Mapk8 (mitogen-activated protein kinase 8) - Rat Genome Database

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Gene: Mapk8 (mitogen-activated protein kinase 8) Rattus norvegicus
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Symbol: Mapk8
Name: mitogen-activated protein kinase 8
RGD ID: 621506
Description: Enables JUN kinase activity and kinesin binding activity. Involved in several processes, including SMAD protein signal transduction; regulation of apoptotic process; and regulation of nucleobase-containing compound metabolic process. Acts upstream of or within neuronal stem cell population maintenance. Located in several cellular components, including axon; dendrite cytoplasm; and perikaryon. Used to study Parkinsonism; alcohol use disorder; brain ischemia; hypertension; and type 2 diabetes mellitus. Biomarker of anti-basement membrane glomerulonephritis; metabolic dysfunction-associated steatotic liver disease; and myocardial infarction. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm; chronic mucocutaneous candidiasis; colorectal adenoma; rectal benign neoplasm; and type 2 diabetes mellitus. Orthologous to human MAPK8 (mitogen-activated protein kinase 8); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; inflammatory response pathway; Rho/Rac/Cdc42 mediated signaling pathway; INTERACTS WITH (+)-taxifolin; (-)-anisomycin; (R)-lipoic acid.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: c-Jun N-terminal kinase 1; c-jun NH2-terminal kinase; JNK; MAP kinase 8; MAPK 8; p54 gamma; SAPK gamma; stress-activated protein kinase JNK1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8168,645,171 - 8,728,225 (-)NCBIGRCr8
mRatBN7.2168,638,897 - 8,721,960 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl168,638,924 - 8,721,981 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx168,658,229 - 8,741,022 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0169,802,931 - 9,885,718 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0168,652,731 - 8,735,493 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0169,620,854 - 9,709,342 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl169,625,177 - 9,709,347 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01611,579,503 - 11,662,858 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4168,925,133 - 9,004,897 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1168,925,181 - 9,004,945 (-)NCBI
Celera166,485,592 - 6,568,388 (+)NCBICelera
Cytogenetic Map16p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
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