Scd (stearoyl-CoA desaturase) - Rat Genome Database

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Gene: Scd (stearoyl-CoA desaturase) Rattus norvegicus
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Symbol: Scd
Name: stearoyl-CoA desaturase
RGD ID: 621176
Description: Enables iron ion binding activity and stearoyl-CoA 9-desaturase activity. Involved in response to fatty acid; response to nutrient; and unsaturated fatty acid biosynthetic process. Located in membrane. Used to study carcinoma. Biomarker of hyperinsulinism; metabolic dysfunction-associated steatohepatitis; and metabolic dysfunction-associated steatotic liver disease. Orthologous to human SCD (stearoyl-CoA desaturase); PARTICIPATES IN eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; fatty acid metabolic pathway; unsaturated fatty acid biosynthetic pathway; INTERACTS WITH (+)-catechin; (-)-epigallocatechin 3-gallate; (R)-carnitine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: acyl-CoA desaturase 1; delta(9)-desaturase 1; delta-9 desaturase 1; fatty acid desaturase 1; Scd1; stearoyl-CoA desaturase 1; stearoyl-Coenzyme A desaturase 1
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81253,218,968 - 253,232,101 (-)NCBIGRCr8
GRCr8 Ensembl1253,218,970 - 253,231,785 (-)EnsemblGRCr8 Ensembl
mRatBN7.21243,269,745 - 243,282,878 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1243,269,747 - 243,282,562 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1251,420,000 - 251,432,600 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01258,116,587 - 258,129,187 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01250,770,154 - 250,782,754 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01264,159,966 - 264,173,061 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1264,160,129 - 264,172,729 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01271,602,885 - 271,615,985 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41249,458,860 - 249,471,460 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1239,084,889 - 239,097,489 (-)NCBICelera
RGSC_v3.11249,717,543 - 249,730,359 (-)NCBI
Cytogenetic Map1q54NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(+/-)-Aegeline  (ISO)
(-)-acanthoic acid  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(R)-carnitine  (EXP)
(R)-noradrenaline  (EXP)
(RS)-coclaurine  (ISO)
(RS)-norcoclaurine  (ISO)
(S)-coclaurine  (ISO)
(S)-nicotine  (ISO)
1,2,3-trilinolenoylglycerol  (ISO)
1,2,3-trilinoleoylglycerol  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,3,7,9-tetramethyluric acid  (EXP)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
1-\{2-[(4-chlorobenzyl)sulfanyl]-2-(2,4-dichlorophenyl)ethyl\}-1H-imidazole  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-nitropyrene  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
25-hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol  (EXP)
3,4-dichloroaniline  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,7-dihydropurine-6-thione  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-tert-Octylphenol  (EXP)
5-fluorouracil  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
7,12-dimethyltetraphene  (EXP)
9-cis,11-trans-octadecadienoic acid  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
Acetyl tributyl citrate  (ISO)
acrolein  (EXP)
acrylamide  (EXP,ISO)
Actein  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-hexachlorocyclohexane  (EXP)
alpha-Zearalanol  (EXP)
amiodarone  (EXP,ISO)
amitriptyline  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
Ammothamnine  (EXP)
amphetamine  (EXP)
ampicillin  (ISO)
andrographolide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimony(0)  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (EXP)
atrazine  (EXP,ISO)
avobenzone  (ISO)
Azaspiracid  (ISO)
azoxystrobin  (ISO)
barium sulfate  (EXP)
benomyl  (EXP)
benzalkonium chloride  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[b]fluorene  (EXP)
benzofurans  (ISO)
benzylpenicillin  (ISO)
beta-hexachlorocyclohexane  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
betulin  (ISO)
bexarotene  (EXP,ISO)
bezafibrate  (EXP,ISO)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
brexpiprazole  (ISO)
bromobenzene  (EXP)
bupropion  (ISO)
buspirone  (EXP)
Butylbenzyl phthalate  (EXP,ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbamazepine  (EXP,ISO)
