCAATGCATGGGACCTCCATTACTAC
ATGACACAGACAGAGGAGCTCAAGTACTCGGTGGACCAGGAGTCCCTTAAGGAGTACTTCCCCA
TTGAGGTGGTCACGGAAGGCTTGCTAAGCATCTACCAGGAGCTGCTGGGACTTTCATTTGAACA
AGTGCCCGATGCTCATGTTTGGAATAAGAGCGTTTCACTTTACACTGTGAAGGATAAAGCTACA
GGAGAGGTCCTGGGGCAGTTCTACCTGGACCTCTATCCAAGGGAAGGAAAATACAACCATGCAG
CCTGCTTCGGTCTCCAGCCAGGCTGCCTTCTCCCTGATGGCAGTCGGATGATGTCTGTGGCCGC
CCTGGTGGTCAACTTCTCTCAGCCTGTAGCAGGTCGGCCCTCTCTCCTGAGACATGATGAAGTG
CGGACTTACTTCCACGAGTTCGGTCACGTCATGCATCAGATCTGTGCGCAGACTGACTTTGCAC
GATTCAGTGGAACAAACGTGGAAACTGACTTTGTAGAGGTGCCATCACAAATGCTTGAAAACTG
GGTGTGGGACGTTGATTCCCTGCGAAAACTGTCAAAGCATTATAAAGATGGACACCCTATCACA
GACGAGCTGCTCGAGAAGCTTGTTGCTTCTAGGCTGGTCAACACAGGTCTTCTGACGCTGCGCC
AAATTGTTTTGAGCAAAGTTGACCAATCTCTCCATACCAATGCGACTCTGGATGCCGCGAGCGA
ATACGCTAAATACTGCACAGAAATTCTGGGAGTTGCAGCTACGCCAGGCACAAATATGCCAGCT
ACTTTTGGACACTTGGCAGGAGGGTATGATGGCCAATATTATGGATATCTTTGGAGTGAAGTGT
TTTCCATGGACATGTTTCACAGCTGTTTTAAAAAAGAGGGGATCATGAATCCAGAGGTTTCTTT
GTACGTTTTCTGTGGGAGGCATCCTTTTTCTGTGGCCAGCGTACTCCACCTACTACAGAGTTTG
TAACCTAAGTGCCTTTGGGGTAACTGAAGCTGCTTCATTAATCTGAGCCATTCCTTTCCAGGCA
CGGTGAGGTGGCTGCCAGGTGGCTGCCAGCCAAGCCTTCCTGGTAGAGACCCCAGTCTCCCTGC
TCATCAGCGACTTGACTGTCAATTATGTCTGAGGCTGGTATATTTCCAGTGTTTCCAAGTTCTG
TTTGGTTCAGAAATTAGAACAAATTACCTAAATCAAGCTCTCAATGCTTATTTAAATCAGCCAA
CTTGTTCTTTGGGCTTTTGTTTCTCTACTAAGTAGCACTCCTCTGCATACATATCGAAATATAT
CATGTATTTTAGGGTGCCATTTCCTCTGTCTCTCCCCCCCAAAAAAATATGTCCAGACAAGCCA
CATTAGGATTCATTCCAAGCACCCCTCTCCCATCCCATCTCGACTAGCAGGCCTTTAAGCTTCT
TTCTCTGACCCTGCCTACCGGCCACCAAGTCTGACACTGACTCCTGTTTAACATTCTGACTTTG
CATGACTTCCCGAATGTCCAGCCCTCCATCCTCCACTGTCTTGTGTCGAGATGGTGCCCTCAAT
AGGGTCTTCTGGAGAGAAACAGTGTGAGTCATTTACTTGCCCGGCTGTTGAGTCATGCTGGCTA
ACCCCAGCTGGCCCTCCAGGGCTGCTCTGCAGCCCTGCCCCATTCTCTGTTGATTGCCTTCCTC
TTAGCCCCCAGCCTGTCTACTTCACAAACTGCCTCTGCCCCTCTTTCTTGTTACCCCACCCCCA
AGCCTCACTACATAATGCAAAGTGGCATCAAACAAGTAGACCTCTCCTGCATCATCTTCCCTGG
CCCTGGGGATTGCCCAGTCTCAAAAGTAGAGGGGTAGCCTCTCAGCTCCGCCCCCCTTCTCACA
TGTATTCCTTCTGTGCGTCGTACTTTACATGGATGGTTTCTTTTAGCACACGCCTGCAGTCCCA
GCGTGTGGGAGGTAGAGGCAGGAGGATCAGGAGTTTACAATCATCTTTGGC

