Bhmt (betaine-homocysteine S-methyltransferase) - Rat Genome Database

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Gene: Bhmt (betaine-homocysteine S-methyltransferase) Rattus norvegicus
Analyze
Symbol: Bhmt
Name: betaine-homocysteine S-methyltransferase
RGD ID: 621496
Description: Enables betaine-homocysteine S-methyltransferase activity and identical protein binding activity. Involved in methionine biosynthetic process; protein methylation; and response to alcohol. Located in cytosol; extracellular space; and nucleus. Part of protein-containing complex. Biomarker of metabolic dysfunction and alcohol associated liver disease. Human ortholog(s) of this gene implicated in cerebral infarction and pulmonary embolism. Orthologous to human BHMT (betaine--homocysteine S-methyltransferase); PARTICIPATES IN methionine cycle/metabolic pathway; remethylation pathway of homocysteine metabolism - cobalamin independent, betaine dependent; choline metabolic pathway; INTERACTS WITH 1-(3-(trifluoromethyl)phenyl)piperazine; 1-benzylpiperazine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: betaine--homocysteine S-methyltransferase 1; betaine-homocysteine methyltransferase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8226,594,852 - 26,614,429 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl226,594,854 - 26,614,715 (-)EnsemblGRCr8
mRatBN7.2224,859,871 - 24,879,449 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl224,859,873 - 24,879,742 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx231,887,170 - 31,906,744 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0229,987,440 - 30,007,012 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0224,813,713 - 24,832,877 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0223,236,573 - 23,256,158 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl223,236,575 - 23,256,158 (-)Ensemblrn6Rnor6.0
Rnor_5.0242,417,998 - 42,437,775 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4223,923,651 - 23,943,320 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera220,935,059 - 20,954,426 (-)NCBICelera
RGSC_v3.1223,844,021 - 23,863,689 (-)NCBI
Cytogenetic Map2q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+/-)-Aegeline  (ISO)
(1->4)-beta-D-glucan  (ISO)
(RS)-coclaurine  (ISO)
(RS)-norcoclaurine  (ISO)
(S)-coclaurine  (ISO)
1,2-dichloroethane  (ISO)
1-(3-(trifluoromethyl)phenyl)piperazine  (EXP)
1-benzylpiperazine  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-nitrofluorene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
amitriptyline  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
andrographolide  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
azoxystrobin  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
buta-1,3-diene  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (EXP)
caffeine  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
ciglitazone  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP)
clofibrate  (EXP)
clomipramine  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
corn oil  (EXP)
coumarin  (EXP)
Cuprizon  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (ISO)
dibutyl phthalate  (ISO)
diethyl maleate  (EXP)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (EXP)
fenthion  (ISO)
fentin chloride  (EXP)
folic acid  (EXP,ISO)
fructose  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
glafenine  (EXP)
glucose  (ISO)
glycine betaine  (ISO)
glyphosate  (EXP)
imidacloprid  (EXP)
imipramine  (EXP)
iodide salt  (EXP)
isoniazide  (ISO)
ketoconazole  (EXP)
L-methionine  (ISO)
lead diacetate  (EXP)
mercury dichloride  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methimazole  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
nefazodone  (EXP)
nimesulide  (EXP)
nitrofen  (EXP)
O-methyleugenol  (ISO)
ochratoxin A  (EXP)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
quercetin  (EXP,ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
streptozocin  (EXP,ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
Torularhodin  (ISO)
tremolite asbestos  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
yohimbine  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Mild neonatal hypoxia exacerbates the effects of vitamin-deficient diet on homocysteine metabolism in rats. Blaise S, etal., Pediatr Res 2005 Jun;57(6):777-82. Epub 2005 Apr 21.
2. Overview of homocysteine and folate metabolism. With special references to cardiovascular disease and neural tube defects. Blom HJ and Smulders Y, J Inherit Metab Dis. 2011 Feb;34(1):75-81. doi: 10.1007/s10545-010-9177-4. Epub 2010 Sep 4.
