Kcnq2 Rat 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene multiple interactions ISO Kcnq2 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Kcnq2 Rat 1,2-dichloroethane increases expression ISO Kcnq2 (Mus musculus) 6480464 ethylene dichloride results in increased expression of KCNQ2 mRNA CTD PMID:28960355 Kcnq2 Rat 17alpha-ethynylestradiol multiple interactions ISO Kcnq2 (Mus musculus) 6480464 ESR1 gene mutant form inhibits the reaction [Ethinyl Estradiol results in increased expression of KCNQ2 more ... CTD PMID:29112739 Kcnq2 Rat 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of KCNQ2 mRNA CTD PMID:29097150 Kcnq2 Rat 17alpha-ethynylestradiol increases expression ISO Kcnq2 (Mus musculus) 6480464 Ethinyl Estradiol results in increased expression of KCNQ2 mRNA CTD PMID:29112739 Kcnq2 Rat 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO Kcnq2 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Kcnq2 Rat 2,2',4,4'-Tetrabromodiphenyl ether increases expression ISO Kcnq2 (Mus musculus) 6480464 2,2',4,4'-tetrabromodiphenyl ether results in increased expression of KCNQ2 mRNA CTD PMID:29112739 Kcnq2 Rat 2,2',4,4'-Tetrabromodiphenyl ether multiple interactions ISO Kcnq2 (Mus musculus) 6480464 ESR1 gene mutant form inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of KCNQ2 more ... CTD PMID:29112739 Kcnq2 Rat 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO Kcnq2 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Kcnq2 Rat 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO Kcnq2 (Mus musculus) 6480464 AHR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of KCNQ2 mRNA] CTD PMID:16891777 Kcnq2 Rat 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO Kcnq2 (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in increased expression of KCNQ2 mRNA CTD PMID:16891777 Kcnq2 Rat 2,3,7,8-Tetrachlorodibenzofuran decreases expression EXP 6480464 2,3,7,8-tetrachlorodibenzofuran results in decreased expression of KCNQ2 mRNA CTD PMID:32109520 Kcnq2 Rat 2,4,4'-trichlorobiphenyl multiple interactions ISO Kcnq2 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Kcnq2 Rat 2-methylcholine affects expression ISO KCNQ2 (Homo sapiens) 6480464 beta-methylcholine affects the expression of KCNQ2 mRNA CTD PMID:21179406 Kcnq2 Rat 3,4-methylenedioxymethamphetamine decreases expression ISO Kcnq2 (Mus musculus) 6480464 N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of KCNQ2 mRNA CTD PMID:20188158 Kcnq2 Rat 3,7-dihydropurine-6-thione decreases expression EXP 6480464 Mercaptopurine results in decreased expression of KCNQ2 mRNA CTD PMID:23358152 Kcnq2 Rat 5-fluorouracil multiple interactions ISO KCNQ2 (Homo sapiens) 6480464 TP53 protein affects the reaction [Fluorouracil results in decreased expression of KCNQ2 mRNA] CTD PMID:15016801 Kcnq2 Rat acrylamide multiple interactions ISO KCNQ2 (Homo sapiens) 6480464 Acrylamide analog affects the activity of [KCNQ2 protein binds to KCNQ3 protein] CTD PMID:16904708 Kcnq2 Rat acrylamide increases activity ISO Kcnq2 (Mus musculus) 6480464 Acrylamide analog results in increased activity of KCNQ2 protein CTD PMID:15139767|PMID:15357987|PMID:15603955 Kcnq2 Rat acrylamide affects activity ISO KCNQ2 (Homo sapiens) 6480464 Acrylamide analog affects the activity of KCNQ2 protein CTD PMID:16904708 Kcnq2 Rat Aflatoxin B2 alpha increases methylation ISO KCNQ2 (Homo sapiens) 