hide sequence

RefSeq Acc Id:

XM_039101583 ⟹ XP_038957511

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	35,133,634 - 35,232,925 (-)	NCBI

RefSeq Acc Id:

XM_039101584 ⟹ XP_038957512

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	35,133,637 - 35,232,926 (-)	NCBI

RefSeq Acc Id:

XM_039101585 ⟹ XP_038957513

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	35,153,414 - 35,232,927 (-)	NCBI

RefSeq Acc Id:

XR_005500227

RefSeq Status:

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	35,135,536 - 35,232,925 (-)	NCBI

RefSeq Acc Id:

XR_005500228

RefSeq Status:

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	35,133,637 - 35,232,926 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_446422	(Get FASTA)	NCBI Sequence Viewer
	XP_006231942	(Get FASTA)	NCBI Sequence Viewer
	XP_038957511	(Get FASTA)	NCBI Sequence Viewer
	XP_038957512	(Get FASTA)	NCBI Sequence Viewer
	XP_038957513	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH72687	(Get FASTA)	NCBI Sequence Viewer
	CAA60630	(Get FASTA)	NCBI Sequence Viewer
	EDM10254	(Get FASTA)	NCBI Sequence Viewer
	EDM10255	(Get FASTA)	NCBI Sequence Viewer
	P42676	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_446422 ⟸ NM_053970
- Peptide Label:	precursor
- UniProtKB:	P42676 (UniProtKB/Swiss-Prot), A0A0G2JSY3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MITLCLSTLRGLHRAGGSRLQLTMTLGKELASPLQAMSSYTAAGRNVLRWDLSPEQIKTRTEQL IAQTKQVYDTVGTIALKEVTYENCLQVLADIEVTYIVERTMLDFPQHVSSDREVRAASTEADKR LSRFDIEMSMREDVFQRIVHLQETCDLEKIKPEARRYLEKSIKMGKRNGLHLSEHIRNEIKSMK KRMSELCIDFNKNLNEDDTSLVFSKAELGALPDDFIDSLEKTDEDKYKVTLKYPHYFPVMKKCC VPETRRKMEMAFHTRCKQENTAILQQLLPLRAQVAKLLGYNTHADFVLELNTAKSTSRVAAFLD DLSQKLKPLGEAEREFILSLKKKECEERGFEYDGKINAWDLHYYMTQTEELKYSVDQESLKEYF PIEVVTEGLLSIYQELLGLSFEQVPDAHVWNKSVSLYTVKDKATGEVLGQFYLDLYPREGKYNH AACFGLQPGCLLPDGSRMMSVAALVVNFSQPVAGRPSLLRHDEVRTYFHEFGHVMHQICAQTDF ARFSGTNVETDFVEVPSQMLENWVWDVDSLRKLSKHYKDGHPITDELLEKLVASRLVNTGLLTL RQIVLSKVDQSLHTNATLDAASEYAKYCTEILGVAATPGTNMPATFGHLAGGYDGQYYGYLWSE VFSMDMFHSCFKKEGIMNPEVGMKYRNLILKPGGSLDGMDMLQNFLQREPNQKAFLMSRGLNGS hide sequence

RefSeq Acc Id:

