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Gene: Adamts4 (ADAM metallopeptidase with thrombospondin type 1 motif, 4) Rattus norvegicus

Analyze

Symbol:

Adamts4

Name:

ADAM metallopeptidase with thrombospondin type 1 motif, 4

RGD ID:

621242

Description:

Predicted to enable metalloendopeptidase activity; protease binding activity; and zinc ion binding activity. Predicted to be involved in extracellular matrix organization and proteolysis. Predicted to act upstream of or within defense response to bacterium. Predicted to be located in extracellular space and nuclear speck. Predicted to be active in extracellular matrix. Biomarker of degenerative disc disease and transient cerebral ischemia. Orthologous to human ADAMTS4 (ADAM metallopeptidase with thrombospondin type 1 motif 4); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

a disintegrin and metallopeptidase with thrombospondin motifs 4; A disintegrin and metalloproteinase with thrombospondin motifs 4; a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4; ADAM-TS 4; ADAM-TS4; ADAMTS-4; Aggrecanase; aggrecanase-1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	86,203,011 - 86,212,500 (+)	NCBI		GRCr8
mRatBN7.2	13	83,670,556 - 83,680,045 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	83,670,183 - 83,680,065 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	86,176,431 - 86,185,920 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	87,574,636 - 87,584,125 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	84,806,145 - 84,815,616 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	89,622,996 - 89,632,485 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	89,622,632 - 89,634,419 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	94,249,862 - 94,259,351 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	87,142,442 - 87,151,783 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	87,336,962 - 87,339,836 (+)	NCBI
Celera	13	83,301,254 - 83,310,782 (+)	NCBI		Celera
Cytogenetic Map	13	q24	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autoimmune interstitial lung, joint, and kidney disease (ISO)

degenerative disc disease (IEP)

gastrointestinal stromal tumor (ISO)

osteoarthritis (ISO)

parathyroid carcinoma (ISO)

rheumatoid arthritis (ISO)

transient cerebral ischemia (IEP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (EXP,ISO)

17beta-estradiol 3-benzoate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-diaminotoluene (ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2-amino-2-deoxy-D-glucopyranose (EXP)

2-butoxyethanol (ISO)

3,3',4,4',5-pentachlorobiphenyl (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-methylcholanthrene (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

aldehydo-D-glucosamine (EXP)

all-trans-retinoic acid (ISO)

amitrole (EXP)

ammonium chloride (EXP)

arsenite(3-) (ISO)

arsenous acid (ISO)

Azoxymethane (ISO)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

beta-D-glucosamine (EXP)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

carbon nanotube (ISO)

carmustine (ISO)

CGP 52608 (ISO)

cisplatin (ISO)

cobalt dichloride (EXP)

copper atom (EXP)

copper(0) (EXP)

Cuprizon (EXP)

curcumin (ISO)

dexamethasone (ISO)

dextran sulfate (ISO)

diarsenic trioxide (ISO)

dimethylarsinic acid (ISO)

dioxygen (EXP,ISO)

dopamine (EXP)

doxorubicin (ISO)

endosulfan (EXP)

ethanol (ISO)

ethylparaben (ISO)

fenoldopam (EXP)

fluoranthene (ISO)

genistein (ISO)

gentamycin (EXP)

graphene oxide (ISO)

inulin (ISO)

L-proline betaine (ISO)

lead diacetate (EXP)

methylarsonic acid (ISO)

methylmercury chloride (EXP)

mono(2-ethylhexyl) phthalate (ISO)

oxaliplatin (EXP)

ozone (ISO)

paclitaxel (ISO)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (ISO)

propanal (ISO)

resveratrol (ISO)

rotenone (EXP)

silicon dioxide (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sotorasib (ISO)

T-2 toxin (ISO)

testosterone (EXP)

tetrachloromethane (EXP,ISO)

thapsigargin (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

topotecan (EXP)

trametinib (ISO)

trichloroethene (EXP)

triclosan (ISO)

trimellitic anhydride (ISO)

triphenyl phosphate (ISO)

tris(2-butoxyethyl) phosphate (ISO)

trovafloxacin (ISO)

urethane (ISO)

valproic acid (ISO)

vanadium atom (ISO)

vanadium(0) (ISO)

