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Gene: Rab8a (RAB8A, member RAS oncogene family) Rattus norvegicus

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Symbol:

Rab8a

Name:

RAB8A, member RAS oncogene family

RGD ID:

621144

Description:

Enables protein tyrosine kinase binding activity. Involved in several processes, including cellular response to insulin stimulus; neurotransmitter receptor transport, endosome to postsynaptic membrane; and regulation of long-term neuronal synaptic plasticity. Located in several cellular components, including Golgi apparatus; dendrite; and neuronal cell body. Is active in glutamatergic synapse. Orthologous to human RAB8A (RAB8A, member RAS oncogene family); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; Rab family mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

Mel; mel transforming oncogene (derived from cell line NK14)- RAB8 homolog; MGC124948; Rab8; ras-related protein Rab-8A

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RAB8A (RAB8A, member RAS oncogene family)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, Panther, PhylomeDB
Mus musculus (house mouse):	Rab8a (RAB8A, member RAS oncogene family)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Rab8a (RAB8A, member RAS oncogene family)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RAB8A (RAB8A, member RAS oncogene family)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RAB8A (RAB8A, member RAS oncogene family)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Rab8a (RAB8A, member RAS oncogene family)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RAB8A (RAB8A, member RAS oncogene family)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	RAB8A (RAB8A, member RAS oncogene family)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Rab8a (RAB8A, member RAS oncogene family)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	RAB8B (RAB8B, member RAS oncogene family)	HGNC	OrthoDB
Alliance orthologs ³
Homo sapiens (human):	RAB8A (RAB8A, member RAS oncogene family)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Rab8a (RAB8A, member RAS oncogene family)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	rab8a (RAB8A, member RAS oncogene family)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	SEC4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	rab-8	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Rab8	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	rab8a	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	17,688,049 - 17,709,412 (-)	NCBI		GRCr8
mRatBN7.2	16	17,654,027 - 17,675,385 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	17,654,034 - 17,675,678 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	17,713,745 - 17,734,289 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	18,845,873 - 18,866,846 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	17,766,676 - 17,787,222 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	19,355,047 - 19,376,776 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	19,355,048 - 19,376,776 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	19,213,378 - 19,235,107 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	18,078,519 - 18,099,882 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	18,079,199 - 18,089,589 (-)	NCBI
Celera	16	17,868,660 - 17,890,021 (-)	NCBI		Celera
Cytogenetic Map	16	p14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

rheumatoid arthritis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (ISO)

17alpha-ethynylestradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,6-dinitrotoluene (EXP)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-sulfonyldiphenol (ISO)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (EXP)

acrylamide (ISO)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

all-trans-retinoic acid (ISO)

amitrole (EXP)

ammonium chloride (EXP)

antirheumatic drug (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bis(2-ethylhexyl) phthalate (EXP)

bisphenol A (EXP,ISO)

caffeine (ISO)

carbon nanotube (ISO)

cefixime (ISO)

cisplatin (ISO)

coumestrol (ISO)

curcumin (ISO)

cyclosporin A (ISO)

DDE (ISO)

dicrotophos (ISO)

doxorubicin (ISO)

Enterolactone (ISO)

epoxiconazole (ISO)

folic acid (ISO)

fonofos (ISO)

FR900359 (ISO)

gemcitabine (ISO)

gentamycin (EXP)

haloperidol (EXP)

isobutanol (ISO)

ivermectin (ISO)

lead(0) (ISO)

lidocaine (EXP)

methapyrilene (ISO)

methimazole (EXP)

mitomycin C (ISO)

mono(2-ethylhexyl) phthalate (EXP)

nitrates (ISO)

paracetamol (EXP,ISO)

parathion (ISO)

phenobarbital (EXP)

piroxicam (ISO)

resveratrol (ISO)

rotenone (ISO)