carbon nanotube  (ISO)
ceric oxide  (EXP)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chlordecone  (ISO)
chloropicrin  (ISO)
chloroprene  (EXP,ISO)
chloroquine  (EXP)
chlorothalonil  (ISO)
chlorotoluron  (ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
chrysin  (ISO)
ciprofibrate  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (EXP,ISO)
citalopram  (ISO)
clavulanic acid  (ISO)
clemizole  (ISO)
clobetasol  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
clomipramine  (ISO)
clopidogrel  (ISO)
clozapine  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
corn oil  (EXP)
corosolic acid  (ISO)
corticosterone  (EXP)
coumarin  (EXP)
coumestrol  (ISO)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (ISO)
cypermethrin  (ISO)
cyproconazole  (ISO)
D-glucose  (EXP,ISO)
DDE  (EXP,ISO)
decabromodiphenyl ether  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
deoxypodophyllotoxin  (ISO)
desmosterol  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
Di-n-octyl phthalate  (ISO)
diallyl trisulfide  (EXP)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dicyclanil  (ISO)
diethyl maleate  (EXP)
diethyl phthalate  (EXP,ISO)
diethylstilbestrol  (ISO)
difenoconazole  (ISO)
dihydrogen  (ISO)
diiodine  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (EXP,ISO)
dimethylarsinous acid  (ISO)
dioxygen  (EXP,ISO)
dipentyl phthalate  (EXP)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diprotium  (ISO)
disodium selenite  (ISO)
diuron  (EXP,ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
Elemicin  (ISO)
ellagic acid  (ISO)
endosulfan  (EXP)
enilconazole  (ISO)
entinostat  (ISO)
erythromycin A  (ISO)
ethanol  (EXP,ISO)
Ethyl icosapentate  (ISO)
ethyl methanesulfonate  (ISO)
Evodiamine  (ISO)
farnesol  (ISO)
fenarimol  (EXP)
fenofibrate  (EXP,ISO)
fentin chloride  (EXP)
ferulic acid  (ISO)
fipronil  (EXP)
fluoxetine  (ISO)
flutamide  (EXP)
fluxapyroxad  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fructose  (EXP,ISO)
furan  (EXP)
gadolinium trichloride  (EXP,ISO)
gamma-hexachlorocyclohexane  (EXP)
Ganoderic acid A  (ISO)
gemcitabine  (ISO)
gemfibrozil  (EXP,ISO)
genistein  (ISO)
gentamycin  (EXP)
ginsenoside Re  (ISO)
glucagon  (ISO)
glucose  (EXP,ISO)
glutathione  (EXP)
glycerol 2-phosphate  (ISO)
glycidol  (EXP)
glycidyl methacrylate  (ISO)
glycine betaine  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycyrrhizinic acid  (ISO)
glyphosate  (ISO)
guggulsterone  (ISO)
GW 3965  (ISO)
GW 4064  (ISO)
GW 7647  (ISO)
haloperidol  (ISO)
Heptachlor epoxide  (ISO)
hexadecanoic acid  (EXP,ISO)
Honokiol  (EXP)
hydrazine  (EXP)
hydrogen peroxide  (EXP)
imipramine  (ISO)
indole-3-methanol  (EXP)
indometacin  (EXP,ISO)
inulin  (ISO)
irinotecan  (ISO)
isobutanol  (ISO)
isoflavones  (ISO)
isoniazide  (ISO)
ketamine  (EXP)
ketoconazole  (EXP,ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
limonene  (EXP)
linoleic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (ISO)
lovastatin  (ISO)
lutein  (ISO)
LY294002  (ISO)
manganese(II) chloride  (EXP)
mercaptopurine  (EXP)
metformin  (EXP,ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
metronidazole  (ISO)
miconazole  (ISO)
mirtazapine  (ISO)
Mitotane  (ISO)
mitoxantrone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Morroniside  (ISO)
Muraglitazar  (EXP,ISO)
N,N-diethyl-m-toluamide  (EXP)
N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide  (ISO)
N-acetyl-L-cysteine  (EXP)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (EXP,ISO)
neomycin  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
nimesulide  (EXP)
NMN zwitterion  (ISO)
NMS-873  (ISO)
nordihydroguaiaretic acid  (EXP)
ochratoxin A  (ISO)
octadecanoic acid  (EXP)
oleic acid  (EXP,ISO)
organophosphorus compound  (EXP)
orotic acid  (EXP)
oroxylin A  (ISO)
orphenadrine  (EXP)
ozone  (EXP,ISO)
p-tert-Amylphenol  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion  (ISO)
paxilline  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorobutyric acid  (ISO)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (EXP,ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorohexanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanesulfonamide  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (ISO)
permethrin  (EXP)
phenethyl caffeate  (EXP)
phenethyl isothiocyanate  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