WIN 55212-2 (ISO)

yohimbine (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

defense response to bacterium (ISO)

extracellular matrix organization (IBA,IEA)

proteolysis (IBA,IEA,ISO)

Cellular Component

extracellular matrix (IBA)

extracellular space (IEA,ISO)

nuclear speck (IEA,ISO)

Molecular Function

metalloendopeptidase activity (IBA,IEA,ISO)

metallopeptidase activity (ISO,ISS)

peptidase activity (ISO,ISS)

protease binding (IEA,ISO)

protein binding (ISO)

zinc ion binding (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	ADAMTS-1 and -4 are up-regulated following transient middle cerebral artery occlusion in the rat and their expression is modulated by TNF in cultured astrocytes.	Cross AK, etal., Brain Res. 2006 May 9;1088(1):19-30. Epub 2006 Apr 21.
2.	Targeting bone alleviates osteoarthritis in osteopenic mice and modulates cartilage catabolism.	Funck-Brentano T, etal., PLoS One. 2012;7(3):e33543. doi: 10.1371/journal.pone.0033543. Epub 2012 Mar 14.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	GOA pipeline	RGD automated data pipeline
8.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	ADAMTS-4 (a disintegrin and metalloproteinase with thrombospondin motifs) is transcriptionally induced in beta-amyloid treated rat astrocytes.	Satoh K, etal., Neurosci Lett 2000 Aug 11;289(3):177-80.
11.	Expression of versican and ADAMTS during rat tooth eruption.	Sone S, etal., J Mol Histol. 2005 May;36(4):281-8.
12.	Expression and regulation of aggrecanase in arthritis: the role of TGF-beta.	Yamanishi Y, etal., J Immunol. 2002 Feb 1;168(3):1405-12.
13.	Rat tail static compression model mimics extracellular matrix metabolic imbalances of matrix metalloproteinases, aggrecanases, and tissue inhibitors of metalloproteinases in intervertebral disc degeneration.	Yurube T, etal., Arthritis Res Ther. 2012 Mar 6;14(2):R51. doi: 10.1186/ar3764.

Additional References at PubMed

PMID:14744861	PMID:15192113	PMID:16583222	PMID:19778785	PMID:20632367	PMID:21257285	PMID:23658023	PMID:23684986	PMID:23845380	PMID:37424113

Genomics

Comparative Map Data

Adamts4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	86,203,011 - 86,212,500 (+)	NCBI		GRCr8
mRatBN7.2	13	83,670,556 - 83,680,045 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	83,670,183 - 83,680,065 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	86,176,431 - 86,185,920 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	87,574,636 - 87,584,125 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	84,806,145 - 84,815,616 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	89,622,996 - 89,632,485 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	89,622,632 - 89,634,419 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	94,249,862 - 94,259,351 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	87,142,442 - 87,151,783 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	87,336,962 - 87,339,836 (+)	NCBI
Celera	13	83,301,254 - 83,310,782 (+)	NCBI		Celera
Cytogenetic Map	13	q24	NCBI

ADAMTS4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	161,184,302 - 161,199,054 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	161,184,302 - 161,199,054 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	161,154,092 - 161,168,844 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	159,426,162 - 159,435,469 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	157,972,611 - 157,981,917	NCBI
Celera	1	134,226,690 - 134,235,997 (-)	NCBI		Celera
Cytogenetic Map	1	q23.3	NCBI
HuRef	1	132,516,482 - 132,525,790 (-)	NCBI		HuRef
CHM1_1	1	162,555,776 - 162,565,083 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	160,321,737 - 160,336,495 (-)	NCBI		T2T-CHM13v2.0

Adamts4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	171,077,698 - 171,089,836 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	171,077,990 - 171,088,206 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	171,250,129 - 171,262,267 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	171,250,421 - 171,260,637 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	173,180,553 - 173,190,053 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	173,087,097 - 173,096,597 (+)	NCBI		MGSCv36	mm8
Celera	1	173,706,617 - 173,716,194 (+)	NCBI		Celera
Cytogenetic Map	1	H3	NCBI
cM Map	1	79.28	NCBI

Adamts4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955468	12,951,155 - 12,958,212 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955468	12,950,333 - 12,958,599 (-)	NCBI	ChiLan1.0	ChiLan1.0

