Skil (SKI-like proto-oncogene) - Rat Genome Database

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Gene: Skil (SKI-like proto-oncogene) Rattus norvegicus
Analyze
Symbol: Skil
Name: SKI-like proto-oncogene
RGD ID: 621399
Description: Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; SMAD binding activity; and identical protein binding activity. Involved in positive regulation of axonogenesis; response to cytokine; and spermatogenesis. Located in acrosomal vesicle and nucleus. Biomarker of ureteral obstruction. Orthologous to human SKIL (SKI like proto-oncogene); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; bisphenol A; Cuprizon.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: SKI-like; SKI-like oncogene; ski/sno related; Skir; Sno
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Skil_v1   Skil_v2  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22112,247,047 - 112,275,176 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2112,247,051 - 112,275,080 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2118,894,757 - 118,922,782 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02117,007,313 - 117,035,338 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02111,716,994 - 111,745,054 (-)NCBIRnor_WKY
Rnor_6.02115,862,932 - 115,891,304 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2115,866,701 - 115,891,097 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02135,558,909 - 135,587,255 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42116,669,375 - 116,691,472 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12116,636,239 - 116,636,434 (-)NCBI
Celera2107,434,508 - 107,462,883 (-)NCBICelera
Cytogenetic Map2q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-butoxyethanol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nonylphenol  (ISO)
4-octylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acetaldehyde  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
ferric oxide  (ISO)
fluoranthene  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glucose  (ISO)
leflunomide  (ISO)
menadione  (ISO)
Nonylphenol  (ISO)
orphenadrine  (EXP)
p-toluidine  (EXP)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
resorcinol  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
Tributyltin oxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
trovafloxacin  (ISO)
valproic acid  (EXP,ISO)
vincristine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. A SnoN-Ccd1 pathway promotes axonal morphogenesis in the mammalian brain. Ikeuchi Y, etal., J Neurosci. 2009 Apr 1;29(13):4312-21.
3. Regulated production of SnoN2 is a feature of testicular differentiation. Itman C, etal., Microsc Res Tech. 2009 Jun 12.
4. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica Lu M, etal., Zhongguo Zhong Yao Za Zhi. 2009 Jan;34(1):84-8.
5. Adenoviral delivery of dominant-negative transforming growth factor beta type II receptor up-regulates transcriptional repressor SKI-like oncogene, decreases matrix metalloproteinase 2 in hepatic stellate cell and prevents liver fibrosis in rats. Marquez-Aguirre A, etal., J Gene Med. 2009 Mar;11(3):207-19.
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. Defective T-cell activation is associated with augmented transforming growth factor Beta sensitivity in mice with mutations in the Sno gene. Pearson-White S and McDuffie M, Mol Cell Biol 2003 Aug;23(15):5446-59.
