Tnrc6b (trinucleotide repeat containing adaptor 6B) - Rat Genome Database

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Gene: Tnrc6b (trinucleotide repeat containing adaptor 6B) Rattus norvegicus
Analyze
Symbol: Tnrc6b
Name: trinucleotide repeat containing adaptor 6B
RGD ID: 621428
Description: Predicted to enable RNA binding activity. Predicted to be involved in miRNA-mediated post-transcriptional gene silencing; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; and positive regulation of nuclear-transcribed mRNA poly(A) tail shortening. Predicted to act upstream of with a positive effect on miRNA-mediated gene silencing by inhibition of translation. Predicted to be located in cytosol. Predicted to be active in P-body and nucleoplasm. Human ortholog(s) of this gene implicated in subserous uterine fibroid and uterine fibroid. Orthologous to human TNRC6B (trinucleotide repeat containing adaptor 6B); PARTICIPATES IN microRNA pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: androgen receptor-related apoptosis-associated protein CBL27; Cbl27; trinucleotide repeat containing 6B; trinucleotide repeat-containing gene 6B protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87114,132,574 - 114,350,010 (+)NCBIGRCr8
mRatBN7.27112,252,351 - 112,469,829 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7112,252,359 - 112,461,790 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7114,007,948 - 114,225,403 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07116,231,483 - 116,448,945 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07116,200,854 - 116,418,318 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07121,930,610 - 122,147,934 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7121,930,615 - 122,147,934 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07121,922,421 - 122,139,717 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47118,993,653 - 119,212,958 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17119,193,462 - 119,235,531 (+)NCBI
Celera7108,576,591 - 108,793,423 (+)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
6-propyl-2-thiouracil  (EXP)
aconitine  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
Brodifacoum  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
chloroprene  (EXP)
chlorpyrifos  (EXP,ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diazinon  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
enzyme inhibitor  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
indometacin  (ISO)
levonorgestrel  (ISO)
melphalan  (ISO)
methapyrilene  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
nickel dichloride  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
phenobarbital  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
propiconazole  (ISO)
SB 431542  (ISO)
succimer  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
testosterone undecanoate  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
triphenyl phosphate  (EXP)
troglitazone  (ISO)
tungsten  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IEA,TAS)
nucleoplasm  (IBA)
P-body  (IBA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Variants in BET1L and TNRC6B associate with increasing fibroid volume and fibroid type among European Americans. Edwards TL, etal., Hum Genet. 2013 Dec;132(12):1361-9. doi: 10.1007/s00439-013-1340-1. Epub 2013 Jul 28.
2. Argonaute proteins at a glance. Ender C and Meister G, J Cell Sci. 2010 Jun 1;123(Pt 11):1819-23.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. Information Derived from GenBank Report RGD, Sept. 2003
Additional References at PubMed
PMID:12477932   PMID:19716330   PMID:22658674   PMID:35352799  


Genomics

Comparative Map Data
Tnrc6b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87114,132,574 - 114,350,010 (+)NCBIGRCr8
mRatBN7.27112,252,351 - 112,469,829 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7112,252,359 - 112,461,790 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7114,007,948 - 114,225,403 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07116,231,483 - 116,448,945 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07116,200,854 - 116,418,318 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07121,930,610 - 122,147,934 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7121,930,615 - 122,147,934 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07121,922,421 - 122,139,717 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47118,993,653 - 119,212,958 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17119,193,462 - 119,235,531 (+)NCBI
Celera7108,576,591 - 108,793,423 (+)NCBICelera
Cytogenetic Map7q34NCBI
TNRC6B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382240,044,834 - 40,335,808 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2240,044,817 - 40,335,808 (+)EnsemblGRCh38hg38GRCh38
GRCh372240,440,838 - 40,731,812 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362238,770,767 - 39,061,758 (+)NCBINCBI36Build 36hg18NCBI36
