Advanced Search (OLGA)

Gene: Ctrl (chymotrypsin-like) Rattus norvegicus

Analyze

Symbol:

Ctrl (Ensembl: Psmb10)

Name:

chymotrypsin-like (Ensembl:proteasome 20S subunit beta 10)

RGD ID:

621501

Description:

Orthologous to human CTRL (chymotrypsin like); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; ammonium chloride.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

chymopasin; chymotrypsin-like protease CTRL-1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CTRL (chymotrypsin like)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Ctrl (chymotrypsin-like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ctrl (chymotrypsin like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CTRL (chymotrypsin like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CTRL (chymotrypsin like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ctrl (chymotrypsin like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CTRL (chymotrypsin like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CTRL (chymotrypsin like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ctrl (chymotrypsin like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Ctrl (chymotrypsin like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	PSMB10 (proteasome 20S subunit beta 10)	HGNC	EggNOG, Ensembl, Inparanoid, PhylomeDB, Treefam
Homo sapiens (human):	CTRB1 (chymotrypsinogen B1)	HGNC	OrthoDB
Homo sapiens (human):	CTRB2 (chymotrypsinogen B2)	HGNC	OrthoDB
Homo sapiens (human):	SOX7 (SRY-box transcription factor 7)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Ctrl (chymotrypsin-like)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	CTRL (chymotrypsin like)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	CTRL (chymotrypsin like)	Alliance	DIOPT (HGNC)
Danio rerio (zebrafish):	ctrl (chymotrypsin-like)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	zgc:171592	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	si:dkey-238d18.3	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	Jon74E	Alliance	DIOPT (Hieranoid\|InParanoid)
Drosophila melanogaster (fruit fly):	CG6592	Alliance	DIOPT (Hieranoid\|InParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	50,737,078 - 50,740,659 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	19	50,737,079 - 50,738,979 (-)	Ensembl				GRCr8
mRatBN7.2	19	33,827,279 - 33,829,129 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	33,827,229 - 33,833,626 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	19	40,642,815 - 40,644,665 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	41,296,130 - 41,297,980 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	43,594,680 - 43,596,530 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	37,905,864 - 37,907,714 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	37,905,864 - 37,907,714 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	19	48,772,599 - 48,775,409 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	19	35,774,031 - 35,775,881 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	19	33,254,828 - 33,256,678 (-)	NCBI		Celera
RGSC_v3.1	19	35,778,911 - 35,780,759 (-)	NCBI
Cytogenetic Map	19	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

long QT syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-trinitrobenzenesulfonic acid (ISO)

acrylamide (EXP)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

atrazine (EXP)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

carnosic acid (ISO)

chlorohydrocarbon (EXP)

chloroquine (EXP)

chlorpyrifos (ISO)

ciguatoxin CTX1B (ISO)

clozapine (EXP)

cocaine (EXP)

copper atom (ISO)

copper(0) (ISO)

Cuprizon (EXP)

dexamethasone (ISO)

folic acid (ISO)

genistein (EXP)

gentamycin (EXP)

haloperidol (EXP)

lead diacetate (ISO)

methamphetamine (EXP)

methotrexate (ISO)

methoxychlor (EXP)

methylmercury chloride (EXP)

mono(2-ethylhexyl) phthalate (ISO)

monosodium L-glutamate (ISO)

N-acetyl-L-cysteine (ISO)

N-ethyl-N-nitrosourea (ISO)

N-nitrosodiethylamine (EXP)

nickel atom (ISO)

okadaic acid (ISO)

ozone (ISO)

paracetamol (EXP)

phenobarbital (ISO)

pirinixic acid (ISO)

plumbagin (ISO)

quercetin (ISO)

SCH-351591 (EXP)

senecionine (ISO)

silicon dioxide (ISO)

sodium dichromate (EXP)

Soman (EXP)

streptozocin (ISO)

sunitinib (ISO)

T-2 toxin (EXP)

tamoxifen (ISO)

Tesaglitazar (EXP)

theophylline (ISO)

thioacetamide (EXP)

trichloroethene (EXP)

triptonide (ISO)

troglitazone (EXP)

uranium atom (ISO)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

proteolysis (IEA,ISO)

proteolysis involved in protein catabolic process (IEA)

Cellular Component

extracellular space (IEA,ISO)

nucleus (IEA)

proteasome complex (IEA)

proteasome core complex (IEA)

Molecular Function

hydrolase activity (IEA)

peptidase activity (IEA,ISO)

protein binding (ISO)

serine-type endopeptidase activity (IEA)

serine-type peptidase activity (IDA,IEA,ISO)

threonine-type endopeptidase activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
4.	GOA pipeline	RGD automated data pipeline
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Molecular cloning and characterization of chymopasin, a novel serine protease from rat pancreas.	Sogame Y, etal., Pancreas 2002 Nov;25(4):378-86.

