Kcnq1 (potassium voltage-gated channel subfamily Q member 1) - Rat Genome Database

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Gene: Kcnq1 (potassium voltage-gated channel subfamily Q member 1) Rattus norvegicus
Analyze
Symbol: Kcnq1
Name: potassium voltage-gated channel subfamily Q member 1
RGD ID: 621503
Description: Enables delayed rectifier potassium channel activity; identical protein binding activity; and outward rectifier potassium channel activity. Involved in several processes, including male gonad development; regulation of secretion; and response to anesthetic. Located in basolateral plasma membrane; sarcolemma; and zymogen granule membrane. Is integral component of plasma membrane. Part of voltage-gated potassium channel complex. Used to study hypertension and long QT syndrome. Human ortholog(s) of this gene implicated in heart conduction disease (multiple) and long QT syndrome (multiple). Orthologous to human KCNQ1 (potassium voltage-gated channel subfamily Q member 1); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; KQT-like 1; Kvlqt1; potassium channel, voltage-gated KQT-like subfamily Q, member 1; potassium voltage-gated channel subfamily KQT member 1; potassium voltage-gated channel, KQT-like subfamily, member 1; potassium voltage-gated channel, subfamily Q, member 1; voltage-gated potassium channel subunit Kv7.1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Kcnq1em9Mcwi   Kcnq1em14Mcwi   Kcnq1dfk   Kcnq1em5Mcwi  
Genetic Models: WTC-Kcnq1dfkKyo SS-Kcnq1em5Mcwi SS-Kcnq1em14Mcwi SS-Kcnq1em9Mcwi
Is Marker For: Strains:   WTC-Kcnq1dfkKyo  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21198,291,711 - 198,624,683 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1198,291,766 - 198,624,669 (+)Ensembl
Rnor_6.01216,293,087 - 216,630,339 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1216,293,087 - 216,630,339 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01223,154,713 - 223,490,458 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41203,383,401 - 203,803,687 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11203,536,853 - 203,957,140 (+)NCBI
Celera1195,860,199 - 196,193,008 (+)NCBICelera
Cytogenetic Map1q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-ropivacaine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-(hydroxymethyl)cytosine  (ISO)
8-Br-cAMP  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aprindine  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atenolol  (ISO)
barium chloride  (ISO)
barium(0)  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bupivacaine  (ISO)
butanal  (ISO)
C60 fullerene  (EXP)
carbon nanotube  (ISO)
chlordecone  (ISO)
Chromanol 293B  (ISO)
clofibrate  (ISO)
daunorubicin  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
folic acid  (ISO)
glycidol  (EXP)
isoprenaline  (EXP,ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
mepivacaine  (ISO)
methapyrilene  (ISO)
mitoxantrone  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
naphthalene  (ISO)
pentanal  (ISO)
phenylmercury acetate  (ISO)
piperonyl butoxide  (ISO)
potassium atom  (ISO)
propranolol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
Terfenadine  (ISO)
testosterone  (EXP)
tributylstannane  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vanadium atom  (EXP)
vanadium(0)  (EXP)
vinclozolin  (EXP)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenergic receptor signaling pathway  (IEA,ISO)
atrial cardiac muscle cell action potential  (ISO)
auditory receptor cell development  (IEA,ISO)
cardiac conduction  (ISO)
cardiac muscle contraction  (ISO)
cellular chloride ion homeostasis  (IEA,ISO)
cellular response to cAMP  (IEA,ISO)
cellular response to epinephrine stimulus  (IEA,ISO)
cellular response to xenobiotic stimulus  (IEA,ISO)
chloride ion homeostasis  (ISO)
circulatory system development  (ISO)
cochlea development  (IEA,ISO)
corticosterone secretion  (IEA,ISO)
detection of mechanical stimulus involved in sensory perception of sound  (IEA,ISO)
