Il2rg (interleukin 2 receptor subunit gamma) - Rat Genome Database

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Gene: Il2rg (interleukin 2 receptor subunit gamma) Rattus norvegicus
Analyze
Symbol: Il2rg
Name: interleukin 2 receptor subunit gamma
RGD ID: 621466
Description: Predicted to enable coreceptor activity; interleukin-15 receptor activity; and interleukin-2 binding activity. Predicted to be involved in cytokine-mediated signaling pathway and positive regulation of phagocytosis. Predicted to act upstream of or within positive regulation of gene expression and positive regulation of lymphocyte differentiation. Predicted to be located in endoplasmic reticulum; external side of plasma membrane; and nucleoplasm. Predicted to be active in plasma membrane. Used to study X-linked severe combined immunodeficiency and combined T cell and B cell immunodeficiency. Human ortholog(s) of this gene implicated in X-linked severe combined immunodeficiency; combined T cell and B cell immunodeficiency; and severe combined immunodeficiency. Orthologous to human IL2RG (interleukin 2 receptor subunit gamma); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-2 signaling pathway; interleukin-4 signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Ab2-183; Cd132; cytokine receptor common subunit gamma; interleukin 2 receptor, gamma (severe combined immunodeficiency); interleukin 2 receptor, gamma chain
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Il2rgem2Mcwi   Il2rgem1Mcwi   Il2rgem3Mcwi   Il2rgem1Kyo   Il2rgem2Kyo   Il2rgem1Hina   Il2rgem6Kyo   Il2rgem5Kyo   Il2rgem1Iexas   Il2rgem4Kyo   Il2rgem3Kyo   Il2rgem1Ang   Il2rgem7Kyo  
Genetic Models: SD-Il2rgem2Mcwi SS-Il2rgem1Mcwi SD-Il2rgem3Mcwi SD-Rag2em3McwiIl2rgem2Mcwi SD-Il2rgem1Ang TM-Il2rgem5Kyo TM-Il2rgem4Kyo F344-Il2rgem3Kyo F344-Il2rgem2Kyo F344-Il2rgem1Kyo F344-Il2rgem1IexasRag2em1Iexas F344-Il2rgem1Iexas W-Il2rgem1Hina F344-Il2rgem7Kyo TM-Prkdcem4KyoIl2rgem5Kyo F344-Prkdcem2KyoIl2rgem6Kyo
Is Marker For: Strains:   F344-Prkdcem2KyoIl2rgem6Kyo   TM-Prkdcem4KyoIl2rgem5Kyo  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X66,395,330 - 66,399,026 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX66,392,542 - 66,399,823 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX67,878,691 - 67,882,351 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X71,379,079 - 71,382,739 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X68,939,986 - 68,943,646 (-)NCBIRnor_WKY
Rnor_6.0X71,165,378 - 71,169,078 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX71,162,585 - 71,169,865 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X72,017,856 - 72,021,516 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X89,342,055 - 89,345,715 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X89,416,495 - 89,419,068 (-)NCBI
CeleraX66,751,239 - 66,754,899 (-)NCBICelera
Cytogenetic MapXq22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Screening for mutations causing X-linked severe combined immunodeficiency in the IL-2R gamma chain gene by single-strand conformation polymorphism analysis. Clark PA, etal., Hum Genet. 1995 Oct;96(4):427-32.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Correlation Between Relative Nasopharyngeal Virus RNA Load and Lymphocyte Count Disease Severity in Patients with COVID-19. Liu Y, etal., Viral Immunol. 2020 Apr 10. doi: 10.1089/vim.2020.0062.
5. Generation of knockout rats with X-linked severe combined immunodeficiency (X-SCID) using zinc-finger nucleases. Mashimo T, etal., PLoS One. 2010 Jan 25;5(1):e8870.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Generation of immunodeficient rats with Rag1 and Il2rg gene deletions and human tissue grafting models. Ménoret S, etal., Transplantation. 2018 Apr 24. doi: 10.1097/TP.0000000000002251.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Structural basis for binding multiple ligands by the common cytokine receptor gamma-chain. Olosz F and Malek TR, J Biol Chem 2002 Apr 5;277(14):12047-52.
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8262055   PMID:9252128   PMID:9916699   PMID:12477932   PMID:15123770   PMID:16227984   PMID:18958875   PMID:19946888   PMID:23918385  