PhIP  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
potassium bromate  (EXP)
potassium chromate  (ISO)
pravastatin  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
procymidone  (ISO)
progesterone  (ISO)
propamocarb  (ISO)
propiconazole  (EXP,ISO)
purine-6-thiol  (EXP)
PX-866  (ISO)
Pyridostigmine bromide  (EXP)
quercetin  (ISO)
reactive oxygen species  (EXP)
rebaudioside A  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rimonabant  (ISO)
ritodrine  (ISO)
rofecoxib  (ISO)
rosiglitazone  (EXP)
rotenone  (EXP)
sarin  (ISO)
saroglitazar  (ISO)
selenium atom  (ISO)
senecionine  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium cholate  (ISO)
sodium dichromate  (EXP)
sodium dodecyl sulfate  (EXP,ISO)
Sodium oleate  (ISO)
starch  (ISO)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP,ISO)
sucrose  (EXP,ISO)
sulconazole  (ISO)
sulfadimethoxine  (EXP)
sulfluramid  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
tamoxifen  (EXP,ISO)
taurine  (ISO)
tauroursodeoxycholic acid  (EXP)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP,ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
tetraphene  (ISO)
Theaflavin 3,3'-digallate  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP,ISO)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
tolcapone  (EXP)
topiramate  (EXP)
topotecan  (ISO)
trans-caffeic acid  (ISO)
tremolite asbestos  (ISO)
triarachidonin  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triclocarban  (EXP)
triclosan  (ISO)
triolein  (ISO)
triphenyl phosphate  (EXP,ISO)
Triptolide  (ISO)
Triton X-100  (ISO)
troglitazone  (EXP,ISO)
trovafloxacin  (EXP,ISO)
tuberostemonine  (ISO)
tunicamycin  (ISO)
ursodeoxycholic acid  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vandetanib  (ISO)
vanillic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
voriconazole  (EXP)
vorinostat  (ISO)
xanthohumol  (ISO)
Yessotoxin  (ISO)
yohimbine  (ISO)
zaragozic acid A  (EXP)
zearalenone  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
endoplasmic reticulum  (IEA,ISO)
endoplasmic reticulum membrane  (IBA,IEA,ISO,ISS)
membrane  (IDA,IEA,ISO)
nucleolus  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Fermented rice bran supplementation mitigates metabolic syndrome in stroke-prone spontaneously hypertensive rats. Alauddin M, etal., BMC Complement Altern Med. 2016 Nov 8;16(1):442. doi: 10.1186/s12906-016-1427-z.
2. Arctium lappa L. polysaccharide can regulate lipid metabolism in type 2 diabetic rats through the SREBP-1/SCD-1 axis. Chen M, etal., Carbohydr Res. 2020 Aug;494:108055. doi: 10.1016/j.carres.2020.108055. Epub 2020 Jun 7.
3. Xanthohumol ameliorates atherosclerotic plaque formation, hypercholesterolemia, and hepatic steatosis in ApoE-deficient mice. Doddapattar P, etal., Mol Nutr Food Res. 2013 Oct;57(10):1718-28. doi: 10.1002/mnfr.201200794. Epub 2013 May 3.
4. Stearoyl-CoA desaturase 1 (Scd1) gene overexpression is associated with genetic predisposition to hepatocarcinogenesis in mice and rats. Falvella FS, etal., Carcinogenesis 2002 Nov;23(11):1933-6.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Pre-germinated brown rice extract ameliorates high-fat diet-induced metabolic syndrome. Hao CL, etal., J Food Biochem. 2019 Mar;43(3):e12769. doi: 10.1111/jfbc.12769. Epub 2019 Jan 13.
7. A plasminogen-like protein selectively degrades stearoyl-CoA desaturase in liver microsomes. Heinemann FS, etal., J Biol Chem 2003 Oct 31;278(44):42966-75. Epub 2003 Aug 19.
8. Lack of stearoyl-CoA desaturase 1 upregulates basal thermogenesis but causes hypothermia in a cold environment. Lee SH, etal., J Lipid Res. 2004 Sep;45(9):1674-82. doi: 10.1194/jlr.M400039-JLR200. Epub 2004 Jun 21.
9. Therapeutic Effect of Gypenosides on Nonalcoholic Steatohepatitis via Regulating Hepatic Lipogenesis and Fatty Acid Oxidation. Li H, etal., Biol Pharm Bull. 2017;40(5):650-657. doi: 10.1248/bpb.b16-00942.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Structure and regulation of rat liver microsomal stearoyl-CoA desaturase gene. Mihara K J Biochem. 1990 Dec;108(6):1022-9.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Expression and regulation of delta5-desaturase, delta6-desaturase, stearoyl-coenzyme A (CoA) desaturase 1, and stearoyl-CoA desaturase 2 in rat testis. Saether T, etal., Biol Reprod 2003 Jul;69(1):117-24. Epub 2003 Feb 19.
