Fat1 (FAT atypical cadherin 1) - Rat Genome Database

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Gene: Fat1 (FAT atypical cadherin 1) Rattus norvegicus
Analyze
Symbol: Fat1
Name: FAT atypical cadherin 1
RGD ID: 621254
Description: Predicted to enable calcium ion binding activity. Involved in cellular response to angiotensin and positive regulation of vascular associated smooth muscle cell migration. Located in cytosol and plasma membrane. Human ortholog(s) of this gene implicated in colorectal cancer; esophagus squamous cell carcinoma; lung non-small cell carcinoma; lung small cell carcinoma; and oral squamous cell carcinoma. Orthologous to human FAT1 (FAT atypical cadherin 1); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cadherin FAT1 isoform +12; Fat; FAT tumor suppressor (Drosophila) homolog; fat tumor suppressor homolog (Drosophila); FAT tumor suppressor homolog 1; FAT tumor suppressor homolog 1 (Drosophila); Fath; protocadherin Fat 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81653,909,759 - 54,029,175 (-)NCBIGRCr8
mRatBN7.21647,177,253 - 47,296,261 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1647,177,248 - 47,296,107 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1652,570,022 - 52,688,896 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01655,947,506 - 56,066,348 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01651,209,418 - 51,328,299 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01650,372,150 - 50,501,716 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1650,372,128 - 50,501,921 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01650,093,077 - 50,220,862 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41650,472,074 - 50,591,399 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11650,472,148 - 50,591,474 (-)NCBI
Celera1645,165,920 - 45,284,243 (-)NCBICelera
Cytogenetic Map16q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-nitrotoluene  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrolein  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
Ampullosporin  (EXP)
arecoline  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atrazine  (EXP,ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromochloroacetic acid  (EXP)
buspirone  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
captan  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
clobetasol  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenzofurans  (ISO)
dibutyl phthalate  (EXP)
dichromium trioxide  (ISO)
dicrotophos  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenamidone  (ISO)
fenthion  (ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (EXP)
fulvestrant  (ISO)
genistein  (EXP)
glyphosate  (EXP)
indometacin  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
methimazole  (EXP)
mitomycin C  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
nicotine  (ISO)
NS-398  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
Ptaquiloside  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
rotenone  (ISO)
Securinine  (ISO)
sevoflurane  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sulfadimethoxine  (EXP)
tamibarotene  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. A monoclonal autoantibody which promotes central nervous system remyelination is highly polyreactive to multiple known and novel antigens. Asakura K, etal., J Neuroimmunol 1996 Mar;65(1):11-9.
2. Angiotensin II induces Fat1 expression/activation and vascular smooth muscle cell migration via Nox1-dependent reactive oxygen species generation. Bruder-Nascimento T, etal., J Mol Cell Cardiol. 2014 Jan;66:18-26. doi: 10.1016/j.yjmcc.2013.10.013.
3. Comprehensive Genomic Profiling Identifies Novel Genetic Predictors of Response to Anti-PD-(L)1 Therapies in Non-Small Cell Lung Cancer. Fang W, etal., Clin Cancer Res. 2019 Aug 15;25(16):5015-5026. doi: 10.1158/1078-0432.CCR-19-0585. Epub 2019 May 13.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Comprehensive genomic profiling of small cell lung cancer in Chinese patients and the implications for therapeutic potential. Hu J, etal., Cancer Med. 2019 Aug;8(9):4338-4347. doi: 10.1002/cam4.2199. Epub 2019 Jun 14.
7. [FAT1 inhibits cell proliferation of esophageal squamous cell carcinoma through regulating the expression of CDK4/CDK6/CCND1 complex]. Hu XL, etal., Zhonghua Zhong Liu Za Zhi. 2018 Jan 23;40(1):14-20. doi: 10.3760/cma.j.issn.0253-3766.2018.01.003.
8. Characterization of genomic alterations in Chinese colorectal cancer patients. Huang W, etal., Jpn J Clin Oncol. 2021 Jan 1;51(1):120-129. doi: 10.1093/jjco/hyaa182.
