Pls3 (plastin 3) - Rat Genome Database

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Gene: Pls3 (plastin 3) Rattus norvegicus
Analyze
Symbol: Pls3
Name: plastin 3
RGD ID: 621409
Description: Predicted to enable actin filament binding activity. Predicted to be a structural constituent of presynaptic actin cytoskeleton. Involved in inner ear auditory receptor cell differentiation. Located in stereocilium. Human ortholog(s) of this gene implicated in congenital diaphragmatic hernia. Orthologous to human PLS3 (plastin 3); PARTICIPATES IN auditory mechanotransduction pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: plastin 3 (T-isoform); plastin-3; T-plastin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X116,401,247 - 116,495,898 (+)NCBIGRCr8
mRatBN7.2X111,589,193 - 111,683,908 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX111,589,254 - 111,683,891 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX113,692,615 - 113,779,538 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X117,183,401 - 117,270,327 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X114,734,740 - 114,821,667 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X119,030,311 - 119,124,268 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX119,030,419 - 119,124,250 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X119,173,230 - 119,266,240 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X29,868,937 - 29,965,118 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X29,923,513 - 29,982,843 (-)NCBI
CeleraX110,881,127 - 110,971,056 (+)NCBICelera
Cytogenetic MapXq34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-azacytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
beauvericin  (ISO)
benzbromarone  (EXP)
benzene  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
bucladesine  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
coumarin  (ISO)
D-glucose  (ISO)
DDT  (EXP)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
enniatin  (ISO)
entinostat  (ISO)
enzyme inhibitor  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fonofos  (ISO)
fulvestrant  (ISO)
gallic acid  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glucose  (ISO)
haloperidol  (ISO)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP,ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
L-ethionine  (EXP)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
malathion  (ISO)
manganese(II) chloride  (EXP)
medroxyprogesterone acetate  (ISO)
methapyrilene  (ISO)
methylmercury chloride  (ISO)
methylmercury(1+)  (EXP)
N-nitrosomorpholine  (EXP)
nefazodone  (EXP)
nickel sulfate  (ISO)
omeprazole  (EXP)
oxaliplatin  (EXP)
paracetamol  (ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
terbufos  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
tunicamycin  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transient expression of the t-isoform of plastins/fimbrin in the stereocilia of developing auditory hair cells. Daudet N and Lebart MC, Cell Motil Cytoskeleton 2002 Dec;53(4):326-36.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Review series: The cell biology of hearing. Schwander M, etal., J Cell Biol. 2010 Jul 12;190(1):9-20. doi: 10.1083/jcb.201001138.
Additional References at PubMed
PMID:7655078   PMID:12477932   PMID:23263861   PMID:24088043  


Genomics

Comparative Map Data
Pls3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X116,401,247 - 116,495,898 (+)NCBIGRCr8
mRatBN7.2X111,589,193 - 111,683,908 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX111,589,254 - 111,683,891 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX113,692,615 - 113,779,538 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X117,183,401 - 117,270,327 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X114,734,740 - 114,821,667 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X119,030,311 - 119,124,268 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX119,030,419 - 119,124,250 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X119,173,230 - 119,266,240 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X29,868,937 - 29,965,118 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X29,923,513 - 29,982,843 (-)NCBI
CeleraX110,881,127 - 110,971,056 (+)NCBICelera
Cytogenetic MapXq34NCBI
PLS3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X115,561,174 - 115,650,861 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX115,561,174 - 115,650,861 (+)EnsemblGRCh38hg38GRCh38
GRCh37X114,795,501 - 114,885,181 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X114,701,765 - 114,791,246 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X114,618,488 - 114,707,970NCBI
CeleraX115,230,242 - 115,320,243 (+)NCBICelera
Cytogenetic MapXq23NCBI
HuRefX104,379,340 - 104,468,198 (+)NCBIHuRef
