Ghsr (growth hormone secretagogue receptor) - Rat Genome Database

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Gene: Ghsr (growth hormone secretagogue receptor) Rattus norvegicus
Symbol: Ghsr
Name: growth hormone secretagogue receptor
RGD ID: 621397
Description: Enables growth hormone secretagogue receptor activity and peptide hormone binding activity. Involved in several processes, including regulation of digestive system process; regulation of secretion by cell; and response to peptide hormone. Acts upstream of or within negative regulation of insulin secretion. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and synaptic membrane. Used to study middle cerebral artery infarction. Biomarker of isolated growth hormone deficiency; multiple endocrine neoplasia; obstructive sleep apnea; status epilepticus; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in obesity. Orthologous to human GHSR (growth hormone secretagogue receptor); PARTICIPATES IN G protein mediated signaling pathway via Galphaq family; ghrelin system pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,5-hexanedione; ammonium chloride.
Type: protein-coding
Previously known as: GH-releasing peptide receptor; ghrelin receptor; GHRP; GHS-R; growth hormone secretagogue receptor type 1
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Ghsrm1Mcwi   Ghsrm2Mcwi   Ghsrm3Mcwi   Ghsrem1Ottc  
Genetic Models: SS-Ghsrm3Mcwi FHH-Ghsrm1Mcwi SS-Ghsrm2Mcwi W-Ghsrem1Ottc
Is Marker For: Strains:   SD-Tg(Th-Ghsros)  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr82112,196,158 - 112,201,666 (+)NCBIGRCr8
mRatBN7.22110,268,489 - 110,271,865 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2110,268,489 - 110,271,865 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2116,922,519 - 116,925,893 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02115,035,078 - 115,038,452 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02109,749,447 - 109,752,824 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02113,065,953 - 113,071,265 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2113,066,885 - 113,070,261 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02132,784,207 - 132,789,319 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42113,269,623 - 113,272,999 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12113,214,584 - 113,217,961 (+)NCBI
Celera2105,470,925 - 105,474,301 (+)NCBICelera
Cytogenetic Map2q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin polymerization or depolymerization  (ISO,ISS)
adult feeding behavior  (ISO,ISS)
cellular response to insulin stimulus  (ISO)
cellular response to insulin-like growth factor stimulus  (IEP)
cellular response to lipopolysaccharide  (IEP)
cellular response to thyroid hormone stimulus  (IEP)
decidualization  (ISO,ISS)
female pregnancy  (IEP)
G protein-coupled receptor signaling pathway  (IBA,IDA,ISO,ISS)
ghrelin secretion  (IMP)
growth hormone secretion  (ISO)
hormone-mediated signaling pathway  (IBA,ISO,ISS)
insulin-like growth factor receptor signaling pathway  (ISO)
learning or memory  (IDA)
negative regulation of appetite  (IMP)
negative regulation of inflammatory response  (ISO,ISS)
negative regulation of insulin secretion  (IDA)
negative regulation of interleukin-1 beta production  (ISO,ISS)
negative regulation of interleukin-6 production  (ISO,ISS)
negative regulation of locomotion involved in locomotory behavior  (IMP)
negative regulation of macrophage apoptotic process  (IMP)
negative regulation of norepinephrine secretion  (IMP)
negative regulation of tumor necrosis factor production  (IMP,ISO,ISS)
positive regulation of appetite  (ISO,ISS)
positive regulation of eating behavior  (IMP)
positive regulation of fatty acid metabolic process  (IMP)
positive regulation of growth  (IMP)
positive regulation of insulin-like growth factor receptor signaling pathway  (ISO)
positive regulation of multicellular organism growth  (ISO,ISS)
positive regulation of small intestinal transit  (IMP)
positive regulation of small intestine smooth muscle contraction  (IMP)
positive regulation of sprouting angiogenesis  (IMP)
positive regulation of vascular endothelial cell proliferation  (IMP)
postsynaptic modulation of chemical synaptic transmission  (EXP,IDA)
regulation of feeding behavior  (IMP)
regulation of gastric motility  (IMP)
regulation of growth hormone secretion  (IMP)
regulation of hindgut contraction  (IMP)
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane  (EXP,IDA,IEP)
regulation of postsynapse organization  (EXP,IDA)
regulation of synapse assembly  (ISO)
regulation of transmission of nerve impulse  (IMP)
response to dexamethasone  (IEP)
response to estradiol  (IEP)
response to follicle-stimulating hormone  (IEP)
response to food  (ISO)
response to growth hormone  (IEP)
response to hormone  (ISO,ISS)
response to L-glutamate  (IEP)
spermatogenesis  (IEP)

Cellular Component
cell surface  (ISO,ISS)
glutamatergic synapse  (EXP,IDA,IEP,IMP)
membrane raft  (ISO,ISS)
neuron projection  (ISO,ISS)
plasma membrane  (IBA,TAS)
postsynapse  (IEA)
Schaffer collateral - CA1 synapse  (EXP,IDA)
synaptic membrane  (IDA,IEP,IMP)

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Ghrelin and growth hormone secretagogue receptor are expressed in the rat adrenal cortex: Evidence that ghrelin stimulates the growth, but not the secretory activity of adrenal cells. Andreis PG, etal., FEBS Lett 2003 Feb 11;536(1-3):173-9.