3. Significant Down-Regulation of Urea Cycle Generates Clinically Relevant Proteomic Signature in Hepatocellular Carcinoma Patients with Macrovascular Invasion. Cao Y, etal., J Proteome Res. 2019 May 3;18(5):2032-2044. doi: 10.1021/acs.jproteome.8b00921. Epub 2019 Mar 29.
4. Isoaspartate, carbamoyl phosphate synthase-1, and carbonic anhydrase-III as biomarkers of liver injury. Carter WG, etal., Biochem Biophys Res Commun. 2015 Mar 13;458(3):626-631. doi: 10.1016/j.bbrc.2015.01.158. Epub 2015 Feb 13.
5. Application of mRNA differential display to liver cirrhosis: reduced fetuin expression in biliary cirrhosis in the rat. Forestier M, etal., Biochem Biophys Res Commun 1996 Aug 14;225(2):377-83.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Early-onset ischaemic stroke: analysis of 58 polymorphisms in 17 genes involved in methionine metabolism. Giusti B, etal., Thromb Haemost. 2010 Aug;104(2):231-42. doi: 10.1160/TH09-11-0748. Epub 2010 May 10.
8. Active-site-mutagenesis study of rat liver betaine-homocysteine S-methyltransferase. Gonzalez B, etal., Biochem J 2003 Mar 15;370(Pt 3):945-52.
9. Combined genealogical, mapping, and expression approaches to identify spontaneously hypertensive rat hypertension candidate genes. Hinojos CA, etal., Hypertension 2005 Apr;45(4):698-704. Epub 2005 Feb 14.
10. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
11. Proteomics reveal a concerted upregulation of methionine metabolic pathway enzymes, and downregulation of carbonic anhydrase-III, in betaine supplemented ethanol-fed rats. Kharbanda KK, etal., Biochem Biophys Res Commun. 2009 Apr 17;381(4):523-7. doi: 10.1016/j.bbrc.2009.02.082. Epub 2009 Feb 23.
12. Rat liver 10-formyltetrahydrofolate dehydrogenase, carbamoyl phosphate synthetase 1 and betaine homocysteine S-methytransferase were co-purified on Kunitz-type soybean trypsin inhibitor-coupled sepharose CL-4B. Kim HS, etal., J Biochem Mol Biol. 2007 Jul 31;40(4):604-9.
13. The clinical significance of betaine, an osmolyte with a key role in methyl group metabolism. Lever M and Slow S, Clin Biochem. 2010 Jun;43(9):732-44. doi: 10.1016/j.clinbiochem.2010.03.009. Epub 2010 Mar 25.
14. S-adenosylmethionine in liver health, injury, and cancer. Lu SC and Mato JM, Physiol Rev. 2012 Oct;92(4):1515-42. doi: 10.1152/physrev.00047.2011.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
19. Betaine homocysteine S-methyltransferase emerges as a new player of the nuclear methionine cycle. Pérez-Miguelsanz J, etal., Biochim Biophys Acta Mol Cell Res. 2017 Jul;1864(7):1165-1182. doi: 10.1016/j.bbamcr.2017.03.004. Epub 2017 Mar 10.
20. GOA pipeline RGD automated data pipeline
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
23. Combined proteomic analysis of liver tissue and serum in chronically alcohol-fed rats. Yamada M, etal., Alcohol Clin Exp Res. 2013 Jan;37 Suppl 1:E79-87. doi: 10.1111/j.1530-0277.2012.01883.x. Epub 2012 Oct 19.
24. BHMT polymorphism and susceptibility to PTE in Chinese patients. Zhang WH, etal., Eur Rev Med Pharmacol Sci. 2023 May;27(9):4098-4102. doi: 10.26355/eurrev_202305_32317.