6480464 aflatoxin B2 results in increased methylation of KCNQ2 intron CTD PMID:30157460 Kcnq2 Rat all-trans-retinoic acid decreases expression ISO KCNQ2 (Homo sapiens) 6480464 Tretinoin results in decreased expression of KCNQ2 mRNA CTD PMID:21934132 Kcnq2 Rat ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of KCNQ2 mRNA CTD PMID:16483693 Kcnq2 Rat aristolochic acid A increases expression ISO KCNQ2 (Homo sapiens) 6480464 aristolochic acid I results in increased expression of KCNQ2 mRNA CTD PMID:33212167 Kcnq2 Rat arsane affects methylation ISO KCNQ2 (Homo sapiens) 6480464 Arsenic affects the methylation of KCNQ2 gene CTD PMID:25304211 Kcnq2 Rat arsenic atom affects methylation ISO KCNQ2 (Homo sapiens) 6480464 Arsenic affects the methylation of KCNQ2 gene CTD PMID:25304211 Kcnq2 Rat arsenite(3-) increases methylation ISO KCNQ2 (Homo sapiens) 6480464 arsenite results in increased methylation of KCNQ2 promoter CTD PMID:23974009 Kcnq2 Rat arsenite(3-) multiple interactions ISO KCNQ2 (Homo sapiens) 6480464 arsenite promotes the reaction [G3BP1 protein binds to KCNQ2 mRNA] CTD PMID:32406909 Kcnq2 Rat astemizole multiple interactions ISO KCNQ2 (Homo sapiens) 6480464 Astemizole inhibits the reaction [Histamine results in decreased activity of [KCNQ2 protein co-treated with KCNQ3 more ... CTD PMID:12147327 Kcnq2 Rat benzimidazoles multiple interactions ISO KCNQ2 (Homo sapiens) 6480464 [Benzimidazoles analog results in increased activity of [KCNQ3 protein binds to KCNQ2 protein]] which results more ... CTD PMID:21723881 Kcnq2 Rat benzo[a]pyrene affects methylation ISO KCNQ2 (Homo sapiens) 6480464 Benzo(a)pyrene affects the methylation of KCNQ2 3' UTR; Benzo(a)pyrene affects the methylation of KCNQ2 intron; more ... CTD PMID:27901495|PMID:30157460 Kcnq2 Rat benzo[a]pyrene increases methylation ISO KCNQ2 (Homo sapiens) 6480464 Benzo(a)pyrene results in increased methylation of KCNQ2 exon CTD PMID:27901495 Kcnq2 Rat bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of KCNQ2 mRNA CTD PMID:25181051 Kcnq2 Rat bisphenol A decreases expression ISO Kcnq2 (Mus musculus) 6480464 bisphenol A results in decreased expression of KCNQ2 mRNA CTD PMID:32156529 Kcnq2 Rat bisphenol A increases expression ISO Kcnq2 (Mus musculus) 6480464 bisphenol A results in increased expression of KCNQ2 mRNA CTD PMID:31250031 Kcnq2 Rat bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of KCNQ2 mRNA CTD PMID:29097150|PMID:30816183 Kcnq2 Rat Bisphenol B decreases expression ISO KCNQ2 (Homo sapiens) 6480464 bisphenol B results in decreased expression of KCNQ2 mRNA CTD PMID:32387340 Kcnq2 Rat cadmium dichloride increases expression ISO KCNQ2 (Homo sapiens) 6480464 Cadmium Chloride results in increased expression of KCNQ2 mRNA CTD PMID:12160620|PMID:38568856 Kcnq2 Rat CGP 52608 multiple interactions ISO KCNQ2 (Homo sapiens) 6480464 CGP 52608 promotes the reaction [RORA protein binds to KCNQ2 gene] CTD PMID:28238834 Kcnq2 Rat chlorpyrifos increases expression ISO Kcnq2 (Mus musculus) 6480464 Chlorpyrifos results in increased expression of KCNQ2 mRNA CTD PMID:37019170 Kcnq2 Rat choline multiple interactions ISO Kcnq2 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation more ... CTD PMID:20938992 Kcnq2 Rat copper atom increases expression EXP 6480464 Copper deficiency results in increased expression of KCNQ2 mRNA CTD PMID:26033743 Kcnq2 Rat