2. Cognitive enhancing effects of ghrelin receptor agonists. Atcha Z, etal., Psychopharmacology (Berl). 2009 Oct;206(3):415-27. doi: 10.1007/s00213-009-1620-6. Epub 2009 Aug 4.
3. DNA regulatory sequences of the rat tyrosine hydroxylase gene direct correct catecholaminergic cell-type specificity of a human growth hormone reporter in the CNS of transgenic mice causing a dwarf phenotype. Banerjee SA, etal., Brain Res Mol Brain Res. 1994 Jul;24(1-4):89-106.
4. Developmental, stage-specific, and hormonally regulated expression of growth hormone secretagogue receptor messenger RNA in rat testis. Barreiro ML, etal., Biol Reprod. 2003 May;68(5):1631-40. Epub 2002 Nov 27.
5. Ghrelin promotes reorganization of dendritic spines in cultured rat hippocampal slices. Berrout L and Isokawa M, Neurosci Lett. 2012 May 16;516(2):280-4. doi: 10.1016/j.neulet.2012.04.009. Epub 2012 Apr 10.
6. Food intake and interdigestive gastrointestinal motility in ghrelin receptor mutant rats. Bülbül M, etal., J Gastroenterol. 2011 Apr;46(4):469-78. doi: 10.1007/s00535-010-0366-6. Epub 2011 Jan 22.
7. Involvement of PKA and ERK pathways in ghrelin-induced long-lasting potentiation of excitatory synaptic transmission in the CA1 area of rat hippocampus. Cavalier M, etal., Eur J Neurosci. 2015 Oct;42(8):2568-76. doi: 10.1111/ejn.13013. Epub 2015 Jul 29.
8. The role of ghrelin and growth hormone secretagogues receptor on rat adipogenesis. Choi K, etal., Endocrinology 2003 Mar;144(3):754-9.
9. Attenuation of cocaine-induced locomotor sensitization in rats sustaining genetic or pharmacologic antagonism of ghrelin receptors. Clifford PS, etal., Addict Biol. 2012 Nov;17(6):956-63. doi: 10.1111/j.1369-1600.2011.00339.x. Epub 2011 Jul 25.
10. GSK1614343, a novel ghrelin receptor antagonist, produces an unexpected increase of food intake and body weight in rodents and dogs. Costantini VJ, etal., Neuroendocrinology. 2011;94(2):158-68. doi: 10.1159/000328968. Epub 2011 Jul 22.
11. Ghrelin and growth hormone (GH) secretagogues potentiate GH-releasing hormone (GHRH)-induced cyclic adenosine 3',5'-monophosphate production in cells expressing transfected GHRH and GH secretagogue receptors. Cunha SR and Mayo KE, Endocrinology 2002 Dec;143(12):4570-82.
12. Comparison of the gastroprokinetic effects of ghrelin, GHRP-6 and motilin in rats in vivo and in vitro. Depoortere I, etal., Eur J Pharmacol. 2005 May 16;515(1-3):160-8.
13. Blockade of pancreatic islet-derived ghrelin enhances insulin secretion to prevent high-fat diet-induced glucose intolerance. Dezaki K, etal., Diabetes. 2006 Dec;55(12):3486-93.
14. Effects of ghrelin on the intracellular calcium concentration in rat aorta vascular smooth muscle cells. Fang H, etal., Cell Physiol Biochem. 2012;30(5):1299-309. doi: 10.1159/000343319. Epub 2012 Oct 22.
