Cdc25b (cell division cycle 25B) - Rat Genome Database

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Gene: Cdc25b (cell division cycle 25B) Rattus norvegicus
Analyze
Symbol: Cdc25b
Name: cell division cycle 25B
RGD ID: 621500
Description: Predicted to enable protein kinase binding activity and protein tyrosine phosphatase activity. Predicted to be involved in G2/M transition of mitotic cell cycle; positive regulation of cell cycle process; and protein phosphorylation. Predicted to act upstream of or within female meiosis I; oocyte maturation; and positive regulation of protein kinase activity. Predicted to be located in centrosome and spindle pole. Predicted to be active in cytoplasm and nucleus. Orthologous to human CDC25B (cell division cycle 25B); PARTICIPATES IN cell cycle pathway, mitotic; mitogen activated protein kinase signaling pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cell division cycle 25 homolog B (S. cerevisiae); cell division cycle 25 homolog B (S. pombe); dual specificity phosphatase Cdc25B; M-phase inducer phosphatase 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83138,860,148 - 138,870,287 (+)NCBIGRCr8
mRatBN7.23118,407,127 - 118,417,272 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3118,407,128 - 118,417,272 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3122,301,484 - 122,311,583 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03130,900,852 - 130,910,946 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03128,557,585 - 128,567,684 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03123,731,539 - 123,741,696 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3123,731,539 - 123,741,339 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03130,229,228 - 130,239,385 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43118,893,716 - 118,903,516 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13118,799,288 - 118,809,089 (+)NCBI
Celera3117,215,222 - 117,225,031 (+)NCBICelera
Cytogenetic Map3q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dichloroethane  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,7-dihydropurine-6-thione  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
busulfan  (ISO)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP,ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
carboplatin  (EXP)
carmustine  (EXP)
CGP 52608  (ISO)
choline  (ISO)
chromium(6+)  (EXP,ISO)
cisplatin  (EXP,ISO)
clofarabine  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumarin  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (EXP)
dicrotophos  (ISO)
dieldrin  (EXP)
dimethyl sulfoxide  (ISO)
doxorubicin  (ISO)
Echimidine  (ISO)
endosulfan  (EXP)
equol  (ISO)
ethanol  (ISO)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
glutathione  (ISO)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
indole-3-methanol  (EXP)
irinotecan  (ISO)
isosilybin A  (ISO)
L-methionine  (ISO)
Lasiocarpine  (ISO)
Licochalcone B  (ISO)
linezolid  (EXP)
mercaptopurine  (EXP)
metformin  (EXP)
methotrexate  (EXP)
methoxyacetic acid  (EXP)
methoxychlor  (EXP)
methylarsonic acid  (ISO)
methylmercury chloride  (EXP,ISO)
mifepristone  (EXP)
Monobutylphthalate  (EXP)
monocrotaline  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (ISO)
naphthalenes  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
nitrofen  (EXP)
Nor-9-carboxy-delta9-THC  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
purine-6-thiol  (EXP)
resveratrol  (ISO)
riddelliine  (ISO)
rotenone  (EXP,ISO)
silibinin  (ISO)
silver(1+) nitrate  (ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
thiram  (ISO)
tioguanine  (EXP)
toluene 2,4-diisocyanate  (ISO)
Tributyltin oxide  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (EXP)
triptonide  (ISO)
trovafloxacin  (ISO)
undecane  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
centrosome  (IEA,ISO,ISS)
cytoplasm  (IBA,IEA,ISO)
nucleus  (IBA,IEA,ISO)
spindle pole  (IEA,ISO,ISS)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Expression of cdc25A and cdc25B phosphatase in breast carcinoma. Ito Y, etal., Breast Cancer. 2004;11(3):295-300.
3. Cdc25A is a novel phosphatase functioning early in the cell cycle. Jinno S, etal., EMBO J 1994 Apr 1;13(7):1549-56.
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. Overexpression of Cdc25B, an androgen receptor coactivator, in prostate cancer. Ngan ES, etal., Oncogene. 2003 Feb 6;22(5):734-9.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Development of a multiplex quantitative PCR signature to predict progression in non-muscle-invasive bladder cancer. Wang R, etal., Cancer Res. 2009 May 1;69(9):3810-8. Epub 2009 Apr 21.
10. Overexpression of CDC25B, CDC25C and phospho-CDC25C (Ser216) in vulvar squamous cell carcinomas are associated with malignant features and aggressive cancer phenotypes. Wang Z, etal., BMC Cancer. 2010 May 25;10:233.
11. Coordinate expression of Cdc25B and ER-alpha is frequent in low-grade endometrioid endometrial carcinoma but uncommon in high-grade endometrioid and nonendometrioid carcinomas. Wu W, etal., Cancer Res. 2003 Oct 1;63(19):6195-9.
Additional References at PubMed
PMID:11912493   PMID:12400006   PMID:15908796   PMID:17332740   PMID:20083600   PMID:22899714   PMID:23326474  