Build 342238,898,445 - 39,043,860NCBI
Celera2224,242,863 - 24,533,872 (+)NCBICelera
Cytogenetic Map22q13.1NCBI
HuRef2223,404,077 - 23,694,839 (+)NCBIHuRef
CHM1_12240,400,124 - 40,690,692 (+)NCBICHM1_1
T2T-CHM13v2.02240,516,397 - 40,807,210 (+)NCBIT2T-CHM13v2.0
Tnrc6b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391580,595,514 - 80,825,287 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1580,595,514 - 80,825,286 (+)EnsemblGRCm39 Ensembl
GRCm381580,711,313 - 80,941,086 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1580,711,313 - 80,941,085 (+)EnsemblGRCm38mm10GRCm38
MGSCv371580,541,743 - 80,771,516 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361580,538,568 - 80,768,341 (+)NCBIMGSCv36mm8
Celera1582,831,358 - 83,061,497 (+)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1537.91NCBI
Tnrc6b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541325,886,077 - 26,048,546 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541325,820,428 - 26,060,681 (+)NCBIChiLan1.0ChiLan1.0
TNRC6B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22349,891,090 - 50,181,077 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12252,577,475 - 52,875,556 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02221,149,646 - 21,240,006 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12238,969,663 - 39,058,432 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2238,850,107 - 39,045,914 (+)Ensemblpanpan1.1panPan2
TNRC6B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11024,852,168 - 25,094,400 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1024,813,854 - 25,094,393 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1024,787,185 - 25,030,572 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01025,602,650 - 25,846,409 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1025,602,509 - 25,846,331 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11025,314,565 - 25,558,084 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01025,637,095 - 25,880,678 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01025,811,506 - 26,055,123 (-)NCBIUU_Cfam_GSD_1.0
Tnrc6b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049458,451,252 - 8,687,007 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364921,461,533 - 1,631,165 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364921,461,572 - 1,697,500 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNRC6B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl58,063,985 - 8,311,429 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.158,052,434 - 8,311,811 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.255,418,164 - 5,430,080 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TNRC6B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11922,823,447 - 22,907,942 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1922,823,937 - 22,898,476 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045102,681,707 - 102,976,263 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tnrc6b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247528,137,532 - 8,336,877 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247528,125,472 - 8,394,809 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tnrc6b
533 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1549
Count of miRNA genes:364
Interacting mature miRNAs:563
Transcripts:ENSRNOT00000033975
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7103146217116738842Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)794811085116738842Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)780221299112308525Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat

Markers in Region
D7Mit13  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27112,308,254 - 112,308,525 (+)MAPPERmRatBN7.2
Rnor_6.07121,986,439 - 121,986,709NCBIRnor6.0
Rnor_5.07121,978,222 - 121,978,492UniSTSRnor5.0
RGSC_v3.47119,049,926 - 119,050,195RGDRGSC3.4
RGSC_v3.47119,049,927 - 119,050,197UniSTSRGSC3.4
RGSC_v3.17119,084,157 - 119,084,427RGD
RH 3.4 Map7877.2UniSTS
RH 3.4 Map7877.2RGD
RH 2.0 Map7663.3RGD
Cytogenetic Map7q34UniSTS
D7Rat129  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr87114,299,483 - 114,299,683 (+)Marker Load Pipeline
mRatBN7.27112,419,298 - 112,419,498 (+)MAPPERmRatBN7.2
Rnor_6.07122,097,408 - 122,097,607NCBIRnor6.0
Rnor_5.07122,089,191 - 122,089,390UniSTSRnor5.0
RGSC_v3.47119,161,518 - 119,161,718RGDRGSC3.4
RGSC_v3.47119,161,519 - 119,161,718UniSTSRGSC3.4
RGSC_v3.17119,195,749 - 119,195,948RGD
Celera7108,743,264 - 108,743,463UniSTS
RH 3.4 Map7877.0UniSTS
RH 3.4 Map7877.0RGD
RH 2.0 Map7661.5RGD
SHRSP x BN Map764.65RGD
Cytogenetic Map7q34UniSTS
AI848765  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27112,469,540 - 112,469,677 (+)MAPPERmRatBN7.2
Rnor_6.07122,147,646 - 122,147,782NCBIRnor6.0
Rnor_5.07122,139,429 - 122,139,565UniSTSRnor5.0