15. Estradiol modulates Kiss1 neuronal response to ghrelin. Frazao R, etal., Am J Physiol Endocrinol Metab. 2014 Mar;306(6):E606-14. doi: 10.1152/ajpendo.00211.2013. Epub 2014 Jan 28.
16. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
17. Effects of ghrelin on gastric distension sensitive neurons and gastric motility in the lateral septum and arcuate nucleus regulation. Gong Y, etal., J Gastroenterol. 2014 Feb;49(2):219-30. doi: 10.1007/s00535-013-0789-y. Epub 2013 Mar 26.
18. Growth hormone secretagogue receptor deficiency in mice protects against obesity-induced hypertension. Harris LE, etal., Physiol Rep. 2014 Mar 20;2(3):e00240. doi: 10.1002/phy2.240. Print 2014.
19. Ghrelin receptor mutations--too little height and too much hunger. Holst B and Schwartz TW, J Clin Invest. 2006 Mar;116(3):637-41.
20. Neuroprotective effect of ghrelin is associated with decreased expression of prostate apoptosis response-4. Hwang S, etal., Endocr J. 2009;56(4):609-17. Epub 2009 Apr 7.
21. Identification and functional analysis of novel human growth hormone secretagogue receptor (GHSR) gene mutations in Japanese subjects with short stature. Inoue H, etal., J Clin Endocrinol Metab. 2011 Feb;96(2):E373-8. doi: 10.1210/jc.2010-1570. Epub 2010 Nov 17.
22. Amidated fish ghrelin: purification, cDNA cloning in the Japanese eel and its biological activity. Kaiya H, etal., J Endocrinol. 2003 Mar;176(3):415-23.
23. Thyroid hormones regulate pituitary growth hormone secretagogue receptor gene expression. Kamegai J, etal., J Neuroendocrinol. 2001 Mar;13(3):275-8.
24. Growth hormone-dependent regulation of pituitary GH secretagogue receptor (GHS-R) mRNA levels in the spontaneous dwarf Rat. Kamegai J, etal., Neuroendocrinology. 1998 Nov;68(5):312-8.
25. Insulin-like growth factor-I down-regulates ghrelin receptor (growth hormone secretagogue receptor) expression in the rat pituitary. Kamegai J, etal., Regul Pept. 2005 Apr 15;127(1-3):203-6.
26. Ghrelin: structure and function. Kojima M and Kangawa K, Physiol Rev. 2005 Apr;85(2):495-522.
27. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Kojima M, etal., Nature 1999 Dec 9;402(6762):656-60.
28. Increase in mRNA concentrations of pituitary receptors for growth hormone-releasing hormone and growth hormone secretagogues after neonatal monosodium glutamate treatment. Kovacs M, etal., J Neuroendocrinol. 2000 Apr;12(4):335-41.
29. Ghrelin inhibits BSCB disruption/hemorrhage by attenuating MMP-9 and SUR1/TrpM4 expression and activation after spinal cord injury. Lee JY, etal., Biochim Biophys Acta. 2014 Dec;1842(12 Pt A):2403-12. doi: 10.1016/j.bbadis.2014.09.006. Epub 2014 Sep 28.
30. Ghrelin protects alveolar macrophages against lipopolysaccharide-induced apoptosis through growth hormone secretagogue receptor 1a-dependent c-Jun N-terminal kinase and Wnt/ß-catenin signaling and suppresses lung inflammation. Li B, etal., Endocrinology. 2015 Jan;156(1):203-17. doi: 10.1210/en.2014-1539.
31. Cardioprotective effects of ghrelin and des-octanoyl ghrelin on myocardial injury induced by isoproterenol in rats. Li L, etal., Acta Pharmacol Sin. 2006 May;27(5):527-35.
32. Rats with a truncated ghrelin receptor (GHSR) do not respond to ghrelin, and show reduced intake of palatable, high-calorie food. MacKay H, etal., Physiol Behav. 2016 Sep 1;163:88-96. doi: 10.1016/j.physbeh.2016.04.048. Epub 2016 Apr 27.
33. Genetic suppression of ghrelin receptors activates brown adipocyte function and decreases fat storage in rats. Mano-Otagiri A, etal., Regul Pept. 2010 Feb 25;160(1-3):81-90. doi: 10.1016/j.regpep.2009.11.010. Epub 2009 Nov 18.