19. Skin-specific deletion of stearoyl-CoA desaturase-1 alters skin lipid composition and protects mice from high fat diet-induced obesity. Sampath H, etal., J Biol Chem. 2009 Jul 24;284(30):19961-73. doi: 10.1074/jbc.M109.014225. Epub 2009 May 8.
20. Eight histidine residues are catalytically essential in a membrane-associated iron enzyme, stearoyl-CoA desaturase, and are conserved in alkane hydroxylase and xylene monooxygenase. Shanklin J, etal., Biochemistry. 1994 Nov 1;33(43):12787-94.
21. Bacterial synthesis of active rat stearyl-CoA desaturase lacking the 26-residue amino-terminal amino acid sequence. Strittmatter P, etal., J Biol Chem. 1988 Feb 15;263(5):2532-5.
22. Construction and sequence of cDNA for rat liver stearyl coenzyme A desaturase. Thiede MA, etal., J Biol Chem 1986 Oct 5;261(28):13230-5.
23. Gene expression profiling in skeletal muscle of Zucker diabetic fatty rats: implications for a role of stearoyl-CoA desaturase 1 in insulin resistance. Voss MD, etal., Diabetologia. 2005 Dec;48(12):2622-30. Epub 2005 Nov 12.
24. (-)-Epigallocatechin-3-Gallate Ameliorates Atherosclerosis and Modulates Hepatic Lipid Metabolic Gene Expression in Apolipoprotein E Knockout Mice: Involvement of TTC39B. Wang W, etal., Front Pharmacol. 2018 Mar 9;9:195. doi: 10.3389/fphar.2018.00195. eCollection 2018.
25. Lipogenesis in fetal rat lung: importance of C/EBPalpha, SREBP-1c, and stearoyl-CoA desaturase. Zhang F, etal., Am J Respir Cell Mol Biol 2004 Feb;30(2):174-83. Epub 2003 Aug 01.
26. Effect of Creosote Bush-Derived NDGA on Expression of Genes Involved in Lipid Metabolism in Liver of High-Fructose Fed Rats: Relevance to NDGA Amelioration of Hypertriglyceridemia and Hepatic Steatosis. Zhang H, etal., PLoS One. 2015 Sep 22;10(9):e0138203. doi: 10.1371/journal.pone.0138203. eCollection 2015.
27. Dingxin Recipe IV attenuates atherosclerosis by regulating lipid metabolism through LXR-α/SREBP1 pathway and modulating the gut microbiota in ApoE-/- mice fed with HFD. Zhang Y, etal., J Ethnopharmacol. 2021 Feb 10;266:113436. doi: 10.1016/j.jep.2020.113436. Epub 2020 Oct 1.
Additional References at PubMed
PMID:10854228   PMID:10899171   PMID:12815040   PMID:14592417   PMID:15907797   PMID:16040962   PMID:16275639   PMID:16357064   PMID:16443825   PMID:16741579   PMID:16809433   PMID:18079124  
PMID:18364238   PMID:18492766   PMID:18665039   PMID:18765284   PMID:19777326   PMID:19787047   PMID:19946888   PMID:20721682   PMID:20732836   PMID:20847127   PMID:22047910   PMID:22871113  
PMID:23012479   PMID:23298201   PMID:23539346   PMID:26098370   PMID:26293158   PMID:27697525   PMID:27923787   PMID:29290651   PMID:30622312   PMID:32048626   PMID:38114435  


Genomics

Comparative Map Data
Scd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81253,218,968 - 253,232,101 (-)NCBIGRCr8
GRCr8 Ensembl1253,218,970 - 253,231,785 (-)EnsemblGRCr8 Ensembl
mRatBN7.21243,269,745 - 243,282,878 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1243,269,747 - 243,282,562 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1251,420,000 - 251,432,600 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01258,116,587 - 258,129,187 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01250,770,154 - 250,782,754 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01264,159,966 - 264,173,061 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1264,160,129 - 264,172,729 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01271,602,885 - 271,615,985 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41249,458,860 - 249,471,460 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1239,084,889 - 239,097,489 (-)NCBICelera
RGSC_v3.11249,717,543 - 249,730,359 (-)NCBI
Cytogenetic Map1q54NCBI
SCD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810100,347,233 - 100,364,826 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10100,347,233 - 100,364,826 (+)EnsemblGRCh38hg38GRCh38
GRCh3710102,106,990 - 102,124,583 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610102,096,762 - 102,114,578 (+)NCBINCBI36Build 36hg18NCBI36
Build 3410102,096,761 - 102,114,577NCBI
Celera1095,844,653 - 95,862,464 (+)NCBICelera
Cytogenetic Map10q24.31NCBI
HuRef1095,735,654 - 95,753,465 (+)NCBIHuRef
CHM1_110102,391,212 - 102,409,039 (+)NCBICHM1_1
T2T-CHM13v2.010101,231,456 - 101,249,056 (+)NCBIT2T-CHM13v2.0
Scd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391944,382,889 - 44,396,148 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1944,382,894 - 44,396,318 (-)EnsemblGRCm39 Ensembl
GRCm381944,394,450 - 44,407,709 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1944,394,455 - 44,407,879 (-)EnsemblGRCm38mm10GRCm38
MGSCv371944,468,940 - 44,482,199 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361944,447,766 - 44,460,864 (-)NCBIMGSCv36mm8