SB 431542 (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium fluoride (ISO)

sulfadimethoxine (EXP)

sunitinib (ISO)

temozolomide (ISO)

terbufos (ISO)

tert-butyl hydroperoxide (ISO)

thalidomide (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

triphenyl phosphate (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

autophagy (IEA)

axonogenesis (IMP)

cell projection organization (IEA)

cellular response to insulin stimulus (IMP)

cilium assembly (IBA,IEA,ISO,ISS)

endocytic recycling (IBA,ISO)

exocytosis (IBA)

glucose homeostasis (IC)

Golgi organization (IEA,ISO,ISS)

Golgi vesicle fusion to target membrane (IEA,ISO)

neurotransmitter receptor transport to postsynaptic membrane (IBA,IDA,IMP)

neurotransmitter receptor transport, endosome to postsynaptic membrane (IDA,IMP)

positive regulation of D-glucose import (IC)

protein localization to cilium (IEA,ISO,ISS)

protein localization to plasma membrane (IDA)

protein transport (IEA)

regulation of autophagy (IEA,ISO,ISS)

regulation of long-term neuronal synaptic plasticity (IDA,IMP)

regulation of protein localization (IMP)

regulation of protein transport (IDA,IMP)

vesicle docking involved in exocytosis (IEA,ISO)

vesicle-mediated transport in synapse (IDA,IMP)

Cellular Component

actin cytoskeleton (IEA,ISO)

cell projection (IEA)

centriolar satellite (IEA,ISO)

centriole (IEA)

centrosome (IEA,ISO,ISS)

ciliary basal body (IEA,ISO,ISS)

ciliary base (IEA,ISO)

ciliary membrane (IEA,ISO)

cilium (IEA,ISO,ISS)

cytoplasm (IEA)

cytoplasmic vesicle (IDA,IEA)

cytoplasmic vesicle membrane (TAS)

cytoskeleton (IEA)

cytosol (IEA,ISO)

dendrite (IDA)

endosome (IBA,IEA)

endosome membrane (IEA,ISO,ISS)

exocytic vesicle (ISO)

glutamatergic synapse (IDA,IMP)

Golgi apparatus (IDA,IEA,ISO)

lysosome (IEA)

membrane (IEA)

midbody (IEA,ISO,ISS)

neuron projection (IEA,ISO)

neuronal cell body (IDA)

non-motile cilium (IEA,ISO)

nucleolus (IEA,ISO)

nucleoplasm (IEA,ISO)

phagocytic vesicle (IEA,ISO,ISS)

phagocytic vesicle membrane (IEA)

plasma membrane (IBA,IEA,ISO)

recycling endosome (IEA,ISO)

recycling endosome membrane (IEA,ISO,ISS)

synapse (EXP,IDA)

synaptic vesicle (IBA)

trans-Golgi network transport vesicle (IBA,IEA,ISO)

Molecular Function

GDP binding (IEA,ISO,ISS)

GTP binding (IEA,ISO,ISS)

GTPase activity (IBA,IEA,ISO)

hydrolase activity (IEA)

myosin V binding (IEA,ISO)

nucleotide binding (IEA)

protein binding (ISO)

protein kinase binding (IPI)

protein tyrosine kinase binding (IPI)

Molecular Pathway Annotations Click to see Annotation Detail View

insulin responsive facilitative sugar transporter mediated glucose transport pathway (IMP,ISO)