34. Molecular analysis of rat pituitary and hypothalamic growth hormone secretagogue receptors. McKee KK, etal., Mol Endocrinol 1997 Apr;11(4):415-23.
35. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
36. Ghrelin protects cortical neuron against focal ischemia/reperfusion in rats. Miao Y, etal., Biochem Biophys Res Commun. 2007 Aug 3;359(3):795-800. Epub 2007 Jun 6.
37. Ghrelin augments afferent response to distension in rat isolated jejunum. Murray CD, etal., Neurogastroenterol Motil. 2006 Dec;18(12):1112-20.
38. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
39. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
40. GOA pipeline RGD automated data pipeline
41. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
42. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
43. Ghrelin triggers the synaptic incorporation of AMPA receptors in the hippocampus. Ribeiro LF, etal., Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):E149-58. doi: 10.1073/pnas.1313798111. Epub 2013 Dec 23.
44. Evidence that stimulation of ghrelin receptors in the spinal cord initiates propulsive activity in the colon of the rat. Shimizu Y, etal., J Physiol. 2006 Oct 1;576(Pt 1):329-38. Epub 2006 Jul 27.
45. Hypothalamic growth hormone secretagogue receptor regulates growth hormone secretion, feeding, and adiposity. Shuto Y, etal., J Clin Invest 2002 Jun;109(11):1429-36.
46. Importance of ghrelin in hypothalamus-pituitary axis on growth hormone release during normal pregnancy in the rat. Szczepankiewicz D, etal., J Physiol Pharmacol. 2010 Aug;61(4):443-9.
47. Glucocorticoids regulate pituitary growth hormone secretagogue receptor gene expression. Tamura H, etal., J Neuroendocrinol. 2000 Jun;12(6):481-5.
48. Orexin Plays a Role in Growth Impediment Induced by Obstructive Sleep Breathing in Rats. Tarasiuk A, etal., Sleep. 2016 Apr 1;39(4):887-97. doi: 10.5665/sleep.5648.
49. Obesity in MENX Rats Is Accompanied by High Circulating Levels of Ghrelin and Improved Insulin Sensitivity. Wiedemann T, etal., Diabetes. 2016 Feb;65(2):406-20. doi: 10.2337/db15-0374. Epub 2015 Oct 28.
50. Ghrelin inhibits sympathetic nervous activity in sepsis. Wu R, etal., Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1697-702. Epub 2007 Oct 2.
51. Upregulation of cardiovascular ghrelin receptor occurs in the hyperdynamic phase of sepsis. Wu R, etal., Am J Physiol Heart Circ Physiol. 2004 Sep;287(3):H1296-302. Epub 2004 May 20.
52. Effects of ghrelin on gastric distention sensitive neurons in the arcuate nucleus of hypothalamus and gastric motility in diabetic rats. Xu L, etal., Peptides. 2013 Oct;48:137-46. doi: 10.1016/j.peptides.2013.08.010. Epub 2013 Aug 18.
53. Down-regulation of ghrelin receptors in the small intestine delays small intestinal transit in vagotomized rats. Yang CG, etal., Mol Med Rep. 2011 Nov-Dec;4(6):1061-5. doi: 10.3892/mmr.2011.571. Epub 2011 Aug 24.
54. [Relationship between Ghrelin and growth hormone secretagogue receptor expression and catch-up growth in rats with intrauterine growth restriction]. Yang HM, etal., Zhongguo Dang Dai Er Ke Za Zhi. 2010 Jul;12(7):563-8.
55. Development and initial characterization of a novel ghrelin receptor CRISPR/Cas9 knockout wistar rat model. Zallar LJ, etal., Int J Obes (Lond). 2018 Jan 30. pii: 10.1038/s41366-018-0013-5. doi: 10.1038/s41366-018-0013-5.
56. Ghrelin receptor deletion reduces binge-like alcohol drinking in rats. Zallar LJ, etal., J Neuroendocrinol. 2018 Nov 20:e12663. doi: 10.1111/jne.12663.
57. Ghrelin modulates physiologic and pathologic retinal angiogenesis through GHSR-1a. Zaniolo K, etal., Invest Ophthalmol Vis Sci. 2011 Jul 23;52(8):5376-86. doi: 10.1167/iovs.10-7152.