Genomics

Comparative Map Data
Il2rg
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X66,395,330 - 66,399,026 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX66,392,542 - 66,399,823 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX67,878,691 - 67,882,351 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X71,379,079 - 71,382,739 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X68,939,986 - 68,943,646 (-)NCBIRnor_WKY
Rnor_6.0X71,165,378 - 71,169,078 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX71,162,585 - 71,169,865 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X72,017,856 - 72,021,516 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X89,342,055 - 89,345,715 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X89,416,495 - 89,419,068 (-)NCBI
CeleraX66,751,239 - 66,754,899 (-)NCBICelera
Cytogenetic MapXq22NCBI
IL2RG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X71,107,404 - 71,111,577 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 EnsemblX71,107,404 - 71,112,108 (-)EnsemblGRCh38hg38GRCh38
GRCh37X70,327,254 - 70,331,427 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X70,243,984 - 70,248,128 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X70,110,279 - 70,114,424NCBI
CeleraX70,681,159 - 70,685,386 (-)NCBICelera
Cytogenetic MapXq13.1NCBI
HuRefX64,146,973 - 64,150,762 (-)NCBIHuRef
CHM1_1X70,219,589 - 70,223,820 (-)NCBICHM1_1
T2T-CHM13v2.0X69,541,496 - 69,545,673 (-)NCBIT2T-CHM13v2.0
Il2rg
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X100,307,991 - 100,311,861 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX100,307,984 - 100,311,861 (-)EnsemblGRCm39 Ensembl
GRCm38X101,264,385 - 101,268,255 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX101,264,378 - 101,268,255 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X98,459,726 - 98,463,545 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X97,467,106 - 97,470,925 (-)NCBIMGSCv36mm8
CeleraX88,180,558 - 88,184,377 (-)NCBICelera
Cytogenetic MapXDNCBI
cM MapX43.9NCBI
Il2rg
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547510,676,870 - 10,680,517 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547510,676,592 - 10,680,565 (-)NCBIChiLan1.0ChiLan1.0
IL2RG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1X70,788,781 - 70,792,982 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X60,375,815 - 60,386,936 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X70,433,355 - 70,437,590 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX70,433,360 - 70,437,590 (-)Ensemblpanpan1.1panPan2
IL2RG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X55,480,846 - 55,488,485 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX55,481,092 - 55,484,751 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX46,308,162 - 46,311,760 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X56,449,759 - 56,453,658 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX56,450,007 - 56,453,637 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X54,418,234 - 54,421,830 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X55,749,655 - 55,753,253 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X55,676,806 - 55,680,404 (-)NCBIUU_Cfam_GSD_1.0
Dog CytomapXqNCBI
Il2rg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X46,725,215 - 46,728,870 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936762487,380 - 491,044 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936762487,414 - 491,028 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL2RG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX57,143,570 - 57,147,256 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X57,143,568 - 57,151,242 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X64,674,048 - 64,677,372 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig CytomapXq13NCBI
IL2RG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X60,905,011 - 60,915,723 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX60,905,343 - 60,909,149 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660652,765,485 - 2,776,292 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il2rg
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249031,402,481 - 1,406,600 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249031,402,586 - 1,406,554 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Il2rg
3 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:288
Count of miRNA genes:177
Interacting mature miRNAs:199
Transcripts:ENSRNOT00000005343, ENSRNOT00000050415
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat

Markers in Region
U21795  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X66,395,261 - 66,395,407 (+)MAPPERmRatBN7.2
Rnor_6.0X71,165,305 - 71,165,450NCBIRnor6.0
Rnor_5.0X72,017,783 - 72,017,928UniSTSRnor5.0
RGSC_v3.4X89,341,982 - 89,342,127UniSTSRGSC3.4
CeleraX66,751,166 - 66,751,311UniSTS
Cytogenetic MapXq31UniSTS
PMC155645P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X66,397,266 - 66,397,791 (+)MAPPERmRatBN7.2
Rnor_6.0X71,167,310 - 71,167,834NCBIRnor6.0
Rnor_5.0X72,019,788 - 72,020,312UniSTSRnor5.0
RGSC_v3.4X89,343,987 - 89,344,511UniSTSRGSC3.4
CeleraX66,753,171 - 66,753,695UniSTS
Cytogenetic MapXq31UniSTS
Il2rg  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X66,395,934 - 66,396,380 (+)MAPPERmRatBN7.2
Rnor_6.0X71,165,978 - 71,166,423NCBIRnor6.0
Rnor_5.0X72,018,456 - 72,018,901UniSTSRnor5.0
RGSC_v3.4X89,342,655 - 89,343,100UniSTSRGSC3.4
CeleraX66,751,839 - 66,752,284UniSTS
Cytogenetic MapXq31UniSTS


Related Rat Strains
The following Strains have been annotated to Il2rg


Genetic Models

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 9 8 19 2 11
Low 1 34 49 41 41 8 11 64 35 39 8
Below cutoff 10