copper(0) increases expression EXP 6480464 Copper deficiency results in increased expression of KCNQ2 mRNA CTD PMID:26033743 Kcnq2 Rat cypermethrin decreases expression ISO KCNQ2 (Homo sapiens) 6480464 cypermethrin results in decreased expression of KCNQ2 protein CTD PMID:36063984 Kcnq2 Rat dorsomorphin multiple interactions ISO KCNQ2 (Homo sapiens) 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... CTD PMID:27188386 Kcnq2 Rat doxorubicin increases expression ISO Kcnq2 (Mus musculus) 6480464 Doxorubicin results in increased expression of KCNQ2 mRNA CTD PMID:36227756 Kcnq2 Rat ethanol affects expression ISO Kcnq2 (Mus musculus) 6480464 Ethanol affects the expression of KCNQ2 mRNA CTD PMID:30319688 Kcnq2 Rat ezogabine multiple interactions ISO Kcnq2 (Mus musculus) 6480464 ezogabine affects the reaction [[Potassium results in increased activity of KCNQ2 protein] which results in more ... CTD PMID:15634793 Kcnq2 Rat ezogabine affects activity ISO KCNQ2 (Homo sapiens) 6480464 ezogabine affects the activity of KCNQ2 protein CTD PMID:26627826 Kcnq2 Rat folic acid multiple interactions ISO Kcnq2 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation more ... CTD PMID:20938992 Kcnq2 Rat histamine multiple interactions ISO KCNQ2 (Homo sapiens) 6480464 Astemizole inhibits the reaction [Histamine results in decreased activity of [KCNQ2 protein co-treated with KCNQ3 more ... CTD PMID:12147327 Kcnq2 Rat indole-3-methanol affects expression EXP 6480464 indole-3-carbinol affects the expression of KCNQ2 mRNA CTD PMID:21396975 Kcnq2 Rat kainic acid increases response to substance ISO KCNQ2 (Homo sapiens) 6480464 KCNQ2 protein mutant form results in increased susceptibility to Kainic Acid CTD PMID:26910900 Kcnq2 Rat L-methionine multiple interactions ISO Kcnq2 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation more ... CTD PMID:20938992 Kcnq2 Rat mancozeb increases activity EXP 6480464 mancozeb results in increased activity of KCNQ2 protein CTD PMID:23542819 Kcnq2 Rat manganese(II) chloride increases expression EXP 6480464 manganese chloride results in increased expression of KCNQ2 mRNA CTD PMID:28801915 Kcnq2 Rat mercaptopurine decreases expression EXP 6480464 Mercaptopurine results in decreased expression of KCNQ2 mRNA CTD PMID:23358152 Kcnq2 Rat mercury dibromide decreases expression ISO KCNQ2 (Homo sapiens) 6480464 mercuric bromide results in decreased expression of KCNQ2 mRNA CTD PMID:26272509 Kcnq2 Rat mercury dibromide multiple interactions ISO KCNQ2 (Homo sapiens) 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... CTD PMID:27188386 Kcnq2 Rat methotrexate decreases expression ISO KCNQ2 (Homo sapiens) 6480464 Methotrexate results in decreased expression of KCNQ2 mRNA CTD PMID:24449571 Kcnq2 Rat methoxychlor affects methylation EXP 6480464 Methoxychlor affects the methylation of KCNQ2 gene CTD PMID:35440735 Kcnq2 Rat N-ethyl-N-nitrosourea increases mutagenesis ISO Kcnq2 (Mus musculus) 6480464 Ethylnitrosourea results in increased mutagenesis of KCNQ2 exon CTD PMID:16464983 Kcnq2 Rat N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of KCNQ2 mRNA CTD PMID:20360939 Kcnq2 Rat paracetamol decreases expression ISO KCNQ2 (Homo sapiens) 6480464 Acetaminophen results in decreased expression of KCNQ2 mRNA CTD PMID:22230336 Kcnq2 Rat PCB138 multiple interactions ISO Kcnq2 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Kcnq2 