58. Acylated ghrelin protects hippocampal neurons in pilocarpine-induced seizures of immature rats by inhibiting cell apoptosis. Zhang R, etal., Mol Biol Rep. 2013 Jan;40(1):51-8. doi: 10.1007/s11033-012-1993-1. Epub 2012 Nov 6.
Additional References at PubMed
PMID:8688086   PMID:9437732   PMID:12511847   PMID:12876464   PMID:12890514   PMID:14993197   PMID:15070777   PMID:15232612   PMID:15448083   PMID:15919752   PMID:16322794   PMID:16338009  
PMID:16417945   PMID:16484324   PMID:16511605   PMID:16513828   PMID:16728494   PMID:16901923   PMID:17003258   PMID:17060947   PMID:17494105   PMID:17895831   PMID:18208550   PMID:18389390  
PMID:19299444   PMID:19490089   PMID:19540432   PMID:19589870   PMID:19703102   PMID:19819980   PMID:20056829   PMID:20152815   PMID:20164026   PMID:20497419   PMID:20596792   PMID:20600421  
PMID:20646435   PMID:20691233   PMID:21269967   PMID:21713709   PMID:21756973   PMID:22100225   PMID:22537050   PMID:22700774   PMID:22886413   PMID:23112170   PMID:23348715   PMID:23608221  
PMID:23698230   PMID:23755116   PMID:24513955   PMID:24525421   PMID:24531567   PMID:24780389   PMID:24797629   PMID:25049077   PMID:25058156   PMID:25230765   PMID:25727097   PMID:26283199  
PMID:26364514   PMID:26490687   PMID:27095593   PMID:27129257   PMID:28409695   PMID:28410130   PMID:28717967   PMID:28801520   PMID:29222553   PMID:29254662   PMID:29317796   PMID:29876881  
PMID:31185255   PMID:32814069   PMID:33264473   PMID:35255434   PMID:35365872   PMID:38187112  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr82112,196,158 - 112,201,666 (+)NCBIGRCr8
mRatBN7.22110,268,489 - 110,271,865 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2110,268,489 - 110,271,865 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2116,922,519 - 116,925,893 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02115,035,078 - 115,038,452 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02109,749,447 - 109,752,824 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02113,065,953 - 113,071,265 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2113,066,885 - 113,070,261 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02132,784,207 - 132,789,319 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42113,269,623 - 113,272,999 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12113,214,584 - 113,217,961 (+)NCBI
Celera2105,470,925 - 105,474,301 (+)NCBICelera
Cytogenetic Map2q24NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh383172,443,291 - 172,448,456 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3172,443,291 - 172,448,456 (-)EnsemblGRCh38hg38GRCh38
GRCh373172,161,081 - 172,166,246 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363173,645,645 - 173,648,897 (-)NCBINCBI36Build 36hg18NCBI36
Build 343173,648,035 - 173,648,905NCBI
Celera3170,559,676 - 170,564,839 (-)NCBICelera
Cytogenetic Map3q26.31NCBI
HuRef3169,531,507 - 169,536,581 (-)NCBIHuRef
CHM1_13172,123,965 - 172,129,130 (-)NCBICHM1_1
T2T-CHM13v2.03175,228,381 - 175,233,536 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39327,425,500 - 27,433,384 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl327,425,500 - 27,432,159 (+)EnsemblGRCm39 Ensembl
GRCm38327,371,351 - 27,379,235 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl327,371,351 - 27,378,010 (+)EnsemblGRCm38mm10GRCm38
MGSCv37327,270,273 - 27,276,932 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36327,562,424 - 27,569,083 (+)NCBIMGSCv36mm8
Celera327,331,821 - 27,338,480 (+)NCBICelera
Cytogenetic Map3A3NCBI
cM Map310.86NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554202,478,877 - 2,487,215 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554202,483,173 - 2,486,414 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v22170,322,815 - 170,331,681 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13170,327,588 - 170,336,389 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03169,448,217 - 169,458,602 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13177,633,039 - 177,638,202 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3177,633,039 - 177,638,202 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.13436,691,132 - 36,694,304 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3436,690,224 - 36,694,312 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3445,703,894 - 45,707,255 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03436,775,648 - 36,779,007 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3436,774,740 - 36,779,009 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13436,714,573 - 36,717,930 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03436,683,080 - 36,686,432 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03436,941,135 - 36,944,502 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024405602103,348,347 - 103,353,683 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936593268,350 - 277,229 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936593268,736 - 273,623 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl13110,983,298 - 111,038,324 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113110,981,465 - 111,006,149 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213119,917,068 - 119,929,590 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11517,008,185 - 17,013,504 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1517,009,369 - 17,012,618 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606325,770,911 - 25,777,537 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462473050,488,887 - 50,492,405 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473050,484,763 - 50,492,443 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Ghsr