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_080889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF410926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC079343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU294902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU294903 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU294904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU294905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU294906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU294907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU294908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU294909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU294910 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU294911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU294912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU294913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU294914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU294915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU294916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU294917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU294918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU294919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU294920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU294921 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU294922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU294923 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU294924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU294925 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000005343   ⟹   ENSRNOP00000005343
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX66,395,336 - 66,399,017 (-)Ensembl
Rnor_6.0 EnsemblX71,165,366 - 71,169,038 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000050415   ⟹   ENSRNOP00000050241
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX66,392,542 - 66,399,823 (-)Ensembl
Rnor_6.0 EnsemblX71,162,585 - 71,169,865 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000075911
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX71,165,785 - 71,167,054 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000075934   ⟹   ENSRNOP00000068438
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX66,392,542 - 66,399,044 (-)Ensembl
Rnor_6.0 EnsemblX71,165,366 - 71,168,612 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076166
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX71,165,912 - 71,166,988 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000077024
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX71,167,829 - 71,169,032 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000102285   ⟹   ENSRNOP00000088633
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX66,392,542 - 66,398,386 (-)Ensembl
RefSeq Acc Id: NM_080889   ⟹   NP_543165
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X66,395,335 - 66,398,996 (-)NCBI
Rnor_6.0X71,165,378 - 71,169,038 (-)NCBI
Rnor_5.0X72,017,856 - 72,021,516 (-)NCBI
RGSC_v3.4X89,342,055 - 89,345,715 (-)RGD
CeleraX66,751,239 - 66,754,899 (-)RGD
Sequence:
RefSeq Acc Id: XM_017601899   ⟹   XP_017457388
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X66,396,342 - 66,399,026 (-)NCBI
Rnor_6.0X71,166,385 - 71,169,078 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039099435   ⟹   XP_038955363
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X66,395,330 - 66,399,026 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_543165   ⟸   NM_080889
- Peptide Label: precursor
- UniProtKB: Q68FU6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017457388   ⟸   XM_017601899
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000068438   ⟸   ENSRNOT00000075934
RefSeq Acc Id: ENSRNOP00000005343   ⟸   ENSRNOT00000005343
RefSeq Acc Id: ENSRNOP00000050241   ⟸   ENSRNOT00000050415
RefSeq Acc Id: XP_038955363   ⟸   XM_039099435
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000088633   ⟸   ENSRNOT00000102285
Protein Domains
Fibronectin type-III

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q7TP53-F1-model_v2 AlphaFold Q7TP53 1-448 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701872
Promoter ID:EPDNEW_R12396
Type:multiple initiation site
Name:Il2rg_1
Description:interleukin 2 receptor subunit gamma
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X71,169,045 - 71,169,105EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621466 AgrOrtholog
BioCyc Gene G2FUF-2104 BioCyc
Ensembl Genes ENSRNOG00000003954 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000005343 ENTREZGENE
  ENSRNOP00000005343.4 UniProtKB/TrEMBL
  ENSRNOP00000050241.3 UniProtKB/TrEMBL
  ENSRNOP00000088633.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005343 ENTREZGENE
  ENSRNOT00000005343.8 UniProtKB/TrEMBL
  ENSRNOT00000050415.7 UniProtKB/TrEMBL
  ENSRNOT00000102285.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7106866 IMAGE-MGC_LOAD
InterPro CXorf65-like UniProtKB/TrEMBL
  Fibronectin_type3 UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  Hempt_rcpt_S_F1_CS UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  IL6_recept-bd UniProtKB/TrEMBL
KEGG Report rno:140924 UniProtKB/TrEMBL
MGC_CLONE MGC:94791 IMAGE-MGC_LOAD
NCBI Gene 140924 ENTREZGENE
PANTHER AB2-183 UniProtKB/TrEMBL
  CYTOKINE RECEPTOR UniProtKB/TrEMBL
  INTERLEUKIN 2 RECEPTOR GAMMA COMMON.B UniProtKB/TrEMBL
  PTHR33887 UniProtKB/TrEMBL
Pfam fn3 UniProtKB/TrEMBL
  Il2rg UniProtKB/TrEMBL
  IL6Ra-bind UniProtKB/TrEMBL
PhenoGen Il2rg PhenoGen
PROSITE FN3 UniProtKB/TrEMBL
  HEMATOPO_REC_S_F1 UniProtKB/TrEMBL
SMART FN3 UniProtKB/TrEMBL
Superfamily-SCOP FN_III-like UniProtKB/TrEMBL
UniProt A0A8I6A886_RAT UniProtKB/TrEMBL
  D3JTH6_RAT UniProtKB/TrEMBL
  D3JTH7_RAT UniProtKB/TrEMBL
  D3JTH8_RAT UniProtKB/TrEMBL
  D3JTI0_RAT UniProtKB/TrEMBL
  Q68FU6 ENTREZGENE, UniProtKB/TrEMBL
  Q7TP53_RAT UniProtKB/TrEMBL
  Q8VHR8_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-11-06 Il2rg  interleukin 2 receptor, gamma  Il2rg  interleukin 2 receptor, gamma chain  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-22 Il2rg  interleukin 2 receptor, gamma chain  Il2rg  interleukin 2 receptor, gamma (severe combined immunodeficiency)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Il2rg  interleukin 2 receptor, gamma (severe combined immunodeficiency)    interleukin 2 receptor, gamma chain  Name updated 1299863 APPROVED
2002-08-07 Il2rg  interleukin 2 receptor, gamma chain      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease mutation causes X-linked severe combined immunodeficiency disease (X-SCID) 633044