Additional References at PubMed
PMID:10417327   PMID:12757931   PMID:15099744   PMID:15217352   PMID:15489334   PMID:15943585   PMID:16396637   PMID:16920841   PMID:17218476   PMID:18230605   PMID:21082674   PMID:21610319  
PMID:23376485   PMID:23533145   PMID:25467853   PMID:29924862  


Genomics

Comparative Map Data
Bhmt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8226,594,852 - 26,614,429 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl226,594,854 - 26,614,715 (-)EnsemblGRCr8
mRatBN7.2224,859,871 - 24,879,449 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl224,859,873 - 24,879,742 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx231,887,170 - 31,906,744 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0229,987,440 - 30,007,012 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0224,813,713 - 24,832,877 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0223,236,573 - 23,256,158 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl223,236,575 - 23,256,158 (-)Ensemblrn6Rnor6.0
Rnor_5.0242,417,998 - 42,437,775 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4223,923,651 - 23,943,320 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera220,935,059 - 20,954,426 (-)NCBICelera
RGSC_v3.1223,844,021 - 23,863,689 (-)NCBI
Cytogenetic Map2q12NCBI
BHMT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38579,111,809 - 79,132,288 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl579,111,809 - 79,132,288 (+)Ensemblhg38GRCh38
GRCh37578,407,632 - 78,428,111 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36578,443,360 - 78,463,869 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34578,443,438 - 78,463,863NCBI
Celera574,300,507 - 74,323,326 (+)NCBICelera
Cytogenetic Map5q14.1NCBI
HuRef573,613,559 - 73,636,443 (+)NCBIHuRef
CHM1_1577,840,080 - 77,860,596 (+)NCBICHM1_1
T2T-CHM13v2.0579,592,579 - 79,615,902 (+)NCBIT2T-CHM13v2.0
Bhmt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391393,753,399 - 93,774,266 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1393,753,183 - 93,774,469 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381393,616,891 - 93,637,758 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1393,616,675 - 93,637,961 (-)Ensemblmm10GRCm38
MGSCv371394,386,846 - 94,407,713 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361394,717,644 - 94,738,511 (-)NCBIMGSCv36mm8
Celera1397,222,393 - 97,243,812 (-)NCBICelera
Cytogenetic Map13C3NCBI
cM Map1347.87NCBI
Bhmt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542521,991,665 - 22,009,855 (-)Ensembl
ChiLan1.0NW_00495542521,992,219 - 22,009,389 (-)NCBIChiLan1.0ChiLan1.0
BHMT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2436,174,948 - 36,195,674 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1534,328,575 - 34,351,766 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0536,181,183 - 36,201,833 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1536,670,854 - 36,691,942 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl536,670,854 - 36,728,993 (-)EnsemblpanPan2panpan1.1
BHMT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1327,732,381 - 27,752,168 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl327,734,108 - 27,752,046 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha328,973,220 - 28,991,599 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0327,652,772 - 27,671,416 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl327,651,360 - 27,671,308 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1327,591,867 - 27,610,507 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0327,570,180 - 27,588,856 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0327,851,113 - 27,869,743 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC101972215
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213183,901,611 - 183,920,782 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365496,938,092 - 6,957,363 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365496,938,100 - 6,956,380 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BHMT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl287,910,603 - 87,935,252 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1287,911,093 - 87,935,252 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2289,406,703 - 89,431,091 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BHMT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1473,331,551 - 73,352,259 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl473,332,259 - 73,352,434 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604922,178,695 - 22,198,656 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bhmt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248693,617,948 - 3,642,860 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248693,618,895 - 3,639,621 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Bhmt