Celera1945,168,530 - 45,181,736 (-)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1937.98NCBI
SCD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28112,231,203 - 112,249,176 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110112,236,522 - 112,254,495 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01096,948,212 - 96,965,633 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110100,428,627 - 100,446,647 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10100,429,615 - 100,442,776 (+)Ensemblpanpan1.1panPan2
SCD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12813,112,741 - 13,129,129 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2813,113,006 - 13,125,801 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2813,283,628 - 13,300,028 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02813,581,765 - 13,598,163 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2813,581,805 - 13,598,155 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12813,128,503 - 13,144,867 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02813,166,524 - 13,182,907 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02813,300,894 - 13,317,236 (+)NCBIUU_Cfam_GSD_1.0
SCD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14111,461,569 - 111,478,020 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114111,461,560 - 111,478,033 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214120,964,681 - 120,980,911 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap14q27NCBI
SCD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1993,380,812 - 93,398,860 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl993,380,914 - 93,398,912 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604854,387,804 - 54,405,855 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Scd
50 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:536
Count of miRNA genes:263
Interacting mature miRNAs:336
Transcripts:ENSRNOT00000018447, ENSRNOT00000075397
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1210980612255980612Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1226175591270518180Rat
1578775Iddm21Insulin dependent diabetes mellitus QTL 214.13blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1245782829270518180Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1218829748263829748Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1248619887269633915Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631836Stl31Serum triglyceride level QTL 314.645e-06blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1247133834270518180Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1210980612255980612Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1237995023269633915Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1233480549270108840Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1200449456256003563Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1234540191270518180Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1233480549270108840Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1210980612255980612Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1223134011262090599Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1210980612255980612Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2314011Gluco56Glucose level QTL 56blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1209203273254203273Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1225108840270108840Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1228180370266453608Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1224633915269633915Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1232312773270518180Rat
2316896Gluco57Glucose level QTL 577.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1238398865255849249Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1212738576257738576Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1208798288253798288Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1228180243255849249Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1210980612255980612Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1210980612255980612Rat
7387289Uae45Urinary albumin excretion QTL 452.860.0021urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1233204160270518180Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1241569529269633915Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1210980612255980612Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1243953669270518180Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1226175591270518180Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233349180270518180Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1210980612255980612Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1228174566270518180Rat