ADAMTS4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	88,652,642 - 88,667,740 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	88,343,086 - 88,352,613 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	136,602,140 - 136,611,469 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	140,514,247 - 140,523,623 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	140,514,247 - 140,523,623 (-)	Ensembl	panpan1.1		panPan2

ADAMTS4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	38	21,283,555 - 21,292,432 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	38	21,284,330 - 21,292,437 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	38	21,358,398 - 21,367,289 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	38	21,401,386 - 21,410,283 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	38	21,402,174 - 21,409,517 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	38	21,289,243 - 21,298,133 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	38	21,703,669 - 21,712,554 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	38	22,112,816 - 22,121,707 (+)	NCBI		UU_Cfam_GSD_1.0

Adamts4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	7,282,484 - 7,291,864 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936903	491,139 - 500,443 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936903	490,718 - 500,443 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ADAMTS4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	89,260,461 - 89,269,244 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	89,260,354 - 89,269,238 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	97,117,041 - 97,125,927 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ADAMTS4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	2,781,184 - 2,791,464 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	2,783,855 - 2,792,170 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	1,829,936 - 1,842,272 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Adamts4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624794	188,207 - 198,934 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624794	187,589 - 196,465 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Adamts4
59 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	113
Count of miRNA genes:	82
Interacting mature miRNAs:	101
Transcripts:	ENSRNOT00000004713
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	20605871	101339738	Rat
7387280	Uae43	Urinary albumin excretion QTL 43	5.69	0.4174	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	66451204	106807694	Rat
738027	Lnnr6	Liver neoplastic nodule remodeling QTL 6	3.3		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	13	74862117	85581182	Rat
1298066	Bp159	Blood pressure QTL 159		0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	46088046	91088046	Rat
738026	Lnnr5	Liver neoplastic nodule remodeling QTL 5	3.29		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	13	59874408	85581182	Rat
10755495	Bp387	Blood pressure QTL 387	3.78		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	34663461	87525369	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	13	31241331	93395974	Rat
2293702	Bss34	Bone structure and strength QTL 34	4.61	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	13	65103704	106807694	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	30395351	101056920	Rat
1354655	Bp241	Blood pressure QTL 241	3.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	56056920	101056920	Rat
4889606	Gluco63	Glucose level QTL 63	2.86	0.003	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	13	80753256	106807694	Rat
8655945	Rf61	Renal function QTL 61	3.6		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	13	69060519	86800898	Rat
71119	Thym2	Thymus enlargement QTL 2	3.8		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	13	46197976	84753113	Rat
1331783	Bp221	Blood pressure QTL 221	3.72886		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	69060519	86800898	Rat
8655959	Pur32	Proteinuria QTL 32	8.4		urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	13	74023918	97213863	Rat
1641901	Alcrsp6	Alcohol response QTL 6			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	13	52362171	97362171	Rat
12879441	Bp396	Blood pressure QTL 396			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	45699983	90699983	Rat
2293687	Bss26	Bone structure and strength QTL 26	4.6	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	13	65103704	106807694	Rat
1300166	Kidm6	Kidney mass QTL 6	3.93		kidney mass (VT:0002707)	single kidney wet weight to body weight ratio (CMO:0000622)	13	69060519	86800898	Rat
619615	Bp80	Blood pressure QTL 80		0.0354	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	39754544	84754544	Rat
12879475	Bp400	Blood pressure QTL 400			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	61825626	106807694	Rat
1581570	Eae17	Experimental allergic encephalomyelitis QTL 17	4.1		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	13	8897350	101631289	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	101056920	Rat
2293341	Glom15	Glomerulus QTL 15	9.1		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	13	74862117	101339893	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_023959	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB042271	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB042272	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB042273	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC099236	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB614460	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473985	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000004713 ⟹ ENSRNOP00000004713

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	83,670,183 - 83,680,065 (+)	Ensembl
Rnor_6.0 Ensembl	13	89,622,632 - 89,634,419 (+)	Ensembl

RefSeq Acc Id:

NM_023959 ⟹ NP_076449

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	86,203,011 - 86,212,500 (+)	NCBI
mRatBN7.2	13	83,670,556 - 83,680,045 (+)	NCBI
Rnor_6.0	13	89,622,996 - 89,632,485 (+)	NCBI
Rnor_5.0	13	94,249,862 - 94,259,351 (+)	NCBI
RGSC_v3.4	13	87,142,442 - 87,151,783 (+)	RGD
Celera	13	83,301,254 - 83,310,782 (+)	RGD

Sequence:

show sequence

ATGGCCTCAATCCATCCCAGCTGCAGCACTGGTACCATGTCCAGGATGGGCTTGCATCCCAGGA
GGGGCTTGACTGGGCACAGACTGCGAAGACTCCAACCCTGCCTGCCGCCCCGCACTGTGCCTTT
CTCTGGTTTGGAGCGGTGGCAGCAGCTGCTGCTGCTGGCCTCCCTCCTGCCTTTAGCCTGGTCA
GCCAGCCCCCTCCCCCGAGAGGAGGAGATCGTGTTTCCAGAGAAGCTCAACGGCAGTAGTATCA
TACCTGGCTCAGGCGTCCCTGCCAGGCTGCTGTACCGATTACCAGCCTTTGGGGAGATATTGTT
ACTAGAACTAGAGCAGGATCCTGGGGTGCAGGTAGAGGGGCTGACAGTACAGTACCTGGGCCAG
GCACCTGAGATGCTGGGTGGGGCAGAGCCAGGTACCTACCTGACTGGCACCATCAATGGAGATC
CGGAGTCGGTGGCGTCTCTGCACTGGGACAGGGGAGCCCTATTGGGGGTATTGCAGTACCGGGG
GGCCGAACTCCACCTCCAGCCTCTGGAAGGAGGCGCCCTTAACTCTGCTGGGGGACCAGGGGCT
CACATCCTACGCCGGAAGAGTCCTGCCAGCAACCGAGGTCCCATATGCAACGTCAAGGCTCCTT
CTGGGAGCCCCAGTCCCATTTCCCGCAGAAACAAGCGCTTCGCTTCGCTGAGTAGATTCGTGGA
GACACTGGTGGTGGCAGATGACAAGATGGCAGCATTCCACGGGGCAGGGTTAAAGCACTACCTG
CTGACGGTCATGGCCGCCGCTGCCAAAGCCTTTAAGCATCCAAGCATCCGAAACCCTGTCAACT
TGGTGGTGACTCGTCTAGTAATCCTGGGGTCGGGCCAGGAAGTGCCCCAAGTGGGGCCAAGTGC
CGCCCAGACCCTACGCAGCTTCTGCACCTGGCAGAAAGGCCTAAACCCTCCGAACGACTCAGAT
CCTGACCACTTTGACACGGCCATTCTGTTCACCCGGCAGGACCTGTGTGGGGTCTCCACCTGTG
ACGCTCTGGGTATGGCTGGTGTGGGCACAGTGTGTGACCCAGCTAGGAGCTGTGCTATTGTGGA
GGACGATGGGCTCCAGTCGGCCTTCACCGCCGCTCATGAACTGGGCCATGTCTTCAACATGCTC
CATGATAACTCCAAACCGTGTGCTAATTTGAATGGGCAGGGGAGTTCCTCTCGCCATGTCATGG
CTCCTGTCATGGCTCACGTGGACCCTGAAGAGCCCTGGTCCCCCTGCAGTGCCCGATTCATCAC
TGACTTCCTGGACAATGGCTATGGACACTGCCTCTTAGACAAACCAGAGGCTCCCCTGCATCTG
CCAGTGACTTTTCCTGGCAAGGACTATGATGCTGACCGCCAGTGCCAACTGACCTTTGGTCCTG
ACTCAAGCCATTGTCCACAGCTGCCACCGCCCTGTGCTGCCCTCTGGTGCTTTGGCCACCTCAA