9. Arecoline N-oxide regulates oral squamous cell carcinoma development through NOTCH1 and FAT1 expressions. Kuo TM, etal., J Cell Physiol. 2019 Aug;234(8):13984-13993. doi: 10.1002/jcp.28084. Epub 2019 Jan 9.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Fat1 deletion promotes hybrid EMT state, tumour stemness and metastasis. Pastushenko I, etal., Nature. 2021 Jan;589(7842):448-455. doi: 10.1038/s41586-020-03046-1. Epub 2020 Dec 16.
13. Expression of the rat homologue of the Drosophila fat tumour suppressor gene. Ponassi M, etal., Mech Dev 1999 Feb;80(2):207-12.
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Exome Sequencing of Oral Squamous Cell Carcinoma Reveals Molecular Subgroups and Novel Therapeutic Opportunities. Su SC, etal., Theranostics. 2017 Feb 26;7(5):1088-1099. doi: 10.7150/thno.18551. eCollection 2017.
18. Regulation and function of the atypical cadherin FAT1 in hepatocellular carcinoma. Valletta D, etal., Carcinogenesis. 2014 Jun;35(6):1407-15. doi: 10.1093/carcin/bgu054. Epub 2014 Mar 3.
Additional References at PubMed
PMID:10650949   PMID:15148305   PMID:15922730   PMID:16014031   PMID:16682528   PMID:17110338   PMID:17500054   PMID:19056867   PMID:19131340   PMID:21423176   PMID:23376485   PMID:26114487  
PMID:38553880  


Genomics

Comparative Map Data
Fat1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81653,909,759 - 54,029,175 (-)NCBIGRCr8
mRatBN7.21647,177,253 - 47,296,261 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1647,177,248 - 47,296,107 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1652,570,022 - 52,688,896 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01655,947,506 - 56,066,348 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01651,209,418 - 51,328,299 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01650,372,150 - 50,501,716 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1650,372,128 - 50,501,921 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01650,093,077 - 50,220,862 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41650,472,074 - 50,591,399 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11650,472,148 - 50,591,474 (-)NCBI
Celera1645,165,920 - 45,284,243 (-)NCBICelera
Cytogenetic Map16q11NCBI
FAT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384186,587,794 - 186,726,696 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4186,587,794 - 186,726,722 (-)EnsemblGRCh38hg38GRCh38
GRCh374187,508,948 - 187,645,010 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364187,745,931 - 187,881,981 (-)NCBINCBI36Build 36hg18NCBI36
Build 344187,884,097 - 188,020,136NCBI
Celera4184,830,318 - 184,965,946 (-)NCBICelera
Cytogenetic Map4q35.2NCBI
HuRef4183,256,134 - 183,392,436 (-)NCBIHuRef
CHM1_14187,485,399 - 187,621,051 (-)NCBICHM1_1
T2T-CHM13v2.04189,934,525 - 190,074,022 (-)NCBIT2T-CHM13v2.0
Fat1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39845,386,137 - 45,505,294 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl845,388,484 - 45,505,294 (+)EnsemblGRCm39 Ensembl
GRCm38844,933,100 - 45,052,257 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl844,935,447 - 45,052,257 (+)EnsemblGRCm38mm10GRCm38
MGSCv37846,035,562 - 46,137,611 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36846,449,031 - 46,551,074 (+)NCBIMGSCv36mm8
Celera847,637,354 - 47,739,945 (+)NCBICelera
Cytogenetic Map8B1.1NCBI
cM Map824.81NCBI
Fat1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540322,502,625 - 22,619,211 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540322,502,625 - 22,618,513 (+)NCBIChiLan1.0ChiLan1.0
FAT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23184,325,014 - 184,472,805 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14184,673,685 - 184,816,828 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04178,752,261 - 178,895,038 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14190,952,728 - 191,093,357 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4190,952,737 - 191,093,357 (-)Ensemblpanpan1.1panPan2
FAT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11644,113,621 - 44,241,187 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1644,128,386 - 44,241,192 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1644,600,636 - 44,727,622 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01646,333,660 - 46,461,020 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1646,348,414 - 46,461,009 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11644,296,352 - 44,423,412 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01644,908,979 - 45,036,005 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01645,046,355 - 45,173,362 (+)NCBIUU_Cfam_GSD_1.0