Markers in Region
Scd1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21243,273,354 - 243,273,430 (+)MAPPERmRatBN7.2
mRatBN7.21243,112,004 - 243,112,080 (+)MAPPERmRatBN7.2
Rnor_6.01264,001,538 - 264,001,613NCBIRnor6.0
Rnor_6.01264,163,576 - 264,163,651NCBIRnor6.0
Rnor_5.01271,606,495 - 271,606,570UniSTSRnor5.0
Rnor_5.01271,446,710 - 271,446,785UniSTSRnor5.0
RGSC_v3.41249,462,307 - 249,462,382UniSTSRGSC3.4
Celera1239,088,336 - 239,088,411UniSTS
Celera1238,929,123 - 238,929,198UniSTS
Cytogenetic Map1q54UniSTS
UniSTS:498485  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21243,273,318 - 243,273,392 (+)MAPPERmRatBN7.2
Rnor_6.01264,163,540 - 264,163,613NCBIRnor6.0
Rnor_5.01271,606,459 - 271,606,532UniSTSRnor5.0
RGSC_v3.41249,462,271 - 249,462,344UniSTSRGSC3.4
Celera1239,088,300 - 239,088,373UniSTS
Cytogenetic Map1q54UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 11 49 113 91 90 59 25 59 6 218 97 11 93 45 60 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000018447   ⟹   ENSRNOP00000018447
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1253,218,970 - 253,231,785 (-)Ensembl
mRatBN7.2 Ensembl1243,269,747 - 243,282,562 (-)Ensembl
Rnor_6.0 Ensembl1264,160,129 - 264,172,729 (-)Ensembl
RefSeq Acc Id: NM_139192   ⟹   NP_631931
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81253,219,131 - 253,231,731 (-)NCBI
mRatBN7.21243,269,908 - 243,282,508 (-)NCBI
Rnor_6.01264,160,129 - 264,172,729 (-)NCBI
Rnor_5.01271,602,885 - 271,615,985 (-)NCBI
RGSC_v3.41249,458,860 - 249,471,460 (-)RGD
Celera1239,084,889 - 239,097,489 (-)RGD
Sequence:
RefSeq Acc Id: XM_006231433   ⟹   XP_006231495
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81253,218,968 - 253,232,101 (-)NCBI
mRatBN7.21243,269,745 - 243,282,878 (-)NCBI
Rnor_6.01264,159,966 - 264,173,061 (-)NCBI
Rnor_5.01271,602,885 - 271,615,985 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_631931 (Get FASTA)   NCBI Sequence Viewer  
  XP_006231495 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA42116 (Get FASTA)   NCBI Sequence Viewer  
  AAM34745 (Get FASTA)   NCBI Sequence Viewer  
  AAM34746 (Get FASTA)   NCBI Sequence Viewer  
  EDL94283 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000018447
  ENSRNOP00000018447.3
GenBank Protein P07308 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_631931   ⟸   NM_139192
- UniProtKB: Q8JZL5 (UniProtKB/Swiss-Prot),   P07308 (UniProtKB/Swiss-Prot),   A6JHF9 (UniProtKB/TrEMBL),   A6JHF3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231495   ⟸   XM_006231433
- Peptide Label: isoform X1
- UniProtKB: Q8JZL5 (UniProtKB/Swiss-Prot),   P07308 (UniProtKB/Swiss-Prot),   A6JHF9 (UniProtKB/TrEMBL),   A6JHF3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018447   ⟸   ENSRNOT00000018447

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P07308-F1-model_v2 AlphaFold P07308 1-358 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690939
Promoter ID:EPDNEW_R1464
Type:single initiation site
Name:Scd_1
Description:stearoyl-CoA desaturase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01264,172,797 - 264,172,857EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621176 AgrOrtholog
BioCyc Gene G2FUF-55589 BioCyc
BioCyc Pathway PWY-5996 [oleate biosynthesis II (animals and fungi)] BioCyc
  PWY3O-1801 [palmitoleate biosynthesis IV (fungi and animals)] BioCyc
BioCyc Pathway Image PWY-5996 BioCyc
  PWY3O-1801 BioCyc
Ensembl Genes ENSRNOG00000013552 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000018447 ENTREZGENE
  ENSRNOT00000018447.6 UniProtKB/Swiss-Prot
InterPro Acyl-CoA_DS UniProtKB/Swiss-Prot
  FADS-1_CS UniProtKB/Swiss-Prot
KEGG Report rno:246074 UniProtKB/Swiss-Prot
NCBI Gene 246074 ENTREZGENE
PANTHER PTHR11351 UniProtKB/Swiss-Prot
  STEAROYL-COA DESATURASE UniProtKB/Swiss-Prot
PhenoGen Scd PhenoGen
PRINTS FACDDSATRASE UniProtKB/Swiss-Prot
PROSITE FATTY_ACID_DESATUR_1 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000013552 RatGTEx
UniProt A6JHF3 ENTREZGENE, UniProtKB/TrEMBL
  A6JHF9 ENTREZGENE, UniProtKB/TrEMBL
  ACOD1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q8JZL5 ENTREZGENE
UniProt Secondary Q8JZL5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-25 Scd  stearoyl-CoA desaturase  Scd1  stearoyl-Coenzyme A desaturase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Scd1  stearoyl-Coenzyme A desaturase 1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Scd1  stearoyl-Coenzyme A desaturase 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_mutations_overexpression overexpression is associated with genetic predisposition to hepatocarcinogenesis 633981
gene_regulation expression is increased by peroxisome proliferators, iron overload and dichloroacetic acid 633981