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. Information Derived from GenBank Report RGD, Sept. 2003
Additional References at PubMed
PMID:8514802   PMID:10531062   PMID:10811619   PMID:12764135   PMID:14712482   PMID:15657445   PMID:15677329   PMID:15967445   PMID:16109768   PMID:16675394   PMID:16966324   PMID:17202138  
PMID:17215516   PMID:17469184   PMID:17510063   PMID:17725545   PMID:18212064   PMID:18334480   PMID:19383336   PMID:19538364   PMID:20386537   PMID:22813962   PMID:23610558   PMID:28350874  
PMID:28447757   PMID:28765970   PMID:29402324   PMID:30847937   PMID:31028803  


Genomics

Comparative Map Data
Skil
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22112,247,047 - 112,275,176 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2112,247,051 - 112,275,080 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2118,894,757 - 118,922,782 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02117,007,313 - 117,035,338 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02111,716,994 - 111,745,054 (-)NCBIRnor_WKY
Rnor_6.02115,862,932 - 115,891,304 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2115,866,701 - 115,891,097 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02135,558,909 - 135,587,255 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42116,669,375 - 116,691,472 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12116,636,239 - 116,636,434 (-)NCBI
Celera2107,434,508 - 107,462,883 (-)NCBICelera
Cytogenetic Map2q24NCBI
SKIL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383170,357,715 - 170,396,849 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl3170,357,342 - 170,396,835 (+)EnsemblGRCh38hg38GRCh38
GRCh373170,075,503 - 170,114,637 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363171,558,208 - 171,593,230 (+)NCBINCBI36Build 36hg18NCBI36
Build 343171,558,217 - 171,593,238NCBI
Celera3168,475,164 - 168,510,628 (+)NCBICelera
Cytogenetic Map3q26.2NCBI
HuRef3167,445,102 - 167,484,187 (+)NCBIHuRef
CHM1_13170,038,968 - 170,078,127 (+)NCBICHM1_1
T2T-CHM13v2.03173,142,367 - 173,181,517 (+)NCBIT2T-CHM13v2.0
Skil
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39331,149,122 - 31,177,072 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl331,149,207 - 31,176,726 (+)EnsemblGRCm39 Ensembl
GRCm38331,095,058 - 31,122,923 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl331,095,058 - 31,122,577 (+)EnsemblGRCm38mm10GRCm38
MGSCv37330,993,983 - 31,021,499 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36331,285,939 - 31,313,455 (+)NCBIMGSCv36mm8
Celera331,009,172 - 31,036,688 (+)NCBICelera
Cytogenetic Map3A3NCBI
cM Map315.12NCBI
Skil
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955420530,528 - 554,551 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955420530,531 - 554,308 (+)NCBIChiLan1.0ChiLan1.0
SKIL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13175,562,001 - 175,600,181 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3175,562,007 - 175,600,181 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03167,372,104 - 167,411,287 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
SKIL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13434,871,770 - 34,898,681 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3434,871,574 - 34,894,854 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3443,882,840 - 43,910,662 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03434,952,312 - 34,980,146 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3434,952,451 - 34,980,135 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13434,895,746 - 34,923,551 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03434,865,482 - 34,893,269 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03435,129,073 - 35,156,913 (+)NCBIUU_Cfam_GSD_1.0
Skil
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602101,488,423 - 101,512,747 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365932,109,223 - 2,132,882 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365932,109,414 - 2,132,871 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SKIL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13109,029,952 - 109,059,173 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113109,029,831 - 109,059,176 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213117,925,964 - 117,940,416 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SKIL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11519,022,167 - 19,059,117 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1519,022,017 - 19,057,004 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606327,802,064 - 27,838,970 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Skil
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473048,377,499 - 48,404,141 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473048,376,625 - 48,404,059 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Skil
129 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:123
Count of miRNA genes:102
Interacting mature miRNAs:107
Transcripts:ENSRNOT00000013191
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)259134147127460910Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)259324377141596857Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