erythrocyte differentiation  (IEA,ISO)
gastric acid secretion  (ISO)
gastrin-induced gastric acid secretion  (IEA,ISO)
gene expression  (IEA,ISO)
glucose metabolic process  (IEA,ISO)
heart development  (IEA,ISO)
inner ear development  (ISO,ISS)
inner ear morphogenesis  (IEA,ISO)
intestinal absorption  (IMP)
iodide transport  (IEA,ISO)
male gonad development  (IEP)
membrane repolarization  (ISO,ISS)
membrane repolarization during action potential  (ISO)
membrane repolarization during atrial cardiac muscle cell action potential  (IEA,ISO)
membrane repolarization during cardiac muscle cell action potential  (ISO)
membrane repolarization during ventricular cardiac muscle cell action potential  (IBA,IEA,ISO)
negative regulation of delayed rectifier potassium channel activity  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of insulin secretion  (IDA)
negative regulation of voltage-gated potassium channel activity  (ISO)
neuromuscular process  (IEA,ISO)
non-motile cilium assembly  (IEA,ISO)
obsolete gene silencing  (IEA)
positive regulation of cardiac muscle contraction  (IEA,ISO)
positive regulation of gastric acid secretion  (IMP)
positive regulation of heart rate  (IEA,ISO)
positive regulation of potassium ion transmembrane transport  (IEA,ISO)
potassium ion export across plasma membrane  (IBA,IEA,ISO)
potassium ion homeostasis  (ISO)
potassium ion import across plasma membrane  (IEA,ISO)
potassium ion transmembrane transport  (IBA,IEA,ISO)
potassium ion transport  (IDA)
regulation of atrial cardiac muscle cell membrane repolarization  (IEA,ISO)
regulation of blood pressure  (IEA,ISO)
regulation of gastric acid secretion  (IEA,ISO,ISS)
regulation of gene expression by genetic imprinting  (IEA,ISO)
regulation of heart rate  (ISO)
regulation of heart rate by cardiac conduction  (IEA,ISO)
regulation of ion transmembrane transport  (IEA)
regulation of membrane potential  (IDA)
regulation of membrane repolarization  (ISO)
regulation of transporter activity  (ISO)
regulation of ventricular cardiac muscle cell membrane repolarization  (IEA,ISO)
regulation of voltage-gated sodium channel activity  (IEA,ISO)
renal absorption  (IEA,ISO,ISS)
renal sodium ion absorption  (ISO)
response to anesthetic  (IDA)
response to epinephrine  (ISO)
response to insulin  (IEA,ISO)
response to nicotine  (IEA,ISO)
rhythmic behavior  (IEA,ISO)
sensory perception of sound  (ISO)
social behavior  (IEA,ISO)
sodium ion transport  (IEA,ISO)
stomach development  (IEA,ISO)
ventricular cardiac muscle cell action potential  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway  (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
1. Alzamora R, etal., J Physiol. 2011 Nov 1;589(Pt 21):5091-107. doi: 10.1113/jphysiol.2011.215772. Epub 2011 Sep 12.
2. Amin AS, etal., Eur Heart J. 2012 Mar;33(6):714-23. doi: 10.1093/eurheartj/ehr473. Epub 2011 Dec 23.
3. Chen X, etal., Vascul Pharmacol. 2002 Jul;39(1-2):33-8.
4. Chen YH, etal., Science. 2003 Jan 10;299(5604):251-4.
5. Chouabe C, etal., EMBO J. 1997 Sep 1;16(17):5472-9.
6. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Gohma H, etal., Physiol Genomics. 2006 Feb 14;24(3):198-206. Epub 2005 Dec 20.
8. Grahammer F, etal., Gastroenterology. 2001 May;120(6):1363-71.
9. Kaufhold MA, etal., Gastroenterology. 2008 Apr;134(4):1058-69. Epub 2008 Jan 18.
10. Kunzelmann K, etal., J Membr Biol 2001 Jan 15,;179(2):155-64.
11. Kuwamura M, etal., Vet Pathol. 2008 Jul;45(4):586-91.
12. Lee WK, etal., Am J Physiol Cell Physiol. 2008 Apr;294(4):C879-92. Epub 2008 Jan 23.
13. Liao T, etal., Am J Physiol Cell Physiol. 2005 Sep;289(3):C564-75. Epub 2005 Apr 20.
14. MGD data from the GO Consortium
15. Nakajo K, etal., Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):18862-7. doi: 10.1073/pnas.1010354107. Epub 2010 Oct 20.
16. NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. Ohya S, etal., Am J Physiol Gastrointest Liver Physiol 2002 Feb;282(2):G277-87.