Rab family mediated signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Functional compartmentalization of endosomal trafficking for the synaptic delivery of AMPA receptors during long-term potentiation.	Brown TC, etal., J Neurosci. 2007 Nov 28;27(48):13311-5.
2.	Fer kinase/FerT and adherens junction dynamics in the testis: an in vitro and in vivo study.	Chen YM, etal., Biol Reprod. 2003 Aug;69(2):656-72. Epub 2003 Apr 16.
3.	Insulin and okadaic acid induce Rab4 redistribution in adipocytes.	Cormont M, etal., J Biol Chem. 1993 Sep 15;268(26):19491-7.
4.	rab15, a novel low molecular weight GTP-binding protein specifically expressed in rat brain.	Elferink LA, etal., J Biol Chem 1992 Mar 25;267(9):5768-75.
5.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6.	Local control of AMPA receptor trafficking at the postsynaptic terminal by a small GTPase of the Rab family.	Gerges NZ, etal., J Biol Chem. 2004 Oct 15;279(42):43870-8. Epub 2004 Aug 5.
7.	Protein transport to the dendritic plasma membrane of cultured neurons is regulated by rab8p.	Huber LA, etal., J Cell Biol. 1993 Oct;123(1):47-55.
8.	Muscle cells engage Rab8A and myosin Vb in insulin-dependent GLUT4 translocation.	Ishikura S and Klip A, Am J Physiol Cell Physiol. 2008 Oct;295(4):C1016-25. Epub 2008 Aug 13.
9.	Rab proteins in endocytosis and Glut4 trafficking.	Kaddai V, etal., Acta Physiol (Oxf). 2008 Jan;192(1):75-88.
10.	The GLUT4 code.	Larance M, etal., Mol Endocrinol. 2008 Feb;22(2):226-33. Epub 2007 Aug 23.
11.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
12.	GOA pipeline	RGD automated data pipeline
13.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
14.	Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosis.	Sahlender DA, etal., J Cell Biol. 2005 Apr 25;169(2):285-95. Epub 2005 Apr 18.
15.	Rab8A and Rab13 are activated by insulin and regulate GLUT4 translocation in muscle cells.	Sun Y, etal., Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):19909-14. doi: 10.1073/pnas.1009523107. Epub 2010 Nov 1.
16.	Lgl1 activation of rab10 promotes axonal membrane trafficking underlying neuronal polarization.	Wang T, etal., Dev Cell. 2011 Sep 13;21(3):431-44. doi: 10.1016/j.devcel.2011.07.007.
17.	GLUT4 translocation: the last 200 nanometers.	Watson RT and Pessin JE, Cell Signal. 2007 Nov;19(11):2209-17. Epub 2007 Jun 21.
18.	Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.	Wilhelm BG, etal., Science. 2014 May 30;344(6187):1023-8. doi: 10.1126/science.1252884.
19.	Insulin action on glucose transporters through molecular switches, tracks and tethers.	Zaid H, etal., Biochem J. 2008 Jul 15;413(2):201-15.

Additional References at PubMed

PMID:12477932	PMID:15489334	PMID:16902405	PMID:17574030	PMID:17646400	PMID:17765678	PMID:18094055	PMID:18504258	PMID:19056867	PMID:19061864	PMID:19625297	PMID:19864458
PMID:20458337	PMID:20592197	PMID:20937701	PMID:21255211	PMID:21844891	PMID:21951725	PMID:22159412	PMID:23389633	PMID:23979707	PMID:24006491	PMID:24421332	PMID:24469809
PMID:24478457	PMID:24625528	PMID:24648492	PMID:24683533	PMID:24947469	PMID:27103069	PMID:28005071	PMID:30053369	PMID:36800997	PMID:38691557

Genomics

Comparative Map Data

Rab8a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	17,688,049 - 17,709,412 (-)	NCBI		GRCr8
mRatBN7.2	16	17,654,027 - 17,675,385 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	17,654,034 - 17,675,678 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	17,713,745 - 17,734,289 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	18,845,873 - 18,866,846 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	17,766,676 - 17,787,222 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	19,355,047 - 19,376,776 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	19,355,048 - 19,376,776 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	19,213,378 - 19,235,107 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	18,078,519 - 18,099,882 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	18,079,199 - 18,089,589 (-)	NCBI
Celera	16	17,868,660 - 17,890,021 (-)	NCBI		Celera
Cytogenetic Map	16	p14	NCBI

RAB8A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	16,111,889 - 16,134,234 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	16,111,889 - 16,134,234 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	16,222,699 - 16,245,044 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	16,083,490 - 16,105,445 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	16,083,489 - 16,105,443	NCBI
Celera	19	16,124,417 - 16,146,398 (+)	NCBI		Celera
Cytogenetic Map	19	p13.11	NCBI
HuRef	19	15,793,443 - 15,815,391 (+)	NCBI		HuRef
CHM1_1	19	16,221,978 - 16,243,940 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	19	16,245,960 - 16,268,300 (+)	NCBI		T2T-CHM13v2.0