7411551Bw131Body weight QTL 13129.60.001body mass (VT:0001259)body weight gain (CMO:0000420)267942638112942638Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)276539322150540526Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)278665616143657569Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)280270434125270434Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)281018907126018907Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)282345893130923501Rat
7207808Bmd89Bone mineral density QTL 894.1femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)288862519133862519Rat
2300165Bmd49Bone mineral density QTL 494.80.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)288862519133862519Rat
2300170Bmd45Bone mineral density QTL 4512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
2300185Bmd46Bone mineral density QTL 468.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
1598862Glom9Glomerulus QTL 93.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)292337601137337601Rat
1598863Cm65Cardiac mass QTL 652.3heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)292337601137337601Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2102803808147803808Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2104559726149559726Rat
1581552Pur12Proteinuria QTL 125.190.0009urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)2112103657148076632Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 23 29 13 19 13 2 2 74 35 38 11 2
Low 20 28 28 28 6 9 3 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000013191   ⟹   ENSRNOP00000013191
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2112,247,051 - 112,275,080 (-)Ensembl
Rnor_6.0 Ensembl2115,866,701 - 115,891,097 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000114271   ⟹   ENSRNOP00000086486
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2112,247,051 - 112,272,810 (-)Ensembl
RefSeq Acc Id: XM_006232237   ⟹   XP_006232299
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22112,247,047 - 112,275,176 (-)NCBI
Rnor_6.02115,862,932 - 115,891,304 (-)NCBI
Rnor_5.02135,558,909 - 135,587,255 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008760949   ⟹   XP_008759171
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22112,247,047 - 112,275,176 (-)NCBI
Rnor_6.02115,862,932 - 115,890,771 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039103605   ⟹   XP_038959533
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22112,247,047 - 112,274,583 (-)NCBI
RefSeq Acc Id: XM_039103606   ⟹   XP_038959534
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22112,247,047 - 112,275,176 (-)NCBI
Reference Sequences
RefSeq Acc Id: XP_006232299   ⟸   XM_006232237
- Peptide Label: isoform X1
- UniProtKB: D3ZWL1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008759171   ⟸   XM_008760949
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000013191   ⟸   ENSRNOT00000013191
RefSeq Acc Id: XP_038959534   ⟸   XM_039103606
- Peptide Label: isoform X1
- UniProtKB: D3ZWL1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959533   ⟸   XM_039103605
- Peptide Label: isoform X1
- UniProtKB: D3ZWL1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000086486   ⟸   ENSRNOT00000114271
Protein Domains
c-SKI SMAD4-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZWL1-F1-model_v2 AlphaFold D3ZWL1 1-677 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691285
Promoter ID:EPDNEW_R1797
Type:initiation region
Name:Skil_1
Description:SKI-like proto-oncogene
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02115,890,970 - 115,891,030EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621399 AgrOrtholog
BioCyc Gene G2FUF-53477 BioCyc
Ensembl Genes ENSRNOG00000009899 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000013191 ENTREZGENE
  ENSRNOP00000013191.2 UniProtKB/TrEMBL
  ENSRNOP00000086486 ENTREZGENE
  ENSRNOP00000086486.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000013191 ENTREZGENE
  ENSRNOT00000013191.6 UniProtKB/TrEMBL
  ENSRNOT00000114271 ENTREZGENE
  ENSRNOT00000114271.1 UniProtKB/TrEMBL
Gene3D-CATH 3.10.260.20 UniProtKB/TrEMBL
  3.10.390.10 UniProtKB/TrEMBL
InterPro c-SKI_SMAD4-bd_dom UniProtKB/TrEMBL
  DNA-bd_dom_put UniProtKB/TrEMBL
  SAND_dom-like UniProtKB/TrEMBL
  Ski_DNA-bd_sf UniProtKB/TrEMBL
  Transform_Ski UniProtKB/TrEMBL
  Tscrpt_reg_SKI_SnoN UniProtKB/TrEMBL
KEGG Report rno:114208 UniProtKB/TrEMBL
NCBI Gene 114208 ENTREZGENE
PANTHER PTHR10005 UniProtKB/TrEMBL
  PTHR10005:SF3 UniProtKB/TrEMBL
Pfam c-SKI_SMAD_bind UniProtKB/TrEMBL
  Ski_Sno UniProtKB/TrEMBL
PhenoGen Skil PhenoGen
SMART c-SKI_SMAD_bind UniProtKB/TrEMBL
Superfamily-SCOP Putativ_DNA_bind UniProtKB/TrEMBL
  SAND_like UniProtKB/TrEMBL
UniProt A0A8I6A1B8_RAT UniProtKB/TrEMBL
  D3ZWL1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-07-10 Skil  SKI-like proto-oncogene  Skil  SKI-like oncogene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-19 Skil  SKI-like oncogene  Skil  SKI-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-14 Skil  SKI-like  Skir  ski/sno related  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2002-08-07 Skir  ski/sno related      Symbol and Name status set to provisional 70820 PROVISIONAL