Additional References at PubMed

PMID:1820020	PMID:9065485

Genomics

Comparative Map Data

Ctrl
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	50,737,078 - 50,740,659 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	19	50,737,079 - 50,738,979 (-)	Ensembl				GRCr8
mRatBN7.2	19	33,827,279 - 33,829,129 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	33,827,229 - 33,833,626 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	19	40,642,815 - 40,644,665 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	41,296,130 - 41,297,980 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	43,594,680 - 43,596,530 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	37,905,864 - 37,907,714 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	37,905,864 - 37,907,714 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	19	48,772,599 - 48,775,409 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	19	35,774,031 - 35,775,881 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	19	33,254,828 - 33,256,678 (-)	NCBI		Celera
RGSC_v3.1	19	35,778,911 - 35,780,759 (-)	NCBI
Cytogenetic Map	19	q12	NCBI

CTRL
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	67,929,574 - 67,931,862 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	67,927,640 - 67,932,365 (-)	Ensembl			hg38	GRCh38
GRCh37	16	67,963,477 - 67,965,765 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	66,520,974 - 66,523,266 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	16	66,520,974 - 66,523,266	NCBI
Celera	16	52,471,930 - 52,474,222 (-)	NCBI		Celera
Cytogenetic Map	16	q22.1	NCBI
HuRef	16	53,837,043 - 53,839,348 (-)	NCBI		HuRef
CHM1_1	16	69,371,652 - 69,373,957 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	16	73,725,348 - 73,727,636 (-)	NCBI		T2T-CHM13v2.0

Ctrl
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	106,658,626 - 106,660,494 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	106,658,635 - 106,660,494 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	8	105,931,994 - 105,933,862 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	105,932,003 - 105,933,862 (-)	Ensembl			mm10	GRCm38
MGSCv37	8	108,455,894 - 108,457,762 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	8	108,820,789 - 108,822,991 (-)	NCBI		MGSCv36	mm8
Celera	8	110,160,042 - 110,161,910 (-)	NCBI		Celera
Cytogenetic Map	8	D3	NCBI
cM Map	8	53.06	NCBI

Ctrl
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955484	8,781,928 - 8,783,929 (+)	Ensembl
ChiLan1.0	NW_004955484	8,781,928 - 8,783,929 (+)	NCBI	ChiLan1.0	ChiLan1.0

CTRL
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	77,456,564 - 77,460,908 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	83,367,990 - 83,370,113 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	48,270,961 - 48,274,248 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	67,658,148 - 67,661,410 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	67,658,451 - 67,660,582 (-)	Ensembl			panPan2	panpan1.1

CTRL
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	81,565,155 - 81,567,472 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	81,565,418 - 81,567,472 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	81,554,912 - 81,557,457 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	82,000,253 - 82,002,798 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	82,000,740 - 82,003,005 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	81,826,462 - 81,829,007 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	81,508,592 - 81,511,137 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	82,150,811 - 82,153,356 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Ctrl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	41,299,179 - 41,302,980 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936475	18,286,133 - 18,288,091 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936475	18,284,495 - 18,288,938 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CTRL
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	28,540,808 - 28,542,773 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	6	28,540,187 - 28,542,820 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