137 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:83
Count of miRNA genes:64
Interacting mature miRNAs:75
Transcripts:ENSRNOT00000015336
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2788777242804738Rat
7387318Stl32Serum triglyceride level QTL 323.20.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)22238462767384627Rat
631682Bp115Blood pressure QTL 1154.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2137410502Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)21185206249003364Rat
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2141244106Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2902351954023519Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat

Markers in Region
RH133381  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2224,859,980 - 24,860,177 (+)MAPPERmRatBN7.2
mRatBN7.21527,691,609 - 27,691,806 (+)MAPPERmRatBN7.2
Rnor_6.01532,882,459 - 32,882,655NCBIRnor6.0
Rnor_6.0223,236,683 - 23,236,879NCBIRnor6.0
Rnor_5.01536,693,588 - 36,693,784UniSTSRnor5.0
Rnor_5.0242,418,108 - 42,418,304UniSTSRnor5.0
RGSC_v3.4223,923,761 - 23,923,957UniSTSRGSC3.4
RGSC_v3.41532,300,411 - 32,300,607UniSTSRGSC3.4
Celera1527,273,354 - 27,273,550UniSTS
Celera220,935,169 - 20,935,365UniSTS
Cytogenetic Map2q12UniSTS
Cytogenetic Map15p13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
10 12 42 144 91 90 59 66 59 6 293 135 6 125 81 80 31 15 15

Sequence


Ensembl Acc Id: ENSRNOT00000015336   ⟹   ENSRNOP00000015336
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl226,594,854 - 26,614,715 (-)Ensembl
mRatBN7.2 Ensembl224,859,873 - 24,879,742 (-)Ensembl
Rnor_6.0 Ensembl223,236,575 - 23,256,158 (-)Ensembl
RefSeq Acc Id: NM_030850   ⟹   NP_110477
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8226,594,852 - 26,614,429 (-)NCBI
mRatBN7.2224,859,871 - 24,879,449 (-)NCBI
Rnor_6.0223,236,573 - 23,256,158 (-)NCBI
Rnor_5.0242,417,998 - 42,437,775 (-)NCBI
RGSC_v3.4223,923,651 - 23,943,320 (-)RGD
Celera220,935,059 - 20,954,426 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_110477 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB53763 (Get FASTA)   NCBI Sequence Viewer  
  AAB95481 (Get FASTA)   NCBI Sequence Viewer  
  AAH78811 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000015336
GenBank Protein O09171 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_110477   ⟸   NM_030850
- UniProtKB: Q6AZ06 (UniProtKB/Swiss-Prot),   O09171 (UniProtKB/Swiss-Prot),   A0A0G2JSK9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015336   ⟸   ENSRNOT00000015336
Protein Domains
Hcy-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O09171-F1-model_v2 AlphaFold O09171 1-407 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691067
Promoter ID:EPDNEW_R1592
Type:multiple initiation site
Name:Bhmt_1
Description:betaine-homocysteine S-methyltransferase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0223,256,157 - 23,256,217EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621496 AgrOrtholog
BioCyc Gene G2FUF-54845 BioCyc
BioCyc Pathway ADENOSYLHOMOCYSCAT-PWY [L-methionine salvage from L-homocysteine] BioCyc
  PWY-3661 [glycine betaine degradation I] BioCyc
  PWY-3661-1 [glycine betaine degradation II (mammalian)] BioCyc
BioCyc Pathway Image ADENOSYLHOMOCYSCAT-PWY BioCyc
  PWY-3661 BioCyc
  PWY-3661-1 BioCyc
Ensembl Genes ENSRNOG00000011200 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000015336 ENTREZGENE
Gene3D-CATH 3.20.20.330 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7130736 IMAGE-MGC_LOAD
InterPro Betaine-hCys_S-MeTrfase_BHMT UniProtKB/Swiss-Prot
  BHMT UniProtKB/Swiss-Prot
  HCY_dom UniProtKB/Swiss-Prot
  HCY_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:81508 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93402 IMAGE-MGC_LOAD
NCBI Gene 81508 ENTREZGENE
PANTHER BETAINE--HOMOCYSTEINE S-METHYLTRANSFERASE 1 UniProtKB/Swiss-Prot
  BETAINE--HOMOCYSTEINE S-METHYLTRANSFERASE 1 UniProtKB/Swiss-Prot
Pfam S-methyl_trans UniProtKB/Swiss-Prot
PhenoGen Bhmt PhenoGen
PIRSF Betaine_HMT UniProtKB/Swiss-Prot
PROSITE HCY UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011200 RatGTEx
Superfamily-SCOP SSF82282 UniProtKB/Swiss-Prot
UniProt A0A0G2JSK9 ENTREZGENE, UniProtKB/TrEMBL
  BHMT1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6AZ06 ENTREZGENE
UniProt Secondary Q6AZ06 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-28 Bhmt  betaine-homocysteine S-methyltransferase  Bhmt  betaine-homocysteine methyltransferase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Bhmt  betaine-homocysteine methyltransferase      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Bhmt  betaine-homocysteine methyltransferase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expression is decreased 2.1 fold in SHR compared with WKY rats 1357414