Adam9 (ADAM metallopeptidase domain 9) - Rat Genome Database

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Gene: Adam9 (ADAM metallopeptidase domain 9) Rattus norvegicus
Analyze
Symbol: Adam9
Name: ADAM metallopeptidase domain 9
RGD ID: 621473
Description: Predicted to enable several functions, including SH3 domain binding activity; metalloendopeptidase activity involved in amyloid precursor protein catabolic process; and protein kinase C binding activity. Involved in response to antineoplastic agent and response to laminar fluid shear stress. Located in basolateral plasma membrane and cell surface. Biomarker of Alzheimer's disease and status epilepticus. Human ortholog(s) of this gene implicated in cone-rod dystrophy 9. Orthologous to human ADAM9 (ADAM metallopeptidase domain 9); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: a disintegrin and metallopeptidase domain 9 (meltrin gamma); a disintegrin and metalloproteinase domain 9 (meltrin gamma); ADAM metallopeptidase domain 9 (meltrin gamma); disintegrin and metalloproteinase domain-containing protein 9; LOC290834; MDC9; meltrin gamma
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81673,725,186 - 73,804,284 (+)NCBIGRCr8
mRatBN7.21667,022,538 - 67,101,647 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1667,022,655 - 67,100,917 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1672,299,877 - 72,378,087 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01675,705,845 - 75,783,765 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01670,952,385 - 71,031,826 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01671,810,377 - 71,887,926 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1671,810,377 - 71,887,926 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01671,459,144 - 71,536,608 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41671,446,498 - 71,526,108 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11671,446,762 - 71,526,373 (+)NCBI
Celera1664,927,252 - 65,004,785 (+)NCBICelera
Cytogenetic Map16q12.4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
aluminium sulfate (anhydrous)  (ISO)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bicalutamide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
cisplatin  (EXP)
clofibrate  (ISO)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
disulfiram  (ISO)
dopamine  (EXP)
dorsomorphin  (ISO)
ebselen  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
fenoldopam  (EXP)
fenthion  (ISO)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
hydrogen peroxide  (ISO)
ivermectin  (ISO)
ketoconazole  (EXP)
lead(0)  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
miconazole  (EXP)
N,N-diethyl-m-toluamide  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP)
phenylmercury acetate  (ISO)
phorbol 12,13-dibutanoate  (ISO)
pioglitazone  (ISO)
progesterone  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sulindac sulfide  (ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
tributylstannane  (EXP)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
yohimbine  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. ADAMs: key components in EGFR signalling and development. Blobel CP Nat Rev Mol Cell Biol. 2005 Jan;6(1):32-43.
2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, etal., Genome Res 1996 Sep;6(9):791-806.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Characterization of pulmonary vascular remodeling and MicroRNA-126-targets in COPD-pulmonary hypertension. Goel K, etal., Respir Res. 2022 Dec 15;23(1):349. doi: 10.1186/s12931-022-02267-4.
6. ADAM9 expression in pancreatic cancer is associated with tumour type and is a prognostic factor in ductal adenocarcinoma. Grutzmann R, etal., Br J Cancer. 2004 Mar 8;90(5):1053-8.
7. Involvement of TACE/ADAM17 and ADAM10 in etoposide-induced apoptosis of germ cells in rat spermatogenesis. Lizama C, etal., J Cell Physiol. 2012 Feb;227(2):829-38. doi: 10.1002/jcp.22795.
8. Identification, cellular distribution and potential function of the metalloprotease-disintegrin MDC9 in the kidney. Mahimkar RM, etal., J Am Soc Nephrol 2000 Apr;11(4):595-603.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. ADAM9, ADAM10, and ADAM15 mRNA levels in the rat brain after kainic acid-induced status epilepticus. Ortiz RM, etal., Brain Res Mol Brain Res. 2005 Jun 13;137(1-2):272-5. Epub 2005 Apr 20.
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Comprehensive gene review and curation RGD comprehensive gene curation
17. Effects of aluminium on ß-amyloid (1-42) and secretases (APP-cleaving enzymes) in rat brain. Wang L, etal., Neurochem Res. 2014 Jul;39(7):1338-45. doi: 10.1007/s11064-014-1317-z. Epub 2014 May 3.
18. Low blood flow after angioplasty augments mechanisms of restenosis: inward vessel remodeling, cell migration, and activity of genes regulating migration. Ward MR, etal., Arterioscler Thromb Vasc Biol. 2001 Feb;21(2):208-13.
19. Increased expression of ADAM 9 and ADAM 15 mRNA in pancreatic cancer. Yamada D, etal., Anticancer Res. 2007 Mar-Apr;27(2):793-9.
20. Expression of ADAM9 in CIN3 lesions and squamous cell carcinomas of the cervix. Zubel A, etal., Gynecol Oncol. 2009 Aug;114(2):332-6. Epub 2009 May 27.
Additional References at PubMed
PMID:8647900   PMID:9857183   PMID:9920899   PMID:10531379   PMID:10825303   PMID:11162558   PMID:11831872   PMID:11955914   PMID:12054541   PMID:12535668   PMID:15361064   PMID:15739225  
PMID:16311053   PMID:17018608   PMID:17704059   PMID:19273593   PMID:21423176   PMID:22480688   PMID:23533145   PMID:24006456  