Rab8a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	72,915,044 - 72,935,210 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	72,915,044 - 72,937,748 (+)	Ensembl		GRCm39 Ensembl
GRCm38	8	72,161,200 - 72,181,366 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	72,161,200 - 72,183,904 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	74,685,099 - 74,705,265 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	75,090,189 - 75,110,355 (+)	NCBI		MGSCv36	mm8
Celera	8	76,516,674 - 76,537,034 (+)	NCBI		Celera
Cytogenetic Map	8	B3.3	NCBI
cM Map	8	34.84	NCBI

Rab8a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955524	1,403,811 - 1,416,005 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955524	1,403,811 - 1,416,005 (-)	NCBI	ChiLan1.0	ChiLan1.0

RAB8A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	20,979,867 - 21,002,037 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	19,985,674 - 20,007,842 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	15,598,029 - 15,619,988 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	16,580,720 - 16,602,189 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	16,580,720 - 16,602,189 (+)	Ensembl	panpan1.1		panPan2

RAB8A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	46,334,601 - 46,351,907 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	46,334,601 - 46,351,907 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	46,249,113 - 46,266,419 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	46,823,033 - 46,840,339 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	46,821,781 - 46,864,926 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	46,057,667 - 46,074,969 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	46,469,207 - 46,486,513 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	46,745,524 - 46,762,829 (-)	NCBI		UU_Cfam_GSD_1.0

Rab8a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	204,836,649 - 204,854,271 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936596	4,385,772 - 4,403,441 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936596	4,385,788 - 4,403,393 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RAB8A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	61,429,523 - 61,450,413 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	61,430,680 - 61,450,351 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	61,176,944 - 61,196,619 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RAB8A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	14,611,938 - 14,634,086 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	14,611,868 - 14,634,487 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666074	4,859,385 - 4,881,900 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rab8a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624908	1,116,610 - 1,132,111 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624908	1,119,356 - 1,132,029 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Rab8a
243 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	647
Count of miRNA genes:	255
Interacting mature miRNAs:	309
Transcripts:	ENSRNOT00000020748
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631561	Hcuc2	Hepatic copper content QTL 2	2.8		liver copper amount (VT:0003065)	liver total copper weight (CMO:0001507)	16	1	39533949	Rat
1582235	Insul8	Insulin level QTL 8	3.3	0.0063	blood insulin amount (VT:0001560)	calculated serum insulin level (CMO:0000359)	16	1	26727669	Rat
2307172	Activ4	Activity QTL 4	3.71	0.00023	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	16	1	33418960	Rat
1354584	Despr6	Despair related QTL 6	3.1	0.0067	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	16	1	39533930	Rat
2302380	Slep6	Serum leptin concentration QTL 6	3.36		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	16	1	32139025	Rat
737819	Hcas4	Hepatocarcinoma susceptibility QTL 4	4.43		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	16	4227609	46975965	Rat
631517	Scl9	Serum cholesterol level QTL 9	3.3		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	16	15726433	21034895	Rat
9590151	Scort8	Serum corticosterone level QTL 8	8.45	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	16	1	30836262	Rat
1354625	Despr7	Despair related QTL 7	3.16	0.016	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	16	1	44977551	Rat
61338	Bp23	Blood pressure QTL 23	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	16	4227609	49227609	Rat
61405	Niddm6	Non-insulin dependent diabetes mellitus QTL 6	3.66	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	16	4227609	48972724	Rat
631830	Alc7	Alcohol consumption QTL 7	2.9		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	16	1	26727669	Rat
7411664	Foco30	Food consumption QTL 30	11	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	16	1	44588133	Rat
1600378	Arunc4	Aerobic running capacity QTL 4		0.03	exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	16	380245	80345693	Rat
70183	BpQTLcluster13	Blood pressure QTL cluster 13	3.654		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	16	4227609	43025077	Rat
1600369	Hcas8	Hepatocarcinoma susceptibility QTL 8			liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	16	1	22477621	Rat
737826	Alc11	Alcohol consumption QTL 11	3.2		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	16	4227609	60252231	Rat
2303566	Bw90	Body weight QTL 90	2		body mass (VT:0001259)	body weight (CMO:0000012)	16	1	39533930	Rat
2312663	Slep9	Serum leptin concentration QTL 9		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	16	832236	59492508	Rat
2306902	Bp339	Blood pressure QTL 339		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	16	3380150	43025077	Rat
1300133	Rf24	Renal function QTL 24	3.64		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	16	3380150	21361552	Rat
2312660	Bw95	Body weight QTL 95		0.05	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	16	832236	59492508	Rat
2312666	Insul16	Insulin level QTL 16		0.01	blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	16	832236	59492508	Rat
634355	Rends4	Renal damage susceptibility QTL 4		0.05	kidney blood vessel morphology trait (VT:0000530)	organ lesion measurement (CMO:0000677)	16	1	26727669	Rat
61372	Bp40	Blood pressure QTL 40	2.2		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	16	4227730	17696785	Rat
2293343	Glom16	Glomerulus QTL 16	7.4		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	16	832236	46053497	Rat
6903319	Bw114	Body weight QTL 114	2.7	0.0037	body mass (VT:0001259)	body weight (CMO:0000012)	16	1	43534949	Rat
2312669	Stl23	Serum triglyceride level QTL 23		0.01	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	16	832236	59492508	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053998	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC071176	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC087584	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC105863	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474031	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ234475	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JN019799	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M83675	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000020748 ⟹ ENSRNOP00000020748

