Uox (urate oxidase) - Rat Genome Database

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Gene: Uox (urate oxidase) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Uox
Name: urate oxidase
RGD ID: 621369
Description: Enables urate oxidase activity. Involved in urate catabolic process. Located in peroxisome. Used to study hyperuricemia; PARTICIPATES IN caffeine metabolic pathway; purine metabolic pathway; .
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: UOX-2; urate oxidase 2; Uri; Uri2; Uri_mapped; uricase; uricase (mapped)
RGD Orthologs
Alliance Genes
More Info homologs ...
Allele / Splice: Uoxem1Cya  
Genetic Models: SD-Uoxem1Cya
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22235,486,867 - 235,523,053 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2235,440,619 - 235,523,029 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2243,283,023 - 243,318,323 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02241,174,028 - 241,208,972 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02236,040,679 - 236,075,987 (+)NCBIRnor_WKY
Rnor_6.02252,452,282 - 252,488,497 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2252,452,269 - 252,488,396 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02270,978,811 - 271,015,097 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42244,795,552 - 244,832,143 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12244,782,291 - 244,818,883 (+)NCBI
Celera2227,465,950 - 227,501,003 (+)NCBICelera
Cytogenetic Map2q44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
peroxisomal matrix  (TAS)
peroxisome  (IBA,IDA,IEA)

Molecular Function
urate oxidase activity  (IBA,IDA,IEA,TAS)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. The nucleotide sequence of a full length cDNA clone encoding rat liver urate oxidase. Alvares K, etal., Biochem Biophys Res Commun 1989 Feb 15;158(3):991-5.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Identification of an amino acid residue involved in the substrate-binding site of rat liver uricase by site-directed mutagenesis. Ito M, etal., Biochem Biophys Res Commun. 1992 Aug 31;187(1):101-7.
4. Nucleotide sequence of cDNA and predicted amino acid sequence of rat liver uricase. Ito M, etal., Eur J Biochem 1988 Apr 15;173(2):459-63.
5. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
6. Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease. Kikuchi M, etal., J Biol Chem. 2004 Jan 2;279(1):421-8. Epub 2003 Oct 15.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Cloning and sequence analysis of cDNA for rat liver uricase. Motojima K, etal., J Biol Chem 1988 Nov 15;263(32):16677-81.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. Isolation and sequence determination of a cDNA clone for rat peroxisomal urate oxidase: liver-specific expression in the rat. Reddy PG, etal., Proc Natl Acad Sci U S A. 1988 Dec;85(23):9081-5.
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Rat urate oxidase: cloning and structural analysis of the gene and 5'-flanking region. Wang XD, etal., Gene 1991 Jan 15;97(2):223-9.
15. Uricase-deficient rat is generated with CRISPR/Cas9 technique. Yu Y, etal., PeerJ. 2020 Apr 27;8:e8971. doi: 10.7717/peerj.8971. eCollection 2020.
Additional References at PubMed
PMID:1783398   PMID:2338140   PMID:11306811   PMID:12477932   PMID:15489334   PMID:24550457   PMID:33648977   PMID:34437605  


Genomics

Variants

.
Variants in Uox
267 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:294
Count of miRNA genes:200
Interacting mature miRNAs:224
Transcripts:ENSRNOT00000021970
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2200990457245990457Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2202446871237938339Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2211744537249053267Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2211744537249053267Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2211744537249053267Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2211744537249053267Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2211744537249053267Rat
2317885Alcrsp28Alcohol response QTL 282.10.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2212828222249053267Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2214226044247136170Rat
2313073Bmd75Bone mineral density QTL 754.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)2215377404237938339Rat
1331767Hrtrt12Heart rate QTL 123.373heart pumping trait (VT:2000009)heart rate (CMO:0000002)2218414747240841241Rat
2293833Kiddil8Kidney dilation QTL 82.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
2293844Kiddil7Kidney dilation QTL 73.5kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
9587428Epfw6Epididymal fat weight QTL 67.470.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)2223389739249053267Rat
7411555Bw132Body weight QTL 1320.001body mass (VT:0001259)body weight gain (CMO:0000420)2223389739249053267Rat
631563Hcuc3Hepatic copper content QTL 33.87liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)2229059610249053267Rat