21 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:141
Count of miRNA genes:111
Interacting mature miRNAs:121
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
2293676Bmd19Bone mineral density QTL 1910.70.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)243162366111362592Rat
2293682Bmd24Bone mineral density QTL 248.90.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)243162366111362592Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)259134147127460910Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)259324377141596857Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
7411551Bw131Body weight QTL 13129.60.001body mass (VT:0001259)body weight gain (CMO:0000420)267942638112942638Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)276539322150540526Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)278665616143657569Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)280270434125270434Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)281018907126018907Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)282345893130923501Rat
7207808Bmd89Bone mineral density QTL 894.1femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)288862519133862519Rat
2300165Bmd49Bone mineral density QTL 494.80.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)288862519133862519Rat
2300170Bmd45Bone mineral density QTL 4512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
2300185Bmd46Bone mineral density QTL 468.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
1598862Glom9Glomerulus QTL 93.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)292337601137337601Rat
1598863Cm65Cardiac mass QTL 652.3heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)292337601137337601Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2102803808147803808Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2104559726149559726Rat

Related Rat Strains
The following Strains have been annotated to Ghsr

Genetic Models
This gene Ghsr is modified in the following models/strains:


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system appendage
Low 27 7
Below cutoff 2 1 1 1 1 1 21 1 2 1


RefSeq Acc Id: ENSRNOT00000034960   ⟹   ENSRNOP00000038418
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2110,268,489 - 110,271,865 (+)Ensembl
Rnor_6.0 Ensembl2113,066,885 - 113,070,261 (+)Ensembl
RefSeq Acc Id: NM_032075   ⟹   NP_114464
Rat AssemblyChrPosition (strand)Source
GRCr82112,197,158 - 112,200,534 (+)NCBI
mRatBN7.22110,268,489 - 110,271,865 (+)NCBI
Rnor_6.02113,066,885 - 113,070,261 (+)NCBI
Rnor_5.02132,784,207 - 132,789,319 (+)NCBI
RGSC_v3.42113,269,623 - 113,272,999 (+)RGD
Celera2105,470,925 - 105,474,301 (+)RGD
RefSeq Acc Id: XM_063282641   ⟹   XP_063138711
Rat AssemblyChrPosition (strand)Source
GRCr82112,196,346 - 112,201,666 (+)NCBI
RefSeq Acc Id: XM_063282642   ⟹   XP_063138712
Rat AssemblyChrPosition (strand)Source
GRCr82112,196,158 - 112,201,666 (+)NCBI
RefSeq Acc Id: NP_114464   ⟸   NM_032075
- UniProtKB: O08725 (UniProtKB/Swiss-Prot),   A6IHG7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000038418   ⟸   ENSRNOT00000034960
RefSeq Acc Id: XP_063138712   ⟸   XM_063282642
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063138711   ⟸   XM_063282641
- Peptide Label: isoform X1
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O08725-F1-model_v2 AlphaFold O08725 1-364 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621397 AgrOrtholog
BioCyc Gene G2FUF-53506 BioCyc
Ensembl Genes ENSRNOG00000024119 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00065023711 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000034960 ENTREZGENE
  ENSRNOT00000034960.2 UniProtKB/Swiss-Prot
  ENSRNOT00065040632 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GHS-R/MTLR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:84022 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ghsr PhenoGen
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000024119 RatGTEx
  ENSRNOG00065023711 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Ghsr  growth hormone secretagogue receptor      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Ghsr  growth hormone secretagogue receptor      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the hypothalamus and pituitary 625699
gene_function an endogenous receptor for ghrelin (GH-releasing peptide) 625699
gene_process mediates growth hormone secretion, food intake, and adiposity in the arcuate nucleus (Arc) of the hypothalamus 625699
gene_product member of of the G protein coupled receptor superfamily 625699