CTRL
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	59,508,058 - 59,510,392 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	59,508,380 - 59,510,330 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666047	22,234,344 - 22,235,738 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ctrl
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624746	18,447,574 - 18,449,964 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624746	18,447,042 - 18,449,888 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Ctrl
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	17	25,672,342 - 25,675,679 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Ctrl
16 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	32
Count of miRNA genes:	30
Interacting mature miRNAs:	31
Transcripts:	ENSRNOT00000026361
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61447	Tcas1	Tongue tumor susceptibility QTL 1	6.08		tongue integrity trait (VT:0010553)	squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)	19	19220689	64220689	Rat
9590298	Uminl5	Urine mineral level QTL 5	3.59	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	19	7997750	52997750	Rat
724546	Kidm3	Kidney mass QTL 3	3.1		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	19	46226778	74246245	Rat
1331737	Uae29	Urinary albumin excretion QTL 29	5.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	36289	74246245	Rat
2313395	Anxrr26	Anxiety related response QTL 26			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	19	44385134	74246245	Rat
1578764	Stresp19	Stress response QTL 19	3.6	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	19	32539615	74246245	Rat
1558656	Prcs1	Prostate cancer susceptibility QTL 1	5		prostate integrity trait (VT:0010571)	percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)	19	31287532	51431640	Rat
9590090	Insglur8	Insulin/glucose ratio QTL 8	10.81	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	19	7997750	52997750	Rat
1331788	Rf45	Renal function QTL 45	2.818		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	19	31777888	74246245	Rat
1554318	Bmd5	Bone mineral density QTL 5	12.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	19	23188586	68188586	Rat
1549835	Tcas7	Tongue tumor susceptibility QTL 7		0.001	tongue integrity trait (VT:0010553)	squamous cell carcinoma of the head and neck tumor number (CMO:0001876)	19	41722546	74246245	Rat
724566	Uae12	Urinary albumin excretion QTL 12	5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	2194317	74246245	Rat
1354633	Bw28	Body weight QTL 28	6.04		body mass (VT:0001259)	body weight (CMO:0000012)	19	40727092	54856850	Rat
8552935	Pigfal10	Plasma insulin-like growth factor 1 level QTL 10	5.7		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	19	7997750	52997750	Rat
631840	Niddm38	Non-insulin dependent diabetes mellitus QTL 38	3.86		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	19	10329076	74246245	Rat
1358200	Insglur2	Insulin/glucose ratio QTL 2	4.1		blood glucose amount (VT:0000188)	serum glucose level (CMO:0000543)	19	5748064	50748064	Rat
7411549	Bw130	Body weight QTL 130	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	19	32365311	74246245	Rat
724518	Uae19	Urinary albumin excretion QTL 19	5.5		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	19	24093973	69093973	Rat
61423	Cia14	Collagen induced arthritis QTL 14	3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	19	10833618	74246245	Rat
2303628	Vencon9	Ventilatory control QTL 9		0.005	respiration trait (VT:0001943)	minute ventilation (CMO:0000132)	19	23188586	68188586	Rat
9590250	Scort11	Serum corticosterone level QTL 11	23.45	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	19	7997750	52997750	Rat
2317848	Alcrsp21	Alcohol response QTL 21	1.899999976158142	0.05	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	19	20109306	65109306	Rat
1354607	Gmadr1	Adrenal mass QTL 1	5.83		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	19	40727092	54856850	Rat
7247442	Uae39	Urinary albumin excretion QTL 39			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	19	2194317	74246245	Rat
1354600	Salc2	Saline consumption QTL 2	9.91	0.001	drinking behavior trait (VT:0001422)	saline drink intake rate (CMO:0001627)	19	40727092	54856850	Rat

Markers in Region

Ctrl

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	19	33,827,809 - 33,827,883 (+)	MAPPER	mRatBN7.2
Rnor_6.0	19	37,906,395 - 37,906,468	NCBI	Rnor6.0
Rnor_5.0	19	48,773,426 - 48,773,499	UniSTS	Rnor5.0
Celera	19	33,255,359 - 33,255,432	UniSTS
Cytogenetic Map	19	q12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	55	151	91	90	59	74	59	6	310	154	2	137	73	88	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_054009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063277740	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063277741	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063277742	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB020757	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC121465	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473972	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ211893	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ234836	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000019	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000026361 ⟹ ENSRNOP00000026361

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	19	33,827,229 - 33,829,140 (-)	Ensembl
Rnor_6.0 Ensembl	19	37,905,864 - 37,907,714 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000026462 ⟹ ENSRNOP00000026462

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	19	33,830,961 - 33,833,328 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000094899 ⟹ ENSRNOP00000094160