Markers in Region
D2Mgh13  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22235,500,980 - 235,501,121 (+)MAPPERmRatBN7.2
Rnor_6.02252,466,425 - 252,466,565NCBIRnor6.0
Rnor_5.02270,992,735 - 270,992,875UniSTSRnor5.0
RGSC_v3.42244,809,623 - 244,809,764RGDRGSC3.4
RGSC_v3.42244,809,624 - 244,809,764UniSTSRGSC3.4
RGSC_v3.12244,796,363 - 244,796,504RGD
Celera2227,479,263 - 227,479,403UniSTS
SHRSP x BN Map2101.1198RGD
SHRSP x BN Map2101.1198UniSTS
Cytogenetic Map2q44UniSTS
UOX  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22235,501,372 - 235,501,478 (+)MAPPERmRatBN7.2
Rnor_6.02252,466,817 - 252,466,922NCBIRnor6.0
Rnor_5.02270,993,127 - 270,993,232UniSTSRnor5.0
RGSC_v3.42244,810,016 - 244,810,121UniSTSRGSC3.4
Celera2227,479,655 - 227,479,760UniSTS
Cytogenetic Map2q44UniSTS
RH136937  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22235,522,789 - 235,522,978 (+)MAPPERmRatBN7.2
Rnor_6.02252,488,234 - 252,488,422NCBIRnor6.0
Rnor_5.02271,014,834 - 271,015,022UniSTSRnor5.0
RGSC_v3.42244,832,230 - 244,832,418UniSTSRGSC3.4
Celera2227,501,090 - 227,501,278UniSTS
Cytogenetic Map2q44UniSTS
AI169989  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22235,503,586 - 235,504,335 (+)MAPPERmRatBN7.2
Rnor_6.02252,469,031 - 252,469,779NCBIRnor6.0
Rnor_5.02270,995,341 - 270,996,089UniSTSRnor5.0
RGSC_v3.42244,812,230 - 244,812,978UniSTSRGSC3.4
Celera2227,481,869 - 227,482,617UniSTS
Cytogenetic Map2q44UniSTS


Genetic Models
This gene Uox is modified in the following models/strains

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 33 33 33 1 1
Low 2 13 4 7 4 3 3 9 3 11 6 3
Below cutoff 2 6 11 4 11 4 5 5 47 18 21 3 5

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC098557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC118117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC088112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D50689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218518 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219405 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J03959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M24396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT161601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X07497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000021970   ⟹   ENSRNOP00000021970
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2235,440,619 - 235,523,029 (+)Ensembl
Rnor_6.0 Ensembl2252,452,269 - 252,488,396 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000102853   ⟹   ENSRNOP00000088332
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2235,486,848 - 235,520,810 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000107313   ⟹   ENSRNOP00000087221
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2235,486,907 - 235,519,709 (+)Ensembl
RefSeq Acc Id: NM_053768   ⟹   NP_446220
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22235,486,867 - 235,522,703 (+)NCBI
Rnor_6.02252,452,311 - 252,488,147 (+)NCBI
Rnor_5.02270,978,811 - 271,015,097 (+)NCBI
RGSC_v3.42244,795,552 - 244,832,143 (+)RGD
Celera2227,465,950 - 227,501,003 (+)RGD
Sequence:
RefSeq Acc Id: XM_006233450   ⟹   XP_006233512
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22235,498,407 - 235,523,053 (+)NCBI
Rnor_6.02252,452,282 - 252,488,497 (+)NCBI
Rnor_5.02270,978,811 - 271,015,097 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_446220   ⟸   NM_053768
- UniProtKB: P09118 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006233512   ⟸   XM_006233450
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000021970   ⟸   ENSRNOT00000021970
RefSeq Acc Id: ENSRNOP00000087221   ⟸   ENSRNOT00000107313
RefSeq Acc Id: ENSRNOP00000088332   ⟸   ENSRNOT00000102853

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P09118-F1-model_v2 AlphaFold P09118 1-303 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691816
Promoter ID:EPDNEW_R2341
Type:single initiation site
Name:Uox_1
Description:urate oxidase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02252,452,297 - 252,452,357EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621369 AgrOrtholog
BioCyc Gene G2FUF-50897 BioCyc
BioCyc Pathway PWY-5691 [urate conversion to allantoin I] BioCyc
Ensembl Genes ENSRNOG00000016339 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000021970 ENTREZGENE
  ENSRNOP00000021970.3 UniProtKB/TrEMBL
  ENSRNOP00000087221.1 UniProtKB/TrEMBL
  ENSRNOP00000088332 ENTREZGENE
  ENSRNOP00000088332.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000021970 ENTREZGENE
  ENSRNOT00000021970.6 UniProtKB/TrEMBL
  ENSRNOT00000102853 ENTREZGENE
  ENSRNOT00000102853.1 UniProtKB/TrEMBL
  ENSRNOT00000107313.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7325917 IMAGE-MGC_LOAD
InterPro Uricase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Uricase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:114768 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108593 IMAGE-MGC_LOAD
NCBI Gene 114768 ENTREZGENE
PANTHER PTHR42874 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Uricase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Uox PhenoGen
PIRSF Urate_oxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS URICASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE URICASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs urate_oxi UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6GEX3_RAT UniProtKB/TrEMBL
  A0A8I6GG42_RAT UniProtKB/TrEMBL
  A0A8L2QB48_RAT UniProtKB/TrEMBL
  P09118 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-25 Uox  urate oxidase  Uri_mapped  uricase (mapped)  Data Merged 737654 APPROVED
2005-11-17 Uri_mapped  uricase (mapped)      Symbol and Name updated 1556543 APPROVED
2004-09-10 Uox  urate oxidase      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Uox  urate oxidase      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Uri  Uricase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the electron-dense peroxisome core 730101