Genomics

Comparative Map Data
Adam9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81673,725,186 - 73,804,284 (+)NCBIGRCr8
mRatBN7.21667,022,538 - 67,101,647 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1667,022,655 - 67,100,917 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1672,299,877 - 72,378,087 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01675,705,845 - 75,783,765 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01670,952,385 - 71,031,826 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01671,810,377 - 71,887,926 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1671,810,377 - 71,887,926 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01671,459,144 - 71,536,608 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41671,446,498 - 71,526,108 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11671,446,762 - 71,526,373 (+)NCBI
Celera1664,927,252 - 65,004,785 (+)NCBICelera
Cytogenetic Map16q12.4NCBI
ADAM9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38838,996,973 - 39,105,261 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl838,996,754 - 39,105,445 (+)EnsemblGRCh38hg38GRCh38
GRCh37838,854,492 - 38,962,780 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36838,973,662 - 39,081,937 (+)NCBINCBI36Build 36hg18NCBI36
Build 34838,973,661 - 39,081,934NCBI
Celera837,806,051 - 37,914,424 (+)NCBICelera
Cytogenetic Map8p11.22NCBI
HuRef837,387,348 - 37,495,887 (+)NCBIHuRef
CHM1_1839,056,582 - 39,164,835 (+)NCBICHM1_1
T2T-CHM13v2.0839,274,115 - 39,382,400 (+)NCBIT2T-CHM13v2.0
Adam9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39825,439,627 - 25,507,138 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl825,439,627 - 25,506,943 (-)EnsemblGRCm39 Ensembl
GRCm38824,949,611 - 25,017,040 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl824,949,611 - 25,016,927 (-)EnsemblGRCm38mm10GRCm38
MGSCv37826,060,083 - 26,127,394 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36826,415,170 - 26,482,339 (-)NCBIMGSCv36mm8
Celera826,416,905 - 26,484,530 (-)NCBICelera
Cytogenetic Map8A2NCBI
cM Map813.7NCBI
Adam9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546314,545,589 - 14,645,419 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546314,545,425 - 14,646,498 (+)NCBIChiLan1.0ChiLan1.0
ADAM9
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2757,559,148 - 57,667,461 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1833,276,626 - 33,384,700 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0838,298,194 - 38,406,706 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1835,473,280 - 35,581,192 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl835,473,278 - 35,581,192 (+)Ensemblpanpan1.1panPan2
ADAM9
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11626,413,345 - 26,551,293 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1626,414,583 - 26,551,122 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1626,936,243 - 27,072,615 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01628,245,576 - 28,382,674 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1628,058,376 - 28,382,944 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11626,539,869 - 26,676,393 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01627,116,645 - 27,253,104 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01627,154,835 - 27,291,400 (-)NCBIUU_Cfam_GSD_1.0
Adam9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494349,072,313 - 49,159,738 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367102,301,730 - 2,387,695 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367102,301,470 - 2,388,533 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADAM9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1547,523,771 - 47,601,710 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11547,523,768 - 47,601,722 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21554,595,430 - 54,674,618 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADAM9
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1837,017,827 - 37,131,462 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl837,017,545 - 37,131,615 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660524,848,368 - 4,962,432 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adam9
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247804,480,647 - 4,612,477 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247804,482,696 - 4,612,475 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adam9
571 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:67
Count of miRNA genes:56
Interacting mature miRNAs:65
Transcripts:ENSRNOT00000041330
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat

Markers in Region
RH136732  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21667,022,996 - 67,023,132 (+)MAPPERmRatBN7.2
Rnor_6.01671,810,682 - 71,810,817NCBIRnor6.0
Rnor_5.01671,459,449 - 71,459,584UniSTSRnor5.0
RGSC_v3.41671,446,803 - 71,446,938UniSTSRGSC3.4
Celera1664,927,557 - 64,927,692UniSTS
RH 3.4 Map16624.5UniSTS
Cytogenetic Map16q12.4UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000041330   ⟹   ENSRNOP00000044741
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1667,022,692 - 67,100,917 (+)Ensembl
Rnor_6.0 Ensembl1671,810,377 - 71,887,926 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096318   ⟹   ENSRNOP00000077805
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1667,022,655 - 67,087,344 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000120151   ⟹   ENSRNOP00000089910
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1667,027,229 - 67,100,917 (+)Ensembl
RefSeq Acc Id: NM_001014772   ⟹   NP_001014772
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81673,725,339 - 73,803,554 (+)NCBI
mRatBN7.21667,022,692 - 67,100,917 (+)NCBI
Rnor_6.01671,810,377 - 71,887,926 (+)NCBI
Rnor_5.01671,459,144 - 71,536,608 (+)NCBI
RGSC_v3.41671,446,498 - 71,526,108 (+)RGD
Celera1664,927,252 - 65,004,785 (+)RGD
Sequence:
RefSeq Acc Id: XM_039094403   ⟹   XP_038950331
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81673,725,192 - 73,804,284 (+)NCBI
mRatBN7.21667,022,538 - 67,101,647 (+)NCBI
RefSeq Acc Id: XM_063275248   ⟹   XP_063131318
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81673,725,186 - 73,787,121 (+)NCBI
RefSeq Acc Id: XM_063275249   ⟹   XP_063131319
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81673,725,199 - 73,804,284 (+)NCBI
RefSeq Acc Id: NP_001014772   ⟸   NM_001014772
- Peptide Label: precursor
- UniProtKB: E9PTA4 (UniProtKB/TrEMBL),   Q58GH6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000044741   ⟸   ENSRNOT00000041330
RefSeq Acc Id: XP_038950331   ⟸   XM_039094403
- Peptide Label: isoform X2
- UniProtKB: Q58GH6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000089910   ⟸   ENSRNOT00000120151
Ensembl Acc Id: ENSRNOP00000077805   ⟸   ENSRNOT00000096318
RefSeq Acc Id: XP_063131318   ⟸   XM_063275248
- Peptide Label: isoform X1
- UniProtKB: Q58GH6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131319   ⟸   XM_063275249
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AAS7 (UniProtKB/TrEMBL)
Protein Domains
Disintegrin   EGF-like   Peptidase M12B

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-E9PTA4-F1-model_v2 AlphaFold E9PTA4 1-845 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700174
Promoter ID:EPDNEW_R10698
Type:initiation region
Name:Adam9_1
Description:ADAM metallopeptidase domain 9
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01671,810,321 - 71,810,381EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621473 AgrOrtholog
BioCyc Gene G2FUF-10951 BioCyc
Ensembl Genes ENSRNOG00000017231 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000041330.5 UniProtKB/TrEMBL
  ENSRNOT00000096318.1 UniProtKB/TrEMBL
  ENSRNOT00000120151.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.390.10 UniProtKB/TrEMBL
  4.10.70.10 UniProtKB/TrEMBL
InterPro ADAM_Cys-rich UniProtKB/TrEMBL
  Blood-coag_inhib_Disintegrin UniProtKB/TrEMBL
  Disintegrin_CS UniProtKB/TrEMBL
  Disintegrin_dom_sf UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  MetalloPept_cat_dom UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/TrEMBL
  Peptidase_M12B_N UniProtKB/TrEMBL
  Reprolysin_adamalysin UniProtKB/TrEMBL
KEGG Report rno:290834 UniProtKB/TrEMBL
NCBI Gene Adam9 ENTREZGENE
PANTHER ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN UniProtKB/TrEMBL
  DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 9 UniProtKB/TrEMBL
Pfam ADAM_CR UniProtKB/TrEMBL
  Disintegrin UniProtKB/TrEMBL
  Pep_M12B_propep UniProtKB/TrEMBL
  Reprolysin UniProtKB/TrEMBL
PhenoGen Adam9 PhenoGen
PRINTS DISINTEGRIN UniProtKB/TrEMBL
PROSITE ADAM_MEPRO UniProtKB/TrEMBL
  DISINTEGRIN_1 UniProtKB/TrEMBL
  DISINTEGRIN_2 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017231 RatGTEx
SMART ACR UniProtKB/TrEMBL
  DISIN UniProtKB/TrEMBL
Superfamily-SCOP Disintegrin UniProtKB/TrEMBL
  Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
UniProt A0A8I5Y224_RAT UniProtKB/TrEMBL
  A0A8I6AAS7 ENTREZGENE, UniProtKB/TrEMBL
  A6IW28_RAT UniProtKB/TrEMBL
  E9PTA4 ENTREZGENE, UniProtKB/TrEMBL
  Q58GH6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-28 Adam9  ADAM metallopeptidase domain 9  Adam9  ADAM metallopeptidase domain 9 (meltrin gamma)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-18 Adam9  ADAM metallopeptidase domain 9 (meltrin gamma)  Adam9  a disintegrin and metallopeptidase domain 9 (meltrin gamma)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-22 Adam9  a disintegrin and metallopeptidase domain 9 (meltrin gamma)  Adam9  a disintegrin and metalloproteinase domain 9 (meltrin gamma)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-30 Adam9  a disintegrin and metalloproteinase domain 9 (meltrin gamma)  Adam9_predicted  a disintegrin and metalloproteinase domain 9 (meltrin gamma) (predicted)  Data merged from RGD:1310302 737654 APPROVED
2005-01-12 Adam9_predicted  a disintegrin and metalloproteinase domain 9 (meltrin gamma) (predicted)      Symbol and Name status set to approved 70820 APPROVED
2002-08-07 Adam9  a disintegrin and metalloproteinase domain 9 (meltrin gamma)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in renal cortical tubule cells and glomerular visceral epithelial cells 632497
gene_expression colocalizes with beta-1-integrin chain 632497
gene_product member of the disintegrin and metalloprotease domain family 632497