18. OMIM Disease Annotation Pipeline
19. Pipeline to import SMPDB annotations from SMPDB into RGD
20. Rapetti-Mauss R, etal., J Physiol. 2013 Jun 1;591(Pt 11):2813-31. doi: 10.1113/jphysiol.2013.251678. Epub 2013 Mar 25.
21. Rasmussen HB, etal., Am J Physiol Heart Circ Physiol 2004 Apr;286(4):H1300-9. Epub 2003 Dec 11.
22. RGD automated data pipeline
23. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. RGD automated import pipeline for gene-chemical interactions
25. Tester DJ, etal., Heart Rhythm. 2005 May;2(5):507-17.
26. Tsevi I, etal., J Cell Physiol. 2005 Feb;202(2):400-10.2: id: 27199802 Error occurred: Document retrieval error: document does notexist
27. Ullrich S, etal., Pflugers Arch. 2005 Dec;451(3):428-36. Epub 2005 Aug 30.
28. Vallon V, etal., Proc Natl Acad Sci U S A. 2005 Dec 6;102(49):17864-9. Epub 2005 Nov 28.
29. Wang Z, etal., Mol Genet Metab. 2002 Apr;75(4):308-16.
30. Yamada Y, etal., Biochem Biophys Res Commun 2002 Jun 7;294(2):199-204.
Additional References at PubMed
PMID:8528244   PMID:8900282   PMID:8900283   PMID:9108097   PMID:9305853   PMID:9314834   PMID:9354802   PMID:10400998   PMID:10646604   PMID:11101505   PMID:11120752   PMID:11299204  
PMID:11799244   PMID:12324418   PMID:12410230   PMID:15004216   PMID:15340049   PMID:16002409   PMID:16452155   PMID:16476578   PMID:17289006   PMID:17556370   PMID:17631610   PMID:18093912  
PMID:18165683   PMID:18331828   PMID:19006182   PMID:19372749   PMID:19491250   PMID:19646991   PMID:20196769   PMID:20533308   PMID:20861072   PMID:21228319   PMID:21957902   PMID:22024150  
PMID:22251082   PMID:22348007   PMID:24184248   PMID:24269949   PMID:24855057   PMID:25037568   PMID:25616413   PMID:25705178   PMID:25786344   PMID:25856227   PMID:27413020   PMID:28059450  
PMID:28189443   PMID:28611207   PMID:32248813   PMID:33667331  


Genomics

Comparative Map Data
Kcnq1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21198,291,711 - 198,624,683 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1198,291,766 - 198,624,669 (+)Ensembl
Rnor_6.01216,293,087 - 216,630,339 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1216,293,087 - 216,630,339 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01223,154,713 - 223,490,458 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41203,383,401 - 203,803,687 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11203,536,853 - 203,957,140 (+)NCBI
Celera1195,860,199 - 196,193,008 (+)NCBICelera
Cytogenetic Map1q42NCBI
KCNQ1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl112,444,684 - 2,849,105 (+)EnsemblGRCh38hg38GRCh38
GRCh38112,445,008 - 2,849,110 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37112,466,238 - 2,870,340 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36112,422,797 - 2,826,916 (+)NCBINCBI36hg18NCBI36
Build 34112,439,259 - 2,826,915NCBI
Celera112,501,049 - 2,905,069 (+)NCBI
Cytogenetic Map11p15.5-p15.4NCBI
HuRef112,256,184 - 2,658,673 (+)NCBIHuRef
CHM1_1112,465,155 - 2,869,215 (+)NCBICHM1_1
Kcnq1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397142,660,614 - 142,980,787 (+)NCBIGRCm39mm39
GRCm39 Ensembl7142,660,099 - 142,980,779 (+)Ensembl
GRCm387143,106,877 - 143,427,050 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7143,106,362 - 143,427,042 (+)EnsemblGRCm38mm10GRCm38
MGSCv377150,293,159 - 150,612,947 (+)NCBIGRCm37mm9NCBIm37
MGSCv367142,916,644 - 143,236,432 (+)NCBImm8
Celera7142,862,859 - 143,182,707 (+)NCBICelera
Cytogenetic Map7F5NCBI
cM Map788.12NCBI
Kcnq1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542214,212,553 - 14,544,556 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542214,212,563 - 14,544,556 (+)NCBIChiLan1.0ChiLan1.0
KCNQ1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1112,498,001 - 2,902,198 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0112,469,750 - 2,874,467 (+)NCBIMhudiblu_PPA_v0panPan3
KCNQ1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11846,554,390 - 46,830,533 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1846,518,908 - 46,830,043 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1845,116,523 - 45,440,309 (+)NCBI