Fat1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494335,113,161 - 35,237,269 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365542,872,713 - 2,996,823 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365542,872,729 - 2,996,821 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FAT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl178,457,187 - 8,580,715 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1178,466,099 - 8,580,715 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2179,339,790 - 9,455,160 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FAT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17132,475,689 - 132,616,151 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7132,483,032 - 132,616,112 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037112,805,078 - 112,980,523 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fat1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476917,801,894 - 17,925,191 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476917,801,796 - 17,924,685 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fat1
632 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:66
Count of miRNA genes:62
Interacting mature miRNAs:65
Transcripts:ENSRNOT00000067486
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162173597566735975Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
631833Sach2Saccharin preference QTL 240.01consumption behavior trait (VT:0002069)calculated saccharin drink intake rate (CMO:0001613)164302484250166018Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
1298529Arunc1Aerobic running capacity QTL 14exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)163195152060148445Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat

Markers in Region
D16Got40  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21647,288,394 - 47,288,612 (+)MAPPERmRatBN7.2
Rnor_6.01650,493,999 - 50,494,218NCBIRnor6.0
Rnor_5.01650,213,067 - 50,213,286UniSTSRnor5.0
RGSC_v3.41650,583,684 - 50,583,901RGDRGSC3.4
RGSC_v3.41650,583,682 - 50,583,901UniSTSRGSC3.4
RGSC_v3.11650,583,759 - 50,583,976RGD
Celera1645,276,598 - 45,276,817UniSTS
RH 3.4 Map16460.7UniSTS
RH 3.4 Map16460.7RGD
RH 2.0 Map16466.8RGD
Cytogenetic Map16q11UniSTS
D8S560  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01339,822,565 - 39,822,615UniSTSRnor5.0
Rnor_5.01650,144,240 - 50,145,628UniSTSRnor5.0
RGSC_v3.41331,417,148 - 31,417,198UniSTSRGSC3.4
Celera1329,718,499 - 29,718,549UniSTS
Cytogenetic Map16q11UniSTS
BF389656  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21647,271,364 - 47,271,503 (+)MAPPERmRatBN7.2
Rnor_6.01650,476,971 - 50,477,109NCBIRnor6.0
Rnor_5.01650,196,039 - 50,196,177UniSTSRnor5.0
RGSC_v3.41650,566,654 - 50,566,792UniSTSRGSC3.4
Celera1645,259,653 - 45,259,791UniSTS
RH 3.4 Map16460.9UniSTS
Cytogenetic Map16q11UniSTS
UniSTS:143077  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21647,197,281 - 47,197,480 (+)MAPPERmRatBN7.2
Rnor_6.01650,392,179 - 50,392,377NCBIRnor6.0
Rnor_5.01650,113,105 - 50,113,303UniSTSRnor5.0
RGSC_v3.41650,492,085 - 50,492,283UniSTSRGSC3.4
Celera1645,185,930 - 45,186,128UniSTS
Cytogenetic Map16q11UniSTS
AU023433  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21647,177,395 - 47,177,537 (+)MAPPERmRatBN7.2
Rnor_6.01650,372,294 - 50,372,435NCBIRnor6.0
Rnor_5.01650,093,220 - 50,093,361UniSTSRnor5.0
RGSC_v3.41650,472,200 - 50,472,341UniSTSRGSC3.4
Celera1645,166,046 - 45,166,187UniSTS
Cytogenetic Map16q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094866 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275777 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005494675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF100960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF177681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ320127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L41684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000067486   ⟹   ENSRNOP00000061869
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1647,177,270 - 47,296,107 (-)Ensembl