TGGCCATGCCATGTGTCAGACTAAGCACTCACCCTGGGCCGATGGTACTCCCTGCGGACCTGCA
CAGGCCTGTATGGGTGGCCGCTGTCTCCACGTGGACCAGCTCAAGGACTTCAATATTCCTCAGG
CTGGAGGCTGGGGTCCCTGGGGACCATGGGGTGACTGCTCCAGGACTTGTGGAGGTGGTGTCCA
ATTCTCCTCCCGGGACTGCACAAAGCCTGTCCCCCGGAATGGTGGAAAGTATTGTGAGGGCCGC
CGTACCCCGTTCCGCTCCTGTAACACTAAGAACTGCCCACATGGCTCAGCATTGACCTTCCGTG
AAGAGCAGTGTGCTGCCTACAACCACCGAACCGACCTCTTCAAGAGTTTTCCGGGGCCCATGGA
CTGGGTTCCGCGCTACACAGGTGTAGCCCCTCGAGACCAGTGCAAACTCACCTGCCAGGCCCGG
GCACTGGGCTACTACTATGTACTGGAGCCACGGGTGGCAGATGGAACTCCCTGTTCCCCAGACT
CTTCCTCTGTCTGTGTCCAGGGCCGCTGTATCCACGCTGGCTGTGATCGAATCATTGGCTCCAA
AAAGAAATTTGACAAGTGCATGGTGTGCGGTGGGAATGGCTCTAGCTGCAGCAAGCAGTCAGGC
TCCTTCAAAAAATTCAGGTACGGATACAGCGATGTGGTCACGATCCCTGCGGGACGCACCCATA
TCCTTGTACGGCAGCAGGGAGGATCTGGCCTCAAGAGCATCTACCTGGCCCTGAAGCTAGCAGA
TGGTTCTTACGCCCTCAATGGTGAATACACGCTGATGCCCTCCTCAACAGATGTGGTACTTCCT
GGGGCAGTCAGCTTGCGCTATAGCGGACGCACGGCAGCCTCAGAGACACTGTCTGGACATGGGC
CGCTGGCCCAGCCCTTGACGCTGCAAGTTCTGGTGGCTGGCAACCCACAGAATGTACGTCTGCG
GTACAGTTTCTTTGTCCCGCGGCCAGTCCCTTCAACGCCACGCCCTCCTCCCCAAAACTGGCTG
CAACGCAGGGCAGAGATTCTGGAGATCCTTCGGAAGCGAACCTGGGCAGGCCGGAAATAACCTC
ACTGTCCCGGCTGCCCTTTTGGGGCGCCGGGGCCTCGGACTCATCTGGGAGAATGAGCGGGCTT
CTGCAGCTGCCTCGTGCTAAAACACAGTAGGGAGGTGTAGAGGGTGAGACCTGCTTGCCTCTCT
GCCCCAAACCGCAGGCTGGCCCTGCCCTGGCTTCCTGCCCTGGGAGGCAGTGATGTGTTGGTGA
ATGGAAAGGAGCCTACCTGACAGTACCCCATCTATTTAACTGCCCCCTCTACCCTGCAGGTCAC
AGGAGGGAGCGGGGAAGACAGGGTGGGGTCCTGGGCCCCAGTTGTATTTATTTAGTATTTATTC
ACTTTTATTTAGCACCAGGGAAGGGGACTAGGAATGGGGAAACTCACCCATTATAGGCCCATCC
TAGCTATGAAATCCAGGGTGTTGGTGACAAATATAAGTGTGTGTGCGCGTTCGCGTGGTGTGTG
TGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTTATGTATGAGGTACAACCTGCC
CTACTTTCCTCTTTTCCTGATTTTTCCCCTGGGAAAAGGAGAGTCAAAGGTAGGATTGCCTTCA
GGGAGTAAGGGATCATCACGTTTTTTTTTTTAAATTGAAGTTTGCTATTTATCTGCTGTTTTTG
GAGTCAGACAAATGTGGGCCATACTTTGGCCCCGCATCTTTGAACATTCCTTTTCTCATGTGCC
AATAATAATACCTCCCTTAGAAATCTGTTGTAAGGATTAAATAATGTAAATAAAGAACTAGCAT
CATGCCTCCCA