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	16	17,655,142 - 17,675,399 (-)	Ensembl
Rnor_6.0 Ensembl	16	19,355,048 - 19,376,776 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000077789 ⟹ ENSRNOP00000073296

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	16	17,654,034 - 17,675,399 (-)	Ensembl
Rnor_6.0 Ensembl	16	19,355,730 - 19,366,485 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000094332 ⟹ ENSRNOP00000086633

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	16	17,654,034 - 17,675,678 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000097895 ⟹ ENSRNOP00000084048

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	16	17,655,142 - 17,662,092 (-)	Ensembl

RefSeq Acc Id:

NM_053998 ⟹ NP_446450

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	16	17,688,049 - 17,709,412 (-)	NCBI
mRatBN7.2	16	17,654,027 - 17,675,385 (-)	NCBI
Rnor_6.0	16	19,355,047 - 19,376,776 (-)	NCBI
Rnor_5.0	16	19,213,378 - 19,235,107 (-)	NCBI
RGSC_v3.4	16	18,078,519 - 18,099,882 (-)	RGD
Celera	16	17,868,660 - 17,890,021 (-)	RGD

Sequence:

show sequence

GTAATATGGCGAAGACCTACGATTACCTGTTCAAGCTGCTGCTGATCGGGGACTCGGGGGTAGG
GAAGACCTGTGTCCTGTTCCGCTTCTCCGAGGACGCCTTCAATTCCACGTTCATCTCTACCATA
GGAATTGACTTTAAAATTAGGACCATAGAGCTCGATGGCAAGAGGATTAAACTGCAGATATGGG
ACACAGCCGGCCAGGAGCGGTTTCGGACAATCACGACAGCCTACTACAGGGGTGCCATGGGTAT
CATGCTGGTCTACGACATTACCAATGAGAAGTCCTTCGACAACATCCGGAATTGGATTCGGAAC
ATTGAGGAGCATGCCTCTGCAGATGTGGAGAAGATGATACTGGGGAATAAGTGTGATGTGAACG
ACAAGAGGCAGGTGTCCAAGGAACGGGGAGAAAAGCTGGCACTCGACTATGGGATCAAGTTCAT
GGAGACCAGCGCGAAGGCCAACATCAATGTGGAGAACGCATTTTTCACTCTCGCCAGGGATATC
AAAGCAAAAATGGACAAAAAATTGGAAGGGAACAGCCCACAGGGGAGCAGCCATGGAGTCAAGA
TCACAGTGGAGCAGCAGAAGAGGACCAGCTTCTTCCGGTGCAGTCTCCTGTGAGGACAAGGTCT
CTGCCCATTTGAGCCTGCGCTCAGCCCAGCTGACTGTGCCTGCCCCGGGCGAGCCTCCACCTCC
GATGCTCGGACACAGCTGCCCGGACTCAATTGAGAAATTGATTATTTTAGTAACCGTCTGATCT
TTTCCACCTTCAGAGATGGACCAAGTTAGAATTTTGCTGTTTTTCCTGTGTCATCTGCCAGTCA