CHM1_1X114,706,001 - 114,796,082 (+)NCBICHM1_1
T2T-CHM13v2.0X113,969,539 - 114,059,207 (+)NCBIT2T-CHM13v2.0
Pls3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X74,829,259 - 74,918,788 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX74,829,260 - 74,918,788 (-)EnsemblGRCm39 Ensembl
GRCm38X75,785,653 - 75,875,182 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX75,785,654 - 75,875,182 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X73,030,993 - 73,120,509 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X72,038,383 - 72,127,258 (-)NCBIMGSCv36mm8
CeleraX67,188,917 - 67,297,722 (-)NCBICelera
Cytogenetic MapXA7.3NCBI
cM MapX38.3NCBI
Pls3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955490122,328 - 221,388 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955490125,913 - 221,152 (-)NCBIChiLan1.0ChiLan1.0
PLS3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X115,004,895 - 115,098,747 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X115,012,733 - 115,102,356 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X104,656,110 - 104,745,702 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X115,160,032 - 115,250,144 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX115,160,032 - 115,250,144 (+)Ensemblpanpan1.1panPan2
PLS3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X88,308,817 - 88,399,682 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX88,308,888 - 88,398,810 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX74,429,089 - 74,519,776 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X90,023,698 - 90,114,659 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX90,022,719 - 90,117,154 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X87,466,392 - 87,557,283 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X89,141,351 - 89,232,259 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X88,976,701 - 89,067,622 (+)NCBIUU_Cfam_GSD_1.0
Pls3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X87,322,781 - 87,411,736 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936499246,042 - 335,440 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936499246,042 - 335,440 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLS3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX94,885,118 - 94,971,659 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X94,885,098 - 94,971,664 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X109,452,808 - 109,539,961 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PLS3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366606528,495,210 - 28,582,236 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pls3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624940120,073 - 216,622 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624940120,073 - 216,522 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pls3
222 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:549
Count of miRNA genes:277
Interacting mature miRNAs:347
Transcripts:ENSRNOT00000060168
Prediction methods:Microtar, Miranda, Pita, Pita,Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X103312877148312877Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X103312877148312877Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX100567703150256146Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
724551Glom1Glomerulus QTL 12.80.0004kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)X75294106120294106Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat

Markers in Region
RH139054  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X111,628,349 - 111,628,511 (+)MAPPERmRatBN7.2
Rnor_6.0X119,069,784 - 119,069,945NCBIRnor6.0
Rnor_5.0X119,211,762 - 119,211,923UniSTSRnor5.0
RGSC_v3.4X29,924,408 - 29,924,569UniSTSRGSC3.4
CeleraX110,920,170 - 110,920,331UniSTS
Cytogenetic MapXq14UniSTS
RH133212  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X111,620,504 - 111,620,713 (+)MAPPERmRatBN7.2
Rnor_6.0X119,061,936 - 119,062,144NCBIRnor6.0
Rnor_5.0X119,203,914 - 119,204,122UniSTSRnor5.0
RGSC_v3.4X29,932,209 - 29,932,417UniSTSRGSC3.4
CeleraX110,912,330 - 110,912,538UniSTS
Cytogenetic MapXq14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000060168   ⟹   ENSRNOP00000056912
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX111,589,254 - 111,683,891 (+)Ensembl
Rnor_6.0 EnsemblX119,030,419 - 119,124,250 (+)Ensembl
RefSeq Acc Id: NM_031084   ⟹   NP_112346
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X116,401,309 - 116,495,898 (+)NCBI
mRatBN7.2X111,589,301 - 111,683,897 (+)NCBI
Rnor_6.0X119,030,419 - 119,124,257 (+)NCBI
Rnor_5.0X119,173,230 - 119,266,240 (+)NCBI
RGSC_v3.4X29,868,937 - 29,965,118 (-)RGD
CeleraX110,881,127 - 110,971,056 (+)RGD
Sequence:
RefSeq Acc Id: XM_006257434   ⟹   XP_006257496