XP_006231942 ⟸ XM_006231880

- Peptide Label:

isoform X3

- Sequence:

show sequence

MITLCLSTLRGLHRAGGSRLQLTMTLGKELASPLQAMSSYTAAGRNVLRWDLSPEQIKTRTEQL
IAQTKQVYDTVGTIALKEVTYENCLQVLADIEVTYIVERTMLDFPQHVSSDREVRAASTEADKR
LSRFDIEMSMREDVFQRIVHLQETCDLEKIKPEARRYLEKSIKMGKRNGLHLSEHIRNEIKSMK
KRMSELCIDFNKNLNEDDTSLVFSKAELGALPDDFIDSLEKTDEDKYKVTLKYPHYFPVMKKCC
VPETRRKMEMAFHTRCKQENTAILQQLLPLRAQVAKLLGYNTHADFVLELNTAKSTSRVAAFLD
DLSQKLKPLGEAEREFILSLKKKECEERGFEYDGKINAWDLHYYMTQTEELKYSVDQESLKEYF
PIEVVTEGLLSIYQELLGLSFEQVPDAHVWNKSVSLYTVKDKATGEVLGQFYLDLYPREGKYNH
AACFGLQPGCLLPDGSRMMSVAALVVNFSQPVAGRPSLLRHDEVRTYFHEFGHVMHQICAQTDF
ARFSGTNVETDFVEVPSQMLENWVWDVDSLRKLSKHYKDGHPITDELLEKLVASRLVNTGLLTL
RQIVLSKVDQSLHTNATLDAASEYAKYCTEILGVAATPGTNMPATFGHLAGGYDGQYYGYLWSE
VFSMDMFHSCFKKEGIMNPEVSLYVFCGRHPFSVASVLHLLQSL

hide sequence

RefSeq Acc Id:

ENSRNOP00000069520 ⟸ ENSRNOT00000082755

RefSeq Acc Id:

ENSRNOP00000059652 ⟸ ENSRNOT00000066925

RefSeq Acc Id:	XP_038957511 ⟸ XM_039101583
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038957512 ⟸ XM_039101584
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038957513 ⟸ XM_039101585
- Peptide Label:	isoform X4

Protein Domains

Peptidase_M3

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P42676-F1-model_v2	AlphaFold	P42676	1-704	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691119

Promoter ID:

EPDNEW_R1644

Type:

initiation region

Name:

Nln_1

Description:

neurolysin

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	34,185,744 - 34,185,804	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621518	AgrOrtholog
BioCyc Gene	G2FUF-54558	BioCyc
Ensembl Genes	ENSRNOG00000011561	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000059652	ENTREZGENE
	ENSRNOP00000059652.1	UniProtKB/TrEMBL
	ENSRNOP00000069520.2	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000066925	ENTREZGENE
	ENSRNOT00000066925.2	UniProtKB/TrEMBL
	ENSRNOT00000082755.2	UniProtKB/TrEMBL
Gene3D-CATH	1.10.1370.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	1.20.1050.40	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.40.390.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7099208	IMAGE-MGC_LOAD
InterPro	MetalloPept_cat_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Neurolysin/TOP_dom2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Neurolysin/TOP_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Pept_M3A_M3B	UniProtKB/Swiss-Prot
	Pept_M3A_M3B	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Pept_M3A_M3B	UniProtKB/TrEMBL
KEGG Report	rno:117041	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:91547	IMAGE-MGC_LOAD
NCBI Gene	117041	ENTREZGENE
PANTHER	PTHR11804	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Peptidase_M3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Nln	PhenoGen
PROSITE	ZINC_PROTEASE	UniProtKB/Swiss-Prot
UniProt	A0A0G2JSY3	ENTREZGENE, UniProtKB/TrEMBL
	A0A0G2JVK4_RAT	UniProtKB/TrEMBL
	NEUL_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary	Q6GQQ4	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-03	Nln	neurolysin	Nln	neurolysin (metallopeptidase M3 family)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Nln	neurolysin (metallopeptidase M3 family)			Symbol and Name status set to approved	1299863	APPROVED
2002-08-07	Nln	neurolysin (metallopeptidase M3 family)			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed in brain, ileum, kidney, and testis	729279
gene_protein	704-amino acid protein	729279

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)