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	19	33,827,229 - 33,829,557 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000099054 ⟹ ENSRNOP00000091409

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	19	33,827,229 - 33,833,626 (-)	Ensembl

RefSeq Acc Id:

NM_054009 ⟹ NP_446461

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	50,737,129 - 50,738,979 (-)	NCBI
mRatBN7.2	19	33,827,279 - 33,829,129 (-)	NCBI
Rnor_6.0	19	37,905,864 - 37,907,714 (-)	NCBI
Rnor_5.0	19	48,772,599 - 48,775,409 (-)	NCBI
RGSC_v3.4	19	35,774,031 - 35,775,881 (-)	RGD
Celera	19	33,254,828 - 33,256,678 (-)	RGD

Sequence:

show sequence

ACGATGTTACTGCTCAGCCTAACCCTTAGCCTGGTCCTTCTTGGCTCCTCCTGGGGCTGTGGTG
TTCCCGCCATCACACCTGCACTGAGCTACAACCAGAGGATTGTCAACGGGGAGAATGCAGTGCC
AGGCTCCTGGCCCTGGCAAGTGTCTCTGCAGGATAACACCGGCTTCCACTTCTGTGGTGGTTCT
CTCATTGCCCCAAACTGGGTGGTCACGGCTGCCCACTGCAAAGTCACGCCTGGACGCCACTTTG
TCATTTTAGGAGAATATGACCGATCTTCCAATGCTGAGCCTATACAGGTGCTCTCCATCTCGAA
GGCGATCACACACCCTAGCTGGAACCCCAACACTATGAACAATGACCTGACTCTTCTGAAGCTT
GCCTCACCAGCCCGGTACACAGCACAAGTCTCACCAGTCTGCCTGGCTTCCTCAAATGAGGCAC
TTCCTGCAGGCCTCACATGCGTCACCACTGGCTGGGGCCGCATCAGTGGTGTGGGCAACGTGAC
ACCAGCACGTCTGCAGCAAGTAGTTCTACCCCTGGTCACTGTGAATCAGTGTCGGCAGTATTGG
GGTTCACGCATTACTGACTCCATGATATGTGCAGGTGGCGCAGGTGCCTCCTCATGTCAGGGTG
ACTCAGGAGGCCCTCTTGTCTGCCAGAAGGGAAACACCTGGGTGCTTATTGGTATTGTCTCCTG
GGGCACTGAGAACTGCAATGTACAAGCACCGGCCATGTACACTCGGGTCAGCAAGTTCAACACC
TGGATCAACCAAGTCATAGCCTACAACTAA

hide sequence

RefSeq Acc Id:

XM_063277740 ⟹ XP_063133810

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	50,737,078 - 50,739,064 (-)	NCBI

RefSeq Acc Id:

XM_063277741 ⟹ XP_063133811

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	50,737,078 - 50,740,659 (-)	NCBI

RefSeq Acc Id:

XM_063277742 ⟹ XP_063133812

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	50,737,078 - 50,739,178 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_446461	(Get FASTA)	NCBI Sequence Viewer
	XP_063133810	(Get FASTA)	NCBI Sequence Viewer
	XP_063133811	(Get FASTA)	NCBI Sequence Viewer
	XP_063133812	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAB20287	(Get FASTA)	NCBI Sequence Viewer
	EDL92419	(Get FASTA)	NCBI Sequence Viewer
	EDL92420	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000026361
	ENSRNOP00000026361.2
	ENSRNOP00000091409
	ENSRNOP00000091409.2

RefSeq Acc Id:	NP_446461 ⟸ NM_054009
- Peptide Label:	precursor
- UniProtKB:	A6IYU1 (UniProtKB/TrEMBL), G3V8J3 (UniProtKB/TrEMBL), Q9EQZ8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLLLSLTLSLVLLGSSWGCGVPAITPALSYNQRIVNGENAVPGSWPWQVSLQDNTGFHFCGGSL IAPNWVVTAAHCKVTPGRHFVILGEYDRSSNAEPIQVLSISKAITHPSWNPNTMNNDLTLLKLA SPARYTAQVSPVCLASSNEALPAGLTCVTTGWGRISGVGNVTPARLQQVVLPLVTVNQCRQYWG SRITDSMICAGGAGASSCQGDSGGPLVCQKGNTWVLIGIVSWGTENCNVQAPAMYTRVSKFNTW INQVIAYN hide sequence

