Hand1 (heart and neural crest derivatives expressed 1) - Rat Genome Database

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Gene: Hand1 (heart and neural crest derivatives expressed 1) Rattus norvegicus
Analyze
Symbol: Hand1
Name: heart and neural crest derivatives expressed 1
RGD ID: 621206
Description: Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding activity; and protein homodimerization activity. Predicted to contribute to transcription cis-regulatory region binding activity. Predicted to be involved in cardiac chamber morphogenesis; in utero embryonic development; and regulation of DNA-templated transcription. Predicted to act upstream of or within several processes, including cartilage morphogenesis; circulatory system development; and regulation of transcription by RNA polymerase II. Located in nucleus. Orthologous to human HAND1 (heart and neural crest derivatives expressed 1); INTERACTS WITH (S)-nicotine; 2,2',4,4'-Tetrabromodiphenyl ether; all-trans-retinoic acid.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: eHand; extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1; heart and neural crest derivatives expressed transcript 1; heart- and neural crest derivatives-expressed protein 1; MGC114332
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Hand1m1Mcwi  
Genetic Models: BN-Hand1m1Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81042,507,117 - 42,509,684 (-)NCBIGRCr8
mRatBN7.21042,006,646 - 42,009,213 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1042,006,651 - 42,009,213 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1046,669,274 - 46,671,841 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01046,159,536 - 46,162,103 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01041,663,162 - 41,665,729 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01043,250,729 - 43,253,296 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1043,250,745 - 43,253,296 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01043,050,068 - 43,052,635 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41043,423,366 - 43,425,933 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11043,436,993 - 43,439,556 (-)NCBI
Celera1041,298,555 - 41,301,122 (-)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. The basic helix-loop-helix transcription factor Hand1 regulates mouse development as a homodimer. Hu D, etal., Dev Biol. 2013 Oct 15;382(2):470-81. doi: 10.1016/j.ydbio.2013.07.025. Epub 2013 Aug 1.
4. Regulation of dHAND protein expression by all-trans retinoic acid through ET-1/ETAR signaling in H9c2 cells. Li W and Li Y, J Cell Biochem. 2006 Oct 1;99(2):478-84.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
10. HAND1 and HAND2 are expressed in the adult-rodent heart and are modulated during cardiac hypertrophy. Thattaliyath BD, etal., Biochem Biophys Res Commun 2002 Oct 4;297(4):870-5.
Additional References at PubMed
PMID:7814632   PMID:9500550   PMID:9500551   PMID:10924525   PMID:11076684   PMID:11802795   PMID:12070084   PMID:12477932   PMID:15073150   PMID:15509787   PMID:15576406   PMID:16043483  
PMID:16759287   PMID:17764670   PMID:17891141   PMID:18276607   PMID:19144722   PMID:19170063   PMID:19586923  


Genomics

Comparative Map Data
Hand1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81042,507,117 - 42,509,684 (-)NCBIGRCr8
mRatBN7.21042,006,646 - 42,009,213 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1042,006,651 - 42,009,213 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1046,669,274 - 46,671,841 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01046,159,536 - 46,162,103 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01041,663,162 - 41,665,729 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01043,250,729 - 43,253,296 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1043,250,745 - 43,253,296 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01043,050,068 - 43,052,635 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41043,423,366 - 43,425,933 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11043,436,993 - 43,439,556 (-)NCBI
Celera1041,298,555 - 41,301,122 (-)NCBICelera
Cytogenetic Map10q22NCBI
HAND1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385154,474,972 - 154,478,227 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5154,474,972 - 154,478,227 (-)EnsemblGRCh38hg38GRCh38
GRCh375153,854,532 - 153,857,787 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365153,834,725 - 153,838,017 (-)NCBINCBI36Build 36hg18NCBI36
Build 345153,834,725 - 153,838,017NCBI
Celera5149,930,197 - 149,933,489 (-)NCBICelera
Cytogenetic Map5q33.2NCBI
HuRef5148,995,253 - 148,998,545 (-)NCBIHuRef
CHM1_15153,286,949 - 153,290,241 (-)NCBICHM1_1
T2T-CHM13v2.05155,008,931 - 155,012,186 (-)NCBIT2T-CHM13v2.0
Hand1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391157,719,539 - 57,722,973 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1157,719,531 - 57,723,644 (-)EnsemblGRCm39 Ensembl
GRCm381157,828,713 - 57,832,147 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1157,828,705 - 57,832,818 (-)EnsemblGRCm38mm10GRCm38
MGSCv371157,642,215 - 57,645,649 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361157,644,908 - 57,648,342 (-)NCBIMGSCv36mm8
Celera1162,581,753 - 62,585,188 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1135.27NCBI
Hand1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554088,848,559 - 8,851,994 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554088,848,723 - 8,851,804 (-)NCBIChiLan1.0ChiLan1.0
HAND1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24149,682,104 - 149,685,485 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15147,821,649 - 147,825,030 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05149,876,970 - 149,880,269 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15155,875,100 - 155,878,374 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5155,875,935 - 155,878,166 (-)Ensemblpanpan1.1panPan2
HAND1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1455,231,061 - 55,234,640 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl455,231,481 - 55,234,265 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha455,122,337 - 55,125,872 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0455,665,601 - 55,669,141 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl455,665,977 - 55,668,761 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1455,496,014 - 55,499,549 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0455,594,450 - 55,597,985 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0456,097,022 - 56,100,557 (+)NCBIUU_Cfam_GSD_1.0
Hand1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213109,840,418 - 109,843,804 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365158,289,315 - 8,293,175 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365158,289,764 - 8,292,937 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HAND1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1668,677,963 - 68,683,342 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11668,679,977 - 68,683,346 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21674,589,577 - 74,592,407 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HAND1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12356,928,164 - 56,935,675 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2356,928,676 - 56,931,785 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603420,731,670 - 20,734,953 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hand1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473334,731,671 - 34,733,759 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473334,731,671 - 34,733,759 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hand1
4 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:124
Count of miRNA genes:109
Interacting mature miRNAs:118
Transcripts:ENSRNOT00000003486
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103449055945579777Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103539226751793994Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102887565052200160Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat

Markers in Region
RH94691  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2178,449,862 - 78,449,971 (+)MAPPERmRatBN7.2
mRatBN7.2178,431,293 - 78,431,402 (+)MAPPERmRatBN7.2
Rnor_6.0179,708,680 - 79,708,788NCBIRnor6.0
Rnor_6.0179,690,305 - 79,690,413NCBIRnor6.0
Rnor_5.0180,970,974 - 80,971,082UniSTSRnor5.0
Rnor_5.0180,946,931 - 80,947,039UniSTSRnor5.0
RGSC_v3.4178,135,062 - 78,135,170UniSTSRGSC3.4
RGSC_v3.4178,153,863 - 78,153,971UniSTSRGSC3.4
Celera172,916,982 - 72,917,090UniSTS
Celera172,898,941 - 72,899,049UniSTS
Cytogenetic Map10q22UniSTS
Cytogenetic Map1q21UniSTS
RH140305  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2178,439,939 - 78,440,147 (+)MAPPERmRatBN7.2
Rnor_6.0179,698,757 - 79,698,964NCBIRnor6.0
Rnor_5.0180,960,864 - 80,961,071UniSTSRnor5.0
RGSC_v3.4178,143,940 - 78,144,147UniSTSRGSC3.4
Celera172,907,059 - 72,907,266UniSTS
RH 3.4 Map1789.3UniSTS
Cytogenetic Map10q22UniSTS
Cytogenetic Map1q21UniSTS


Genetic Models
This gene Hand1 is modified in the following models/strains:


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 12 2 2 2 3
Low 3 16 12 4 4 15
Below cutoff 7 16 12 10 12 5 6 10 10 13 7 5

Sequence


RefSeq Acc Id: ENSRNOT00000003486   ⟹   ENSRNOP00000003486
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1042,006,651 - 42,009,213 (-)Ensembl
Rnor_6.0 Ensembl1043,250,745 - 43,253,296 (-)Ensembl
RefSeq Acc Id: NM_021592   ⟹   NP_067603
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81042,507,117 - 42,509,684 (-)NCBI
mRatBN7.21042,006,646 - 42,009,213 (-)NCBI
Rnor_6.01043,250,729 - 43,253,296 (-)NCBI
Rnor_5.01043,050,068 - 43,052,635 (-)NCBI
RGSC_v3.41043,423,366 - 43,425,933 (-)RGD
Celera1041,298,555 - 41,301,122 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_067603 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH97324 (Get FASTA)   NCBI Sequence Viewer  
  CAA69334 (Get FASTA)   NCBI Sequence Viewer  
  EDM04506 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000003486.3
  ENSRNOP00055041052
  ENSRNOP00060034178
  ENSRNOP00065008439
GenBank Protein P97832 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_067603   ⟸   NM_021592
- UniProtKB: Q4V8L8 (UniProtKB/Swiss-Prot),   P97832 (UniProtKB/Swiss-Prot),   A6HEQ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000003486   ⟸   ENSRNOT00000003486
Protein Domains
bHLH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97832-F1-model_v2 AlphaFold P97832 1-216 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621206 AgrOrtholog
BioCyc Gene G2FUF-25015 BioCyc
Ensembl Genes ENSRNOG00000002582 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055028788 UniProtKB/Swiss-Prot
  ENSRNOG00060023832 UniProtKB/Swiss-Prot
  ENSRNOG00065007426 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000003486.6 UniProtKB/Swiss-Prot
  ENSRNOT00055049854 UniProtKB/Swiss-Prot
  ENSRNOT00060041261 UniProtKB/Swiss-Prot
  ENSRNOT00065011582 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7444552 IMAGE-MGC_LOAD
  IMAGE:7460879 IMAGE-MGC_LOAD
InterPro bHLH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:59112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:114327 IMAGE-MGC_LOAD
  MGC:114332 IMAGE-MGC_LOAD
NCBI Gene 59112 ENTREZGENE
PANTHER BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HEART- AND NEURAL CREST DERIVATIVES-EXPRESSED PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hand1 PhenoGen
PROSITE BHLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002582 RatGTEx
  ENSRNOG00055028788 RatGTEx
  ENSRNOG00060023832 RatGTEx
  ENSRNOG00065007426 RatGTEx
SMART HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP HLH, helix-loop-helix DNA-binding domain UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6HEQ1 ENTREZGENE, UniProtKB/TrEMBL
  HAND1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q4V8L8 ENTREZGENE
UniProt Secondary Q4V8L8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-17 Hand1  heart and neural crest derivatives expressed 1  Hand1  heart and neural crest derivatives expressed transcript 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Hand1  heart and neural crest derivatives expressed transcript 1    eHand protein  Name updated 1299863 APPROVED
2002-08-07 Hand1  eHand protein      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression present in adult heart 727442