GGCCTATCCGTCCCCTGCCGCATTGCCATAGATGGAGAGAGGTGGGTTGGGGCAAGGCAGCCTC
CATCTCCAGCCTTCTGCCCCTCCACCACAGAAGGGAGGTCAGTGGCAGTGCCCAGCCTGCCTGG
CCCCATACTCCAAGCACCACCACCAGGGCCACTGAGGGCCAAGCCTGGCACCTGCCTTCACCCG
TTCTCAGTTGTGGACAAGTGACAACCTTGTCCACTGTCTCCTTACGTGTCAAACCAAAGGGAAG
CACAAACTAAGGAAAGCCCACTTAGAGGACTTTGGAAGAAGTGGCTGGCTCCCATGACCAGAGC
AGGATGGGAGTCTGCAGTCCAGACTGAGGTGACATCACCACCACTCTCCCATGACCCACTGCCT
CAGTGGGCCCCAAAACCGGCTCCCTCATCTTCTCCTCCTCTGCCTGGCTCTAATCGGATGTTCC
TTTTCTAGCTAAGATGATTTTTTATTTTTTCAGATTCCTAACACCATGAAATGATTCTGTCATT
GATTTTCTAGCAGCATACCTGGGAGATTCAGAACCAGCGTGGTTGCCCTGCGCCCACAGGGCAC
CTGGTCCCTGAGACCCAGACAAGCATTCCATGGCACAGTGCTACCCTGCAGTCTTCACCCAGTT
GTGTTGTGACAGCTCTGTCCTCCTGGAAAGACTGATTGGGACCAGATGTCCTGTGGGAGGGGTG
TCATCTGAGAGCACCTTCCTTTTCACTCTAACCCTTCCCCGATGCTGCTGTCAGTCAAGCTGTC
AGCATCAAAATCTCTCCCTTTTTTGAAATTAAAACCAACGTACCAGCAATAGTCATCCGCCCTC
CCCTGGAGTCTCTGATGTACCATGTTTACACTGACCAGTGCACTCAGAAAATCAGATTAAAGTG
TATTTAAGAGGAAGCAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_446450	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA41997	(Get FASTA)	NCBI Sequence Viewer
	AAH71176	(Get FASTA)	NCBI Sequence Viewer
	AAH87584	(Get FASTA)	NCBI Sequence Viewer
	AAI05864	(Get FASTA)	NCBI Sequence Viewer
	AEJ31940	(Get FASTA)	NCBI Sequence Viewer
	EDL90831	(Get FASTA)	NCBI Sequence Viewer
	EDL90832	(Get FASTA)	NCBI Sequence Viewer
	EDL90833	(Get FASTA)	NCBI Sequence Viewer
	EDL90834	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000073296
	ENSRNOP00000073296.2
GenBank Protein	P35280	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_446450 ⟸ NM_053998
- UniProtKB:	Q3B8Q4 (UniProtKB/Swiss-Prot), Q6DKL2 (UniProtKB/Swiss-Prot), P35280 (UniProtKB/Swiss-Prot), F8V328 (UniProtKB/TrEMBL), A6K9Q5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAKTYDYLFKLLLIGDSGVGKTCVLFRFSEDAFNSTFISTIGIDFKIRTIELDGKRIKLQIWDT AGQERFRTITTAYYRGAMGIMLVYDITNEKSFDNIRNWIRNIEEHASADVEKMILGNKCDVNDK RQVSKERGEKLALDYGIKFMETSAKANINVENAFFTLARDIKAKMDKKLEGNSPQGSSHGVKIT VEQQKRTSFFRCSLL hide sequence