Ensembl Acc Id:

ENSRNOP00000026361 ⟸ ENSRNOT00000026361

Ensembl Acc Id:

ENSRNOP00000091409 ⟸ ENSRNOT00000099054

Ensembl Acc Id:

ENSRNOP00000026462 ⟸ ENSRNOT00000026462

Ensembl Acc Id:

ENSRNOP00000094160 ⟸ ENSRNOT00000094899

RefSeq Acc Id:	XP_063133811 ⟸ XM_063277741
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_063133812 ⟸ XM_063277742
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_063133810 ⟸ XM_063277740
- Peptide Label:	isoform X1

Protein Domains

Peptidase S1

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-G3V8J3-F1-model_v2	AlphaFold	G3V8J3	1-264	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701093

Promoter ID:

EPDNEW_R11617

Type:

multiple initiation site

Name:

Ctrl_1

Description:

chymotrypsin-like

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	19	37,907,727 - 37,907,787	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621501	AgrOrtholog
BioCyc Gene	G2FUF-5801	BioCyc
Ensembl Genes	ENSRNOG00000019353	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000026361	ENTREZGENE
	ENSRNOT00000026361.6	UniProtKB/TrEMBL
	ENSRNOT00000099054	ENTREZGENE
	ENSRNOT00000099054.2	UniProtKB/TrEMBL
Gene3D-CATH	2.40.10.10	UniProtKB/TrEMBL
	3.60.20.10	UniProtKB/TrEMBL
InterPro	Ntn_hydrolases_N	UniProtKB/TrEMBL
	Pept_cys/ser_Trypsin-like	UniProtKB/TrEMBL
	Peptidase_S1/S6_AS	UniProtKB/TrEMBL
	Peptidase_S1_PA_chymotrypsin	UniProtKB/TrEMBL
	Peptidase_S1_S6	UniProtKB/TrEMBL
	Peptidase_S1A	UniProtKB/TrEMBL
	Proteasome_bsu_C	UniProtKB/TrEMBL
	Proteasome_bsu_CS	UniProtKB/TrEMBL
	Proteasome_sua/b	UniProtKB/TrEMBL
	Proteasome_suB-type	UniProtKB/TrEMBL
	TRYPSIN_SER	UniProtKB/TrEMBL
KEGG Report	rno:117184	UniProtKB/TrEMBL
NCBI Gene	117184	ENTREZGENE
PANTHER	CHYMOTRYPSIN-LIKE PROTEASE CTRL-1	UniProtKB/TrEMBL
	CHYMOTRYPSIN-RELATED	UniProtKB/TrEMBL
Pfam	Pr_beta_C	UniProtKB/TrEMBL
	Proteasome	UniProtKB/TrEMBL
	Trypsin	UniProtKB/TrEMBL
PhenoGen	Ctrl	PhenoGen
PRINTS	CHYMOTRYPSIN	UniProtKB/TrEMBL
PROSITE	PROTEASOME_BETA_1	UniProtKB/TrEMBL
	PROTEASOME_BETA_2	UniProtKB/TrEMBL
	TRYPSIN_DOM	UniProtKB/TrEMBL
	TRYPSIN_HIS	UniProtKB/TrEMBL
	TRYPSIN_SER	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000019353	RatGTEx
SMART	Tryp_SPc	UniProtKB/TrEMBL
Superfamily-SCOP	Pept_Ser_Cys	UniProtKB/TrEMBL
	SSF56235	UniProtKB/TrEMBL
UniProt	A0A8I6AFJ4_RAT	UniProtKB/TrEMBL
	A6IYU1	ENTREZGENE, UniProtKB/TrEMBL
	A6IYU2_RAT	UniProtKB/TrEMBL
	G3V8J3	ENTREZGENE, UniProtKB/TrEMBL
	Q9EQZ8	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-09-10	Ctrl	chymotrypsin-like			Symbol and Name status set to approved	1299863	APPROVED
2002-08-07	Ctrl	chymotrypsin-like			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed in the acinar cells, but not in the islet or duct cells	632572

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Send us a Message

Imported Disease Annotations - ClinVar