RGSC_v3.47119,212,670 - 119,212,806UniSTSRGSC3.4
Celera7108,793,135 - 108,793,271UniSTS
Cytogenetic Map7q34UniSTS
STS-R92764  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27112,341,689 - 112,341,813 (+)MAPPERmRatBN7.2
Rnor_6.07122,019,873 - 122,019,996NCBIRnor6.0
Rnor_5.07122,011,656 - 122,011,779UniSTSRnor5.0
RGSC_v3.47119,083,984 - 119,084,107UniSTSRGSC3.4
Celera7108,665,371 - 108,665,494UniSTS
Cytogenetic Map7q34UniSTS
RH140722  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27112,460,468 - 112,460,677 (+)MAPPERmRatBN7.2
Rnor_6.07122,138,573 - 122,138,781NCBIRnor6.0
Rnor_5.07122,130,356 - 122,130,564UniSTSRnor5.0
RGSC_v3.47119,203,597 - 119,203,805UniSTSRGSC3.4
Celera7108,784,062 - 108,784,270UniSTS
RH 3.4 Map7876.7UniSTS
Cytogenetic Map7q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_138845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006242061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594648 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594649 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594650 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF275151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212411 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225278 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000033975   ⟹   ENSRNOP00000036077
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7112,252,359 - 112,458,166 (+)Ensembl
Rnor_6.0 Ensembl7121,930,638 - 122,147,934 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000091270   ⟹   ENSRNOP00000073908
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7112,252,359 - 112,458,166 (+)Ensembl
Rnor_6.0 Ensembl7121,930,615 - 122,140,091 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102287   ⟹   ENSRNOP00000079479
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7112,326,723 - 112,461,790 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106327   ⟹   ENSRNOP00000080619
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7112,326,723 - 112,458,166 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108883   ⟹   ENSRNOP00000092295
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7112,339,468 - 112,458,166 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114032   ⟹   ENSRNOP00000085877
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7112,444,239 - 112,458,581 (+)Ensembl
RefSeq Acc Id: NM_138845   ⟹   NP_620200
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87114,132,574 - 114,350,010 (+)NCBI
mRatBN7.27112,252,392 - 112,469,829 (+)NCBI
Rnor_6.07121,930,638 - 122,147,934 (+)NCBI
Rnor_5.07121,922,421 - 122,139,717 (+)NCBI
RGSC_v3.47118,993,653 - 119,212,958 (+)RGD
Celera7108,576,591 - 108,793,423 (+)RGD
Sequence:
RefSeq Acc Id: XM_006242061   ⟹   XP_006242123
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87114,219,641 - 114,350,010 (+)NCBI
mRatBN7.27112,339,452 - 112,469,829 (+)NCBI
Rnor_6.07122,017,593 - 122,147,934 (+)NCBI
Rnor_5.07121,922,421 - 122,139,717 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039078366   ⟹   XP_038934294
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87114,186,322 - 114,350,010 (+)NCBI
mRatBN7.27112,306,143 - 112,469,829 (+)NCBI
RefSeq Acc Id: XM_039078367   ⟹   XP_038934295
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87114,148,821 - 114,350,010 (+)NCBI
mRatBN7.27112,288,700 - 112,469,829 (+)NCBI
RefSeq Acc Id: XM_039078369   ⟹   XP_038934297
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87114,276,624 - 114,350,010 (+)NCBI
mRatBN7.27112,402,528 - 112,469,829 (+)NCBI
RefSeq Acc Id: XM_063262961   ⟹   XP_063119031
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87114,173,264 - 114,350,010 (+)NCBI
RefSeq Acc Id: XM_063262962   ⟹   XP_063119032
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87114,186,373 - 114,350,010 (+)NCBI
RefSeq Acc Id: XM_063262963   ⟹   XP_063119033
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87114,173,258 - 114,350,010 (+)NCBI
RefSeq Acc Id: XM_063262964   ⟹   XP_063119034
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87114,234,521 - 114,350,010 (+)NCBI
RefSeq Acc Id: XM_063262965   ⟹   XP_063119035
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87114,173,264 - 114,350,010 (+)NCBI
RefSeq Acc Id: XM_063262966   ⟹   XP_063119036
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87114,173,264 - 114,350,010 (+)NCBI
RefSeq Acc Id: XM_063262968   ⟹   XP_063119038
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87114,219,641 - 114,350,010 (+)NCBI
RefSeq Acc Id: XM_063262969   ⟹   XP_063119039
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87114,219,643 - 114,350,010 (+)NCBI
RefSeq Acc Id: XM_063262970   ⟹   XP_063119040
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87114,173,264 - 114,350,010 (+)NCBI
RefSeq Acc Id: XM_063262971   ⟹   XP_063119041
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87114,173,264 - 114,350,010 (+)NCBI
RefSeq Acc Id: XM_063262972   ⟹   XP_063119042