Rnor_6.0 Ensembl1650,372,168 - 50,501,716 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000081023   ⟹   ENSRNOP00000073466
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1647,177,272 - 47,296,107 (-)Ensembl
Rnor_6.0 Ensembl1650,372,128 - 50,501,921 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095529   ⟹   ENSRNOP00000086783
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1647,177,257 - 47,281,431 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100392   ⟹   ENSRNOP00000091558
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1647,177,272 - 47,296,107 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105877   ⟹   ENSRNOP00000090183
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1647,177,272 - 47,296,107 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112869   ⟹   ENSRNOP00000096269
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1647,177,248 - 47,296,107 (-)Ensembl
RefSeq Acc Id: NM_031819   ⟹   NP_114007
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81653,909,776 - 54,028,609 (-)NCBI
mRatBN7.21647,177,270 - 47,296,107 (-)NCBI
Rnor_6.01650,372,168 - 50,501,716 (-)NCBI
Rnor_5.01650,093,077 - 50,220,862 (-)NCBI
RGSC_v3.41650,472,074 - 50,591,399 (-)RGD
Celera1645,165,920 - 45,284,243 (-)RGD
Sequence:
RefSeq Acc Id: XM_017600259   ⟹   XP_017455748
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81653,909,759 - 54,029,175 (-)NCBI
mRatBN7.21647,177,253 - 47,296,260 (-)NCBI
Rnor_6.01650,372,151 - 50,501,628 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017600262   ⟹   XP_017455751
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81653,909,759 - 54,029,175 (-)NCBI
mRatBN7.21647,177,253 - 47,296,260 (-)NCBI
Rnor_6.01650,372,151 - 50,501,628 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039094866   ⟹   XP_038950794
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81653,909,759 - 54,029,175 (-)NCBI
mRatBN7.21647,177,253 - 47,296,260 (-)NCBI
RefSeq Acc Id: XM_063275777   ⟹   XP_063131847
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81653,909,759 - 54,029,175 (-)NCBI
RefSeq Acc Id: XM_063275778   ⟹   XP_063131848
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81653,909,759 - 54,028,053 (-)NCBI
RefSeq Acc Id: XM_063275779   ⟹   XP_063131849
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81653,909,759 - 54,025,825 (-)NCBI
RefSeq Acc Id: XM_063275780   ⟹   XP_063131850
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81653,909,759 - 54,029,175 (-)NCBI
RefSeq Acc Id: XM_063275781   ⟹   XP_063131851
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81653,909,759 - 54,028,052 (-)NCBI
RefSeq Acc Id: XM_063275782   ⟹   XP_063131852
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81653,909,759 - 54,025,825 (-)NCBI
RefSeq Acc Id: XM_063275783   ⟹   XP_063131853
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81653,909,759 - 54,029,175 (-)NCBI
RefSeq Acc Id: XM_063275784   ⟹   XP_063131854
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81653,909,759 - 54,029,175 (-)NCBI
RefSeq Acc Id: XM_063275785   ⟹   XP_063131855
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81653,912,156 - 54,029,175 (-)NCBI
RefSeq Acc Id: XR_005494675
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81653,912,155 - 54,029,175 (-)NCBI
mRatBN7.21647,179,649 - 47,296,261 (-)NCBI
RefSeq Acc Id: NP_114007   ⟸   NM_031819
- Peptide Label: precursor
- UniProtKB: Q9WU10 (UniProtKB/TrEMBL),   A6JPS5 (UniProtKB/TrEMBL),   G3V9W9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455751   ⟸   XM_017600262
- Peptide Label: isoform X4
- UniProtKB: A6JPS5 (UniProtKB/TrEMBL),   G3V9W9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455748   ⟸   XM_017600259
- Peptide Label: isoform X2
- UniProtKB: A0A0G2K5L1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000061869   ⟸   ENSRNOT00000067486
Ensembl Acc Id: ENSRNOP00000073466   ⟸   ENSRNOT00000081023
RefSeq Acc Id: XP_038950794   ⟸   XM_039094866
- Peptide Label: isoform X6
- UniProtKB: A0A0G2K5L1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000096269   ⟸   ENSRNOT00000112869
Ensembl Acc Id: ENSRNOP00000086783   ⟸   ENSRNOT00000095529
Ensembl Acc Id: ENSRNOP00000091558   ⟸   ENSRNOT00000100392
Ensembl Acc Id: ENSRNOP00000090183   ⟸   ENSRNOT00000105877
RefSeq Acc Id: XP_063131850   ⟸   XM_063275780