ROS_Cfam_1.01847,186,461 - 47,510,762 (+)NCBI
UMICH_Zoey_3.11846,634,218 - 46,955,821 (+)NCBI
UNSW_CanFamBas_1.01846,214,974 - 46,538,652 (+)NCBI
UU_Cfam_GSD_1.01846,962,029 - 47,285,048 (+)NCBI
Kcnq1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049472,763,921 - 3,051,025 (+)NCBI
SpeTri2.0NW_004936794707,122 - 994,206 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNQ1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl21,675,360 - 1,989,111 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.121,675,323 - 1,989,110 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
KCNQ1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.112,261,448 - 2,661,840 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl12,261,845 - 2,661,863 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603899,462,284 - 99,862,831 (+)NCBIVero_WHO_p1.0
Kcnq1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476715,252,961 - 15,613,373 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
D1Wox9  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21198,324,342 - 198,324,465 (+)MAPPERmRatBN7.2
Rnor_6.01216,325,697 - 216,325,819NCBIRnor6.0
Rnor_5.01223,187,127 - 223,187,249UniSTSRnor5.0
RGSC_v3.41203,416,020 - 203,416,143RGDRGSC3.4
RGSC_v3.41203,416,021 - 203,416,143UniSTSRGSC3.4
RGSC_v3.11203,569,473 - 203,569,596RGD
Celera1195,892,798 - 195,892,916UniSTS
RH 2.0 Map11090.4RGD
Cytogenetic Map1q41UniSTS
BF389163  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21198,432,655 - 198,432,778 (+)MAPPERmRatBN7.2
Rnor_6.01216,433,507 - 216,433,629NCBIRnor6.0
Rnor_5.01223,294,687 - 223,294,809UniSTSRnor5.0
Celera1196,001,646 - 196,001,768UniSTS
RH 3.4 Map11562.8UniSTS
Cytogenetic Map1q41UniSTS
AA964210  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21198,440,181 - 198,440,334 (+)MAPPERmRatBN7.2
Rnor_6.01216,440,655 - 216,440,807NCBIRnor6.0
Rnor_5.01223,302,427 - 223,302,579UniSTSRnor5.0
Celera1196,009,173 - 196,009,325UniSTS
Cytogenetic Map1q41UniSTS
Kcnq1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21198,376,261 - 198,377,441 (+)MAPPERmRatBN7.2
Rnor_6.01216,378,790 - 216,379,969NCBIRnor6.0
Rnor_5.01223,238,047 - 223,239,226UniSTSRnor5.0
RGSC_v3.41203,468,249 - 203,469,428UniSTSRGSC3.4
Celera1195,944,729 - 195,945,908UniSTS
Cytogenetic Map1q41UniSTS
RH134033  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21198,624,450 - 198,624,663 (+)MAPPERmRatBN7.2
Rnor_6.01216,630,124 - 216,630,336NCBIRnor6.0
Rnor_5.01223,490,243 - 223,490,455UniSTSRnor5.0
RGSC_v3.41203,803,472 - 203,803,684UniSTSRGSC3.4
Celera1196,192,793 - 196,193,005UniSTS
Cytogenetic Map1q41UniSTS
BE120633  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera1196,055,838 - 196,056,016UniSTS
RH 3.4 Map11521.6UniSTS
Cytogenetic Map1q41UniSTS
AU047567  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21198,406,029 - 198,406,285 (+)MAPPERmRatBN7.2
Rnor_6.01216,407,652 - 216,407,907NCBIRnor6.0
Rnor_5.01223,266,918 - 223,267,173UniSTSRnor5.0
Celera1195,974,267 - 195,974,522UniSTS
Cytogenetic Map1q41UniSTS
AU047338  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21198,549,957 - 198,550,091 (+)MAPPERmRatBN7.2
Rnor_6.01216,555,699 - 216,555,832NCBIRnor6.0
Celera1196,118,406 - 196,118,539UniSTS
Cytogenetic Map1q41UniSTS
AU049425  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21198,460,069 - 198,460,200 (+)MAPPERmRatBN7.2
Rnor_6.01216,460,860 - 216,460,988NCBIRnor6.0
Rnor_5.01223,322,674 - 223,322,802UniSTSRnor5.0
Celera1196,028,682 - 196,028,810UniSTS
Cytogenetic Map1q41UniSTS
UniSTS:465396  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21198,472,540 - 198,472,837 (+)MAPPERmRatBN7.2
Rnor_6.01216,473,690 - 216,473,986NCBIRnor6.0
Rnor_6.01216,480,009 - 216,480,305NCBIRnor6.0
Rnor_5.01223,341,181 - 223,341,477UniSTSRnor5.0
Rnor_5.01223,335,504 - 223,335,800UniSTSRnor5.0
Celera1196,041,145 - 196,041,441UniSTS
Cytogenetic Map1q41UniSTS
Kcnq1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21198,292,160 - 198,292,200 (+)MAPPERmRatBN7.2
Rnor_6.01216,293,482 - 216,293,521NCBIRnor6.0
