Mt-atp8 (mitochondrially encoded ATP synthase membrane subunit 8) - Rat Genome Database

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Gene: Mt-atp8 (mitochondrially encoded ATP synthase membrane subunit 8) Rattus norvegicus
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Symbol: Mt-atp8
Name: mitochondrially encoded ATP synthase membrane subunit 8
RGD ID: 621240
Description: Predicted to contribute to proton-transporting ATP synthase activity, rotational mechanism. Involved in response to hyperoxia. Part of proton-transporting ATP synthase complex. Human ortholog(s) of this gene implicated in multiple sclerosis and urinary bladder cancer. Orthologous to human MT-ATP8 (mitochondrially encoded ATP synthase membrane subunit 8); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ATP synthase 8, mitochondrial; ATP synthase F0 subunit 8; Atp8; ATPase subunit 8; mitochondrially encoded ATP synthase 8
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2MT7,758 - 7,961 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2MT7,758 - 7,961 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2MT7,758 - 7,961 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2MT7,758 - 7,961 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2MT7,758 - 7,961 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2MT7,758 - 7,961 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2MT7,758 - 7,961 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2MT7,758 - 7,961 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2MT7,758 - 7,961 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2MT7,758 - 7,961 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblMT7,758 - 7,961 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0MT7,758 - 7,961 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblMT7,758 - 7,961 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0MT7,758 - 7,961 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4MT7,758 - 7,961 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Cytogenetic MapMT NCBI


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Investigation on mitochondrial tRNA(Leu/Lys), NDI and ATPase 6/8 in Iranian multiple sclerosis patients. Ahari SE, etal., Cell Mol Neurobiol. 2007 Sep;27(6):695-700. Epub 2007 Jul 6.
2. Effects of hyperoxia on mitochondrial multienzyme complex III and V in premature newborn rat lung. Cai C, etal., J Huazhong Univ Sci Technolog Med Sci. 2008 Apr;28(2):207-10. Epub 2008 May 15.
3. The nucleotide sequences of several tRNA genes from rat mitochondria: common features and relatedness to homologous species. Cantatore P, etal., Nucleic Acids Res 1982 May 25;10(10):3279-89.
4. Mitochondrial DNA mutations in chemical carcinogen-induced rat bladder and human bladder cancer. Chen GF, etal., Oncol Rep. 2004 Aug;12(2):463-72.
5. Mutation of mitochondrial ATP8 gene improves hepatic energy status in a murine model of acute endotoxemic liver failure. Eipel C, etal., Life Sci. 2011 Feb 14;88(7-8):343-9. Epub 2010 Dec 15.
6. The complete nucleotide sequence of the Rattus norvegicus mitochondrial genome: cryptic signals revealed by comparative analysis between vertebrates. Gadaleta G, etal., J Mol Evol 1989 Jun;28(6):497-516.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
9. A point mutation in the mitochondrial DNA of diabetes-prone BHE/cdb rats. Mathews CE, etal., FASEB J 1995 Dec;9(15):1638-42.
10. Identification of two proteins associated with mammalian ATP synthase. Meyer B, etal., Mol Cell Proteomics. 2007 Oct;6(10):1690-9. Epub 2007 Jun 17.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Comprehensive gene review and curation RGD comprehensive gene curation
17. The mtDNA nt7778 G/T polymorphism affects autoimmune diseases and reproductive performance in the mouse. Yu X, etal., Hum Mol Genet. 2009 Dec 15;18(24):4689-98. Epub 2009 Sep 16.
18. [Altered expression of mitochondrial DNA encoding ATP 6, 8 and encoding protein in energy metabolism during cold preservation and reperfusion injury in rat liver transplantation]. Zhang Y, etal., Zhonghua Yi Xue Za Zhi. 2010 Mar 16;90(10):708-11.
Additional References at PubMed
PMID:34800366  


Genomics

Comparative Map Data
Mt-atp8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2MT7,758 - 7,961 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2MT7,758 - 7,961 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2MT7,758 - 7,961 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2MT7,758 - 7,961 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2MT7,758 - 7,961 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2MT7,758 - 7,961 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2MT7,758 - 7,961 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2MT7,758 - 7,961 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2MT7,758 - 7,961 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2MT7,758 - 7,961 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblMT7,758 - 7,961 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0MT7,758 - 7,961 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblMT7,758 - 7,961 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0MT7,758 - 7,961 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4MT7,758 - 7,961 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Cytogenetic MapMT NCBI
MT-ATP8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38MT8,366 - 8,572 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblMT8,366 - 8,572 (+)EnsemblGRCh38hg38GRCh38
GRCh37MT8,366 - 8,572 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36MT8,367 - 8,573 (+)NCBINCBI36Build 36hg18NCBI36
mt-Atp8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39MT7,766 - 7,969 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblMT7,766 - 7,969 (+)EnsemblGRCm39 Ensembl
GRCm38MT7,766 - 7,969 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblMT7,766 - 7,969 (+)EnsemblGRCm38mm10GRCm38
MGSCv37MT7,766 - 7,969 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MT-ATP8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1MT7,803 - 8,006 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblMT7,803 - 8,006 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaMT7,803 - 8,006 (+)NCBIDog10K_Boxer_Tasha
MT-ATP8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblMT8,959 - 9,162 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1MT8,959 - 9,162 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2MT8,959 - 9,162 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Mt-atp8
6 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:9
Count of miRNA genes:9
Interacting mature miRNAs:9
Transcripts:ENSRNOT00000046201
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
7 11 49 102 77 75 47 23 47 6 190 93 82 35 52 28

Sequence


Ensembl Acc Id: ENSRNOT00000046201   ⟹   ENSRNOP00000042521
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblMT7,758 - 7,961 (+)Ensembl
Rnor_6.0 EnsemblMT7,758 - 7,961 (+)Ensembl
Ensembl Acc Id: ENSRNOP00000042521   ⟸   ENSRNOT00000046201

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P11608-F1-model_v2 AlphaFold P11608 1-67 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621240 AgrOrtholog
BioCyc Gene G2FUF-17 BioCyc
BioCyc Pathway PWY-7980 [ATP biosynthesis] BioCyc
BioCyc Pathway Image PWY-7980 BioCyc
Ensembl Genes ENSRNOG00000033299 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000046201.3 UniProtKB/Swiss-Prot
InterPro ATP8_mammal UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP8_metazoa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:26196 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 26196 ENTREZGENE
PANTHER ATP SYNTHASE PROTEIN 8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR13722 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ATP-synt_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mt-atp8 PhenoGen
RatGTEx ENSRNOG00000033299 RatGTEx
UniProt ATP8_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q35736 ENTREZGENE
  Q5UAJ5 ENTREZGENE, UniProtKB/TrEMBL
  Q8HIC8 ENTREZGENE, UniProtKB/TrEMBL
  Q8SEZ4_RAT UniProtKB/TrEMBL
UniProt Secondary Q35736 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-03-17 Mt-atp8  mitochondrially encoded ATP synthase membrane subunit 8  Mt-atp8  mitochondrially encoded ATP synthase 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-09 Mt-atp8  mitochondrially encoded ATP synthase 8  mt-Atp8  ATP synthase 8, mitochondrial  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-11 mt-Atp8  ATP synthase 8, mitochondrial      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 mt-Atp8  ATP synthase 8, mitochondrial      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease point mutations may be associated with diabetes  
gene_process may mediate mitochondrial translation and transcription mechanisms 631900