Genomics

Comparative Map Data
Cdc25b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83138,860,148 - 138,870,287 (+)NCBIGRCr8
mRatBN7.23118,407,127 - 118,417,272 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3118,407,128 - 118,417,272 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3122,301,484 - 122,311,583 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03130,900,852 - 130,910,946 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03128,557,585 - 128,567,684 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03123,731,539 - 123,741,696 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3123,731,539 - 123,741,339 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03130,229,228 - 130,239,385 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43118,893,716 - 118,903,516 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13118,799,288 - 118,809,089 (+)NCBI
Celera3117,215,222 - 117,225,031 (+)NCBICelera
Cytogenetic Map3q36NCBI
CDC25B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38203,786,951 - 3,806,115 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl203,786,772 - 3,806,121 (+)EnsemblGRCh38hg38GRCh38
GRCh37203,767,598 - 3,786,762 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36203,724,401 - 3,734,762 (+)NCBINCBI36Build 36hg18NCBI36
Celera203,838,270 - 3,848,633 (+)NCBICelera
Cytogenetic Map20p13NCBI
HuRef203,724,986 - 3,735,364 (+)NCBIHuRef
CHM1_1203,776,654 - 3,787,027 (+)NCBICHM1_1
T2T-CHM13v2.0203,817,891 - 3,837,037 (+)NCBIT2T-CHM13v2.0
Cdc25b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392131,028,356 - 131,040,431 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2131,028,869 - 131,040,417 (+)EnsemblGRCm39 Ensembl
GRCm382131,186,436 - 131,198,511 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2131,186,949 - 131,198,497 (+)EnsemblGRCm38mm10GRCm38
MGSCv372131,012,687 - 131,024,233 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362130,878,520 - 130,889,906 (+)NCBIMGSCv36mm8
Celera2132,410,981 - 132,422,509 (+)NCBICelera
Cytogenetic Map2F1NCBI
cM Map263.29NCBI
Cdc25b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541514,629,132 - 14,650,116 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541514,637,295 - 14,647,181 (+)NCBIChiLan1.0ChiLan1.0
CDC25B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2214,749,003 - 4,769,167 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1204,745,828 - 4,765,995 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0203,877,255 - 3,883,458 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1203,626,097 - 3,645,179 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl203,626,107 - 3,645,179 (+)Ensemblpanpan1.1panPan2
CDC25B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12417,552,206 - 17,561,791 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2417,553,316 - 17,561,759 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2417,381,964 - 17,391,536 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02417,971,255 - 17,980,600 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2417,971,273 - 17,980,568 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12417,566,166 - 17,575,511 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02417,676,969 - 17,686,318 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02418,004,858 - 18,014,203 (-)NCBIUU_Cfam_GSD_1.0
Cdc25b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640166,465,682 - 166,482,670 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493648514,897,050 - 14,914,034 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDC25B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1731,910,825 - 31,929,242 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11731,910,824 - 31,929,418 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21736,244,262 - 36,262,979 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CDC25B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1234,482,709 - 34,493,737 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl234,483,771 - 34,494,071 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660719,958,886 - 9,969,775 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdc25b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247414,882,516 - 4,892,925 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247414,871,275 - 4,892,730 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cdc25b
46 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:515
Count of miRNA genes:228
Interacting mature miRNAs:270
Transcripts:ENSRNOT00000051064
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)384091273129091273Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)3115638168135181505Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3112287552135181505Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat

Markers in Region
RH131478  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23118,416,950 - 118,417,265 (+)MAPPERmRatBN7.2
Rnor_6.03123,741,375 - 123,741,689NCBIRnor6.0
Rnor_5.03130,239,064 - 130,239,378UniSTSRnor5.0
RGSC_v3.43118,903,552 - 118,903,866UniSTSRGSC3.4
Celera3117,225,067 - 117,225,381UniSTS
RH 3.4 Map31013.1UniSTS
Cytogenetic Map3q36UniSTS
RH133919  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23118,416,101 - 118,416,311 (+)MAPPERmRatBN7.2
Rnor_6.03123,740,526 - 123,740,735NCBIRnor6.0
Rnor_5.03130,238,215 - 130,238,424UniSTSRnor5.0
RGSC_v3.43118,902,703 - 118,902,912UniSTSRGSC3.4
Celera3117,224,218 - 117,224,427UniSTS
RH 3.4 Map31013.0UniSTS
Cytogenetic Map3q36UniSTS
Cdc25b  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23118,411,929 - 118,412,755 (+)MAPPERmRatBN7.2
Rnor_6.03123,736,354 - 123,737,179NCBIRnor6.0
Rnor_5.03130,234,043 - 130,234,868UniSTSRnor5.0
RGSC_v3.43118,898,531 - 118,899,356UniSTSRGSC3.4
Celera3117,220,046 - 117,220,871UniSTS
Cytogenetic Map3q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000051064   ⟹   ENSRNOP00000051129
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3118,407,182 - 118,417,270 (+)Ensembl
Rnor_6.0 Ensembl3123,731,539 - 123,741,339 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101513   ⟹   ENSRNOP00000088213
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3118,407,128 - 118,417,272 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103719   ⟹   ENSRNOP00000096779
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3118,407,182 - 118,417,270 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000119042   ⟹   ENSRNOP00000091343
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3118,407,128 - 118,417,272 (+)Ensembl
RefSeq Acc Id: NM_001389213   ⟹   NP_001376142
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83138,860,173 - 138,870,287 (+)NCBI
mRatBN7.23118,407,157 - 118,417,272 (+)NCBI
RefSeq Acc Id: NM_133572   ⟹   NP_598256
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83138,860,173 - 138,870,287 (+)NCBI
mRatBN7.23118,407,157 - 118,417,272 (+)NCBI
Rnor_6.03123,731,539 - 123,741,339 (+)NCBI
Rnor_5.03130,229,228 - 130,239,385 (+)NCBI
RGSC_v3.43118,893,716 - 118,903,516 (+)RGD
Celera3117,215,222 - 117,225,031 (+)RGD
Sequence:
RefSeq Acc Id: XM_039104193   ⟹   XP_038960121
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83138,860,148 - 138,870,287 (+)NCBI
mRatBN7.23118,407,132 - 118,417,094 (+)NCBI
RefSeq Acc Id: XM_039104195   ⟹   XP_038960123
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83138,861,330 - 138,870,287 (+)NCBI
mRatBN7.23118,408,304 - 118,417,094 (+)NCBI
RefSeq Acc Id: XM_063283040   ⟹   XP_063139110
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83138,860,148 - 138,870,287 (+)NCBI
RefSeq Acc Id: NP_598256   ⟸   NM_133572
- Peptide Label: isoform 1
- UniProtKB: P48966 (UniProtKB/Swiss-Prot),   F1LQS5 (UniProtKB/TrEMBL),   A6HQC8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000051129   ⟸   ENSRNOT00000051064
RefSeq Acc Id: XP_038960121   ⟸   XM_039104193
- Peptide Label: isoform X1
RefSeq Acc Id: NP_001376142   ⟸   NM_001389213
- Peptide Label: isoform 2
- UniProtKB: A0A8I6GIX5 (UniProtKB/TrEMBL),   A0A8I6A7K8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960123   ⟸   XM_039104195
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000091343   ⟸   ENSRNOT00000119042
Ensembl Acc Id: ENSRNOP00000088213   ⟸   ENSRNOT00000101513
Ensembl Acc Id: ENSRNOP00000096779   ⟸   ENSRNOT00000103719
RefSeq Acc Id: XP_063139110   ⟸   XM_063283040
- Peptide Label: isoform X2
Protein Domains
Rhodanese

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P48966-F1-model_v2 AlphaFold P48966 1-574 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692446
Promoter ID:EPDNEW_R2971
Type:initiation region
Name:Cdc25b_1
Description:cell division cycle 25B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03123,731,582 - 123,731,642EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621500 AgrOrtholog
BioCyc Gene G2FUF-47820 BioCyc
Ensembl Genes ENSRNOG00000021248 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000051064.3 UniProtKB/TrEMBL
  ENSRNOT00000101513.1 UniProtKB/TrEMBL
  ENSRNOT00000103719.1 UniProtKB/TrEMBL
  ENSRNOT00000119042.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro MPI_Phosphatase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodanese-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodanese-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:171103 UniProtKB/Swiss-Prot
NCBI Gene 171103 ENTREZGENE
PANTHER M-PHASE INDUCER PHOSPHATASE 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam M-inducer_phosp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodanese UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cdc25b PhenoGen
PRINTS MPIPHPHTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE RHODANESE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000021248 RatGTEx
SMART RHOD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52821 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A7K8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AR92_RAT UniProtKB/TrEMBL
  A0A8I6GIX5 ENTREZGENE, UniProtKB/TrEMBL
  A6HQC8 ENTREZGENE, UniProtKB/TrEMBL
  A6HQC9_RAT UniProtKB/TrEMBL
  A6HQD0_RAT UniProtKB/TrEMBL
  A6HQD1_RAT UniProtKB/TrEMBL
  F1LQS5 ENTREZGENE, UniProtKB/TrEMBL
  MPIP2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-01-23 Cdc25b  cell division cycle 25B  Cdc25b  cell division cycle 25 homolog B (S. pombe)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-01-29 Bsnd  cell division cycle 25 homolog B (S. pombe)  Cdc25b  cell division cycle 25 homolog B (S. cerevisiae)  Name updated 1299863 APPROVED
2005-01-20 Cdc25b  cell division cycle 25 homolog B (S. cerevisiae)    cell division cycle 25B  Name updated 1299863 APPROVED
2002-08-07 Cdc25b  cell division cycle 25B      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression predominantly expressed in late G1 724653