Rnor_5.01223,155,108 - 223,155,147UniSTSRnor5.0
RGSC_v3.41203,383,796 - 203,383,835UniSTSRGSC3.4
Celera1195,860,594 - 195,860,633UniSTS
Cytogenetic Map1q41UniSTS
Kcnq1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21198,367,696 - 198,367,736 (+)MAPPERmRatBN7.2
Rnor_6.01216,370,232 - 216,370,271NCBIRnor6.0
Rnor_5.01223,229,489 - 223,229,528UniSTSRnor5.0
RGSC_v3.41203,459,643 - 203,459,682UniSTSRGSC3.4
Celera1195,936,161 - 195,936,200UniSTS
Cytogenetic Map1q41UniSTS
Kcnq1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21198,334,404 - 198,334,444 (+)MAPPERmRatBN7.2
Rnor_6.01216,335,834 - 216,335,873NCBIRnor6.0
Rnor_5.01223,197,264 - 223,197,303UniSTSRnor5.0
RGSC_v3.41203,426,076 - 203,426,115UniSTSRGSC3.4
Celera1195,902,856 - 195,902,895UniSTS
Cytogenetic Map1q41UniSTS
Kcnq1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21198,623,523 - 198,623,667 (+)MAPPERmRatBN7.2
Rnor_6.01216,629,197 - 216,629,340NCBIRnor6.0
Rnor_5.01223,489,316 - 223,489,459UniSTSRnor5.0
RGSC_v3.41203,802,545 - 203,802,688UniSTSRGSC3.4
Celera1196,191,866 - 196,192,009UniSTS
Cytogenetic Map1q41UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164747424209747424Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
631260Tcas2Tongue tumor susceptibility QTL 24.93tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1192485903199050587Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1181759564214537555Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1197814409242814409Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1196248093241248093Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1181133855226133855Rat
1331790Bp201Blood pressure QTL 2013.127arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1198211513225126682Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1188377360224054420Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642722214537671Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1180359209210702199Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1197697768238755659Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1184550676229550676Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1182623426219932796Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
634338Hcar4Hepatocarcinoma resistance QTL 44.6liver integrity trait (VT:0010547)liver tumorous lesion number to liver area ratio (CMO:0001210)1193422268214537671Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1197670404242670404Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1176550523221550523Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1578778Pur4Proteinuria QTL 43.30.003total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1185145134221264292Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1359018Hrtrt20Heart rate QTL 203.08heart pumping trait (VT:2000009)heart rate (CMO:0000002)1185356336202902618Rat
1558658Bw59Body weight QTL 593.50.0003body mass (VT:0001259)body weight (CMO:0000012)1178784622223784622Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1192825253243914732Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1181829673224569684Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1185356336231689108Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
1358292Cm37Cardiac mass QTL 376.20.00000081heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1196248093241248093Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1197814409242814409Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
6480780Insul18Insulin level QTL 184.11blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1189607473200611765Rat
6480783Insul19Insulin level QTL 194.33blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1197489281200611765Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1180359209218108781Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1193113876238113876Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
10059590Kidm44Kidney mass QTL 443.420.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1191033875236033875Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)