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Protein Sequences


Protein RefSeqs	NP_076449	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAB16473	(Get FASTA)	NCBI Sequence Viewer
	BAB16474	(Get FASTA)	NCBI Sequence Viewer
	BAB16475	(Get FASTA)	NCBI Sequence Viewer
	EDL94619	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000004713.6
GenBank Protein	Q9ESP7	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_076449 ⟸ NM_023959

- UniProtKB:

D4A0C5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MASIHPSCSTGTMSRMGLHPRRGLTGHRLRRLQPCLPPRTVPFSGLERWQQLLLLASLLPLAWS
ASPLPREEEIVFPEKLNGSSIIPGSGVPARLLYRLPAFGEILLLELEQDPGVQVEGLTVQYLGQ
APEMLGGAEPGTYLTGTINGDPESVASLHWDRGALLGVLQYRGAELHLQPLEGGALNSAGGPGA
HILRRKSPASNRGPICNVKAPSGSPSPISRRNKRFASLSRFVETLVVADDKMAAFHGAGLKHYL
LTVMAAAAKAFKHPSIRNPVNLVVTRLVILGSGQEVPQVGPSAAQTLRSFCTWQKGLNPPNDSD
PDHFDTAILFTRQDLCGVSTCDALGMAGVGTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNML
HDNSKPCANLNGQGSSSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEAPLHL
PVTFPGKDYDADRQCQLTFGPDSSHCPQLPPPCAALWCFGHLNGHAMCQTKHSPWADGTPCGPA
QACMGGRCLHVDQLKDFNIPQAGGWGPWGPWGDCSRTCGGGVQFSSRDCTKPVPRNGGKYCEGR
RTPFRSCNTKNCPHGSALTFREEQCAAYNHRTDLFKSFPGPMDWVPRYTGVAPRDQCKLTCQAR
ALGYYYVLEPRVADGTPCSPDSSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGNGSSCSKQSG
SFKKFRYGYSDVVTIPAGRTHILVRQQGGSGLKSIYLALKLADGSYALNGEYTLMPSSTDVVLP
GAVSLRYSGRTAASETLSGHGPLAQPLTLQVLVAGNPQNVRLRYSFFVPRPVPSTPRPPPQNWL
QRRAEILEILRKRTWAGRK

hide sequence

Ensembl Acc Id:

ENSRNOP00000004713 ⟸ ENSRNOT00000004713

Protein Domains

Disintegrin Peptidase M12B TSP type-1

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9ESP7-F1-model_v2	AlphaFold	Q9ESP7	1-630	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621242	AgrOrtholog
BioCyc Gene	G2FUF-17380	BioCyc
Ensembl Genes	ENSRNOG00000003538	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000004713.8	UniProtKB/TrEMBL
Gene3D-CATH	2.20.100.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	2.60.120.830	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.40.1620.60	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.40.390.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	ADAM_CR_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ADAM_Cys-rich	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ADAM_spacer1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ADAMTS/ADAMTS-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ADAMTS_ADAMTS-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ADAMTS_CR_3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MetalloPept_cat_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Peptidase_M12B	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TSP1_rpt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TSP1_rpt_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:66015	UniProtKB/Swiss-Prot
NCBI Gene	66015	ENTREZGENE
PANTHER	A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 4	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	ADAM_CR_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ADAM_CR_3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ADAM_spacer1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Reprolysin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TSP_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Adamts4	PhenoGen
PRINTS	ADAMTSFAMILY	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	ADAM_MEPRO	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TSP1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ZINC_PROTEASE	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000003538	RatGTEx
SMART	ACR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TSP1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	Metalloproteases ('zincins'), catalytic domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF82895	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A6JFW3_RAT	UniProtKB/TrEMBL
	ATS4_RAT	UniProtKB/Swiss-Prot
	D4A0C5	ENTREZGENE, UniProtKB/TrEMBL
	Q9ESP7	ENTREZGENE
UniProt Secondary	Q9ESP6	UniProtKB/Swiss-Prot
	Q9ESP8	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-09-18	Adamts4	ADAM metallopeptidase with thrombospondin type 1 motif, 4	Adamts4	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-02-19	Adamts4	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4	Adamts4	a disintegrin and metallopeptidase with thrombospondin motifs 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-20	Adamts4	a disintegrin and metallopeptidase with thrombospondin motifs 4		ADAMTS-4	Name updated	1299863	APPROVED
2002-08-07	Adamts4	ADAMTS-4			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_disease	may be involved in arthritic diseases through the destruction of aggrecan	724707
gene_function	cleaves and may play a role in the turnover of aggrecan, a cartilage proteoglycan	724707

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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