Ensembl Acc Id:

ENSRNOP00000073296 ⟸ ENSRNOT00000077789

Ensembl Acc Id:

ENSRNOP00000020748 ⟸ ENSRNOT00000020748

Ensembl Acc Id:

ENSRNOP00000086633 ⟸ ENSRNOT00000094332

Ensembl Acc Id:

ENSRNOP00000084048 ⟸ ENSRNOT00000097895

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P35280-F1-model_v2	AlphaFold	P35280	1-207	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699990

Promoter ID:

EPDNEW_R10512

Type:

multiple initiation site

Name:

Rab8a_1

Description:

RAB8A, member RAS oncogene family

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	16	19,376,784 - 19,376,844	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621144	AgrOrtholog
BioCyc Gene	G2FUF-11874	BioCyc
Ensembl Genes	ENSRNOG00000014621	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000077789	ENTREZGENE
	ENSRNOT00000077789.2	UniProtKB/Swiss-Prot
Gene3D-CATH	3.40.50.300	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7098881	IMAGE-MGC_LOAD
	IMAGE:7316419	IMAGE-MGC_LOAD
	IMAGE:7457017	IMAGE-MGC_LOAD
InterPro	P-loop_NTPase	UniProtKB/Swiss-Prot
	Small_GTP-bd_dom	UniProtKB/Swiss-Prot
	Small_GTPase	UniProtKB/Swiss-Prot
	Small_GTPase_Rab	UniProtKB/Swiss-Prot
KEGG Report	rno:117103	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:105355	IMAGE-MGC_LOAD
	MGC:124948	IMAGE-MGC_LOAD
	MGC:91545	IMAGE-MGC_LOAD
NCBI Gene	117103	ENTREZGENE
PANTHER	LD44762P	UniProtKB/Swiss-Prot
Pfam	Ras	UniProtKB/Swiss-Prot
PhenoGen	Rab8a	PhenoGen
PRINTS	RASTRNSFRMNG	UniProtKB/Swiss-Prot
PROSITE	RAB	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000014621	RatGTEx
SMART	ARF	UniProtKB/Swiss-Prot
	RAB	UniProtKB/Swiss-Prot
	RAN	UniProtKB/Swiss-Prot
	RAS	UniProtKB/Swiss-Prot
	RHO	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF52540	UniProtKB/Swiss-Prot
UniProt	A0A0G2K553_RAT	UniProtKB/TrEMBL
	A0A8I5ZYA9_RAT	UniProtKB/TrEMBL
	A0A8I6GF58_RAT	UniProtKB/TrEMBL
	A0A8L2QAL6_RAT	UniProtKB/TrEMBL
	A6K9Q3_RAT	UniProtKB/TrEMBL
	A6K9Q4_RAT	UniProtKB/TrEMBL
	A6K9Q5	ENTREZGENE, UniProtKB/TrEMBL
	F8V328	ENTREZGENE, UniProtKB/TrEMBL
	P35280	ENTREZGENE
	Q3B8Q4	ENTREZGENE
	Q5M970_RAT	UniProtKB/TrEMBL
	Q6DKL2	ENTREZGENE
	RAB8A_RAT	UniProtKB/Swiss-Prot
UniProt Secondary	Q3B8Q4	UniProtKB/Swiss-Prot
	Q6DKL2	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-01-20	Rab8a	RAB8A, member RAS oncogene family	Mel	mel transforming oncogene (derived from cell line NK14)- RAB8 homolog	Symbol and Name updated	1299863	APPROVED
2002-08-07	Mel	mel transforming oncogene (derived from cell line NK14)- RAB8 homolog			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed in spinal cord, heart, kidney, liver, and lung	633184

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

RGD Manual Annotations

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Imported Disease Annotations - CTD

RGD Manual Annotations