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X116,401,247 - 116,495,898 (+)NCBI
mRatBN7.2X111,589,193 - 111,683,908 (+)NCBI
Rnor_6.0X119,030,311 - 119,124,268 (+)NCBI
Rnor_5.0X119,173,230 - 119,266,240 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006257438   ⟹   XP_006257500
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X116,435,471 - 116,495,898 (+)NCBI
mRatBN7.2X111,623,522 - 111,683,908 (+)NCBI
Rnor_6.0X119,064,289 - 119,124,268 (+)NCBI
Rnor_5.0X119,173,230 - 119,266,240 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017602163   ⟹   XP_017457652
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X116,435,465 - 116,495,898 (+)NCBI
mRatBN7.2X111,623,470 - 111,683,908 (+)NCBI
Rnor_6.0X119,064,288 - 119,124,268 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017602164   ⟹   XP_017457653
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X116,435,678 - 116,495,898 (+)NCBI
mRatBN7.2X111,623,675 - 111,683,908 (+)NCBI
Rnor_6.0X119,065,041 - 119,124,268 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063280325   ⟹   XP_063136395
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X116,410,687 - 116,495,898 (+)NCBI
RefSeq Acc Id: XM_063280326   ⟹   XP_063136396
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X116,401,821 - 116,495,898 (+)NCBI
RefSeq Acc Id: XM_063280327   ⟹   XP_063136397
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X116,435,678 - 116,495,898 (+)NCBI
RefSeq Acc Id: NP_112346   ⟸   NM_031084
- UniProtKB: Q63598 (UniProtKB/Swiss-Prot),   A6KGB3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257496   ⟸   XM_006257434
- Peptide Label: isoform X1
- UniProtKB: Q63598 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006257500   ⟸   XM_006257438
- Peptide Label: isoform X3
- UniProtKB: Q63598 (UniProtKB/Swiss-Prot),   A6KGB3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017457652   ⟸   XM_017602163
- Peptide Label: isoform X1
- UniProtKB: Q63598 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017457653   ⟸   XM_017602164
- Peptide Label: isoform X1
- UniProtKB: Q63598 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000056912   ⟸   ENSRNOT00000060168
RefSeq Acc Id: XP_063136396   ⟸   XM_063280326
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063136395   ⟸   XM_063280325
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063136397   ⟸   XM_063280327
- Peptide Label: isoform X3
- UniProtKB: A6KGB3 (UniProtKB/TrEMBL)
Protein Domains
Calponin-homology (CH)   EF-hand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63598-F1-model_v2 AlphaFold Q63598 1-630 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701972
Promoter ID:EPDNEW_R12496
Type:multiple initiation site
Name:Pls3_1
Description:plastin 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X119,030,430 - 119,030,490EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621409 AgrOrtholog
BioCyc Gene G2FUF-1433 BioCyc
Ensembl Genes ENSRNOG00000027520 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000060168.3 UniProtKB/TrEMBL
Gene3D-CATH 1.10.418.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7311086 IMAGE-MGC_LOAD
InterPro Actinin_actin-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CH-domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CH_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fimbrin/Plastin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81748 UniProtKB/TrEMBL
MGC_CLONE MGC:109253 IMAGE-MGC_LOAD
NCBI Gene 81748 ENTREZGENE
PANTHER PTHR19961 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR19961:SF32 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EF-hand_7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00307 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pls3 PhenoGen
PROSITE ACTININ_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ACTININ_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_HAND_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50021 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000027520 RatGTEx
SMART EFh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00033 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47576 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6KGB3 ENTREZGENE, UniProtKB/TrEMBL
  F1LPK7_RAT UniProtKB/TrEMBL
  PLST_RAT UniProtKB/Swiss-Prot
  Q562B2_RAT UniProtKB/TrEMBL
  Q63598 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Pls3  plastin 3  Pls3  plastin 3 (T-isoform)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Pls3  plastin 3 (T-isoform)      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Pls3  plastin 3 (T-isoform)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in stereocilia in the developing cochlea 731234
gene_product member of the plastins/fimbrin family of actin bundling proteins 731234