Rat pentetrazol increases response to substance ISO KCNQ2 (Homo sapiens) 6480464 KCNQ2 protein mutant form results in increased susceptibility to Pentylenetetrazole CTD PMID:26910900 Kcnq2 Rat phenethyl caffeate multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of KCNQ2 mRNA CTD PMID:20360939 Kcnq2 Rat phenylmercury acetate decreases expression ISO KCNQ2 (Homo sapiens) 6480464 Phenylmercuric Acetate results in decreased expression of KCNQ2 mRNA CTD PMID:26272509 Kcnq2 Rat phenylmercury acetate multiple interactions ISO KCNQ2 (Homo sapiens) 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... CTD PMID:27188386 Kcnq2 Rat potassium atom multiple interactions ISO Kcnq2 (Mus musculus) 6480464 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone affects the reaction [[Potassium results in increased activity of KCNQ2 protein] which results in more ... CTD PMID:15634793 Kcnq2 Rat potassium atom increases activity ISO Kcnq2 (Mus musculus) 6480464 Potassium results in increased activity of KCNQ2 protein CTD PMID:15634793 Kcnq2 Rat purine-6-thiol decreases expression EXP 6480464 Mercaptopurine results in decreased expression of KCNQ2 mRNA CTD PMID:23358152 Kcnq2 Rat SB 431542 multiple interactions ISO KCNQ2 (Homo sapiens) 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... CTD PMID:27188386 Kcnq2 Rat sodium arsenite increases expression ISO KCNQ2 (Homo sapiens) 6480464 sodium arsenite results in increased expression of KCNQ2 mRNA CTD PMID:17879257|PMID:38568856 Kcnq2 Rat sodium arsenite decreases expression ISO Kcnq2 (Mus musculus) 6480464 sodium arsenite results in decreased expression of KCNQ2 mRNA CTD PMID:37682722 Kcnq2 Rat thallium atom increases import ISO KCNQ2 (Homo sapiens) 6480464 KCNQ2 protein results in increased import of Thallium CTD PMID:21723881 Kcnq2 Rat thallium atom multiple interactions ISO KCNQ2 (Homo sapiens) 6480464 [Benzimidazoles analog results in increased activity of [KCNQ3 protein binds to KCNQ2 protein]] which results more ... CTD PMID:21723881 Kcnq2 Rat thallium atom multiple interactions ISO Kcnq2 (Mus musculus) 6480464 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone affects the reaction [[Potassium results in increased activity of KCNQ2 protein] which results in more ... CTD PMID:15634793 Kcnq2 Rat thifluzamide decreases expression ISO KCNQ2 (Homo sapiens) 6480464 thifluzamide results in decreased expression of KCNQ2 mRNA CTD PMID:33512557 Kcnq2 Rat titanium dioxide decreases methylation ISO Kcnq2 (Mus musculus) 6480464 titanium dioxide results in decreased methylation of KCNQ2 gene CTD PMID:35295148 Kcnq2 Rat triphenyl phosphate multiple interactions ISO Kcnq2 (Mus musculus) 6480464 [tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in increased expression of KCNQ2 more ... CTD PMID:29112739 Kcnq2 Rat triptonide increases expression ISO Kcnq2 (Mus musculus) 6480464 triptonide results in increased expression of KCNQ2 mRNA CTD PMID:33045310 Kcnq2 Rat valproic acid affects expression ISO KCNQ2 (Homo sapiens) 6480464 Valproic Acid affects the expression of KCNQ2 mRNA CTD PMID:25979313 Kcnq2 Rat valproic acid increases methylation ISO KCNQ2 (Homo sapiens) 6480464 Valproic Acid results in increased methylation of KCNQ2 gene CTD PMID:29154799 Kcnq2 Rat valproic acid affects splicing EXP 6480464 Valproic Acid affects the splicing of KCNQ2 mRNA CTD PMID:29427782