Mapk8 (mitogen-activated protein kinase 8) - Rat Genome Database

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Gene: Mapk8 (mitogen-activated protein kinase 8) Rattus norvegicus
Symbol: Mapk8
Name: mitogen-activated protein kinase 8
RGD ID: 621506
Description: Enables JUN kinase activity and kinesin binding activity. Involved in several processes, including SMAD protein signal transduction; regulation of apoptotic process; and regulation of nucleobase-containing compound metabolic process. Acts upstream of or within neuronal stem cell population maintenance. Located in several cellular components, including axon; dendrite cytoplasm; and perikaryon. Used to study Parkinsonism; alcohol use disorder; brain ischemia; hypertension; and type 2 diabetes mellitus. Biomarker of anti-basement membrane glomerulonephritis; metabolic dysfunction-associated steatotic liver disease; and myocardial infarction. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm; chronic mucocutaneous candidiasis; colorectal adenoma; rectal benign neoplasm; and type 2 diabetes mellitus. Orthologous to human MAPK8 (mitogen-activated protein kinase 8); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; inflammatory response pathway; Rho/Rac/Cdc42 mediated signaling pathway; INTERACTS WITH (-)-anisomycin; (R)-lipoic acid; (R)-noradrenaline.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: c-Jun N-terminal kinase 1; c-jun NH2-terminal kinase; JNK; MAP kinase 8; MAPK 8; p54 gamma; SAPK gamma; stress-activated protein kinase JNK1
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8168,645,171 - 8,728,225 (-)NCBIGRCr8
mRatBN7.2168,638,897 - 8,721,960 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl168,638,924 - 8,721,981 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx168,658,229 - 8,741,022 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0169,802,931 - 9,885,718 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0168,652,731 - 8,735,493 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0169,620,854 - 9,709,342 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl169,625,177 - 9,709,347 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01611,579,503 - 11,662,858 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4168,925,133 - 9,004,897 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1168,925,181 - 9,004,945 (-)NCBI
Celera166,485,592 - 6,568,388 (+)NCBICelera
Cytogenetic Map16p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Acute Liver Failure  (ISO)
Acute Otitis Media  (ISO)
alcohol use disorder  (IDA)
Alzheimer's disease  (ISO)
Animal Disease Models  (ISO)
anogenital venereal wart  (ISO)
anti-basement membrane glomerulonephritis  (IEP)
Arenaviridae infectious disease  (ISO)
atopic dermatitis  (ISO)
bacterial pneumonia  (ISO)
brain ischemia  (IDA)
candidiasis  (ISO)
Cardiomegaly  (ISO)
chronic mucocutaneous candidiasis  (ISO)
chronic obstructive pulmonary disease  (ISO)
Cockayne syndrome B  (ISO)
Colonic Neoplasms  (ISO)
colorectal adenocarcinoma  (ISO)
colorectal adenoma  (ISO)
Contrast-Induced Nephropathy  (IDA)
dengue disease  (ISO)
endometriosis  (ISO)
Endotoxemia  (IEP)
extrahepatic cholestasis  (ISO)
Helicobacter Infections  (ISO)
hepatitis  (ISO)
hepatocellular carcinoma  (ISO)
Hyperalgesia  (ISO)
hypertension  (IDA)
Infectious Ectromelia  (ISO)
influenza A  (ISO)
Intestinal Neoplasms  (ISO)
Kuhnt-Junius degeneration  (ISO)
Liver Reperfusion Injury  (IEP)
megacolon  (ISO)
metabolic dysfunction-associated steatotic liver disease  (IEP)
myocardial infarction  (IEP)
Myocardial Reperfusion Injury  (IDA,IEP)
Neoplastic Cell Transformation  (ISO)
Oxygen-Induced Retinopathy  (ISO)
pancreatic adenocarcinoma  (ISO)
pancreatic ductal adenocarcinoma  (ISO)
Parkinsonism  (IDA)
pre-malignant neoplasm  (ISO)
Pseudomonas Infections  (ISO)
rectal benign neoplasm  (ISO)
Reperfusion Injury  (IDA,ISO)
schizophrenia  (ISO)
Sepsis  (IDA)
steatotic liver disease  (ISO)
Stomach Neoplasms  (ISO)
Stroke  (IDA)
trigeminal neuralgia  (ISO)
type 2 diabetes mellitus  (IDA,ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View