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063131854   ⟸   XM_063275784
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063131853   ⟸   XM_063275783
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063131847   ⟸   XM_063275777
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AEP7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131848   ⟸   XM_063275778
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AEP7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131851   ⟸   XM_063275781
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063131852   ⟸   XM_063275782
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063131849   ⟸   XM_063275779
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AEP7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131855   ⟸   XM_063275785
- Peptide Label: isoform X8
Protein Domains
Cadherin   EGF-like   Laminin G

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700116
Promoter ID:EPDNEW_R10636
Type:multiple initiation site
Name:Fat1_1
Description:FAT atypical cadherin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01650,501,878 - 50,501,938EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621254 AgrOrtholog
BioCyc Gene G2FUF-11308 BioCyc
Ensembl Genes ENSRNOG00000030954 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000067486.2 UniProtKB/TrEMBL
  ENSRNOT00000081023.2 UniProtKB/TrEMBL
  ENSRNOT00000095529.1 UniProtKB/TrEMBL
  ENSRNOT00000100392.1 UniProtKB/TrEMBL
  ENSRNOT00000105877.1 UniProtKB/TrEMBL
  ENSRNOT00000112869.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.200 UniProtKB/TrEMBL
  Cadherins UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
InterPro Cadherin UniProtKB/TrEMBL
  Cadherin UniProtKB/TrEMBL
  Cadherin-like UniProtKB/TrEMBL
  Cadherin_CS UniProtKB/TrEMBL
  ConA-like_subgrp UniProtKB/TrEMBL
  EG-like_dom UniProtKB/TrEMBL
  EGF-like_Ca-bd UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  Laminin_G UniProtKB/TrEMBL
  NOTCH1_EGF-like UniProtKB/TrEMBL
KEGG Report rno:83720 UniProtKB/TrEMBL
NCBI Gene 83720 ENTREZGENE
PANTHER CADHERIN-23 UniProtKB/TrEMBL
  CADHERIN-87A UniProtKB/TrEMBL
  FAT ATYPICAL CADHERIN 2 UniProtKB/TrEMBL
  NEURAL-CADHERIN 2-RELATED UniProtKB/TrEMBL
Pfam Cadherin UniProtKB/TrEMBL
  EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  Laminin_G_2 UniProtKB/TrEMBL
PhenoGen Fat1 PhenoGen
PRINTS CADHERIN UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/TrEMBL
  CADHERIN_1 UniProtKB/TrEMBL
  CADHERIN_2 UniProtKB/TrEMBL
  EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  LAM_G_DOMAIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000030954 RatGTEx
SMART EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  LamG UniProtKB/TrEMBL
  SM00112 UniProtKB/TrEMBL
Superfamily-SCOP Cadherin UniProtKB/TrEMBL
  ConA_like_lec_gl UniProtKB/TrEMBL
  EGF/Laminin UniProtKB/TrEMBL
  SSF57184 UniProtKB/TrEMBL
UniProt A0A0G2K5L1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ADX6_RAT UniProtKB/TrEMBL
  A0A8I6AEP7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AQL3_RAT UniProtKB/TrEMBL
  A0A8I6GFB7_RAT UniProtKB/TrEMBL
  A6JPS5 ENTREZGENE, UniProtKB/TrEMBL
  G3V9W9 ENTREZGENE, UniProtKB/TrEMBL
  Q9WU10 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-06-05 Fat1  FAT atypical cadherin 1  Fat1  FAT tumor suppressor homolog 1 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-25 Fat1  FAT tumor suppressor homolog 1 (Drosophila)  Fat  FAT tumor suppressor homolog 1 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Fat  FAT tumor suppressor homolog 1 (Drosophila)  Fat1  FAT tumor suppressor homolog 1 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-19 Fat1  FAT tumor suppressor homolog 1 (Drosophila)  Fath  fat tumor suppressor homolog (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Fath  fat tumor suppressor homolog (Drosophila)  Fat  FAT tumor suppressor (Drosophila) homolog  Symbol and Name updated 1299863 APPROVED
2002-08-07 Fat  FAT tumor suppressor (Drosophila) homolog      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains a large protocadherin with 34 cadherin repeats, five epidermal growth factor (EGF)-like repeats containing a single laminin A-G domain and a putative transmembrane portion followed by a cytoplasmic sequence 632716
gene_expression expressed in fetal epithelial cell layers and in the CNS 632716