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87114,219,643 - 114,350,010 (+)NCBI
RefSeq Acc Id: NP_620200   ⟸   NM_138845
- UniProtKB: A0A8I5ZQG5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242123   ⟸   XM_006242061
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZQG5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000036077   ⟸   ENSRNOT00000033975
Ensembl Acc Id: ENSRNOP00000073908   ⟸   ENSRNOT00000091270
RefSeq Acc Id: XP_038934295   ⟸   XM_039078367
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZQG5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934294   ⟸   XM_039078366
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZQG5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934297   ⟸   XM_039078369
- Peptide Label: isoform X7
- UniProtKB: A0A8I5ZQG5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000079479   ⟸   ENSRNOT00000102287
Ensembl Acc Id: ENSRNOP00000080619   ⟸   ENSRNOT00000106327
Ensembl Acc Id: ENSRNOP00000092295   ⟸   ENSRNOT00000108883
Ensembl Acc Id: ENSRNOP00000085877   ⟸   ENSRNOT00000114032
RefSeq Acc Id: XP_063119033   ⟸   XM_063262963
- Peptide Label: isoform X4
- UniProtKB: A0A8I5ZQG5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119031   ⟸   XM_063262961
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K6R0 (UniProtKB/TrEMBL),   A0A8I5ZQG5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119036   ⟸   XM_063262966
- Peptide Label: isoform X6
- UniProtKB: A0A8I5ZQG5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119041   ⟸   XM_063262971
- Peptide Label: isoform X11
- UniProtKB: A0A8I5ZQG5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119035   ⟸   XM_063262965
- Peptide Label: isoform X5
- UniProtKB: A0A8I5ZQG5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119040   ⟸   XM_063262970
- Peptide Label: isoform X10
- UniProtKB: F1LV37 (UniProtKB/TrEMBL),   A0A8I5ZQG5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119032   ⟸   XM_063262962
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZQG5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119038   ⟸   XM_063262968
- Peptide Label: isoform X8
- UniProtKB: A0A8I5ZQG5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119039   ⟸   XM_063262969
- Peptide Label: isoform X9
- UniProtKB: A0A8I6ADQ2 (UniProtKB/TrEMBL),   A0A8I5ZQG5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119042   ⟸   XM_063262972
- Peptide Label: isoform X12
- UniProtKB: A0A8I5ZQG5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119034   ⟸   XM_063262964
- Peptide Label: isoform X4
- UniProtKB: A0A8I5ZQG5 (UniProtKB/TrEMBL)
Protein Domains
Argonaute hook   TNRC6 PABC binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LV37-F1-model_v2 AlphaFold F1LV37 1-1818 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695499
Promoter ID:EPDNEW_R6024
Type:multiple initiation site
Name:Tnrc6b_1
Description:trinucleotide repeat containing 6B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07121,930,668 - 121,930,728EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621428 AgrOrtholog
BioCyc Gene G2FUF-32695 BioCyc
Ensembl Genes ENSRNOG00000024907 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000033975.6 UniProtKB/TrEMBL
  ENSRNOT00000091270.2 UniProtKB/TrEMBL
  ENSRNOT00000102287.1 UniProtKB/TrEMBL
  ENSRNOT00000106327.1 UniProtKB/TrEMBL
  ENSRNOT00000108883.1 UniProtKB/TrEMBL
  ENSRNOT00000114032.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.330 UniProtKB/TrEMBL
InterPro Argonaute_hook_dom UniProtKB/TrEMBL
  GW182_domain UniProtKB/TrEMBL
  Nucleotide-bd_a/b_plait_sf UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/TrEMBL
  TNRC6_PABC-bd UniProtKB/TrEMBL
  TNRC6B_RRM UniProtKB/TrEMBL
NCBI Gene 192178 ENTREZGENE
PANTHER PTHR13020:SF32 UniProtKB/TrEMBL
  TRINUCLEOTIDE REPEAT-CONTAINING GENE 6 UniProtKB/TrEMBL
Pfam Ago_hook UniProtKB/TrEMBL
  TNRC6-PABC_bdg UniProtKB/TrEMBL
PhenoGen Tnrc6b PhenoGen
RatGTEx ENSRNOG00000024907 RatGTEx
Superfamily-SCOP SSF54928 UniProtKB/TrEMBL
UniProt A0A0G2K6R0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZN70_RAT UniProtKB/TrEMBL
  A0A8I5ZQG5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A501_RAT UniProtKB/TrEMBL
  A0A8I6ADQ2 ENTREZGENE, UniProtKB/TrEMBL
  F1LV37 ENTREZGENE, UniProtKB/TrEMBL
  Q6P7B1_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-02 Tnrc6b  trinucleotide repeat containing adaptor 6B  Tnrc6b  trinucleotide repeat containing 6B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-22 Tnrc6b  trinucleotide repeat containing 6B  Cbl27  androgen receptor-related apoptosis-associated protein CBL27  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Cbl27  androgen receptor-related apoptosis-associated protein CBL27      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Cbl27  androgen receptor-related apoptosis-associated protein CBL27      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the spleen 634611